March 12-23, 2018 SCK CEN, Mol, Belgium. 09: h Welcome, SCK CEN film & Introduction Hans Vanmarcke, SCK CEN

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1 Two-week training course on radiationinduced effects with particular emphasis on genetics, development, teratology, cognition as well as space-related health issues March 12-23, 2018, Mol, Belgium Preliminary programme Week 1 March 12 16, 2018 Day 1 Monday March 12, : h Welcome, film & Introduction Hans Vanmarcke, 10:00-10:30 h Presentation of the theoretical and practical programme of two weeks Sarah Baatout, 10:30-10:45 h Break 10:45-11:30 h Research programmes Radiobiology unit Sarah Baatout, 11:30 12:30 h Basic radiobiology Notions and units of doses in radiation protection Sarah Baatout, 12:30 13:30 h Lunch in the cafeteria 13:30-14:30 h Basic radiobiology History of medical use for radiation purposes Sarah Baatout, 14:30 15:00 h Tutorial Biosafety Visit of the new animal facility Brit Proesmans, 15:30-16:00 h Molecular biology Visit of the genomic platform facilities at Roel Quintens, 16:00 17:00 h Society Introduction to the international advisory bodies UNSCEAR Part 1 Hans Vanmarcke, Two-week training course on radiation-induced effects with particular emphasis on genetics, development, Page 1 of 6 March 12-23, 2018, Mol, Belgium

2 Day 2 Tuesday March 13, :00-10:30 h Society The ethics of justifying nuclear technology applications Gaston Meskens, 10:30-11:00 h Break 11:00-12:00 h Cancer Use of radiopharmaceuticals for radio-diagnostics and radiotherapeutics An Aerts, 12:00 13:30 h Lunch at the cafeteria 13:30 14:15 h Practical Dev. Biol. Dissection of pregnant mice Mieke Neefs, Jasmine Buset, 14:15-15:00 h Practical Dev. Biol. Observations of radiation-induced external and forelimb skeletal malformations in foetuses Jasmine Buset, Mieke Neefs, Hanane Derradji, 15:30 16:30 h Radiation-induced non cancer effects Cardiovascular risks An Aerts, 16:30 17:30 h Space Space radiation and dosimetry Olivier Van Hoey, Day 3 Wednesday March 14, :00-10:00 h Molecular biology New technologies in molecular biology : the best is yet to come Pieter Monsieurs, 10:00-10:20 h Break 10:20-11:20 h Basic radiobiology Radiation biomarkers : An overview Roel Quintens, 11:20-11:30 h Short break 11:30-12:30 h Dev. Biol. Prenatal effects of radiation Hanane Derradji 13:30-14:45 h Dev. Biol. Brain development, funtioning and associated disorders Mieke Verslegers, 14:45 15:15 h Break 15:15 16:00 h Dev. Biol. Dental cone beam computed tomography in children Niels Belmans, 16:00 17:00 h Epidemiology Results of the IARC/WHO and INWORKS nuclear workers study regarding cancer mortality Luc Holmstock, Two-week training course on radiation-induced effects with particular emphasis on genetics, development, Page 2 of 6 March 12-23, 2018, Mol, Belgium

3 Day 4 Thursday March 15, :00-10:00 h Basic radiobiology Introduction to radiochemistry and radionuclides Andrew Dobney, 10:00-10:30 h Break 10:30-11:30 h Basic radiobiology Essentials of radioactive decay and of actinide chemistry Andrew Dobney, 11:30-12:30 h Society Introduction to the international advisory bodies Part 2 Hans Vanmarcke, 13:30 14:15 h Practical Dev. Biol. Brain dissection 14:15 15:00 h Practical Dev. Biol. Neuron culture Part 1 Mieke Neefs, André Claude Mfossa, Mieke Neefs, André Claude Mfossa, 15:30 16:30 h Practical Dev. Biol. Neuron culture Part 2 Mieke Neefs, André Claude Mfossa, 16:30-17:30 h Dev.Biol. Medical dosimetry of new-born and paediatric patients Jérémie Dabin, Day 5 Friday March 16, :00-10:00 h Radioecology An introduction to radioecological research: from molecular to ecosystem Nele Horemans, May Van Hees, 10:00-10:30 h Break 10:30-11:30 h Radioecology Testing effects of radionuclides in the environment using an ecotoxicological approach Nele Horemans, May Van Hees, 11:30-12:30 h Cancer Cancer classification Sarah Baatout, 13:30-15:00 h Basic radiobiology Radiation epidemiology Sarah Baatout, 15:30-16:30 h Basic radiobiology Acute radiation syndrome Sarah Baatout, Two-week training course on radiation-induced effects with particular emphasis on genetics, development, Page 3 of 6 March 12-23, 2018, Mol, Belgium

