Branded Ingredient Brochure

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1 Branded Ingredient Brochure Y4554/516 Plaza Francesc Macià, Barcelona. Spain

2 The first Health Food Ingredient for Mobility Mobilee is a patented natural ingredient with a unique composition that is particularly rich in hyaluronic acid, polysaccharides and collagen. Mobilee has been developed according to the strictest standards of Researched by Bioiberica, the leaderin joint health Mobilee is the result of years of research conducted by bioibérica, the leading joint-health biotechnology company. With more than 35 years of experience in the pharmaceutical and clinical efficacy and safety. Numerous clinical trials have shown its efficacy in improving mobility and in joint and muscle care. Mobilee is the first functional ingredient for mobility, which opens the door to the development of an innovative new area with great potential. nutraceutical industries, Bioibérica is one of the leading companies in the field of products, active ingredients and personalized medicine for joint health and mobility.

3 Mobility and Joint Care: a Growing Market Consumers 4-65 Active LifeStyle Joint Discomfort 43% Recent studies have shown that consumers aged between 4 and 65 are increasingly concerned with maintaining an active lifestyle and look for products that allow them to maintain this lifestyle, which is associated with a good state of health. (1) In recent years the amount of physical activity people undertake in their spare time has grown considerably among the 45 to 65 age group. In Europe, more than 4% of the population in this age range practices sport on a regular basis. (2) 43% of the population aged between 45 and 65 suffer from joint problems. (3) Moreover, more than half of those who suffer joint problems are not satisfied with the treatment they receive. (4) 1- Ten nutraceutical trends for 212 INNOVA. 2- Eurobarometer Sports and Physical Activiity National Center for Health Statistics. Health, United States, 211: Hyattsville, md Estudio CONfEPAR, Confederación Española de Pacientes Reumáticos (28). 4 - Estudio CONFEPAR, Confederación Española de Pacientes Reumáticos (28).

4 What is Mobilee? The effect of Mobilee More than a hyaluronic acid Mobilee is a natural ingredient extracted from rooster comb, rich in hyaluronic acid, polysaccharides and collagen. Sodium Hyaluronate [C14H2NNaO11]n Hydrolized Proteins (mainly collagen) polypeptides, peptides and amino acids. Polysaccharides. Unique composition Mobilee is a patented ingredient with a unique, natural composition whose synergy demonstrates greater efficacy than the individual pure ingredients alone. (1) 1- Torrent et al (29) Osteoarthritis and Cartilage. 17( 1): S , 3, 2, 1, None IL-1b (1mg/ml) IL-1b + Mobilee (5µg/ml) Torrent et al (21) Osteoarthritis and Cartilage. 18(2): S Study carried out with human fibroblasts grown in the presence of IL-1B. Anti-inflammatory effect Mobilee reduces the release of Prostaglandin E2 (PGE2), an important proinflammatory mediator. Reduction in the level of synovial effusion (mm) Placebo Mobilee *P<.5 Sanchez et al (213) Ann Nutr Metab 63 (suppl. 1): 538 Mobilee reduces synovial effusion, a common sign of inflammation. Reduction of Joint discomfort Increase of muscular strength How does Mobilee work? Lubricating the joints When there is joint discomfort, the quantity and quantity of hyaluronic acid in the synovial fluid of the joints is drastically reduced. Mobilee lubricates the joints, stimulating endogenous synthesis of Hyaluronic Acid and resulting in a tenfold increase in its secretion into the synovial fluid. eha (µg/ml) (synoviocytes from OA patients) x1 Placebo Mobilee (2µg/ml) Torrent et al (29) Osteoarthritis and Cartilage. 17(1): S * ** 2 *** Peak torque (24º/sec extension) *P<.5 Months **P<.5 ***P<.1 Placebo Mobilee Placebo Mobilee Sanchez et al (213) Ann Nutr Metab 63 (suppl. 1): 538 Martínez-Puig et al (213) Mediterr J Nutr Metab.6:63-68 Mobilee improves mobility

5 Why Mobilee? The first functional ingredient for mobility Mobilee is a unique ingredient that opens the door to a broad growing market. Safe and effective Numerous scientific studies and four randomized double-blind clinical trials have shown that Mobilee is safe and effective. Easy to formulate Thanks to its low dose (4-8 mg) and its organoleptic properties, Mobilee, is easy to formulate and does not change either the smell or taste of the foodstuff it s added to. Solid regulatory Mobilee has been authorized as a Novel Food by the European Comission, EFSA and has received organoleptic GRAS status in the USA.

6 The leader in joint health Bioibérica is a biotechnology company specializing in the research, manufacture and commercialization of biomolecules such as Chondroitin Sulfate, glucosamine, Heparin and Hyaluronic Acid. More than 4 years of experience testify to our expertise in joint health. Taking a 36º approach, the company focusses on this therapeutic area from all angles: prevention, diagnosis and treatment. Bioibérica leads the pharmaceuticals market in chondro-protective products for the treatment of arthritis, the nutraceutical and food sectors with products aimed at prevention and treatment of mobility and joint problems, and the personalized medicine area, with diagnostic genetic testing, biomarker tests and cell therapy. A partnership to succeed in mobility Bioibérica makes its knowledge available to all of its partners: Technical knowledge of the molecules we research and produce. Medical and scientific knowledge, working together with the main kols. Market knowledge thanks to our international presence and specialization. For the joint development of the market. Your success is our goal