ORDER INFORMATION AND PRODUCT DATA. Immunoglobulin Class A: IgA E: IgE G: IgG Product Code M: IgM O: IgGM Product Classification

Transcription

1 ORDER INFORMATION AND PRODUCT DATA FI G 1601: 16 single test strips 1208: 12 microplate strips with 8 wells each 9601: 96 individual break-apart wells (12 microplate strips with 8 wells each) 5001: 50 individual tubes 0001: 100 individual tubes 1003: 10 slides with 3 fields each 1005: 10 slides with 5 fields each 2005: 20 slides with 5 fields each 1010: 10 slides with 10 fields each 1050: 10 slides with 50 fields each 1096: 10 slides with 96 fields each 1001: 10 slides to be incubated with 1 patient serum each 1002: 10 slides to be incubated with 2 patient sera each Immunoglobulin Class A: IgA E: IgE G: IgG Product Code M: IgM O: IgGM Product Classification P: Polyvalent (IgM) AF: Fluorescence-labelled antibodies for EUROIMMUN IIFT X: low-avide antibodies of class IgG CA: Control for EUROIMMUN IIFT (autoimmunity) H: high-avide antibodies of class IgG CI: Control for EUROIMMUN IIFT (infectious serology) CV: Control for EUROIMMUN IIFT (determination of further antibodies) CW: Control for EUROIMMUN Westernblot/EUROLINE-WB DA: EUROASSAY test system (autoimmunity) DL: EUROLINE test system (autoimmunity) DN: EUROLINE test system (infectious serology) DP: EUROLINE test system (allergology) DW: Westernblot/EUROLINE-WB test system (autoimmunity) DY: Westernblot/EUROLINE-WB test system (infectious serology) EA: Microplate ELISA test system (autoimmunity) EI: Microplate ELISA test system (infectious serology) EP: Microplate ELISA test system (allergology) EQ: Microplate ELISA test system (serum proteins and tumour markers) EV: Microplate ELISA test system (determination of further antibodies) FA: Test system for indirect immunofluorescence (autoimmunity) FB: Single slides for indirect immunofluorescence (autoimmunity) FI: Test system for indirect immunofluorescence (infectious serology) FK: Single slides for indirect immunofluorescence (infectious serology) FV: Test system for indirect immunofluorescence (determination of further antibodies) FX: Single slides for indirect immunofluorescence (determination of further antibodies) MN: EUROArray for Molecular Genetic Determinations RA: Radioimmunoassay (autoimmunity) RD: Radioimmunoassay (direct detection of autoantigens, hormone determination) ZF: Further reagents for EUROIMMUN IIFT ZZ: Other items for EUROIMMUN IIFT When placing an order, please indicate quantity, order number and designation of the required product. Examples: 2 x FA liver, monkey (2 test systems with 10 slides each, 10 fields per slide) 1 x FA kidney, rat / stomach, rat (1 test system with 20 slides, 5 fields per slide) 2 x FI G Measles virus (2 IgG class test systems with 10 slides each, 3 fields per slide) Test systems comprise all reagents needed to perform the serological investigation, for diagnostics in indirect immunofluorescence, e.g. slides, FITC-labelled antibodies human immunoglobulin, positive and negative control sera (not available for some products) as well as embedding medium, cover glasses, sachets of PBS and Tween 20. EUROSORB for the determination of IgM class antibodies is not included in the immunofluorescence test systems. Single slides are supplied with cover glasses only. Substrates consisting of cell cultures and tissues which do not appear in this catalogue can be made to specification. In addition, BIOCHIP Mosaics can be produced according to individual requirements. Apart from the customary package sizes and slide formats, special sizes are available as well. Quotations can be provided upon request. 62

2 Fluorescence-Labelled : Fluorescein (FITC) for EUROIMMUN IIFT Antiserum AF FITC-labelled anti-human IgA 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) AF FITC-labelled anti-human IgG 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) AF FITC-labelled anti-human IgM 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) AF FITC-labelled anti-human IgM 1.5 ml (ready for use) AF (IgA + IgG + IgM goat) 6.0 ml (ready for use) AF FITC-labelled anti-human Ig 1.5 ml (ready for use) AF (IgA + IgG goat) 6.0 ml (ready for use) AF FITC-labelled anti-human C3c 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) AF FITC-labelled anti-human IgG 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) primate absorbed AF FITC-labelled anti-human IgA 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) with Evans Blue AF FITC-labelled anti-human IgG 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) with Evans Blue AF FITC-labelled anti-human IgM 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) with Evans Blue AF FITC-labelled anti-human IgM 1.5 ml (ready for use) AF (IgA + IgG + IgM goat) 6.0 ml (ready for use) with Evans Blue AF FITC-labelled anti-human Ig 1.5 ml (ready for use) AF (IgA + IgG goat) 6.0 ml (ready for use) with Evans Blue Fluorescence- Labelled AF FITC-labelled anti-human C3c 1.5 ml (ready for use) AF (goat) 6.0 ml (ready for use) with Evans Blue 63

3 Controls for EUROIMMUN IIFT: Organ-Specific Autoantibodies Control (Ready for Use) CA autoantibody-free control IgG 0.1 ml (aab negative) CA antibodies thyroid microsomes IgG 0.1 ml and thyroglobulin (MAb + TAb control) CA antibodies thyroid microsomes IgG 0.1 ml (MAb control) CA antibodies thyroglobulin IgG 0.1 ml (TAb control) CA antibodies pancreas islets IgG 0.1 ml (islet cell ab control) CA antibodies pancreas islets IgG 0.1 ml control with indication of titer and JDF units CA antibodies glutamic acid decarboxylase IgG 0.1 ml (GAD ab control) CA antibodies parathyroid gland IgG 0.1 ml (parathyroid gland ab control) CA antibodies adrenal cortex IgG 0.1 ml (adrenal cortex ab control) CA antibodies ovary: theca cells IgG 0.1 ml (ovary ab control) CA antibodies ovary: zona pellucida IgG 0.1 ml (zona pellucida ab control) Controls for the Determination of Autoantibodies CA antibodies testis: Leydig cells IgG 0.1 ml (testis ab control) CA antibodies spermatozoa IgG 0.1 ml (spermatozoa ab control) CA antibodies pituitary gland antigens IgG 0.1 ml (pituitary gland ab control) CA antibodies brain: grey matter IgG 0.1 ml (stiff man syndrome; SMS control) CA antibodies Purkinje cell cytoplasm IgG 0.1 ml (Yo ab control) CA antibodies neurone nuclei: Ri antigen IgG 0.1 ml (Ri ab control) CA antibodies neurone nuclei: Hu antigen IgG 0.1 ml (Hu ab control) CA antibodies myelin IgG 0.1 ml (myelin ab control) CA antibodies myelin-associated IgG 0.1 ml glycoprotein (M ab control) CA antibodies neuroendothelium IgG 0.1 ml (neuroendothelium ab control) CA antibodies neurofilaments IgG 0.1 ml (neurofilament ab control) CA antibodies non-medullated nerves IgG 0.1 ml (non-medullated nerves ab control) CA antibodies granulocyte cytoplasm, IgG 0.1 ml cytoplasmic pattern (canca control, PR3-ab control) CA antibodies granulocyte cytoplasm, IgG 10 x 60 µl, ready for use CA aliquots from positive control for ANCA diagnostics 80 x 60 µl, ready for use (10 different fluorescence patterns) CA antibodies granulocyte cytoplasm, cytoplasmic pattern IgG 0.1 ml (canca control), control serum with indication of titer 64

