个人简历. Commun, PNAS, Angew Chem Int Ed 等专业杂志发表 40 余篇高水平学术论文 ;

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1 个人简历 席建忠, 北京大学工学院, 教授, 博士生导师, 国家杰出青年基金 资助 (2013) 1996 年毕业于北京理工大学化工与材料学院,2000 年在清华大学生物系获得细胞与分子生物学硕士,2004 年在加州大学洛杉矶分校获得生物医学工程专业博士学位 2005 年, 加入北京大学工学院生物医学工程系 目前担任中国化学会化学生物学专业委员会委员 中国医师协会临床精准医疗专业委员 中国医药生物技术协会生物芯片分会常务委员 中国生物医学工程学会生物医学测量分会委员等职务 研究方向 : 主要从事大规模功能基因技术的研发, 药物筛选 药效评估动物模型等方面, 取得了突出成绩, 在 Nature, Nat Biotechnol, Nat Cell Biol, Nat Commun, PNAS, Angew Chem Int Ed 等专业杂志发表 40 余篇高水平学术论文 ; 主持或承担过国家自然科学基金 4 项,973 课题 2 项及 863 课题 2 项 在成果应用转化方面, 席建忠教授实验也取得良好的进展 先后申报 4 项发明专利, 其中 2 项已获得授权 研发出的自组装细胞芯片 TALEN 等技术平台, 已经为清华 北大 中科院等数十家科研单位提供有力的技术支持 ; 并且与他们通力合作, 在自噬形成机制 (Nature Cell Biology, 2012) HIV 基因治疗 (Cell Reports, 2012) 植物育种(Nature Biotechnology, 2013) 转基因动物模型 (Nature, 2014) 干细胞诱导分化(Cell Research, 2014) 等多个方面取得了重要成果, 极大地推动我国在这些研究领域的发展 1

2 发表论文 : 1. Shenyi Yin, Yu Fan, Hanshuo Zhang, Zhihua Zhao, Yang Hao, Juan Li, Changhong Sun, Junyu Yang, Zhengjun Yang, Xiao Yang, Jian Lu and Jianzhong Jeff Xi*, Differential TGFβ Pathway Targeting by mir-122 in Humans and Mice affects Liver Cancer Metastasis, Nature Communications, 2016, 7: doi: /ncomms Dou L, Meng X, Sui X, Wang S, Shen T, Huang X, Guo J, Fang W, Man Y, Xi J*, Li J*, MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes. Sci Rep. s 5, Article number: (2015) 3. Dou L, Wang S, Sui X, Meng X, Shen T, Huang X, Guo J, Fang W, Man Y, Xi J*, Li J*, MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression. Cell Physiol Biochem 35: , Cui C, Wang Y, Yang K, Wang Y, Yang J, Xi J, Zhao M, Wu J, Peng S, Preparation and Characterization of RGDS/Nanodiamond as a Vector for VEGF-siRNA Delivery. Journal of Biomedical Nanotechnology, 11:1, 70-80, Zhang Y, Sun J, Zou Y, Chen W, Zhang W, Xi JJ, Jiang X*, Barcoded microchips for biomolecular assays, Anal Chem. 87(2):900-6, Haisong Liu, Huan Yang, Dicong Zhu, Xin Sui, Juan Li, Zhen Liang, Lei Xu, Zeyu Chen, Anzhi Yao, Long Zhang, Xi Zhang, Xing Yi, Meng Liu, Shiqing Xu, Wenjian Zhang, Hua Lin, Lan Xie, Jinning Lou, Yong Zhang, Jianzhong Xi *, Hongkui Deng*, Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells, Cell research 20: , Sun C, Fan Y, Li J, Wang G, Zhang H*, Xi JJ*, Efficient production of a gene mutant cell line through integrating TALENs and high-throughput cell cloning. J Lab Autom. 20(1):46-50, Zhang H, Li J, Hou S, Wang G, Jiang M, Sun C, Hu X, Zhuang F, Dai J*, Xi J*, Engineered TAL Effector Modulators for the Large-scale Gain-of-Function Screening, Nucleic Acid Research 42(14):e114, Hao Y, Yang J, Yin S, Zhang H, Fan Y, Sun C and Xi J*. The Synergistic Regulation of VEGF-mediated Angiogenesis Through mir-190 and Target Genes, RNA, 20, 1-9, Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong Y-N, Peng X, Xi J, Chen S, Wang F & Shao F, Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome, Nature 513(7517):237-41, Yao J, Huang J, Hai T, Wang X, Qin G, Zhang H, Wu R, Cao C, Xi JJ, Yuan Z, Zhao J, Efficient bi-allelic gene knockout and site-specific knock-in mediated by 2

