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1 EFFECTS OF BILAYER GELATIN/BETA TRICALCIUM PHOSPHATE SPONGES LOADED WITH MESENCHYMAL STEM CELLS, CHONDROCYTES, BMP-2, AND PRP ON OSTEOCHONDRAL DEFECTS OF THE TALUS IN HORSES Courtney James and Jessica Gladney
2 WHAT IS OSTEOCHONDROSIS? AKA Osteochondrosis Dessecans Failure of complete endochondral ossification during bone growth May cause joint inflammation, changes in articular surface, bone chips, bone cysts, etc.
3 TERMS TO KNOW Talus- bone in the hock joint PRP- platelet rich plasma MSCs- mesenchymal stem cells Chondrocytes- cartilage building and maintenance cells BMP-2- causes cell differentiation Bilayer-gelatin/ beta-tricalcium phosphate sponges- basis for building bone matrix QCT- quantitative computed tomography- measures bone mineral density
4 IMPORTANCE IN EQUINE LAMENESS Prevalent throughout the entire industry Difficult to treat Steroid Injections Scoping NSAIDS
5 WHAT IS THE MAIN QUESTION? Is bone scaffolding a possible solution to treating osteochondrosis in horses? Why bilayer? AC and SB Treat both areas of the joint.
6 WHAT IS THE HYPOTHESIS? This study is aimed to evaluate the efficacy of bilayer scaffolds: a gelatin/ beta-tricalcium sponge loaded with chondrocytes, MSCs, and PRP and a GT sponge loaded with MSCs and BMP-2 for the repair of osteochondral defects of the talus in horses. (Seo et al.)
7 FIGURE 1 What do these radiographs show? (A and B)- radiographs of the induced defect after surgery (C and D)- radiographs of the defects at 4 months
8 FIGURE 2 (A)- appearance of the tarsal defect of test group A (treated) at 4 months after surgery (B)- appearance of defect on untreated test group B Notice a difference between A and B?
9 FIGURE 3 AC View (A)- appearance of defects at 4 months after surgery from test group A (B)- defect at 4 months on test group B SB View (C and D)- defects from test group A and test group B
10 FIGURE 4 What does Safranin-O stain for? Positive for cartilage (A and B)- Safranin-O staining of test group A and test group B shows that test group A has more Safranin-o positive cells What is the staining used in C and D for? Type 2 collagen (C and D)- appearance of defects in test group A and B using immunostaining
11 RESULTS All horses recovered from surgery and completed the study Test group showed decrease in tarsal defect severity compared to control group in all assays- Radiographs, Quantitative Computed Analysis, Macroscopic, and Histologic
12 CONCLUSION AND LIMITATIONS Bone scaffolding is a possible treatment for osteochondrosis in horses PRP growth factor concentration not measured Assumption that left and right hind joint is the same Short time period- only 4 months Horses euthanized, cannot see the long term effects of bilayer scaffolding
13
14 SOURCES Seo, J.P.T., Takafumi. Tsuzuki, Nao. Haneda, Shingo. Yamada, Kazutaka. Furuoka, Hidefumi. Tabata, Yasuhiko. Sasaki, Naoki., Effects of bilayer gelatin/beta- tricalcium phosphate sponges loaded with mesenchymal stem cells, chondrocytes, bone morphogenetic protein-2, and platelet rich plasma on osteochondral defects of the talus in horses.. Research in Veterinary Science, : p %252Ffeatures%252Fdrugdirectory%252Foctupdate%252FUPJ02800.jpg%3Bhttp%253A%252F%252Fwww.webmd.com%252Fdrugs%252F2%252Fdrug-6160%252Fdepo-medrolinjection%252Fdetails%3B288%3B216 %2F&h=0&w=0&tbnid=FXObwWveTv2qkM&zoom=1&tbnh=258&tbnw=181&docid=A4ydYqb1zXT0bM&tbm=isch&client=firefoxa&ei=eJ9XVJa5MsegNtLkgPgG&ved=0CAQQsCUoAA petmeds.com%252Fimages%252Fproducts%252F420%252F108142_420.jpg%3Bhttp%253A%252F%252Fwww.1800petmeds.com%252FPrevicox-prod html %3B420%3B US:official&channel=fflb&biw=1280&bih=619&source=lnms&tbm=isch&sa=X&ei=8aJXVNxhhaU2qZeCyAI&ved=0CAYQ_AUoAQ#facrc=_&imgdii=_&imgrc=1x5PnbjxyBrpaM %253A%3BdVjj0sr6ZEU5NM%3Bhttp%253A%252F%252Fm.memegen.com%252Fwsyb2z.jpg%3Bhttp%253A%252F%252Fwww.memegen.com%252Fmeme%252Fwsyb2z %3B578%3B650 US:official&channel=fflb&biw=1280&bih=619&source=lnms&tbm=isch&sa=X&ei=3y5YVNHiEJG0yASvx4KQCA&ved=0CAYQ_AUoAQ#rls=org.mozilla:en- US:official&channel=fflb&tbm=isch&q=naughty+race+horse&facrc=_&imgdii=_&imgrc=-o2bFV3QZDBZeM%253A%3BZuNNrCET91f8CM%3Bhttp%253A%252F%252Fmedia-cachecd0.pinimg.com%252F236x%252F80%252F08%252F9e%252F80089edde296d3c97bbe68a7a5e16a40.jpg%3Bhttp%253A%252F%252Fwww.pinterest.com%252Fthawes%252Fgirls-bestfriend-a-horse%252F%3B236%3B189
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