WE VE GOT THE POWDER THE KEY TO YOUR NEW MEDICATED CHEWING GUM

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1 WE VE GOT THE POWDER THE KEY TO YOUR NEW MEDICATED CHEWING GUM

2 Health in Gum is a powdered excipient specially designed to formulate and produce medicated chewing gum It combines gum base and sweeteners in a unique matrix product to which you can add active ingredients to create compressed chewing gum Health in Gum is a new oral drug-delivery system designed to fit the demands of the pharmaceutical and nutraceutical industries INNOVATION at your service Medicated chewing gum is an innovative drug-delivery system that releases active ingredients through the mechanical action of chewing, and offers a wide range of advantages: Attractive format, highly patient compliant Immediate effect, local and systemic It is easy to use: Health in Gum performs excellently using standard tableting equipment It is a great solution for sensitive APIs: it works at room temperature and has a water activity value of 0.5% Reduced exposure to gastrointestinal side effects Suitable for therapeutic and functional use Inherent benefits of chewing With the CAFOSA GUARANTEE Cafosa is part of Wrigley (subsidiary of Mars Inc.) and is the world s leading gum base supplier. Gum base is the main ingredient in chewing gum, used in confectionery and pharmaceutical industries.

3 MAKING COMPRESSED CHEWING GUM has never been so easy FITS your needs Choose the grade that suits your requirements Add the desired active ingredient Choose your flavours Mix all the ingredients Compress the product to create your medicated chewing gum Example formula Dimenhydrinate 20 mg Tablet Gum (for 1500mg total gum piece) Weight % mg Dimenhydrinate 1,33 20,0 HEALTH IN GUM 93, ,0 Powder Flavour 1,80 27,0 Lubricant 1,50 22,5 Glidant 0,90 13,5 Liquid Flavour 0,60 9,0 Intense Sweeteners 0,20 3,0 HiG PWD 01 HiG PWD 03 HiG PWD 04 Gum Base content 25% 35% 30% Polyol content Sorbitol/Xylitol Sorbitol/Isomalt Sorbitol/Mannitol/Xylitol Presence of plasticizer Triacetin No presence Triacetin Water activity (Max) 0,50% 0,30% 0,50% Particle size (d50/µm) FITS your business FITS your company Can be produced in your own or partner s facilities Health in Gum has been created to help you expand and develop your product range, creating new market opportunities in both the pharmaceutical and nutraceutical industries. These are just a few examples: No need for additional chewinggum specific equipment Works perfectly with standard tableting machines MIXING DIRECT COMPRESSION RESULT YOUR MEDICATED CHEWING GUM Applications in the pharmaceutical industry Antihistamines / Analgesics / Decongestants / Antacids / Anti-infectives / and much more Applications in the nutraceutical industry Amino acids / Antioxidants / Dietary fiber / Energy supplements / Minerals / Vitamins / Weight-loss supplements / and much more

4 WITH ALL THE BENEFITS of chewing Your final product will have not only the effects of the added active ingredient, but also all the benefits of chewing. API PROPERTIES + BENEFITS OF CHEWING = MORE THERAPEUTIC BENEFITS Oral health Weight management Stress relief Alertness and concentration EXCELLENCE first Our priority is to offer safe products made with the highest quality ingredients to ensure excellence. To do this we use the most appropriate models and techniques. Cafosa s Health in Gum facilities meet the highest international standards including ISO 9001, FSSC and ISO Our HACCP system ensures compliance with the most demanding food-safety standards. At Cafosa, we have a goal: to be a trusted partner to our customers, providing solutions that allow them to grow and differentiate themselves in the market through close collaboration and ongoing innovation. This is how we created Health in Gum : using the very latest technology to create the best quality compressed chewing gum for our customers. Because at Cafosa we ve always known that the future belongs to those who dare to look forward.

5 Health in Gum Av. Diagonal 474, 3ª planta Barcelona (Spain) T / Fax / info@healthingum.com

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