4 Controls for EUROIMMUN IIFT: Organ-Specific Autoantibodies Control (Ready for Use) CA antibodies granulocyte cytoplasm, perinuclear pattern IgG 0.1 ml (panca control), control serum with indication of titer CA antibodies granulocyte cytoplasm, perinuclear pattern IgG 0.1 ml (panca control, MPO ab control) CA antibodies granulocyte cytoplasm, perinuclear pattern IgG 0.1 ml (panca control, MPO ab control) control serum with indication of titer CA antibodies granulocyte cytoplasm, IgG 0.1 ml perinuclear pattern (xanca control) CA antibodies thrombocytes IgG 0.1 ml (thrombocyte ab control) CA antibodies renal glomeruli IgG 0.1 ml (Goodpasture syndrome; GBM ab control) CA antibodies renal tubuli IgG 0.1 ml (TBM ab control) CA antibodies alveolar basement membrane IgG 0.1 ml (ABM ab control) CA antibodies liver-specific protein IgG 0.1 ml (LSP ab control) CA antibodies liver membrane IgG 0.1 ml (LMA control) CA M antibodies bile ducts IgM 0.1 ml (bile ducts IgM control) CA antibodies bile canaliculi IgG 0.1 ml (bile canaliculi ab control) CA antibodies liver-kidney microsomes IgG 0.1 ml (LKM ab control) CA antibodies parietal cells IgG 0.1 ml (PCA control) CA antibodies intrinsic factor IgG 0.1 ml (intrinsic factor ab control) CA antibodies parietal cells + intrinsic factor IgG 0.1 ml (PCA + intrinsic factor ab control) Controls for the Determination of Autoantibodies CA A antibodies intestinal goblet cells IgA 0.1 ml (ulcerative colitis; UC IgA control) CA G antibodies intestinal goblet cells IgG 0.1 ml (ulcerative colitis; UC IgG control) CA antibodies pancreas acini IgG 0.1 ml (Crohn s disease 1 control) CA antibodies pancreas secretion IgG 0.1 ml (Crohn s disease 2 control) CA antibodies striated muscles IgG 0.1 ml (myasthenia gravis control) CA antibodies striation IgG 0.1 ml (heart 1 ab control) CA antibodies intercalated discs IgG 0.1 ml (heart 2 ab control) CA antibodies epidermis: desmosomes IgG 0.1 ml (pemphigus vulgaris control) CA antibodies epidermis: basement membrane IgG 0.1 ml (bullous pemphigoid control) CA antibodies keratin IgG 0.1 ml (filaggrin ab control) 65

5 Controls for EUROIMMUN IIFT: Systemic Autoantibodies Control (Ready for Use) CA antibodies cell nuclei IgG 0.1 ml (ANA control), homogeneous pattern CA antibodies cell nuclei (ANA control), IgG 8 aliquots concentrate 50 µl each CA homogeneous pattern, control serum with 96 aliquots concentrate 50 µl each indication of titer, reference serum W 1064 (66/233) CA antibodies cell nuclei, IgG 20 x 60 µl, ready for use CA aliquots from positive control for ANA diagnostics 80 x 60 µl, ready for use (20 different fluorescence patterns) CA antibodies cell nuclei (ANA control), IgG 0.1 ml homogeneous pattern control serum with indication of titer CA antibodies dsdna IgG 0.1 ml (dsdna ab control) CA antibodies cell nuclei IgG 0.1 ml (ANA control), nucleolar pattern CA antibodies RNA IgG 0.1 ml (RNA ab control) CA antibodies cell nuclei IgG 0.1 ml (ANA control), granular pattern CA antibodies U1-nRNP IgG 0.1 ml CA antibodies Sm IgG 0.1 ml CA antibodies SS-A (Ro) IgG 0.1 ml Controls for the Determination of Autoantibodies CA antibodies SS-B (La) IgG 0.1 ml CA antibodies Scl-70 IgG 0.1 ml CA antibodies PCNA (cyclin I) IgG 0.1 ml CA antibodies mitosin (cyclin II) IgG 0.1 ml CA antibodies Sp100 (nuclear granula, IgG 0.1 ml nuclear dots; PBC-associated) CA antibodies Ku IgG 0.1 ml (Ku ab control) CA antibodies nuclear membrane IgG 0.1 ml CA antibodies cell nuclei IgG 0.1 ml (ANA control), centromere pattern CA antibodies spindle fibers (MSA-1) IgG 0.1 ml CA antibodies mitochondria IgG 0.1 ml (AMA control) CA antibodies mitochondria IgG 0.1 ml (AMA M2 control; PBC-associated) CA antibodies mitochondria IgG 0.1 ml (AMA M9 control) CA antibodies ribosomes IgG 0.1 ml CA antibodies Golgi apparatus IgG 0.1 ml CA antibodies F-actin IgG 0.1 ml (F-actin control) CA antibodies vimentin IgG 0.1 ml CA antibodies histidyl-trna synthetase IgG 0.1 ml (Jo-1 ab control) 66

6 Controls for EUROIMMUN IIFT: Systemic Autoantibodies Control (Ready for Use) CA antibodies smooth muscles IgG 0.1 ml (ASMA control) CA A antibodies endomysium IgA 0.1 ml (endomysium IgA control) CA A antibodies endomysium plus gliadin (GAF-3X) IgA 0.1 ml (endomysium plus gliadin GAF-3X IgA control) CA antibodies reticulin IgG 0.1 ml (reticulin ab control) CA G antibodies elastin IgG 0.1 ml (elastin ab control) CA G antibodies vascular endothelium IgG 0.1 ml (vascular endothelium ab control) Further control sera for the determination of autoantibodies available upon request. Controls for the Determination of Autoantibodies 67

7 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI A antibodies Bordetella pertussis IgA 0.1 ml IgA positive control CI G antibodies Bordetella pertussis IgG 0.1 ml CI M antibodies Bordetella pertussis IgM 0.1 ml IgM positive control CI Z Bordetella pertussis/parapertussis IgA, IgG, IgM 0.1 ml negative control CI A antibodies Bordetella parapertussis IgA 0.1 ml IgA positive control CI G antibodies Bordetella parapertussis IgG 0.1 ml CI M antibodies Bordetella parapertussis IgM 0.1 ml IgM positive control CI G * antibodies Haemophilus influenzae IgG 0.1 ml CI Z Haemophilus influenzae IgA, IgG, IgM 0.1 ml negative control CI A antibodies Helicobacter pylori IgA 0.1 ml IgA positive control CI G antibodies Helicobacter pylori IgG 0.1 ml CI M antibodies Helicobacter pylori IgM 0.1 ml IgM positive control CI Z Helicobacter pylori IgA, IgG, IgM 0.1 ml negative control Controls for Infectious Serology CI A antibodies Campylobacter jejuni IgA 0.1 ml IgA positive control CI G antibodies Campylobacter jejuni IgG 0.1 ml CI Z Campylobacter jejuni/coli IgA, IgG, IgM 0.1 ml negative control CI G * antibodies Campylobacter coli IgG 0.1 ml CI G * antibodies Klebsiella pneumoniae IgG 0.1 ml CI Z * Klebsiella pneumoniae IgA, IgG, IgM 0.1 ml negative control CI G antibodies Treponema pallidum IgG 0.1 ml FTA CI M antibodies Treponema pallidum IgM 0.1 ml FTA IgM positive control CI Z Treponema pallidum IgA, IgG, IgM 0.1 ml FTA negative control CI G antibodies Treponema pallidum IgG 50 µl serum concentrate for FTA absorption CI G antibodies Reiter spirochetes IgG 0.1 ml unspecific FTA CI G antibodies Borrelia afzelii/b. burgdorferi/b. garinii IgG 0.1 ml CI M antibodies Borrelia afzelii/b. burgdorferi/b. garinii IgM 0.1 ml IgM positive control *) Currently not available as IVD in the European Union. 68

