New Results. in Depression Research. Edited by H. Hippius. G. L. Klerman. N. Matussek With the Assistance of M. Schmauss
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2 New Results in Depression Research Edited by H. Hippius. G. L. Klerman. N. Matussek With the Assistance of M. Schmauss With 68 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
3 Professor Dr. Hanns Hippius Psychiatrische Klinik und Poliklinik der U niversihit M unchen, NuI3baumstraI3e 7, 8000 Munchen 2, FRG Professor Dr. Gerald L. Klerman Department of Psychiatry, Cornell University Medical School 21 Bloomingdale Road, White Plains, NY 10605, USA Professor Dr. Norbert Matussek Psychiatrische Klinik der Universitat Munchen, NuI3baumstraI3e 7, 8000 Munchen 2, FRG Dr. Max Schmauss Psychiatrische Klinik und Poliklinik der Universitat Munchen, NuI3baumstraI3e 7, 8000 Munchen 2, FRG ISBN-13 : e-isbn-13: DOl: / Library of Congress Cataloging in Publication Data. New results in depression research. Includes index. 1. Depression, Mental. I. Hippius, Hanns. II. Klerman, Gerald L., III. Matussek, N. (Norbert), [DNLM: 1. Depressive Disorder. WM 171 N532) RC537.N ' This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under 54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich. Springer-Verlag Berlin Heidelberg 1986 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.
4 Contents Murnau and the History of Psychiatry H. HIPPIUS, P. HOFF, and U. MUNCH.. 1 Evidence for Increase in Rates of Depression in North America and Western Europe in Recent Decades G. L. KLERMAN. With 5 Figures The Affective Disorders: Results from the Epidemiologic Catchment Area Study (ECA) M. M. WEISSMAN, J. K. MYERS, P. J. LEAF, G. L. TISCHLER, and C. E. HOLZER. With 2 Figures The Course of Major Depression, Atypical Bipolar Disorder, and Bipolar Disorder J. ANGST. With 3 Figures Validating Depressive Subtypes H. KATSCHNIG, D. NUTZINGER, and H. SCHANDA Personality and Bipolar Disorder R. M. A. HIRSCHFELD Self-Report Inventories in the Study of Depression P. PICHOT Bereavement and Its Relation to Clinical Depression P. J. CLAYTON Familial Classification of Depressive Illnesses G. WINOKUR Recent Genetic Findings in Mood Disorders E. S. GERSHON, J. I. NURNBERGER, and N. SITARAM Repeated Treatment with Antidepressant Drugs: Responses Mediated by Brain Dopamine Receptors J. MAl Latest Findings in the Treatment of Depression P. KIELHOLZ. With 4 Figures
5 VI Contents Treatment of Atypical Depression: Phenelzine, Imipramine, and Placebo. M. R. LIEBOWITZ, F. M. QUITKIN, J. W. STEWART, P. J. MCGRATH, W. HARRISON, J. RABKIN, E. TRICAMO, J. S. MARKOWITZ, and D. F. KLEIN Biology, Therapeutics, and Prophylaxis in Recurrent Depression D. J. KUPFER, E. FRANK, and J. M. PEREL. With 1 Figure Reduced Lithium Dosage Improves Prophylaxis: A Possible Mechanism. A. COPPEN and C. Sw ADE... Effects of Lithium on Cell Membranes: Relation to Prophylactic Response. W. GRElL, M. HAAG, and D. VAN CALKER. With 8 Figures Dimensional Classification as an Instrument for Biological Research in Endogenous Depression M. PHILIPP, W. MAIER, and O. BENKERT. With 5 Figures Biochemical Markers of Serotonin Functions in Depression and Suicidal Behavior M. ASBERG, B. MARTENSSON, and A. WAGNER A Biochemical and Neuroendocrine Study of the Serotonergic System in Depression T. KOYAMA and H. Y. MELTZER. With 13 Figures Responses to Clonidine in Acute and Remitted Depressed Patients L. J. SIEVER, E. F. COCCARO, F. MAN, R. C. MOHS, and K. L. DAVIS. With 3 Figures Investigations of the Cholinergic-Adrenergic Balance in Affective Disorders. H. BECKMANN. With 3 Figures The Role of the Hypothalamus-Pituitary-Adrenocortical System in Depression. D. VON ZERSSEN, M. BERGER, P. DOERR, C. LAUER, C. KRIEG, and K.-M. PIRKE. With 3 Figures Studies of the Hypothalamus-Pituitary-Adrenocortical System: An Example of Progress in Psycho neuroendocrinology F. HOLSBOER, U. VON BARDELEBEN, and A. GERKEN With 10 Figures Pharmacoendocrine Studies in Health Subjects and Depressed Patients. G. LAAKMANN, A. HINZ, and E. NEULINGER With 7 Figures 250 Subject Index
6 List of Contributors You will find the address at the beginning of the respective contribution Adan, F. 189 Angst, J. 26 Asberg, M. 156 Bardeleben, U. von 217 Beckmann, H. 196 Benkert, O. 145 Berger, M. 205 Clayton, P. J. 59 Coccaro, E. F. 189 Coppen, A. 126 Davis, K. L. 189 Doerr, P. 205 Frank, E. 118 Gerken, A. 217 Gershon, E. S. 79 Greil, W. 131 Haag, M. 131 Harrison, W. 112 Hinz, A. 250 Hippius, H. 1 Hirschfeld, R. M. A. 45 Hoff, P. 1 Holsboer, F. 217 Holzer, C. E. 16 Katschnig, H. 36 Kielholz, P. 99 Klein, D. F. 112 Klerman, G. L. 7 Koyama, T. 169 Krieg, C. 205 Kupfer, D. J. 118 Laakmann, G. 250 Lauer, C. 205 Leaf, P. J. 16 Liebowitz, M. R. 112 Maier, W. 145 Maj, J. 90 Markowitz, J. S. 112 Martensson, B. 145 McGrath, P. J. 112 Meltzer, H. Y. 169 Mohs, R. C. 189 Munch, U. 1 Myers, J. K.16 Neulinger, E. 250 Nurnberger, J. I. 79 Nutzinger, D. 36 Perel,J.M. 118 Philipp, M. 145 Pichot, P. 53 Pirke, K.-M Quitkin, F. M. 112 Rabkin, J. 112 Schanda, H. 36 Siever, L. J. 189 Sitaram, N. 79 Stewart, J. W. 112 Swade, C. 126 Tischler, G. L. 16 Tricamo, E. 112 van Calker, D. 131 Wagner, A. 156 Weissman, M. M. 16 Winokur, G. 70 Zerssen, D. von 205
7 Acknowledgement We would like to acknowledge the kind support of the Organon Company and to express our special thanks to Dr. G. Weiland and Dr. K. Geissler (Organon GmbH, Munich). Furthermore, we would like to thank Dr. B. Bondy, I. von Denffer, Dr. F. J. Freisleder, Dr. M. Haag, M. Hoehe, Dr. P. Hoff, Dr. G. Jungkunz, Dr. F. Muller-Spahn and C. Wooding-Deane, of the Department of Psychiatry, University of Munich, for summarizing the discussions. The subject index was composed by Dr. F. J. Freisleder. For his assistance in the preparation, realization, and publication of the symposium, we would like to express our special gratitude to Dr. M. Schmauss. H. HIPPIUS G. L. KLERMAN N. MATussEK
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