A brief presentation of The TERA Foundation

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1 A brief presentation of The TERA Foundation David Watts on behalf of Prof. Ugo Amaldi and all my colleagues at TERA

2 TERA Overview Direction: Prof. Ugo Amaldi AQUA (Advanced QUAlity Assurance) Cyclinac Group - supervised by Prof. F. Sauli - 3 students - 1 post-doc - involved in several European projects PARTNER, ENVISION, and INTERVISION - 4 students - 2 engineers - Main projects are Caboto, TULIP, Idra... - Also involved in European projects... PARTNER 2

3 TERA Overview Direction: Prof. Ugo Amaldi AQUA (Advanced QUAlity Assurance) Cyclinac Group - supervised by Prof. F. Sauli - 3 students - 1 post-doc - involved in several European projects PARTNER, ENVISION, and INTERVISION - 4 students - 2 engineers - Main projects are Caboto, TULIP, Idra... - Also involved in European projects... PARTNER TERA s administration is in Novara, Italy, while both groups carry out their research on the CERN Meyrin site (building 182). 3

4 Cyclinac Group The hadrontherapy community requires accelerating structures that are compact, have a high reliabilty, and appropriate beam parameters: 4

5 Cyclinac Group The hadrontherapy community requires accelerating structures that are compact, have a high reliabilty, and appropriate beam parameters: - active energy modulation - high repetition rate 3D spot scanning beam delivery with multipainting 5

6 Cyclinac: cyclotron + high freq linac Cell Coupled Linac Standing-wave structure RF frequency: 5.7 GHz 2.5 ms-long pulse at 300 Hz 6

7 TULIP: TUrning LInac for Protontherapy cyclotro n RF rotating joints RF Power sources C-band linac Section 1 W 0 W 1 C-band linac Section 2 SM 1 W 2 Line with 2% momentum acceptance SM 2 Beam dose delivery Cell Coupled Linac Standing-wave structure RF frequency: 5.7 GHz 2.5 ms-long pulse at 100 Hz 7

8 Test Cavities These structures operate at high-gradient and have similar high requirements on reliability as CLIC. Such structures must be tested... 8

reliability as CLIC. Such structures must be tested.

already high-power tested C-band: 5.7 GHz Three 5.

9 Test Cavities These structures operate at high-gradient and have similar high requirements on reliability as CLIC. Such structures must be tested... S-band: 3 GHz One 3 GHz TERA Single-Cell Cavity already high-power tested C-band: 5.7 GHz Three 5.7 GHz TERA Single-Cell Cavities 2 conventional maching and 1 diamond machining 9

10 Why do we need Quality Assurance? The use of protons or ions as a radiotheraputic beam requires a higher precision in the correct delivery of the prescibed treatment plan. 10

11 Why do we need Quality Assurance? The use of protons or ions as a radiotheraputic beam requires a higher precision in the correct delivery of the prescibed treatment plan. 11

12 Why do we need Quality Assurance? The use of protons or ions as a radiotheraputic beam requires a higher precision in the correct delivery of the prescibed treatment plan. Uncertainties may arise from: Dose delivery uncertainties Delivery system Beam modelling CT units and range Spatial uncertainties Patient positioning Target delineation Organ motion Patient anatomy, motion, repositioning 12

13 The AQUA Overview Envision WP3 CNAO, PSI, MGH, AGH Un. Envision WP2 13

14 Proton Range Radiography Principle Energy loss of each proton is proportional to the integrated relative electron density of the target 14

diagnostic monoenergetic beam of higher energy and lower intensity Measure each

15 Proton Range Radiography Principle Energy loss of each proton is proportional to the integrated relative electron density of the target Implementation Use a diagnostic monoenergetic beam of higher energy and lower intensity Measure each proton s position and residual range Build the 2D integrated density image: a proton radiograph 15

16 Proton Range Radiography Purposes of 2D PRR Optimal patient positioning (low dose radiography) Treatment planning verification CT Scan First step towards Proton CT Simulation PRR Realization N. Depauw and J. Seco, Phys. Med. Biol. 56 (2011) First Proton Range Radiography prototype PRR10 (2010) 16

17 U. Amaldi et al, Nucl. Instr. and Meth. A629(2011)337 PSI PRR10 Beam Tests CNAO 1 mm Ø Lung (.20) Trabecular bone (1.16) Breast 50/50 (.99) 17

18 U. Amaldi et al, Nucl. Instr. and Meth. A629(2011)337 PSI PRR10 Beam Tests CNAO 1 mm Ø Lung (.20) Trabecular bone (1.16) Breast 50/50 (.99) For 1x1 mm 2 pixels and an image size of 30x30 cm 2 (10 5 pixels) 10 7 proton tracks to be recorded (possible in 10 seconds with 1 MHz readout rate) 18

19 U. Amaldi et al, Nucl. Instr. and Meth. A629(2011)337 PSI PRR10 Beam Tests CNAO 1 mm Ø Lung (.20) Trabecular bone (1.16) Breast 50/50 (.99) For 1x1 mm 2 pixels and an image size of 30x30 cm 2 (10 5 pixels) 10 7 proton tracks to be recorded (possible in 10 seconds with 1 MHz readout rate) Present R&D Larger area (30x30 cm 2 ) 48 scintillators (~ 15 cm tissue equivalent) Faster readout electronics ~ 1 MHz 19