8 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI Z Borrelia afzelii/b. burgdorferi/b. garinii IgA, IgG, IgM 0.1 ml negative control CI 213a-0101 M antibodies Borrelia (OspC antigen) IgM 0.1 ml IgM positive control CI 213b-0101 G antibodies Borrelia (VlsE antigen) IgG 0.1 ml CI Z * Listeria monocytogenes IgA, IgG, IgM 0.1 ml negative control CI G * antibodies Listeria monocytogenes 1/2a IgG 0.1 ml CI G * antibodies Listeria monocytogenes 4b IgG 0.1 ml CI P antibodies Legionella pneumophila serotypes 1 or 4 IgM 0.1 ml positive control CI G * antibodies Legionella pneumophila serotype 1 IgG 0.1 ml CI Z Legionella pneumophila/non-pneumophila IgA, IgG, IgM 0.1 ml negative control CI 215b-0101 P antibodies Legionella pneumophila mixture IgM 0.1 ml IgM positive control CI 215d-0101 P antibodies Legionella pneumophila mixture IgM 0.1 ml IgM positive control CI 215f-0101 P antibodies Legionella pneumophila mixture IgM 0.1 ml IgM positive control CI 215h-0101 P antibodies Legionella pneumophila mixture IgM 0.1 ml IgM positive control CI G * antibodies Yersinia enterocolitica IgG 0.1 ml (for diagnosing various forms of arthritis) CI Z * Yersinia enterocolitica IgA, IgG, IgM 0.1 ml negative control (for diagnosing various forms of arthritis) CI A antibodies Chlamydia trachomatis IgA 0.1 ml IgA positive control Controls for Infectious Serology CI G antibodies Chlamydia trachomatis IgG 0.1 ml CI M antibodies Chlamydia trachomatis IgM 0.1 ml IgM positive control CI Z Chlamydia IgA, IgG, IgM 0.1 ml negative control CI A antibodies Chlamydia pneumoniae IgA 0.1 ml IgA positive control CI G antibodies Chlamydia pneumoniae IgG 0.1 ml CI M antibodies Chlamydia pneumoniae IgM 0.1 ml IgM positive control CI A antibodies Chlamydia psittaci IgA 0.1 ml IgA positive control CI G antibodies Chlamydia psittaci IgG 0.1 ml CI 219a-0101 G * antibodies Afipia felis IgG 0.1 ml CI 219a-0101 Z * Afipia felis IgA, IgG, IgM 0.1 ml negative control *) Currently not available as IVD in the European Union. 69

9 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI 219b-0101 G antibodies Bartonella henselae IgG 0.1 ml CI 219b-0101 M antibodies Bartonella henselae IgM 0.1 ml IgM positive control CI 219b-0101 Z Bartonella henselae/quintana IgA, IgG, IgM 0.1 ml negative control CI 219d-0101 G antibodies Bartonella quintana IgG 0.1 ml CI 219d-0101 M antibodies Bartonella quintana IgM 0.1 ml IgM positive control CI G antibodies Mycoplasma hominis IgG 0.1 ml CI Z Mycoplasma hominis/pneumoniae and IgA, IgG, IgM 0.1 ml Ureaplasma urealyticum negative control CI G antibodies Mycoplasma pneumoniae IgG 0.1 ml CI M antibodies Mycoplasma pneumoniae IgM 0.1 ml IgM positive control CI G antibodies Ureaplasma urealyticum IgG 0.1 ml CI A antibodies Leishmania donovani IgA 0.1 ml IgA positive control CI G antibodies Leishmania donovani IgG 0.1 ml CI M antibodies Leishmania donovani IgM 0.1 ml IgM positive control Controls for Infectious Serology CI Z Leishmania donovani IgA, IgG, IgM 0.1 ml negative control CI G antibodies Plasmodia IgG 0.1 ml CI Z Plasmodia IgA, IgG, IgM 0.1 ml negative control CI A antibodies Echinococcus granulosus IgA 0.1 ml IgA positive control CI G antibodies Echinococcus granulosus IgG 0.1 ml CI Z Echinococcus granulosus IgA, IgG, IgM 0.1 ml negative control CI A * antibodies Toxoplasma gondii IgA 0.1 ml IgA positive control CI G antibodies Toxoplasma gondii IgG 0.1 ml CI H high-avid antibodies Toxoplasma gondii IgG 0.1 ml CI M antibodies Toxoplasma gondii IgM 0.1 ml IgM positive control CI X low-avid antibodies Toxoplasma gondii IgG 0.1 ml CI Z Toxoplasma gondii IgA, IgG, IgM 0.1 ml negative control CI G * antibodies HIV-1 IgG 0.1 ml CI Z * HIV-1/2 IgA, IgG, IgM 0.1 ml negative control *) Currently not available as IVD in the European Union. 70

10 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI G * antibodies HIV-2 IgG 0.1 ml CI G antibodies Herpes simplex virus 1 (HSV-1) IgG 0.1 ml CI M antibodies Herpes simplex virus 1 (HSV-1) IgM 0.1 ml IgM positive control CI Z HSV-1/HSV-2 IgA, IgG, IgM 0.1 ml negative control CI G antibodies Herpes simplex virus 2 (HSV-2) IgG 0.1 ml CI M antibodies Herpes simplex virus 2 (HSV-2) IgM 0.1 ml IgM positive control CI G antibodies human herpes virus 6 (HHV-6) IgG 0.1 ml CI M antibodies human herpes virus 6 (HHV-6) IgM 0.1 ml IgM positive control CI Z human herpes virus 6 (HHV-6) IgA, IgG, IgM 0.1 ml negative control CI A antibodies Cytomegalovirus (CMV) IgA 0.1 ml IgA positive control CI G antibodies Cytomegalovirus (CMV) IgG 0.1 ml CI H high-avid antibodies Cytomegalovirus (CMV) IgG 0.1 ml CI M antibodies Cytomegalovirus (CMV) IgM 0.1 ml IgM positive control CI X low-avid antibodies Cytomegalovirus (CMV) IgG 0.1 ml CI Z Cytomegalovirus (CMV) IgA, IgG, IgM 0.1 ml negative control CI G antibodies Rubella virus IgG 0.1 ml CI H high-avid antibodies Rubella virus IgG 0.1 ml Controls for Infectious Serology CI X low-avid antibodies Rubella virus IgG 0.1 ml CI Z Rubella virus IgA, IgG, IgM 0.1 ml negative control CI G antibodies SARS coronavirus IgG 0.1 ml CI Z SARS coronavirus IgA, IgG, IgM 0.1 ml negative control CI G antibodies Measles virus IgG 0.1 ml CI M antibodies Measles virus IgM 0.1 ml IgM positive control CI Z Measles virus IgA, IgG, IgM 0.1 ml negative control CI G antibodies Mumps virus IgG 0.1 ml CI M antibodies Mumps virus IgM 0.1 ml IgM positive control *) Currently not available as IVD in the European Union. 71

