Current Topics in Pathology
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1 Current Topics in Pathology 80 Managing Editors C.L. Berry E. Grundmann Editorial Board H. Cottier, P.I Dawson, H. Denk, C.M. Fenoglio-Preiser Ph.U.Heitz, O.H.Iversen, F.Nogales, N.Sasano, G.Seifert J.C.E. Underwood, Y. Watanabe
2 Biological Characterization of Bone Tumors Contributors J. Althoff D.B.v. Bassewitz. A. Bosse V. Bouropoulou. J.J. Brooks W. Dierschauer G. Edel. E. Grundmann. A. Harle W. Hiddemann H.I Hohling. N. Jiang G. Jundt M. Kolve V.A. LiVolsi W. Mellin P. Quint A. Roessner A. Schulz F. Sim. C. Sorg. T. Spelsberg G.c. Steiner IQ. Trojanowski E. Vollmer L.E. Wold P. Wuisman. G. Zwadlo Editor A.Roessner Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong
3 A. ROESSNER,, GerhaFd-Domagk-Institut fur Pathologie der Universitat, DomagkstraBe 17, D-4400 Munster c.l. BERRY,, Department of Morbid Anatomy, The London Hospital Medical College, Whitechapel, London E1 1 BB, Great Britain E. GRUNDMANN,, Gerhard-Domagk-Institut fur Pathologie der Universitat, DomagkstraBe 17, D-4400 Munster With 119 Figures, Some in Color ISBN-13: DOl: / e-isbn-13: Library of Congress Cataloging-in-Publication Data. Biological characterization of bone tumors/ contributors, J. Althoff... ret al.]; editor, A. Roessner. p. cm. - (Current topics in pathology; 80) Includes index. ISBN-13: (U.S.:alk. paper)i.bones-tumors-histopathology. 2. Bones - Tumors - Diagnosis. 3. Diagnosis immunohistochemistry. I. Althoff, J. II. Roessner, Albert. III. Series: Current topics in pathology; v. 80. [DNLM: 1. Bone Neoplasms -pathology. WI CU821H v. 80/WE 258 B615] RB1.E6 vol. 80 [RC280.B6] s - dc20 [616.99'27107] DNLM/DLC for Library of Congress CIP This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. Springer-Verlag Berlin Heidelberg 1989 Softcover reprint of the hardcover 1st edition 1989 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2122/ Printed on acid-free paper
4 List of Contributors. ALTHOFF, J., Dr. BASSEWITZ, D.B.v., BOSSE, A., Dr. BOUROPOULOU, v., MD BROOKS, J.J., MD DIERSCHAUER, W. EOEL, G., GRUNOMANN, E., Institut fur Medizinische Physik, Abt. Mikroanalytik, Schmeddingstral3e 50, D-4400 Munster Gerhard-Domagk-Institut fur Pathologie der Gerhard-Domagk-Institut fur Pathologie der Department of Pathology, Apostle Paul Hospital, 4 Artemidos Street, Ag. Stefanos, GR , Greece Surgical Pathology Section Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Gerhard-Domagk-Institut fur Pathologie der Gerhard-Domagk-Institut fur Pathologie der Gerhard-Domagk-Institut fur Pathologie der HARLE, A., Orthopiidische Klinik der WWU, Albert-Schweitzer-Stral3e 33, D-4400 Munster HIDOEMANN, W., HOHLING, H.J., Med. Klinik Abt. A der WWU, Albert-Schweitzer-Stral3e 33, D-4400 Munster Institut fur Medizinische Physik, Abt. Mikroanalytik, Schmeddingstral3e 50, D-4400 Munster
5 VI JIANG, N., MD JUNDT, G., Dr. KOLVE, M., Dr. LIVOLSI, VA., MD MELLIN, W., Dr. QUINT, P., Dr. ROESSNER, A., SCHULZ, A., SIM, F., MD SORG, C., SPELSBERG, T., MD STEINER, G.C., MD List of Contributors Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA Zentrum fur Pathologie, Klinikum der UniversiHit, Langhansstral3e 10, D-6300 Giel3en Gerhard-Domagk-Institut fur Pathologie der Surgical Pathology Section Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Gerhard-Domagk-Institut fur Pathologie der Institut fur Medizinische Physik, Abt. Mikroanalytik, Schmeddingstral3e 50, D-4400 Munster Gerhard-Domagk-Institut fur Pathologie der Zentrum fur Pathologie, Klinikum der UniversiHit, Langhansstral3e 10, D-6300 Giel3en Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA Institut fur Experimentelle Dermatologie der WWU, Von-Esmarch-Stral3e 56, D-4400 Munster Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA Department of Pathology, Hospital for Joint Diseases, Orthopaedic Institute, 301 East 17th Street, New York, NY 10003, USA
6 List of Contributors VII TROJANOWSKI, J.Q., MD VOLLMER, E., Dr. Dr. WOLD, L.E., MD WmSMAN, P., Dr. ZWADLO, G., Dr. Surgical Pathology Section Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Gerhard-Domagk-Institut fur Pathologie der WWU, DomagkstraBe 17, D-4400 Munster Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA Orthopadische Klinik der WWU, Albert-Schweitzer-StraBe 33, D-4400 Munster Institut fur Experimentelle Dermatologie der WWU, Von-Esmarch-StraBe 56, D-4400 Munster
