The Shanghai Regional Report on the Progress in TCM Development. Xiaodong Cheng

Transcription

1 The Shanghai Regional Report on the Progress in TCM Development Xiaodong Cheng Tongji University Shanghai Consortium for Globalization of Chinese Medicine Aug. 28 th, 2011 Shanghai, China Shanghai Consortium for Globalization of Chinese Medicine 12 members Tongji University Shanghai University of TCM Fudan University Shanghai Jiao Tong University East China University of Science & Technology Second Military Medical University Shanghai Institutes for Biological Sciences, CAS Pasteur Institute of Shanghai, CAS Shanghai Research Center for TCM Modernization Shanghai Innovative Research Center of TCM Shanghai R&D Center for Standardization of TCM Johnson & Johnson China

2 The 1 st Class Clinical Training Beijing arbin antong The 2 nd Class Trainee From Mainland ong Kong Taiwan Project: The Clinical Trial of Cangpu Soup Time: Fund: 3 million RMB Source: Shanghai Key Project Atherosclerosis causes severe complications.

3 verview of present progress Finished assessment indicators Status Ethics committee approval Establish methods and standards of quality control for herb materials and pharmaceutical preparation Design the technology for decoction preparation Purchase authentic and sufficient traditional Chinese herb materials Simvastatin and placebo Enrollment 94 Melanoma initiating cells Kem 1 chondroitin sulfate proteoglycan 4 (CSPG4)

4 SFC I Collaborative Program Dr. Xiaodong Cheng Tongji University Dr. Soldano Ferrone University of Pittsburgh Targeting of melanoma initiating cells with CSPG4-specific monoclonal antibodies and Chinese medical herbs of Leguminosae family Astragalus Root extract ex8 and Sophora Flavescens Ait The Active Components of Fuzheng uayu Decoction Action against Liver Fibrosis relating to Angiogenesis --- Shanghai University of TCM endothelial cell proliferation model CAMs model zebrafish angiogenesis model

5 Safety Evaluation and Quality Control on Toxic Medicinal erbs Research interests Isolation and identification of toxic compounds Inspection methods (qualitative and quantitative) Metabolism pathway and toxicokinetics Toxicity and mechanism Quality control 1 2 P450 1 PAs metabolism Totally, 105 papers about toxic medicinal herbs have been published, two patents have been applied and three safety standards have been established and adopted by Ch.P. 2 C S C 2 36KDa 27KDa 21KDa 36KDa 千里光 千里光 Senecio scandens 川楝子 川楝素 toosendanin 川楝子 Melia toosendan Cliv AC 阿多尼弗林碱 adonifoline Pro-caspase-3 (35KDa) Cleaved caspase-3 (19KDa) Cleaved caspase-3 (17KDa) Actin (43KDa) --- Shanghai R&D Center for Standardization of TCM Ac Ac Engineering Center for Traditional Chinese Medicine Modernization, Engineering Research Center for TCM --- East China University of Science and Technology Research Groups: System biology laboratory Modern technology and process laboratory Machinery and equipment laboratory Engineering Center for TCM Modernization (founded) Developing (ew building) Engineering of traditional Chinese medicine Year

6 Discovery of atural Products with novel structures and interesting biological activities Dozens of plants of Abies genus, Veratrum genus, Incarvillea genus, Rhododendron genus, Euonymus genus were studied systematicaly, about 1060 compounds with various structure types have been isolated. Among these, there are 254 new compounds, including 10 new carbon skeleton compounds. 5 compounds with novel skeletons were reviewed in ot Press of atural Product Reports. --- Modern Research Center for TCM, Second Military Medical University KDD: knowledge discovery from databases to extract information with literatures and other documents from various sources Clustering: use cluster analysis tools to group TCM prescriptions, compound scaffolds, etc into a number of subfamilies for identifying common features in each subfamilies SIRC TCM Information Quality Evaluation System (STIQES): proprietarily developed by SIRC to evaluate credibility, safety and availability of TCM information for prescriptions, herbs and active compounds SAPR TM TCM Database Service Upgrade Launched four-level reliable information services for multinational clients from pharmaceutical, healthcare and skincare industries such as J&J, DSM, DAE, Pierre Fabre --- Shanghai Innovative Research Center of TCM

7 A ew TCM Drug Developed- DanQi Tablet Water-soluble phenolic acids Phenolic acids otoginsenoside s Sanqi saponins Saponins + Lipophilic tanshinones Salvia otoginseng Flavones, proteins, amino acids --- Shanghai Research Center for TCM Modernization Thank you!