11 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI Z Mumps virus IgA, IgG, IgM 0.1 ml negative control CI A antibodies Varicella zoster virus (VZV) IgA 0.1 ml IgA positive control CI G antibodies Varicella zoster virus (VZV) IgG 0.1 ml CI H high-avid antibodies Varicella zoster virus (VZV) IgG 0.1 ml CI M antibodies Varicella zoster virus (VZV) IgM 0.1 ml IgM positive control CI X low-avid antibodies Varicella zoster virus (VZV) IgG 0.1 ml CI Z Varicella zoster virus (VZV) IgA, IgG, IgM 0.1 ml negative control CI G antibodies TBE virus IgG 0.1 ml CI M antibodies TBE virus IgM 0.1 ml IgM positive control CI Z TBE virus IgA, IgG, IgM 0.1 ml negative control CI G antibodies West Nile virus IgG 0.1 ml CI H high-avid antibodies West Nile virus IgG 0.1 ml CI M antibodies West Nile virus IgM 0.1 ml IgM positive control Controls for Infectious Serology CI X low-avid antibodies West Nile virus IgG 0.1 ml CI Z West Nile virus IgA, IgG, IgM 0.1 ml negative control CI G antibodies Japanese encephalitis virus IgG 0.1 ml CI M antibodies Japanese encephalitis virus IgM 0.1 ml IgM positive control CI Z antibodies Japanese encephalitis virus IgA, IgG, IgM 0.1 ml negative control CI G antibodies Yellow fever virus IgG 0.1 ml CI M antibodies Yellow fever virus IgM 0.1 ml IgM positive control CI Z Yellow fever virus IgA, IgG, IgM 0.1 ml negative control CI 266a-0101 G antibodies Dengue virus IgG 0.1 ml CI 266a-0101 M antibodies Dengue virus IgM 0.1 ml IgM positive control CI 266a-0101 Z Dengue virus IgA, IgG, IgM 0.1 ml negative control CI A antibodies Respiratory syncytial virus (RSV) IgA 0.1 ml IgA positive control CI G antibodies Respiratory syncytial virus (RSV) IgG 0.1 ml CI M antibodies Respiratory syncytial virus (RSV) IgM 0.1 ml IgM positive control 72

12 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI Z Respiratory syncytial virus (RSV) IgA, IgG, IgM 0.1 ml negative control CI A antibodies Adenovirus IgA 0.1 ml IgA positive control CI G antibodies Adenovirus IgG 0.1 ml CI M antibodies Adenovirus IgM 0.1 ml IgM positive control CI Z Adenovirus IgA, IgG, IgM 0.1 ml negative control CI A antibodies Influenza virus type A IgA 0.1 ml IgA positive control CI G antibodies Influenza virus type A IgG 0.1 ml CI M antibodies Influenza virus type A IgM 0.1 ml IgM positive control CI Z Influenza virus type A/B IgA, IgG, IgM 0.1 ml negative control CI A antibodies Influenza virus type B IgA 0.1 ml IgA positive control CI G antibodies Influenza virus type B IgG 0.1 ml CI M antibodies Influenza virus type B IgM 0.1 ml IgM positive control CI A antibodies Parainfluenza virus types 1-4 IgA 0.1 ml IgA positive control CI G antibodies Parainfluenza virus types 1-4 IgG 0.1 ml CI M antibodies Parainfluenza virus types 1-4 IgM 0.1 ml IgM positive control CI Z Parainfluenza virus IgA, IgG, IgM 0.1 ml negative control CI G antibodies Coxsackie virus IgG 0.1 ml Controls for Infectious Serology CI Z Coxsackie virus IgA, IgG, IgM 0.1 ml negative control CI 275a-0101 G antibodies Echo virus IgG 0.1 ml CI 275a-0101 Z Echo virus IgA, IgG, IgM 0.1 ml negative control CI 277a G * antibodies Sandfly fever virus IgG 0.1 ml CI 277a Z * Sandfly fever virus IgA, IgG, IgM 0.1 ml negative control CI 278h G antibodies Hantavirus IgG 0.1 ml CI 278h M antibodies Hantavirus IgM 0.1 ml IgM positive control CI 278h Z Hantavirus IgA, IgG, IgM 0.1 ml negative control CI A antibodies Epstein-Barr virus capsid antigen (EBV-CA) IgA 0.1 ml IgA positive control *) Currently not available as IVD in the European Union. 73

13 Controls for EUROIMMUN IIFT: Infectious Serology Control (Ready for Use) CI G antibodies Epstein-Barr virus capsid antigen (EBV-CA) IgG 0.1 ml CI H high-avid antibodies Epstein-Barr virus capsid antigen (EBV-CA) IgG 0.1 ml CI M antibodies Epstein-Barr virus capsid antigen (EBV-CA) IgM 0.1 ml IgM positive control CI X low-avid antibodies Epstein-Barr virus (EBV-CA) IgG 0.1 ml CI Z Epstein-Barr virus (EBV) IgA, IgG, IgM 0.1 ml negative control CI C antibodies Epstein-Barr virus nuclear antigen (EBNA) IgG 0.1 ml complement-binding, positive control CI A antibodies Epstein-Barr virus early antigen (EBV-EA) IgA 0.1 ml IgA positive control CI G antibodies Epstein-Barr virus early antigen (EBV-EA) IgG 0.1 ml CI H high-avid antibodies Epstein-Barr virus early antigen (EBV-EA) IgG 0.1 ml CI X low-avid antibodies Epstein-Barr virus early antigen (EBV-EA) IgG 0.1 ml CI 279a-0101 Z * Crimean Congo fever virus IgA, IgG, IgM 0.1 ml negative control CI A antibodies Candida albicans IgA 0.1 ml IgA positive control CI G antibodies Candida albicans IgG 0.1 ml Controls for Infectious Serology CI M antibodies Candida albicans IgM 0.1 ml IgM positive control CI Z Candida albicans IgA, IgG, IgM 0.1 ml negative control CI 293a-0101 G antibodies Chikungunya virus IgG 0.1 ml CI 293a-0101 M antibodies Chikungunya virus IgM 0.1 ml IgM positive control CI 293a-0101 Z Chikungunya virus IgA, IgG, IgM 0.1 ml negative control Further control sera for infectious serology available upon request. Controls for EUROIMMUN IIFT: Determination of Further Control (Ready for Use) CV A antibodies Saccharomyces cerevisiae IgA 0.1 ml IgA positive control CV G antibodies Saccharomyces cerevisiae IgG 0.1 ml CV M antibodies Saccharomyces cerevisiae IgM 0.1 ml IgM positive control CV Z Saccharomyces cerevisiae IgA, IgG, IgM 0.1 ml negative control CV A antibodies gliadin (GAF-3X) IgA 0.1 ml (gliadin-gaf-3x IgA control) CV G antibodies gliadin (GAF-3X) IgG 0.1 ml (gliadin-gaf-3x IgG control) 74

