Do Viruses Play a Role in Childhood Leukaemia?
|
|
|
- Phyllis Wilcox
- 5 years ago
- Views:
Transcription
1 CHILDREN with LEUKAEMIA, 6 September 2004 Do Viruses Play a Role in Childhood Leukaemia? Robin A. Weiss
2 Natural Bioweapons of Mass Destruction A Richter Scale of Viruses and Global Mortality HIV HBV + HCV Measles RSV, Rota Flu Dengue HPV Tobacco Malaria Non-HIV TB Accidents Suicide Vaccines - weapons of mass protection - led to the eradication or reduction of: West Nile SARS Ebola Polio Hanta 3 2 Smallpox Yellow Fever Polio MMR Log 10 1 vcjd
3 Human Global Cancer Burden ~ 5 x 10 6 new cases each year ~ 1 x 10 6 due to infection Potentially preventable by vaccination Viruses (DNA, RNA) Bacteria (H. pylori) Helminths
4 Human viruses associated with malignancy Virus Malignancy Incubation Period (years) Human Papilloma Viruses HPV types 16, 18: Cervical cancer 5-50 HPV types 5, 8: Skin cancer 5-50 Hepatitis B virus (HBV) Liver cancer Hepatitis C virus (HCV) Liver cancer Epstein-Barr virus (EBV) Lymphoma 5-50 Carcinoma KSHV (HHV-8) Kaposi's sarcoma Lymphoma? Human T-cell leukaemia virus (HTLV-1) Leukaemia HIV Kaposi's, Lymphoma 5-15
5 Leukaemia and Lymphoma caused by Animal Viruses Retroviruses CLL, ALL, AML, Lymphoma Primates, cattle, cats, mice, chickens, fish Herpesviruses Lymphoma Primates, chickens, frogs
6 Genes involved in cancer
7 Direct How do viruses affect oncogenesis? EBV: Virus encodes oncogenes HTLV-I: Virus activates oncogene HPV: Virus knocks out tumour suppressor genes Indirect HCV: Tissue destruction regeneration + mutation HIV: Immune deficiency opportunistic infections opportunistic tumours
8 Multifactorial Causes of Cancer 1. Liver cancer HBV alone: medium frequency Aflatoxin alone: rare HBV + aflatoxin: synergistic 70-fold relative risk 2. Squamous skin cancer Ultraviolet light Papilloma viruses Epidermodysplasia verruciformis gene
9 Multifactorial Causes of Cancer 3. Burkitt's Lymphoma Epstein-Barr Virus (EBV) Holoendemic malaria BL cases Malaria belt Chromosome translocation involving c-myc Inflammation in the jaw?
10 One virus two or more diseases EBV: Infectious mononucleosis Burkitt's lymphoma Immunoblastic lymphoma Hodgkin's disease Nasopharyngeal carcinoma Leiomyosarcoma KSHV: HTLV: Kaposi's sarcoma Primary effusion lymphoma Multicentric Castleman's disease Adult T-cell leukaemia Spastic paraparesis However, most infected people develop none of these diseases.
11 Adult T-cell leukaemia (ATL) A malignancy of CD4 + T-helper lymphocytes Mean survival after diagnosis 5 months The commonest leukaemia in Japan; also frequent in the West Indies and West Africa Caused by human T-cell leukaemia virus type 1 Transmitted in infancy by milk, but only presents in adults
12 Paradox: oncogenic human viruses that don't cause cancer Adenoviruses: AdV 2, 5 & 12 Highly oncogenic in new born rats due to E1A, E1B, E4 & E5 Papovaviruses: BK, JC Highly oncogenic in baby hamsters due to Large T and small t transformation SV40: The 'BK' virus of macaques Oncogenic in rodents Not oncogenic in monkeys Reported in human mesothelioma, osteosarcoma and paediatric neural tumors?
13 Epidemiological evidence for viruses in childhood leukaemia? Kinlen: population mixing Rare outcome of common infection No specific virus identified Rural versus urban: zoonosis? Lymphocytic chorio-meningitis virus? Leukaemia in children with AIDS?