2 (10 5 pixels) 10 7 proton tracks to be recorded

Present R&D Larger area (30x30 cm 2 ) 48

20 U. Amaldi et al, Nucl. Instr. and Meth. A629(2011)337 PSI PRR10 Beam Tests CNAO 1 mm Ø Lung (.20) Trabecular bone (1.16) Breast 50/50 (.99) For 1x1 mm 2 pixels and an image size of 30x30 cm 2 (10 5 pixels) 10 7 proton tracks to be recorded (possible in 10 seconds with 1 MHz readout rate) Present R&D Larger area (30x30 cm 2 ) 48 scintillators (~ 15 cm tissue equivalent) Faster readout electronics ~ 1 MHz PRR30 in construction 20

21 Under construction: PRR30 Range Finder 48 Plastic scintillators 3mm each (15cm water equ) WLS fiber to SiPM ADC readout triggered by 2 scintillators in coincidence 21

22 Under construction: PRR30 Range Finder 48 Plastic scintillators 3mm each (15cm water equ) WLS fiber to SiPM ADC readout triggered by 2 scintillators in coincidence 30MeV to 190MeV Residual Energy 22

23 Under construction: PRR30 Range Finder 48 Plastic scintillators 3mm each (15cm water equ) WLS fiber to SiPM ADC readout triggered by 2 scintillators in coincidence 30MeV to 190MeV Residual Energy Tracker Two 30x30cm triple-gem detectors 2D XY strip readout (400um pitch) Readout electronics capable of 1M events/sec 23

ADC readout triggered by 2 scintillators in coincidence

triple-gem detectors 2D XY strip readout (400um pitch)

24 Under construction: PRR30 Range Finder 48 Plastic scintillators 3mm each (15cm water equ) WLS fiber to SiPM ADC readout triggered by 2 scintillators in coincidence 30MeV to 190MeV Residual Energy Tracker Two 30x30cm triple-gem detectors 2D XY strip readout (400um pitch) Readout electronics capable of 1M events/sec New development was needed! 24

25 High-speed GEM readout New developments in GEM readout technology Main goal: ~ 1 MHz DATA THROUGHPUT 25

dedicated ASIC for GEM chambers GEMROC Hybrid Front End

26 High-speed GEM readout New developments in GEM readout technology Main goal: ~ 1 MHz DATA THROUGHPUT Novel dedicated ASIC for GEM chambers GEMROC Hybrid Front End board developed by AGH Cracow University in collaboration with TERA 26

27 Conclusions - TERA Foundation is involved in hadrontherapy research directed by Prof. Ugo Amaldi 27

28 Conclusions - TERA Foundation is involved in hadrontherapy research directed by Prof. Ugo Amaldi - TERA has it s office in Novara but carries out its research at CERN 28

29 Conclusions - TERA Foundation is involved in hadrontherapy research directed by Prof. Ugo Amaldi - TERA has it s office in Novara but carries out its research at CERN - TERA consists of 7 students and 4 postdocs/engineers and a few senior ppl and administration 29

30 Conclusions - TERA Foundation is involved in hadrontherapy research directed by Prof. Ugo Amaldi - TERA has it s office in Novara but carries out its research at CERN - TERA consists of 7 students and 4 postdocs/engineers and a few senior ppl and administration - TERA s main projects are CABOTO, TULIP, PRR10, PRR30, IVI 30

31 Conclusions - TERA Foundation is involved in hadrontherapy research directed by Prof. Ugo Amaldi - TERA has it s office in Novara but carries out its research at CERN - TERA consists of 7 students and 4 postdocs/engineers and a few senior ppl and administration - TERA s main projects are CABOTO, TULIP, PRR10, PRR30, IVI - The TERA Foundation would benefit highly from a medical beam facility located at CERN 31

32 Backup Slides 32

deposit the bulk of their energy at the end of their range in the Bragg peak.

33 Relative dose [%] Why Hadrontherapy? X-ray gamma neutron proton carbon 10 million habitants (20000pts/ year) Depth in water [cm] Protons and ions deposit the bulk of their energy at the end of their range in the Bragg peak. -better conformity of dose distribution Hoffmann, -Higher RBE at tumour site PPARC lower dose to healthy tissues both on entry and exit channels 12% of Xray patients (2400pts/year) Hoffmann, PPARC

34 In-beam PET Proton and ion therapy results in B+ activation of tissues which can be measured by a PET detector and used to verify the treatment plan immediately following irradiation 34

35 In-beam PET Detectors In-beam PET using mrpc In-beam PET using crystals 35

ACCELERATORS FOR HADRONTHERAPY

ACCELERATORS FOR HADRONTHERAPY Alberto Degiovanni CERN-BE IVICFA s Fridays: Medical Physics Valencia, 31.10.2014 Introduction: the icon of hadrontherapy Position of the Bragg peak depends on beam energy