14 Controls for EUROIMMUN Westernblots/EUROLINE-WB Control (50-fold concentrate) CW A antibodies Helicobacter pylori IgA 0.1 ml IgA positive control CW G antibodies Helicobacter pylori IgG 0.1 ml CW ZA antibodies Helicobacter pylori IgA 0.1 ml IgA negative control CW ZG antibodies Helicobacter pylori IgG 0.1 ml IgG negative control CW YM antibodies Treponema pallidum IgM 0.1 ml IgM weakly reactive control CW G antibodies Borrelia afzelii IgG 0.1 ml (Westernblot/EUROLINE-WB) CW M antibodies Borrelia afzelii IgM 0.1 ml IgM positive control (Westernblot/EUROLINE-WB) CW YM antibodies Borrelia afzelii IgM 0.1 ml IgM weakly reactive control (Westernblot/EUROLINE-WB) CW ZG antibodies Borrelia afzelii IgG 0.1 ml IgG negative control (Westernblot/EUROLINE-WB) CW ZM antibodies Borrelia afzelii IgM 0.1 ml IgM negative control (Westernblot/EUROLINE-WB) CW G antibodies Borrelia afzelii IgG 0.1 ml 2 (Westernblot/EUROLINE-WB) CW G antibodies Borrelia burgdorferi IgG 0.1 ml CW M antibodies Borrelia burgdorferi IgM 0.1 ml IgM positive control CW YM antibodies Borrelia burgdorferi IgM 0.1 ml IgM weakly reactive control CW ZG antibodies Borrelia burgdorferi IgG 0.1 ml IgG negative control Controls for Infectious Serology CW ZM antibodies Borrelia burgdorferi IgM 0.1 ml IgM negative control CW G antibodies Borrelia garinii IgG 0.1 ml CW M antibodies Borrelia garinii IgM 0.1 ml IgM positive control CW YM antibodies Borrelia garinii IgM 0.1 ml IgM weakly reactive control CW ZG antibodies Borrelia garinii IgG 0.1 ml IgG negative control CW ZM antibodies Borrelia garinii IgM 0.1 ml IgM negative control CW A antibodies Yersinia enterocolitica IgA 0.1 ml IgA positive control (for diagnosing various forms of arthritis) CW G antibodies Yersinia enterocolitica IgG 0.1 ml (for diagnosing various forms of arthritis) 75

15 Controls for EUROIMMUN Westernblots/EUROLINE-WB Control (50-fold concentrate) CW YA antibodies Yersinia enterocolitica IgA 0.1 ml IgA weakly reactive control (for diagnosing various forms of arthritis) CW ZA antibodies Yersinia enterocolitica IgA 0.1 ml IgA negative control (for diagnosing various forms of arthritis) CW ZG antibodies Yersinia enterocolitica IgG 0.1 ml IgG negative control (for diagnosing various forms of arthritis) CW G antibodies Herpes simplex virus (HSV) IgG 0.1 ml CW ZG antibodies Herpes simplex virus (HSV) IgG 0.1 ml IgG negative control CW ZM antibodies Herpes simplex virus (HSV) IgM 0.1 ml IgM negative control CW G antibodies Epstein-Barr virus (EBV) IgG 0.1 ml Controls for Infectious Serology 76

16 EUROASSAY for the Determination of Autoantibodies (Test Systems) Substrate Slides x Fields DA G thyroid peroxidase (TPO) IgG EUROASSAY strip 10 x 03 DA G thyroglobulin (TG) with antigens 10 x 05 DA G myeloperoxidase (MPO) IgG EUROASSAY strip 10 x 03 DA G proteinase 3 (PR3) with antigens 10 x 05 DA G AMA M2, LKM-1, SLA/LP IgG EUROASSAY strip 10 x 03 with antigens DA G LKM-1, LC-1, SLA/LP IgG EUROASSAY strip 10 x 03 DA G with antigens 10 x 05 DA G Liver Profile IgG EUROASSAY strip 10 x 03 AMA M2, LKM-1, LC-1, SLA/LP with antigens DA G Anti-ENA ProfilePlus IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens 10 x 05 Jo-1 separately) DA G Anti-ENA ProfilePlus with AMA M2 IgG EUROASSAY strip 10 x 03 (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens Jo-1, AMA M2 separately) DA G SLE Profile IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, dsdna, with antigens 10 x 05 histones, ribosomal P-proteins separately) DA G Anti-ENA ProfilePlus with dsdna IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, dsdna, Jo-1, with antigens 10 x 05 SS-A, SS-B, Scl-70 separately) DA G Anti ENA Profile IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B separately) with antigens 10 x 05 DA G Anti-ENA ProfilePlus with centromere protein B IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens 10 x 05 Jo-1, centromere protein B separately) DA G Anti-ENA ProfilePlus with histones IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens 10 x 05 Jo-1, histones separately) DA G Anti-ENA ProfilePlus with PM-Scl IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens 10 x 05 Jo-1, PM-Scl separately) DA G SLE Profile 2 IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, dsdna, with antigens 10 x 05 histones, nucleosomes separately) DA G SLE Profile 3 IgG EUROASSAY strip 10 x 03 DA G (dsdna, histones, nucleosomes, with antigens 10 x 05 ribosomal P-proteins separately) EUROASSAY/EUROLINE Westernblot DA G Anti-ENA ProfilePlus with Ro-52 IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens 10 x 05 Jo-1, Ro-52 separately) DA G Scl-70, Jo-1, PM-Scl IgG EUROASSAY strip 10 x 03 DA G with antigens 10 x 05 DA G Anti-ENA ProfilePlus with ribosomal P-proteins IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, SS-A, SS-B, Scl-70, with antigens 10 x 05 Jo-1, ribosomal P-proteins separately) DA G Anti-ENA ProfilePlus with nucleosomes IgG EUROASSAY strip 10 x 03 DA G (nrnp/sm, Sm, nucleosomes, Jo-1, with antigens 10 x 05 SS-A, SS-B, Scl-70 separately) DA O AMA Profile IgGM EUROASSAY strip 10 x 03 (AMA M2, M4, M9 separately) with antigens If requested the EUROASSAY can be manufactured individually, thus offering special antigen combinations, e.g. dsdna, histones, nucleosomes, PM-Scl, nrnp/sm, Sm, SS-A (60 kda), Ro-52, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere protein B, AMA M2, M4, M9, SLA/LP, LC-1, LKM-1. Slides with only one field can be delivered as special format. 77