14 The 'hygiene' hypothesis Is early infection protective? asthma Is delayed infection more pathogenic? Polio virus: infantile paralysis EBV: infectious mononucleosis If this hypothesis applied to childhood leukaemia: incidence with social class incidence with age
15 Conclusions No direct evidence for a virus Could be more than one kind of virus Could be an infection other than a virus Infection may be necessary but not sufficient Infection might not be relevant to childhood leukaemia
16 Welcome to Church House and the International Scientific Conference for Childhood Leukaemia incidence causal mechanisms prevention
Viruses and Human Cancer
Viruses and Human Cancer Robin A Weiss Division of Infection & Immunity University College London Viruses: The Invisible Enemy Venice, 21 September 2010 Overview 1842: Domenico Rigoni-Stern, Verona: no
VIRUSES AND CANCER Michael Lea
VIRUSES AND CANCER 2010 Michael Lea VIRAL ONCOLOGY - LECTURE OUTLINE 1. Historical Review 2. Viruses Associated with Cancer 3. RNA Tumor Viruses 4. DNA Tumor Viruses HISTORICAL REVIEW Historical Review
An Overview. Paediatric Oncology. In Malawi
An Overview of Paediatric Oncology In Malawi 15.6 % of all cancers are attributable to infections 21% -100,000/yr in Africa; 9% - 375,000/yr in West Pidani et al 1990 IN AFRICA EARLY ACQUISITION OF VIRUSES
Viruses. Properties. Some viruses contain other ingredients (e.g., lipids, carbohydrates), but these are derived from their host cells.
Viruses Properties They are obligate intracellular parasites. Probably there are no cells in nature that escape infection by one or more kinds of viruses. (Viruses that infect bacteria are called bacteriophages.)
Multiple Choice Questions - Paper 1
Multiple Choice Questions - Paper 1 Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could
ENVIRONMENTAL FACTORS IN VIRUS-ASSOCIATED HUMAN CANCERS
ENVIRONMENTAL FACTORS IN VIRUS-ASSOCIATED HUMAN CANCERS Joint Graduate Seminar Depar tment of Microbiology The Chinese University of Hong Kong PhD Candidate: Zhang Chuqing Super visor: Professor Paul Chan
CONTENTS NOTE TO THE READER... 1
CONTENTS NOTE TO THE READER.... 1 List of Participants... 3 PREAMBLE... 11 A. GENERAL PRINCIPLES AND PROCEDURES...11 1. Background...11 2. Objective and scope.....................................................................................
UC Berkeley Berkeley Scientific Journal
UC Berkeley Berkeley Scientific Journal Title Can A Virus Cause Cancer: A Look Into The History And Significance Of Oncoviruses Permalink https://escholarship.org/uc/item/6c57612p Journal Berkeley Scientific
Lecture 10 VIROLOGY Assistant prof.dr. Baheeja A. alkhalidi
Lecture 10 VIROLOGY Assistant prof.dr. Baheeja A. alkhalidi Viruses are microbes that REQUIRE a host cell to replicate. By themselves they cannot replicate. They border on the edge of living and non-living.
Viruses and cancer: Should we be more afraid?