3 TALENs in pigs. Sci Rep. 4:6926, Fan Y, Yin S, Hao Y. Yang J, Zhang H, Sun C, Ma M, Chang Q, and Xi, J*. mir-19b promotes tumor growth and metastasis via targeting TP53, RNA, 20(6):765-72, Ji D, Chen Z, Li M, Zhan T, Yao Y, Zhang Z, Xi J, Yan L, Gu J, MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1 Molecular Cancer 13:86, Yi Zhang, Lu Zhang, Jiashu Sun, Yulei Liu, Xingjie Ma, Shangjin Cui, Liying Ma, Jianzhong Jeff Xi, Xingyu Jiang. Point-of-Care Multiplexed Assays of Nucleic Acids Using Microcapillary-based Loop-Mediated Isothermal Amplification, Analytical Chemistry 86: , Ren X, Sun J, Housden B.E, Hu Y, Roesel C, Lin S, Liu L-P, Yang Z, Mao D, Sun L, Wu Q, Ji J-Y, Xi J, Mohr S, Xu J, Perrimon N, Ni J-Q, Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9, Proceedings of the National Academy of Sciences 110: , Shan Q, Wang Y, Li J, Zhang Y, Chen K, Liang Z, Zhang K, Liu J, Xi J, Qiu J-L, Gao C*, Targeted Genome Modification of Crop Plants Using the CRISPR/Cas System, Nature Biotech. 31, 686, Zhang H, Wu PY, Ma M, Ye Y, Hao Y, Yang J, Yin S, Sun C, Phan JH, Wang MD*, Xi J *. An integrative approach for the large-scale identification of human genome kinases regulating cancer metastasis, Nanomedicine 9(6):732-6, Chen J, Ma M, Shen N, Xi J*, Tian W*. Integration of cancer gene co-expression network and metabolic network to uncover potential cancer drug targets, J Proteome Res. 12(6): , Zhang Y, Qiao L, Ren Y, Wang X, Gao M, Tang Y, Xi J, Fu T-M, Jiang X, Two dimensional barcode-inspired automatic analysis for arrayed microfluidic immunoassays, Biomicrofluidics 7, , Chang N, Sun C, Gao L, Zhu D, Xu X, Zhu X, Xiong J-X*, and Xi J*. Genome Editing via the RNA-guided Cas9 Nuclease in Zebrafish Embryos, Cell Research, 23(4):465-72, Rong Y, Liu M, Ma L, Du W, Zhang H, Tian Y, Li Y, Ren H, Zhang C, Li L, Chen S, Xi J* & Li Yu*, Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation, Nature Cell Biology 14(9):924-34, Zhao Wang, Juan Li, Gancheng Wang, Mingjun Jiang, Shenyi Yin, Changhong Sun, Hanshuo Zhang, Fengfeng Zhuang* and Jianzhong Jeff Xi*, An Integrated Chip for the High-throughput Synthesis of Transcription-Activator-like Effectors, Angew. Chem. Int. Ed., 124:34, , Ming Xu, Hao-Di Wu, Rong-Chang Li, Hai-Bo Zhang, Meng Wang, Jin Tao, 3