17 EUROLINE for the Determination of Autoantibodies (Test Systems) Substrate DL G Neuronal Antigens Profile IgG membrane strip with antigens 16 x 01 (amphiphysin, PNMA2 (Ma-2), Ri, Yo, Hu separately) DL G Gangliosides Profile 1 IgG membrane strip with antigens 16 x 01 (GM1, GD1b, GQ1b separately) DL M Gangliosides Profile 1 IgM membrane strip with antigens 16 x 01 (GM1, GD1b, GQ1b separately) DL G Gangliosides Profile 2 IgG membrane strip with antigens 16 x 01 (GM1, GM2, GM3, GD1a, GD1b, GT1b, GQ1b separately) DL M Gangliosides Profile 2 IgM membrane strip with antigens 16 x 01 (GM1, GM2, GM3, GD1a, GD1b, GT1b, GQ1b separately) DL G myeloperoxidase (MPO) IgG membrane strip with antigens 16 x 01 proteinase 3 (PR3) DL G myeloperoxidase (MPO) IgG membrane strip with antigens 16 x 01 proteinase 3 (PR3) glomerular basement membrane (GBM) DL G Liver Profile 2 IgG membrane strip with antigens 16 x 01 (AMA M2, M2-3E, LKM-1, LC-1, SLA/LP separately) DL G Liver Profile IgG membrane strip with antigens 16 x 01 (AMA M2, LKM-1, LC-1, SLA/LP separately) DL G Profile Autoimmune Liver Diseases IgG membrane strip with antigens 16 x 01 (AMA M2, M2-3E, Sp100, PML, gp210, LC-1, LKM-1, SLA/LP, Ro-52 separately) DL G Myositis Profile IgG membrane strip with antigens 16 x 01 (Mi-2, Ku, PM-Scl, Jo-1, PL-7, PL-12, Ro-52 separately) DL G Myositis Profile 2 IgG membrane strip with antigens 16 x 01 (Mi-2, Ku, PM-Scl, U1-nRNP 70K, U1-nRNP A, U1-nRNP C, SRP, Jo-1, PL-7, PL-12, OJ, EJ, Ro-52 separately) EUROASSAY/EUROLINE Westernblot DL G Anti-ENA ProfilePlus 1 IgG membrane strip with antigens 16 x 01 (nrnp/sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1 separately) DL G ANA Profile 3 IgG membrane strip with antigens 16 x 01 (nrnp/sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, centromere protein B, PCNA, dsdna, nucleosomes, histones, ribosomal P-proteins, AMA M2 separately) DL G ANA Profile 1 IgG membrane strip with antigens 16 x 01 (nrnp/sm, Sm, SS-A, Ro-52, SS-B, Scl-70, Jo-1, centromere protein B, dsdna, nucleosomes, histones, ribosomal P-proteins separately) 78

18 EUROLINE for Infectious Serology (Test Systems) Substrate DN G EUROLINE Borrelia-RN-AT IgG membrane strip with antigens 32 x 01 DN G (p18, p19, p20, p21, p58, 240 x 01 OspC (p25), p39, p83, LBb, LBa, VlsE Bg, VlsE Bb, VlsE Ba separately) DN M EUROLINE Borrelia-RN-AT IgM membrane strip with antigens 32 x 01 DN M (OspC Bg nativ, OspC Bb nativ, 240 x 01 OspC Ba nativ, p39, VlsE Bb separately) DN G Malaria Profile 1 IgG membrane strip with antigens 16 x 01 (Plasmodium falciparum HRP-2 and MSP-2, Plasmodium vivax MSP and CSP separately) DN G * TO.R.C.H. Profile IgG membrane strip with antigens 16 x 01 (Toxoplasma gondii, Rubella virus, CMV, HSV-1, HSV-2 separately) DN M * TO.R.C.H. Profile IgM membrane strip with antigens 16 x 01 (Toxoplasma gondii, Rubella virus, CMV, HSV-1, HSV-2 separately) DN 278h G Hanta virus Profile 1 IgG membrane strip with antigens 16 x 01 PUUV (Puumala virus) DOBV (Dobrava virus) HNTV (Hantaan virus) DN 278h M Hanta virus Profile 1 IgM membrane strip with antigens 16 x 01 PUUV (Puumala virus) DOBV (Dobrava virus) HNTV (Hantaan virus) DN G EBV Profile 2 IgG membrane strip with antigens 16 x 01 (VCA gp125, VCA p19, EBNA-1, p22, EA-D separately) DN M EBV Profile 2 IgM membrane strip with antigens 16 x 01 (VCA gp125, VCA p19, EBNA-1, p22, EA-D separately) EUROLINE for Allergology (Test Systems) From , all allergy profiles will contain cross-reactive carbohydrate determinants (CCD). Substrate DP E allergy profile inhalation IgE membrane strip with allergens 16 x 01 (g1, g3, g6, g12, t2, t3, t4, t7, w1, w6, w9, d1, d2, e1, e2, e3, m1, m2, m3, m6) DP E allergy profile inhalation 2 IgE membrane strip with allergens 16 x 01 (g6, g12, t2, t3, t4, w6, w9, d1, d2, e1, e2, e3, e6, e82, e84, es4, m1, m2, m3, m6) EUROASSAY/EUROLINE Westernblot DP E allergy profile pediatric inhalation IgE membrane strip with allergens 16 x 01 (g6, g12, t2, t3, t4, w6, w8, w9, d1, d2, e1, e2, e3, e6, e82, e84, m1, m2, m3, m6) DP E allergy profile Mediterranean inhalation IgE membrane strip with allergens 16 x 01 (g2, g6, t3, t4, t9, t11, t23, t210, w1, w6, w9, w19, d1, d2, d70, e1, e2, e3, m2, m6) DP E allergy profile inhalation South East Asia IgE membrane strip with allergens 16 x 01 (gs1, ts19, t104, t119, t223, ds1, i6, e1, e2, es172, e6, e71, e82, e84, ms1, ms4, m5, m12, m45, u134) DP E allergy profile inhalation Korea 1 IgE membrane strip with allergens 16 x 01 (g2, g3, g6, g12, ts3, ts11, ts14, ts15, t4, t7, t12, t19, t71, w100, f1, f2, f14, f23, f234, f95) DP E allergy profile inhalation Korea 2 IgE membrane strip with allergens 16 x 01 (w1, w6, w8, w11, w14, w12, m1, m2, m3, m6, e1, e2, i6, h1, d1, d2, g7, ts4, t1, t16) DP E allergy profile inhalation China IgE membrane strip with allergens 16 x 01 (gs23, ts21, t3, t8, t11, t12, t14, t70, ws18, w1, w6, w9, es1, d1, d2, i6, ms5, m1, u73, u80) *) Currently not available as IVD in the European Union. 79