Viruses and cancer: Should we be more afraid? Viruses and cancer: Should we be more afraid? During the past 30 years it has become exceedingly clear that several viruses play significant roles in the development
108 INDEX. Oesophageal cancer 7 4 Oralleukoplakias 64, 67
Subject Index A antigen, Marek's disease virus 15,16,22 Acquired immune deficiency syndrome 2, 34, 81-91 role of cytomegalovirus in 93-104 Acute hepatitis 6 Acute hepatitis B 54 Acute liver disease 1 Adenomas
Chapter 18. Viral Genetics. AP Biology
Chapter 18. Viral Genetics 2003-2004 1 A sense of size Comparing eukaryote bacterium virus 2 What is a virus? Is it alive? DNA or RNA enclosed in a protein coat Viruses are not cells Extremely tiny electron
number Done by حسام أبو عوض Lara Abdallat Dr. Maha
number 18 Done by حسام أبو عوض Lara Abdallat Dr. Maha Continuing with the causes of cancer development In the previous lecture, the effect of chemicals on the development of cancer was discussed. In this
Chapters 21-26: Selected Viral Pathogens
Chapters 21-26: Selected Viral Pathogens 1. DNA Viral Pathogens 2. RNA Viral Pathogens 1. DNA Viral Pathogens Smallpox (pp. 623-4) Caused by variola virus (dsdna, enveloped): portal of entry is the respiratory
Nucleic acid Strands Family Example Accession Base pairs
Table 16.1 Classification of viruses based on nucleic acid composition. Note that NCBI BioProject accessions begin PRJNA and typically encompass several segments. Adapted from Schaechter et al. (1999)
Supplementary Information
Electronic Supplementary Material (ESI) for Molecular BioSystems. This journal is The Royal Society of Chemistry 2014 Supplementary Information Supplementary table S1- Hu-PPI and Hu-Vir PPI data before
Viruses. Rotavirus (causes stomach flu) HIV virus
Viruses Rotavirus (causes stomach flu) HIV virus What is a virus? A virus is a microscopic, infectious agent that may infect any type of living cell. Viruses must infect living cells in order to make more
Lecture 2. [Pathophysiology]
![Lecture 2. [Pathophysiology]](/thumbs/83/88432253.jpg "Lecture 2. [Pathophysiology]")
II. Rate of Growth Most benign tumors grow slowly, and most cancers (malignant tumors) grow much faster. However, there are some exceptions to this generalization e.g., the rate of growth of leiomyomas
Cancer 101 Spring Family Cancer Retreat 4/18/15. Amish Shah, M.D. New Mexico Cancer Center
Cancer 101 Spring Family Cancer Retreat 4/18/15 Amish Shah, M.D. New Mexico Cancer Center Topics to cover What is Cancer? Screening Diagnosis/Staging Treatment Basics Clinical Trials Surveillance What
6 December 2012 Last updated at 01:15 GMT. Cancer's global toll
6 December 2012 Last updated at 01:15 GMT Cancer's global toll How a simple infection can trigger cancer By Joanne Silberner PRI's The World A girl in Uganda with Burkitt's lymphoma, caused by a virus
AP Biology. Viral diseases Polio. Chapter 18. Smallpox. Influenza: 1918 epidemic. Emerging viruses. A sense of size
Hepatitis Viral diseases Polio Chapter 18. Measles Viral Genetics Influenza: 1918 epidemic 30-40 million deaths world-wide Chicken pox Smallpox Eradicated in 1976 vaccinations ceased in 1980 at risk population?
For any cancer and for infection-related cancer, immediate ART was associated with a lower cancer risk in the first three models but not in models D,
Immediate ART in START Cuts Risk of Infection-Linked Cancer About 75% Conference on Retroviruses and Opportunistic Infections (CROI), February 22-25, 2016, Boston Mark Mascolini People who started antiretroviral
virology MCQs 2- A virus commonly transmitted by use of contaminated surgical tools & needles produces a disease called serum hepatitis.
virology MCQs 1- A virus which causes AIDS is: a- Small pox virus. b- Coxsackie B virus. c- Mumps virus. d- Rubella virus. e- HIV-III virus. 2- A virus commonly transmitted by use of contaminated surgical
Chapter 4 Cellular Oncogenes ~ 4.6 -
Chapter 4 Cellular Oncogenes - 4.2 ~ 4.6 - Many retroviruses carrying oncogenes have been found in chickens and mice However, attempts undertaken during the 1970s to isolate viruses from most types of
19/06/2013. Viruses are not organisms (do not belong to any kingdom). Viruses are not made of cells, have no cytoplasm, and no membranes.