4 Xin-Heng Feng, Yun-Bo Guo, Su-Fang Li, Shao-Ting Lai, Peng Zhou, Lin-Lin Li, Hua-Qian Yang, Guan-Zheng Luo, Yan Bai, Jianzhong J. Xi, Wei Gao, Qi-De Han, You-Yi Zhang, Xiu-Jie Wang, Xu Meng*, Shi-Qiang Wang*. Mir-24 Regulates Junctophilin-2 Expression in Cardiomyocytes, Circulation Research, 111: , Ping Yin, Dong Deng, Chuangye Yan, Xiaojing Pan, Jianzhong Jeff Xi, Nieng Yan, and Yigong Shi*. Specific DNA-RNA Hybrid Recognition by TAL Effectors, Cell Reports, 2(4):707-13, Yi Zhang, Xuwei Wang, Lusheng Song, Chuanlai Xu, Liying Ma, Zhanhua Li, Jianzhong Xi* and Xingyu Jiang*. Matrix-localization for fast analysis of arrayed microfluidic immunoassays, Anal. Methods, 4, 3466, Zhao Wang, Huang Huang, Hanshuo Zhang, Chang Hong Sun, Yang Hao, Junyu Yang, Yu Fan, and Jianzhong Xi*, A Magnetic Bead-Integrated Chip for the Large Scale Manufacture of Normalized esirnas, PLoS ONE, 7(6): e39419, Junyu Yang, Yang Hao, Jianzhong Jeff Xi*. Therapeutic Application of MicroRNAs against Human Cancers, J Lab Autom., Feb;18(1):30-3, Hanshuo Zhang, Yang Hao, Junyu Yang, Ying Zhuo, Juan Li, Changhong Sun, Shenyi Yin, Yanyi Huang and Jianzhong Xi*, Genome-wide Functional Screening of mir-23b as a Pleiotropic Modulator Suppressing Cancer Metastasis, Nature Communications, 2:554, Huang Huang, Qing Chang, Changhong Sun, Shenyi Yin, Juan Li and Jianzhong Xi*, A polyacrylamide microbead-integrated chip for the large-scale manufacture of ready-to-use esirna, Lab on a Chip, 11(6): , Huiping Yuan, Xiaoyong Zhang, Xiuqing Huang, Yonggang Lu, Weiqing Tang, Yong Man, Shu Wang, Jianzhong Xi* and Jian Li*, NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of b-cells via JNK, p38 MAPK and p53 Pathways, PLoS ONE, 5(12): e15726, Yu Z, Zhu Y, Zhang Y, Li J, Fang Q, Xi J, Yao B*. Nanoliter droplet array for microrna detection based on enzymatic stem-loop probes ligation and SYBR Green real-time PCR, Talanta, 85(4):1760-5, Smith AH, Robinson EM, Zhang XQ, Chow EK, Lin Y, Osawa E, Xi J and Ho D. Triggered release of therapeutic antibodies from nanodiamond complexes, Nanoscale, 3(7):2844-8, Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, Li YS, Chien S*, Wang N*. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells, Proc Natl Acad Sci USA., 107(7):3240-4, Li J, et al. Xi J*, Wang X*, Real-Time Polymerase Chain Reaction MicroRNA Detection Based on Enzymatic Stem-Loop Probes Ligation, Anal. Chem., 81: 4

5 , Wang J,et al. Xi J*, Huang Y*, A Chip-to-chip Nanoliter Microfluidic Dispenser. Lab on a Chip, 9: , Yao B, Li J, et al. Xi J*, Quantitative analysis of zeptomole micrornas based on isothermal ramification amplification, RNA 15: , Xu Ji, Zhihong Li, Jianzhong Xi, Juan Li, Yangyuan Wang, A piezoresistive cantilever for lateral force detection fabricated by a monolithic post-cmos process, Journal of Micromechanics and Microengineering, 11: 1-11, Xi J*, Jacob J, Montemagno C, Self-assembled microdevices driven by muscle, Nature Materials 4: , Xi Jianzhong*, Ho Dean, Chiu Ben, Montemagno Carlo, Lessons learned from engineering biologically-active hybrid nano/micro-devices, Advanced Functional Materials, 15, , Qiong Wu, Zhong Zheng, Jianzhong Xi, Haijun Gao and Guo-qiang Chen, Production of Hydroxyalkanoate Monomers by Microbial Fermentation. Journal of Chemical Engineering of Japan, 36: , Jianzhong Xi, Qiong Wu, Yongbin Yan, Zengming Zhang, Peter H.F Yu, Man-ken Cheung, Riqing Zhang and Guoqiang Chen. Hyperproduction of polyesters consisting of medium-chain-length hydroxyalkanoate monomers by strain Pseudomonas stutzeri Antonie van Leeuwenhoek, 78: 43-49, Chen Guoqiang, Wu Qiong, Xi Jianzhong and Yu H.Peter. Microbial production of biopolyesters-polyhydroxyalkanoates, Progress of Natural Sciences, 10: , 2000 专著 : Jianzhong Xi, MicroRNAs in Cancer, one chapter in the book of RNA and Cancer (Jane Y. Wu Ed), Springer,