7 Preface During the past few years, a considerable number of monographs on bone tumors have been published. They are mainly restricted to bone tumors as clinical-pathological entities, since their diagnosis, more than that of other tumors, requires the interdisciplinary cooperation between orthopedic specialist, radiologist, and pathologist. However, investigations concerning the histogenesis of bone tumors are rather limited, although they might be helpful in explaining the unique morphological heterogeneity of tumors of the skeletal system. Furthermore, the histogenetic approach in the study of bone tumors may facilitate the interpretation of the advanced cytobiological methods available for improving classification and diagnosis. Therefore, this volume presents recent pathological advances in the biological characterization of bone tumors. A major chapter deals with the differential diagnosis of Ewing's sarcoma as regards its demarcation from the so-called neuroectodermal tumor of bone. The analysis of the ground substances in bone-forming tumors may be helpful for their classification. Therefore the volume includes a chapter on the biochemical and histochemical analysis of different osteosarcoma types. Recently it has become clear that in addition to different collagen types which are not specific for bone tissue, several bone-specific proteins occur, one of which is osteonectin. Its distribution is obviously important for the classification and diagnosis of osteoblastic tumors. Proliferative behavior is of major importance for the diagnosis of malignant tumors. The present volume includes one contribution applying immunohistological methods and another using flow cytometry to study this problem. The results may facilitate the diagnosis of borderline malignant bone tumors. The steroid receptors in giant cell tumor of bone have recently attracted clinical interest. This problem is discussed in an additional chapter. As is well known, the histogenesis of chordoma is peculiar and immunohistochemical methods have proved valuable for further characterizing this tumor and facilitating its differential diagnosis. Special interest is focused on the entity of chondroid chordoma. Finally, the group of so-called fibrohistiocytic tumors has been under discussion in recent years. As several bone tumor entities belong to this group (malignant fibrous histiocytoma of bone, benign fibrous
8 x Preface histiocytoma, giant cell tumor, nonossifying fibroma), a critical consideration of the group in the light of recent results with advanced morphological methods seems necessary. We hope that the use of cytomorphological investigations for the biological characterization of bone tumors may improve the understanding of their morphological heterogeneity. For practical purposes, this volume offers new data on advanced morphological methods promoting the classification and diagnosis of bone tumors. I would very much like to thank all contributors for their cooperation. Special appreciation is due to the staff of Springer-Verlag for their excellent cooperation in preparing this volume. A. ROESSNER
9 Contents Neuroectodermal Tumor Versus Ewing's Sarcoma Immunohistochemical and Electron Microscopic Observations. With 20 Figures G.C. STEINER Immunohistological Demonstration of Osteonectin in Normal Bone Tissue and in Bone Tumors. With 12 Figures A. SCHULZ and G. JUNDT Tumor Bone Formation in Different Osteosarcomas: Topological, Biochemical, and Histochemical Analyses. With 17 Figures J. ALTHOFF, P. QUINT, H.J. HelBLING, A. ROESSNER, and E. GRUNDMANN The Proliferation Behavior of Bone Tumors Investigated with the Monoclonal Antibody Ki-67. With 15 Figures E. VOLLMER, A. ROESSNER, P. WUISMAN, A. HARLE, and E. GRUND MANN Flow Cytometric DNA Analysis of Bone Tumors. With 8 Figures W. MELLIN, W. DmRSCHAUER, W. HIDDEMANN, A. ROESSNER, G. EDEL, P. WUISMAN, A. HARLE, and E. GRUNDMANN Steroid Receptors and Giant Cell Tumor of Bone. With 6 Figures L.E. WOLD, T. SPELSBERG, N. JIANG, and F. SIM Chondroid Chordoma: A Low-Grade Chondrosarcoma and Its Differential Diagnosis. With 10 Figures J.J. BROOKS, J.Q. TROJANOWSKI, and v.a. LIVOLSI Immunohistochemical Investigation of Chordomas: Histogenetic and Differential Diagnostic Aspects. With 16 Figures V. BOUROPOULOU, A. BOSSE, A. ROESSNER, E. VOLLMER, G. EDEL, P. WUISMAN, and A. HARLE
10 XII Contents The Cytogenesis of Macrophages and Osteoclast-like Giant Cells in Bone Tumors with Special Emphasis on the So-Called Fibrohistiocytic Tumors. With 15 Figures A. ROESSNER, E. VOLLMER, G. ZWADLO, C. SORG, M. KOLVE, D.B. V. BASSEWITZ, P. WU1SMAN, A. HARLE, and E. GRUNDMANN Subject Index Indexed in ISR
Current Topics in Pathology 77
Current Topics in Pathology 77 Managing Editors C.L. Berry E. Grundmann Editorial Board H. Cottier, P.I Dawson, H. Denk, C.M. Fenoglio-Preiser Ph.U.Heitz, O.H.Iversen, F.Nogales, N.Sasano, G.Seifert IC.E.
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