VIRUSES Many diseases of plants and animals are caused by bacteria or viruses that invade the body. Bacteria and viruses are NOT similar kinds of micro-organisms. Bacteria are classified as living organisms,
Tumour Structure and Nomenclature. Paul Edwards. Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge
Tumour Structure and Nomenclature Paul Edwards Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge Malignant Metastasis Core idea of cancer Normal Cell Slightly
What is DNA? DNA is a double helix formed by base pairs attached to a sugar-phosphate backbone.
What is DNA? DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person s body has the same DNA. Most DNA is located in the cell nucleus
Aging and Cancer in HIV
Aging and Cancer in HIV Ronald Mitsuyasu, MD Professor of Medicine Director, UCLA Center for Clinical AIDS Research and Education Group Chairman, AIDS Malignancy Consortium (AMC) Age distribution of HIV-infected
Persistent Infections
Persistent Infections Lecture 17 Biology 3310/4310 Virology Spring 2017 Paralyze resistance with persistence WOODY HAYES Acute vs persistent infections Acute infection - rapid and self-limiting Persistent
CE Unit. Viruses and Vaccines
CE Unit Viruses and Vaccines DO NOT WRITE What is a virus? Have you ever had a virus? What is a vaccine? How is a virus different from bacteria? What are the deadliest viruses? 10. Dengue fever 50 million
Activation of cellular proto-oncogenes to oncogenes. How was active Ras identified?
Dominant Acting Oncogenes Eugene E. Marcantonio, M.D. Ph.D. Oncogenes are altered forms of normal cellular genes called proto-oncogenes that are involved in pathways regulating cell growth, differentiation,
COURSE: Medical Microbiology, PAMB 650/720 - Fall 2008 Lecture 16
COURSE: Medical Microbiology, PAMB 650/720 - Fall 2008 Lecture 16 Tumor Immunology M. Nagarkatti Teaching Objectives: Introduction to Cancer Immunology Know the antigens expressed by cancer cells Understand
Chapter 9, Part 1: Biology of Cancer and Tumor Spread
PATHOPHYSIOLOGY Name Chapter 9, Part 1: Biology of Cancer and Tumor Spread I. Cancer Characteristics and Terminology Neoplasm new growth, involves the overgrowth of tissue to form a neoplastic mass (tumor).
Introduction to Virology
Introduction to Virology Course Medical Microbiology Unit V Microorganisms Essential Question How do you detect a viral infection and what can be done to prevent it? TEKS 103.207 (c) 4B, 4C, 4D, 5A, 5C,
Epidemiology of SV40-Associated Tumors
Epidemiology of SV40-Associated Tumors Susan G. Fisher, Ph.D. Chief, Division of Epidemiology Community & Preventive Medicine University of Rochester Background Mass polio immunization program in U.S.
For more information about how to cite these materials visit
Author(s): David Miller, M.D., Ph.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/
Transplantation and oncogenic risk: the role of viruses
Transplantation and oncogenic risk: the role of viruses VIM 2014, Katoomba Associate Professor Angela Webster angela.webster@sydney.edu.au What can transplantation help us understand about infection and
Paul Murray University of Birmingham
Paul Murray University of Birmingham College of Medical and Dental Sciences The people of the Midlands have every reason to be supremely proud of this great centre of healing, of teaching and of research.
Size nm m m
1 Viral size and organization Size 20-250nm 0.000000002m-0.000000025m Virion structure Capsid Core Acellular obligate intracellular parasites Lack organelles, metabolic activities, and reproduction Replicated
HIV and Malignancy Alaka Deshpande, Himanshu Soni
HIV and Malignancy Alaka Deshpande, Himanshu Soni Emergence of new infectious disease was documented in 1981. Within a short span of time it became a pandemic. It was Acquired Immunodeficiency Syndrome
Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS
Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS APRIL 2017 Infectious viruses are a global health threat Since the approval of the first antiviral drug
Epstein-Barr Virus 1
Epstein-Barr Virus 1 Herpesviruses dsdna, linear, enveloped, 180-200 nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV HSV-2 virus particle. Note that
Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS
Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS MAY 2017 1 Infectious viral pathogens are a significant global health threat to mankind 2 Since the approval
Warts are a skin virus!