19 EUROLINE for Allergology (Test Systems) From , all allergy profiles will contain cross-reactive carbohydrate determinants (CCD). Substrate DP E allergy profile inhalation Middle East IgE membrane strip with allergens 16 x 01 (g1, g6,g12, t2, t3, t7, t9, w1, w6, w8, d1, d2, i6, e1, e84, m1, m2, m3, m5, m6) DP E allergy profile inhalation Gulf IgE membrane strip with allergens 16 x 01 (g6, g12, t2, t3, t7, t9, w1, w6, d1, d2, i6, e1, e2, e3, e17, m1, m2, m3, m5, m6) DP E allergy profile inhalation Turkey IgE membrane strip with allergens 16 x 01 (gs12, gs15, gs21, g12, ts23, ts24, t9, t70, ws19, ws20, ws21, d1, d2, i6, es2, es172, e1, e2, e3, e4, e6, e80, e81, ms11, ms12, m1, m2, m3, m6) DP E * allergy profile inhalation India IgE membrane strip with allergens 16 x 01 (g6, g12, g20, t18, w4, w27, w29, ds1, d2, i6, e1, e2, e11, e85, m3, m37, u81, u126, u129, u140) DP E allergy profile food IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f45, f4, f5, f9, f13, f14, f17, f20, f49, f84, f237, f25, f31, f35, f85, f3, f23) DP E allergy profile food 2 IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f78, f4, f5, f14, f10, f13, f17, f20, f49, f84, f95, f25, f31, f35, f85, f3, f23) DP E allergy profile food South East Asia 1 IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f4, f9, f10, f14, f13, f17, f63, f64, f83, fs10, fs14, f23, f24, f80, f179, f105, f336) DP E * allergy profile food South East Asia 2 IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f4, f9, f10, f14, f13, f17, f63, f340, f83, fs10, fs14, f23, f24, f80, f179, f105, f336) DP E allergy profile food Korea 1 IgE membrane strip with allergens 16 x 01 (f1, f2, f14, f81, f3, f23, f40, f41, f234, f26, f27, f83, fs15, f95, f4, f6, f9, f292, f47, f48) DP E allergy profile food Korea 2 IgE membrane strip with allergens 16 x 01 (f1, f2, f14, f81, f3, f23, f40, f41, f234, f26, f27, f83, fs15, f95, f4, f6, f9, f292, f47, f48) EUROASSAY/EUROLINE Westernblot DP E allergy profile food China IgE membrane strip with allergens 16 x 01 (f1, f2, f4, f7, f27, f88, fs35, f13, f14, fs40, f25, f292, fs42, f23, f234, f3, f41, f56, fs41, fs77) DP E allergy profile food Middle East IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f78, e204, f4, f14, f45, f13, f17, f20, f33, f49, f29, f25, f31, f85, f48, f89, f88) DP E allergy profile food Gulf IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f105, f4, f14, f45, fs36, f13, f29, f33, f44, f93, f25, f31, f48, f83, f88, f3, f23) DP E allergy profile food Cyprus 1 IgE membrane strip with allergens 16 x 01 (f1, f2, f75, f76, f77, f78, f81, f4, f45, f5, f14, f7, f79, f9, f10, f13, f144, f17, f20, f49) DP E allergy profile food Cyprus 2 IgE membrane strip with allergens 16 x 01 (f177, f23, f234, f24, f258, f3, f37, f40, f41, f80, f48, f108, f132, f212, f25, f292, f31, f35, f47, f96) DP E allergy profile food Cyprus 3 IgE membrane strip with allergens 16 x 01 (f26, f63, f83, f88, f237, f29, f32, f328, f33, f44, f49, f72, f84, f95, f281, f86, f89, f90, f105, f93) DP E allergy profile food Turkey IgE membrane strip with allergens 16 x 01 (f1, f75, f2, f169, f78, f4, f79, f9, f14, f10, f13, f17, f144, U87, f222, f73, f33, f44, f49, f92, f84, f146, f328, f25, f31, f35, f48, f95, f97, f122, f132, fs14, fs10, fs43, f83) DP E allergy profile food India IgE membrane strip with allergens 16 x 01 (f2, f75, f168, f4, f9, f14, f13, f36, f49, f50, f35, f38, f48, f244, f83, f89, f74, f240, f23, f24) DP E allergy profile atopy IgE membrane strip with allergens 16 x 01 (g6, g12, t3, w6, d1, e1, e2, e3, m2, m6, f1, f2, f3, f4, f9, f14, f17, f31, f35, f49) *) Currently not available as IVD in the European Union. 80

20 EUROLINE for Allergology (Test Systems) From , all allergy profiles will contain cross-reactive carbohydrate determinants (CCD). Substrate DP E allergy profile atopy 3 IgE membrane strip with allergens 16 x 01 (g6, t3, t4, w6, d1, d2, e1, e2, e3, m2, m3, f1, f75, f2, f3, f4, f13, f14, f31, f49) DP E allergy profile pollen-food cross reactions IgE membrane strip with allergens 16 x 01 (g6, t3, w6, f4, f5, f13, f17, f20, f48, f89, f271, f275, f44, f49, f348, f237, f328, f31, f35, f85) DP E allergy profile pediatrics IgE membrane strip with allergens 16 x 01 (gx, t3, w6, d1, d2, e1, e2, e3, m2, m3, m6,f1, f2, f3, f4, f9, f13, f14, f17, f31, f35, f49, f75, f76, f77, f78) DP E allergy profile atopy China IgE membrane strip with allergens 16 x 01 (ts20, w1, w6, ds1, h1, e1, e2, i6, ms1, u80, f1, f2, f13, f14, f27, f88, fs33, fs34, f23, f234) DP E allergy profile atopy China 2 IgE membrane strip with allergens 16 x 01 (w18, w6, u80, ds1, es1, ms5, f245, fs56, fs43, fs42, fs34) DP E allergy profile atopy China 3 IgE membrane strip with allergens 16 x 01 (ts22, w6, us1, ds1, es1, h1, ms5, f245, fs9, fs43, fs56, fs34, fs44) DP E allergy profile insect venoms IgE membrane strip with allergens 16 x 01 (i1, i3) Westernblot/EUROLINE-WB for the Determination of Autoantibodies (Test Systems) Antigen and Antigen Source DW G EUROLINE-WB whole antigen, SDS extract IgG 16 x 01 DW G neuronal antigens (Hu, Yo, Ri) of primate cerebellum 24 x 01 plus recombinant Hu, Yo and Ri plus recombinant Hu, Yo and Ri DW G EUROLINE-WB whole antigen, SDS extract IgG 16 x 01 DW G HEp-2 cell antigens of HEp-2 cells plus native SS-A 30 x 01 (nucleolar, cytoplasmic, mitochondrial) and recombinant CENP B and Ro-52 plus CENP B, SS-A and Ro-52 Westernblot/EUROLINE-WB for Infectious Serology (Test Systems) Antigen and Antigen Source EUROASSAY/EUROLINE Westernblot DY A Helicobacter pylori whole antigen, IgA 16 x 01 DY A SDS extract 30 x 01 DY G Helicobacter pylori whole antigen, IgG 16 x 01 DY G SDS extract 30 x 01 DY G Treponema pallidum 15 kda, 17 kda, IgG 16 x 01 DY G 45 kda (tmpa), 47 kda 24 x 01 DY M Treponema pallidum 15 kda, 17 kda, IgM 16 x 01 DY M 45 kda (tmpa), 47 kda 24 x 01 DY G EUROLINE-WB 15 kda, 17 kda, 45 kda (tmpa) 47 kda, IgG 16 x 01 DY G Treponema pallidum plus purified cardiolipin 24 x 01 plus cardiolipin DY M EUROLINE-WB 15 kda, 17 kda, 45 kda (tmpa) 47 kda, IgM 16 x 01 DY M Treponema pallidum plus purified cardiolipin 24 x 01 plus cardiolipin DY G Borrelia afzelii whole antigen, SDS extract of IgG 16 x 01 DY G Borrelia afzelii 30 x 01 DY G 32 x 01 DY G 240 x 01 81