4 Week 2 March 19 23, 2018 Day 6 Monday March 19, :00-10:00 h Dissection of mouse ovaries and culture of oocytes at germinal vesicle stage Jasmine Buset, 10:00-11:00 h Molecular biology Background for qrt-pcr experiment Roel Quintens, 11:00-11:30 h Tutorial Apoptosis Technical introduction about RNA extraction Roel Quintens, 11:30-11:45 h Break 11:45-12:30 h Practical Dev. Biol. Immunofluorescence staining and phase contrast microscopy observations of brain slices and neuronal cultures André Claude Mfossa & Mieke Verslegers, 13:30 15:00 h Space Space microbiology : Control and use of microbes to support human life in space Natalie Leys, Felice Mastroleo, h Break h Practical Dev. Biol. Fixation of oocytes in 1 st meiosis Jasmine Buset, Day 7 Tuesday March 20, :00-10:30 h Practical Apoptosis RNA extraction from irradiated cells Ann Janssen & Bjorn Baselet, 10:00-11:00 h Practical Apoptosis Quality control of extracted RNA Ann Janssen & Bjorn Baselet, 11:00-12:45 h Break during the practical exercises Practical Apoptosis Reverse transcription of X-irradiated whole blood samples (break foreseen during incubation) Ann Janssen & Bjorn Baselet, 12:45 13:30 h Lunch at the cafeteria h Molecular biology Epigenetics in radiation biology Roel Quintens, 14:30 15:15 h Practical Dev. Biol. Staining of the chromosome preparations of the oocytes in 1 st meiosis Jasmine Buset, 15:15 16:00 h Break + photoshoot (students and lecturers) Two-week training course on radiation-induced effects with particular emphasis on genetics, development, Page 4 of 6 March 12-23, 2018, Mol, Belgium

5 16:00 16:30 h From one of the world's most resistant animal to astronaut protection Bdelloid rotifers Bjorn Baselet, 16:30-17:30 h Cancer Cancer epidemiology & etiology Sarah Baatout, Day 8 Wednesday March 21, :00-09:30 h Cancer Introduction to hadron therapy Dosimetric aspects Sabina Chiriotti Alvarez, 09:30-10:45 h Practical Apoptosis Radiation-induced gene expression in whole blood: quantitative PCR of DNA damage response and apoptosis genes + lecture (incl. break run of the qpcr) Roel Quintens, Ann Janssen, 10:45-11:15 h Break 11:15-11:45 h Space Space (radiation) health effects Marjan Moreels, 11:45 12:30 h Space Introduction to space programmes Marjan Moreels & Sarah Baatout, 13:30 15:00 h NN NN 15:15-15:45 h Break 15:45-16:30 h Space Unraveling non-cancer effects of spaceflight: How are the brain and skin affected in astronauts Greta Lamers, 16:30 17:15 h Practical Apoptosis Discussion of qpcr results Roel Quintens, Day 9 Thursday March 22, :00-10:15 h Dev. Biol. Radiation-induced molecular effects in the embryo Rafi Benotmane, 10:15-10:45 h Break 10:45-11:30 h Practical Dev. Biol. Effect on neuron cells Sectioning of the mouse hippocampus a focus on ageing Emma Coninx, 11:30-12:15 h Cancer Fundamental research in the field of hadron therapy Katrien Konings, 12:15 13:30 h Lunch at the cafeteria Two-week training course on radiation-induced effects with particular emphasis on genetics, development, Page 5 of 6 March 12-23, 2018, Mol, Belgium

6 13:30-14:00 h Space Impact of space flight on the immune system Richard Deyhle Jr 14:00 15:30 h Dev. Biol. Radiation-induced cognitive effects Rafi Benotmane, 15:30 16:30 h Radiation-induced non cancer effects The role of intercellular communication in low dose radiation-induced atherosclerosis Raghda Ramadan, Day 10 Friday March 23, :00-10:00 h Radioecology Visit of the lab facilities of Biosphere Impact Studies Nele Horemans, May Van Hees, 10:00-10:30 h Break 10:30-11:15 h Cancer Thyroid cancer Hanane Derradji, 11:15 12:30 h Space Animals in space Sarah Baatout, 12:30 13:30 h Lunch at cafeteria :30 h Practical Dev. Biol. Observation of meiotic chromosomes Jasmine Buset, 14:30-15:30 h Conclusions, feedback & evaluation of the training course Sarah Baatout, 15:30 15:45 h End of course Two-week training course on radiation-induced effects with particular emphasis on genetics, development, Page 6 of 6 March 12-23, 2018, Mol, Belgium