Viruses Warts are a skin virus! Herpes mouth virus: Other Viral Diseases Measles Polio Smallpox Influenza Hepatitis B Virus Viruses & Cancer Human Papilloma Virus HPV Tree Man - HPV Is a Virus a Living
Virus. Landmarks in Virology. Introduction to Virology. Landmarks in Virology. Definitions. Definitions. Latin for slimy liquid or poison
Landmarks in Virology Introduction to Virology Scott M. Hammer, M.D. Introduction of concept of filterable agents for plant pathogens (Mayer, Ivanofsky, Beijerinck in late 1880 s) First filterable agent
Suggested Exercises and Projects 395
Suggested Exercises and Projects 395 Projects These suggested projects are taken in part from the recent book A Course in Mathematical Biology: Quantitative Modeling with Mathematical and Computational
Screening donors and donations for transfusion transmissible infectious agents. Alan Kitchen
Screening donors and donations for transfusion transmissible infectious agents Alan Kitchen Aim Not to teach you microbiology To provide and awareness of the big picture To provide an understanding of
1. Basic principles 2. 6 hallmark features 3. Abnormal cell proliferation: mechanisms 4. Carcinogens: examples. Major Principles:
Carcinogenesis 1. Basic principles 2. 6 hallmark features 3. Abnormal cell proliferation: mechanisms 4. Carcinogens: examples Carcinogenesis Major Principles: 1. Nonlethal genetic damage is central to
Infection, Detection, Prevention...
Infection, Detection, Prevention... A disease is any change that disrupts the normal function of one or more body systems. Non infectious diseases are typically caused by exposure to chemicals or are inherited.
Cancer Fundamentals. Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource
Cancer Fundamentals Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource Cancer Overview Leading cause of death in US 1.2 million diagnosed each year More common after age
Tumor Immunology. Tumor (latin) = swelling
Tumor Immunology Tumor (latin) = swelling benign tumor malignant tumor Tumor immunology : the study of the types of antigens that are expressed by tumors how the immune system recognizes and responds to
1966 CDC assessment of US Health
Infectious Disease Epidemiology BMTRY 713 (A. Selassie, DrPH) Lecture 14 Emerging and New IDs Learning Objectives 1. Describe the threat of emerging and new infectious agents 2. Identify the contributing
Viruses. Objectives At the end of this sub section students should be able to:
Name: 3.5 Responses to Stimuli Objectives At the end of this sub section students should be able to: 3.5.4 Viruses 1. Explain the problem of defining what a virus is - living or non-living? 2. show you
Non-reproductive tissues and cells
Colour key Tested pathogen VIRAL Minimum requirements as set out in Directive 2004/23/EC More stringent testing - legy binding on national level More stringent testing - recommended on national level Not
Carcinogenesis. Carcinogenesis. 1. Basic principles 2. 6 hallmark features 3. Abnormal cell proliferation: mechanisms 4. Carcinogens: examples
Carcinogenesis 1. Basic principles 2. 6 hallmark features 3. Abnormal cell proliferation: mechanisms 4. Carcinogens: examples Major Principles (cont d) 4. Principle targets of genetic damage: 4 classes
Immune surveillance hypothesis (Macfarlane Burnet, 1950s)
TUMOR-IMMUNITÄT A.K. Abbas, A.H. Lichtman, S. Pillai (6th edition, 2007) Cellular and Molecular Immunology Saunders Elsevier Chapter 17, immunity to tumors Immune surveillance hypothesis (Macfarlane Burnet,
Chronic Viral Infections vs. Our Immune System: Revisiting our view of viruses as pathogens
Chronic Viral Infections vs. Our Immune System: Revisiting our view of viruses as pathogens Tiffany A. Reese Assistant Professor Departments of Immunology and Microbiology Challenge your idea of classic
Viruses. Poxviridae. DNA viruses: 6 families. Herpesviridae Adenoviridae. Hepadnaviridae Papovaviridae Parvoviridae
Viruses DNA viruses: 6 families Poxviridae Herpesviridae Adenoviridae Hepadnaviridae Papovaviridae Parvoviridae Human herpesviruses Three subfamilies (genome structure, tissue tropism, cytopathologic effect,
Prof. Leo Kinlen. An infective basis in childhood Leukaemia: the evidence of epidemiology
Prof. Leo Kinlen An infective basis in childhood Leukaemia: the evidence of epidemiology INFECTION-LINKED CANCERS Primary liver cancer Hepatitis B virus Primary liver cancer Hepatitis C virus Burkitt s
Can Mechanism plus Statistical Relevance add up to Good Enough Causation?