21 Westernblot/EUROLINE-WB for Infectious Serology (Test Systems) Antigen and Antigen Source DY M Borrelia afzelii whole antigen, SDS extract of IgM 16 x 01 DY M Borrelia afzelii 30 x 01 DY M 32 x 01 DY M 240 x 01 DY G EUROLINE-WB whole antigen, SDS extract of IgG 16 x 01 DY G Borrelia Borrelia afzelii plus VlsE 30 x 01 DY G 240 x 01 DY M EUROLINE-WB whole antigen, SDS extract of IgM 16 x 01 DY M Borrelia Borrelia afzelii plus VlsE 30 x 01 DY M 240 x 01 DY G Borrelia burgdorferi whole antigen, SDS extract of IgG 16 x 01 DY G Borrelia burgdorferi sensu stricto 30 x 01 DY G 32 x 01 DY G 240 x 01 DY M Borrelia burgdorferi whole antigen, SDS extract of IgM 16 x 01 DY M Borrelia burgdorferi sensu stricto 30 x 01 DY M 32 x 01 DY M 240 x 01 DY G Borrelia garinii whole antigen, SDS extract IgG 16 x 01 DY G of Borrelia garinii 30 x 01 DY G 32 x 01 DY G 240 x 01 DY M Borrelia garinii whole antigen, SDS extract of IgM 16 x 01 DY M Borrelia garinii 30 x 01 DY M 32 x 01 DY M 240 x 01 DY A Yersinia enterocolitica isolated virulence factors IgA 16 x 01 DY A Detection of antibodies virulence factors of the (release proteins, Yop) 30 x 01 Yersinia enterocolitica pathogen in human serum of Yersinia enterocolitica (for diagnosing various forms of arthritis). EUROASSAY/EUROLINE Westernblot DY G Yersinia enterocolitica isolated virulence factors IgG 16 x 01 DY G Detection of antibodies virulence factors of the (release proteins, Yop) 30 x 01 Yersinia enterocolitica pathogen in human serum of Yersinia enterocolitica (for diagnosing various forms of arthritis). DY G Echinococcus granulosus whole antigen, IgG 16 x 01 DY G SDS extract 24 x 01 DY G EUROLINE-WB whole antigen, SDS extract of the IgG 16 x 01 DY G Herpes simplex virus 1 (HSV-1) HSV-1 strain McIntire plus gg2 24 x 01 plus HSV-2 type-specific purified by affinity chromatography glycoprotein G2 DY M EUROLINE-WB whole antigen, SDS extract of the IgM 16 x 01 DY M Herpes simplex virus 1 (HSV-1) HSV-1 strain McIntire plus gg2 24 x 01 plus HSV-2 type-specific purified by affinity chromatography glycoprotein G2 DY G * Cytomegalovirus whole antigen, IgG 16 x 01 DY G * (CMV) SDS extract 24 x 01 DY M * Cytomegalovirus whole antigen, IgM 16 x 01 DY M * (CMV) SDS extract 24 x 01 DY G Rubella virus whole antigen IgG 24 x 01 DY G Epstein-Barr virus whole antigen, IgG 16 x 01 DY G (EBV) SDS extract 24 x 01 DY M Epstein-Barr virus whole antigen, IgM 16 x 01 DY M (EBV) SDS extract 24 x 01 *) Currently not available as IVD in the European Union. 82

22 Microplate ELISA for the Determination of Autoantibodies (Test Systems) Antigen and Antigen Source Calibration EA G thyroid peroxidase recombinant, expression with IgG 10/50/500 IU/ml 96 x 01 (TPO) Baculovirus vector in insect cells EA G thyroglobulin native, human IgG 20/100/1000 IU/ml 96 x 01 (TG) thyroid gland EA G TSH receptor native, IgG 0/1/2/8/40 IU/l 96 x 01 (thyrotropin receptor) porcine thyrocytes EA G TSH receptor native, IgG 0.1/1/2/8/40 IE/l 96 x 01 (thyrotropin receptor) porcine thyrocytes Fast ELISA EA G GAD recombinant IgG 5/15/35/120/ 96 x 01 glutamic acid decarboxylase 250/2000 IU/ml EA G GAD/IA2 Pool recombinant IgG 4/10/20/70/ 96 x 01 glutamic acid decarboxylase/ 145/450 IU/ml tyrosine phosphatase EA G IA2 recombinant IgG 10/20/75/250/400/ 96 x 01 tyrosine phosphatase 4000 IU/ml EA G ANCA Profile (proteinase 3, MPO, elastase, native, human IgG semi-quantitative 12 x 08 cathepsin G, BPI, lactoferrin separately) neutrophil granulocytes recombinant, human c-dna expressed in human cell line EA G canca: native, human IgG 2/20/200 RU/ml 96 x 01 proteinase 3 neutrophil granulocytes (capture test) EA G canca: native, human IgG 2/20/200 RU/ml 96 x 01 proteinase 3 neutrophil granulocytes (PR3-hn-hr) recombinant, human c-dna expressed in human cell line EA G panca: native, human IgG 2/20/200 RU/ml 96 x 01 myeloperoxidase (MPO) neutrophil granulocytes EA G glomerular basement membrane alpha-3-chain of type IV collagen, IgG 2/20/200 RU/ml 96 x 01 (GBM) incl. NC1 domain, from bovine kidney EA G soluble liver antigen/ recombinant SLA/LP IgG 2/20/200 RU/ml 96 x 01 liver-pancreas antigen (SLA/LP) expression in E. coli EA G cytosolic recombinant formiminotransferase IgG semi-quantitative 96 x 01 liver antigen type 1 cyclodeaminase, expression with (LC-1) baculovirus vector in insect cells EA G liver-kidney microsomes recombinant cytochrome P450 IID6, IgG 2/20/200 RU/ml 96 x 01 LKM-1 expression with baculovirus vector in insect cells EA G parietal cells native, H+/K+ ATPase, IgG 2/20/200 RU/ml 96 x 01 (PCA) porcine gastric mucosa EA G intrinsic factor native, porcine IgG 2/20/200 RU/ml 96 x 01 gastric mucosa Microplate ELISA for the Determination of Autoantibodies EA G BP180-4X recombinant, expression in E. coli, IgG 2/20/200 RU/ml 48 x 01 tetramer of the NC16A domain EA G cyclic citrullinated peptides highly purified synthetic IgG 1/5/20/100/200 RU/ml 96 x 01 (CCP) CCP (second generation) EA G histones native, mixture of individually isolated IgG 2/20/200 RU/ml 96 x 01 histone types H1/H2a/H2b/H3/H4, bovine EA G double-stranded DNA highly purified genomic IgG 10/100/800 IU/ml 96 x 01 (dsdna) double-stranded DNA EA G dsdna-ncx highly purified genomic IgG 10/100/800 IU/ml 96 x 01 double-stranded DNA, complexed with nucleosomes EA G C1q native, IgG 2/20/200 RU/ml 96 x 01 human C1q 83