Can Mechanism plus Statistical Relevance add up to Good Enough Causation? BSPS Conference 2009 14 th July 2009 University of East Anglia Brendan Clarke Department of Science and Technology Studies UCL
The Struggle with Infectious Disease. Lecture 6
The Struggle with Infectious Disease Lecture 6 HIV/AIDS It is generally believed that: Human Immunodeficiency Virus --------- causes ------------- Acquired Immunodeficiency Syndrome History of HIV HIV
Introduction to Virology. Landmarks in Virology
Introduction to Virology Scott M. Hammer, M.D. Landmarks in Virology Introduction of concept of filterable agents for plant pathogens (Mayer, Ivanofsky, Beijerinck in late 1880 s) First filterable agent
BIT 120. Copy of Cancer/HIV Lecture
BIT 120 Copy of Cancer/HIV Lecture Cancer DEFINITION Any abnormal growth of cells that has malignant potential i.e.. Leukemia Uncontrolled mitosis in WBC Genetic disease caused by an accumulation of mutations
The Search for Infectious Causes of Human Cancers: Where and Why? Harald zur Hausen Deutsches Krebsforschungszentrum Heidelberg, Germany
The Search for Infectious Causes of Human Cancers: Where and Why? Harald zur Hausen Deutsches Krebsforschungszentrum Heidelberg, Germany Annual Global Cancer Incidence due to Infections 2 017 000 = 18.6%
General Properties of Viruses
1 I. Viruses as Agents of Disease. V. F. Righthand, Ph.D. August 15, 2001 General Properties of Viruses Viruses can infect every form of life. There are hundreds of different viruses that can produce diseases
CELL BIOLOGY - CLUTCH CH CANCER.
!! www.clutchprep.com CONCEPT: OVERVIEW OF CANCER Cancer is a disease which is primarily caused from misregulated cell division, which form There are two types of tumors - Benign tumors remain confined
Lecture 2 Evolution in action: the HIV virus
Lecture 2 Evolution in action: the HIV virus Peter and Rosemary Grant Barry Sinervo The HIV/AIDS pandemic Life expectancy in Botswana What is HIV? What is HIV? HIV is a retrovirus (i.e., RNA-based) with
Chapter 17. Infectious Diseases
Chapter 17 Infectious Diseases Lesson 1 What is an infectious disease? Infectious disease Is any disease that is caused by an agent that can be passed from one living thing to another. Disease causing
CE Unit 7. Viruses and Vaccines
CE Unit 7 Viruses and Vaccines DO NOT WRITE What is a virus? Have you ever had a virus? What is a vaccine? How is a virus different from bacteria? What are the deadliest viruses? 10. Dengue fever 50 million
Viruses. Non-cellular organisms. Premedical - Biology
Viruses Non-cellular organisms Premedical - Biology Size the smallest 20 nm and more Non-cellular: viruses are infectious particles plant, animal, bacterial = bacteriophages virion = nucleic acid + protein
MOLECULAR BASIS OF ONCOGENESIS
MOLECULAR BASIS OF ONCOGENESIS MUDr. Jiří Vachtenheim, CSc. 1 Cell processes which result also in cell cycle effects. Differentiation. Differentiated cells are usually in the G0 phase of the cell cycle.
Chapter 38 Viral Infections
Chapter 38 Viral Infections Primary Objectives of This Chapter Chapter 38 introduces a wide variety of important human viral diseases and serves as an introduction to Medical Virology. It is considered
Medical Virology Pathogenesis of viral infection
Medical Virology Pathogenesis of viral infection Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Pathogenesis of viral infection Viral
Name: Class: Date: ID: A
Name: Class: Date: Chapter 17 Quiz Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Of the following risks to human health, which causes the most human
Vaccine Intervention Against Virus-induced Tumours
Vaccine Intervention Against Virus-induced Tumours LEUKAEMIA AND LYMPHOMA RESEARCH Vaccine Intervention against Virus-induced Tumours Edited by J. M. Goldman Consultant Physician Royal Postgraduate Medical
Paul D. Cosman, PhD Natural Medicine
Paul D. Cosman, PhD Natural Medicine Understanding Lyme disease and Lyme disease as a causative factor in Cancer Links! Borrelia Burgdorferi, the causative bacteria in Lyme Disease, is capable of transforming
Non-reproductive tissues and cells
Colour key Minimum requirements as set out in Directive 2004/23/EC More stringent - legy binding on national level More stringent - recommended on national level Not legy binding and not recommended on
Cancer Key facts The problem Cancer causes
Cancer Key facts Cancer is a leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) in 2008 (1). Lung, stomach, liver, colon and breast cancer cause the most cancer
Cancer Association of South Africa (CANSA) Fact Sheet on the Top Ten Cancers per Population Group
Cancer Association of South Africa (CANSA) Fact Sheet on the Top Ten Cancers per Population Group Introduction There are more than 200 different types of cancer. It is also referred to as malignancies,
Transformation and Oncogenesis
Transformation and Oncogenesis Lecture 18 Biology 3310/4310 Virology Spring 2018 Cause and effect, means and ends, seed and fruit, cannot be severed; for the effect already blooms in the cause, the end
Viruses Tomasz Kordula, Ph.D.
Viruses Tomasz Kordula, Ph.D. Resources: Alberts et al., Molecular Biology of the Cell, pp. 295, 1330, 1431 1433; Lehninger CD Movie A0002201. Learning Objectives: 1. Understand parasitic life cycle of
1. Virus 2. Capsid 3. Envelope
VIRUSES BIOLOGY II VOCABULARY- VIRUSES (22 Words) 1. Virus 2. Capsid 3. Envelope 4. Provirus 5. Retrovirus 6. Reverse transcriptase 7. Bacteriophage 8. Lytic Cycle 9. Virulent 10. Lysis 11. Lysogenic Cycle
Epidemiology of AYA tumours. Dan Stark, MD Consultant in Medical Oncology Leeds UK
Epidemiology of AYA tumours Dan Stark, MD Consultant in Medical Oncology Leeds UK Summary Why we should study the epidemiology of AYA tumours What is already known What is not already known and is important
Baby Friendly Vaccines
Baby Friendly Vaccines What exactly are Baby Friendly Vaccines? Background on Immunity Immunity is the ability of the body to resist and fight germs (disease causing organisms) that can cause infectious
Available online at WSN 76 (2017) EISSN HPV Vaccines. Katarzyna Sitarz
Available online at www.worldscientificnews.com WSN 76 (2017) 209-215 EISSN 2392-2192 HPV Vaccines ABSTRACT Katarzyna Sitarz Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University,
Fayth K. Yoshimura, Ph.D. September 7, of 7 RETROVIRUSES. 2. HTLV-II causes hairy T-cell leukemia
1 of 7 I. Diseases Caused by Retroviruses RETROVIRUSES A. Human retroviruses that cause cancers 1. HTLV-I causes adult T-cell leukemia and tropical spastic paraparesis 2. HTLV-II causes hairy T-cell leukemia
VIRUSES. 1. Describe the structure of a virus by completing the following chart.
AP BIOLOGY MOLECULAR GENETICS ACTIVITY #3 NAME DATE HOUR VIRUSES 1. Describe the structure of a virus by completing the following chart. Viral Part Description of Part 2. Some viruses have an envelope
Viruses associated with human cancer
Available online at www.sciencedirect.com Biochimica et Biophysica Acta 1782 (2008) 127 150 www.elsevier.com/locate/bbadis Review Viruses associated with human cancer Margaret E. McLaughlin-Drubin, Karl
Environmental and Infectious Causes of Malignancy
University of Massachusetts Medical School escholarship@umms Cancer Concepts: A Guidebook for the Non- Oncologist Radiation Oncology 8-25-2014 Environmental and Infectious Causes of Malignancy Beth Israel
Killer Viruses: The Why and The How. Amesh Adalja
Killer Viruses: The Why and The How Amesh Adalja MD @AmeshAA Disclosures Stockholder: Merck, Luminex, Evolent Bondholder: UPMC Speaker s Bureau: Merck, Roche Consultant: Roche Funding: Open Philanthropy
Unit 4 Student Guided Notes
Structure of Viruses Discovery of the Virus Unit 4 Student Guided Notes Many human epidemics were well documented and observed in history, but. The following 3 discoveries shaped our knowledge of viruses
Herpesviruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics
Herpesviruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Enveloped icosahedral capsid (T=16), diameter 125 nm Diameter of enveloped virion 200 nm Capsid
Loss of early innate immune control leads to severe EBV
Loss of early innate immune control leads to severe EBV Disease The History of Epstein Barr Virus Glandular Fever (Drusenfieber), Pfeiffer, 1889 Infectious Mononucleosis, Sprunt, 1920 The History of Epstein
CS/PoliSci/Statistics C79 Societal Risks & The Law
CS/PoliSci/Statistics C79 Societal Risks & The Law Nicholas P. Jewell Department of Statistics & School of Public Health (Biostatistics) University of California, Berkeley March 19, 2013 1 Nicholas P.
Non-reproductive tissues and cells Recommending authority/ association
Colour key Minimum requirements as set out in Directive 2004/23/EC More stringent - legy binding More stringent - recommended Not legy binding and not recommended Tested pathogen Donor test/ technique
ESTIMATING DISEASE BURDEN ASSOCIATED WITH ONCOGENIC VIRUSES ABSTRACT
ORIGINAL ARTICLE ESTIMATING DISEASE BURDEN ASSOCIATED WITH ONCOGENIC VIRUSES Kanwal Baloch 1, Ameer Afzal Memon 2, Ikram Din Ujjan 3, Furqan Ahmed Bhatti 4 1-4 Department of Pathology, Liaquat University
Viruses. CLS 212: Medical Microbiology Miss Zeina Alkudmani
Viruses CLS 212: Medical Microbiology Miss Zeina Alkudmani History Through the 1800s, many scientists discovered that something smaller than bacteria could cause disease and they called it virion (Latin
BLOCK 12 Viruses of the ENT
BLOCK 12 Viruses of the ENT Acute infections Introduction Pharyngitis, Common cold, Sinusitis, Otitis media Recurrent infections Herpes zoster oticus Chronic infections HIV and ENT manifestations Neoplasms
CANCER. Inherited Cancer Syndromes. Affects 25% of US population. Kills 19% of US population (2nd largest killer after heart disease)
CANCER Affects 25% of US population Kills 19% of US population (2nd largest killer after heart disease) NOT one disease but 200-300 different defects Etiologic Factors In Cancer: Relative contributions
Adolescent vaccination strategies
Adolescent vaccination strategies Gregory Hussey Vaccines for Africa Initiative Institute of Infectious Diseases & Molecular Medicine University of Cape Town www.vacfa.uct.ac.za gregory.hussey@uct.ac.za