Lung Physiology. Jamie Havrilak, PhD Postdoctoral Research Associate Layden Lab October 26th, 2018
|
|
- Ruth Fowler
- 5 years ago
- Views:
Transcription
1 Lung Physiology Jamie Havrilak, PhD Postdoctoral Research Associate Layden Lab October 26th, 2018
2 Nkx2.1- Lung epithelium Endomucin- Vasculature
3
4
5 Alveoli/Capillaries: Site of Gas Exchange in the Lung
6 Alveoli/Capillaries: Site of Gas Exchange in the Lung Artery CO 2 Air O 2 Capillary Vein
7 Alveoli/Capillaries: Site of Gas Exchange in the Lung Artery CO 2 Air O 2 Capillary Nkx2.1- epithelium Endomucin- blood vessels SMA-smooth muscle Vein
8
9 Alveolar Surface Area= sq ft ( m 2 ) Respired Air 11,000 liters/day
10
11 proximal Generation and organization of cell types distal
12 Epithelium -Ciliated cells -Goblet cells -Club cells -Alveolar type 1 and type 2 cells proximal distal Mesenchyme -Endothelial cells -Smooth muscle cells -fibroblasts -Pericytes
13 Distal Alveolus
14
15
16
17 Lung Diseases Respiratory Distress (RDS) Bronchopulmonary Dysplasia (BPD) Congenital Diaphragmatic Hernia (CDH) Asthma Pulmonary hypertension Lung Cancer Emphysema COPD Cystic fibrosis
18
19 Cystic Fibrosis
20 Common Lung Diseases Respiratory Distress (RDS) Chronic lung diseases of early infancy (BPD) Congenital Diaphragmatic Hernia (CDH) Asthma Pulmonary hypertension Lung Cancer Emphysema COPD Cystic fibrosis Why study lung development? If we understand how the lung develops, we can figure out how to repair it.
21 Stages of Human and Mouse Lung Development Alveolar Saccular Canalicular Pseudoglandular Embryonic Mouse (days): E9 E12 E16 E17 PN4 PN14 Human (weeks): 3w 7w 17w 26w 38w 18m Conception Branching morphogenesis begins Surfactant synthesis begins Birth Alveoli number increases Bud initiation Patterning is complete Formation of alveoli Lungs continue to develop after birth Havrilak and Shannon, 2015
22 Alveolar Saccular Canalicular Pseudoglandular Embryonic Mouse (days): E9 E12 E16 E17 PN4 PN14 Human (weeks): 3w 7w 17w 26w 38w 18m Conception Branching morphogenesis begins Surfactant synthesis begins Birth Alveoli number increases Bud initiation Patterning is complete Formation of alveoli Havrilak and Shannon, 2015 Premature Birth Respiratory Distress Disrupts Lung Development
23 Each of the germ layers gives rise to many different cell types Developmental Biology, 9e, Figure 1.7
24
25 Image from Zorn and Wells, 2009
26 The tracheal groove, arising from the foregut endoderm, branches to give rise to the conducting airways
27 Nkx2.1- Lung epithelium Early Stages of Lung Development I. Embryonic I. Embryonic E-cadherinendoderm Endomucin- Vasculature I. Embryonic II. Pseudoglandular II. Pseudoglandular II. Pseudoglandular Mesenchyme Havrilak and Shannon, Lung Development 2015 Image modified from the Pulmonary Biology Division website Epithelium
28 Lung Branching Morphogenesis Metzger et al, Nature 2008
29 Later Stages of Lung Development in the Mouse III. Canalicular IV. Saccular V. Alveolar V. Alveolar V. Alveolar
30 Lung Branching Morphogenesis Metzger et al, Nature 2008
31 Tissue interactions govern early lung morphogenesis Importance of Lung Mesenchyme Lung mesenchyme is essential for lung development Branching and differentiation of the epithelium depends on a close association with the lung mesenchyme. Mesenchyme Epithelium
32 Lung mesenchyme is necessary for lung epithelial branching Wessells, 1970
33 Lung Mesenchyme (M) Attracts Lung Epithelium (E) E M Mesenchymal inducers are diffusible
34 Lung epithelial development driven by mesenchymal signals How do we induce lung formation? Rankin and Zorn, 2015, J. Cell Biochem.
35 FGF signaling is an essential component of the regulatory networks between epithelium and mesenchyme in the developing lung Fgf10- is expressed in distal lung mesenchyme Signals to Fgf receptors in epithelium Deletion of FGF10 results in lung agenesis, as does deletion of its receptor FGFR2b. Image modified from Sekine, et al.,1999 Image modified from Cardoso and Kotton, 2008 Image modified from Min, et al.,1998 Genes and Dev
36 Interactions Between Multiple Signaling Pathways When? Where? How much? Gene regulatory network governing respiratory specification Rankin and Zorn, 2015, J. Cell Biochem.
37 Lung Morphogenesis and Differentiation 50 Cell Types Need to Orchestrate Proper: Regulation of Processes: Place Time Cell Types Cell Numbers Size Function Repair Commitment Specification Restriction Differentiation Proliferation Maturation Morphogenesis Patterning
38 Translational applications Currently no effective treatments Respiratory distress syndrome Chronic obstructive pulmonary disease Idiopathic pulmonary fibrosis Pathways that are activated during development may be activated during adult lung repair Model human disease (lung organoids) New or improved clinical therapies
39 Pluripotent stem cell (PSC)-derived organoids. Meritxell Huch, and Bon-Kyoung Koo Development 2015;142: Published by The Company of Biologists Ltd
40 Induced pluripotent stem cell (ipsc)
41 Meritxell Huch, and Bon-Kyoung Koo Development 2015;142:
42 Go through many different stages before it can become a lung cell Rankin and Zorn, 2015, J. Cell Biochem.
43 Interactions Between Multiple Signaling Pathways Gene regulatory network governing respiratory specification Rankin and Zorn, 2015, J. Cell Biochem.
44 How do we make a lung in a dish? Briana R Dye et al. elife Sciences 2015;4:e05098
45 Briana R Dye et al. elife Sciences 2015;4:e05098 Lung spheroids
46 Briana R Dye et al. elife Sciences 2015;4:e05098
47 3D Lung Organoids Chen, et al., 2017, Nature Cell Biology
48 Potential application of lung organoids in modeling human diseases Chen, et al., 2017, Nature Cell Biology
49 Thank you! Questions?
Histology and development of the respiratory system
Histology and development of the respiratory system Árpád Dobolyi Semmelweis University, Department of Anatomy, Histology and Embryology Outline of the lecture 1. Structure of the trachea 2. Histology
More informationDevelopment of Respiratory System. Dr. Sanaa Alshaarawy& Dr. Saeed Vohra
Development of Respiratory System Dr. Sanaa Alshaarawy& Dr. Saeed Vohra OBJECTIVES At the end of the lecture the students should be able to: Identify the development of the laryngeotracheal (respiratory)
More informationFunction of Breathing. Jeanine D Armiento, M.D., Ph.D. Respiratory Portion. Conducting Portion. Critical to the Development of the Lung
Function of Breathing Jeanine D Armiento, M.D., Ph.D. Associate Professor Department of Medicine P&S 9-449 5-3745 jmd12@columbia.edu Air Sacs (alveoli) Ventilation-air conduction Moving gas in and out
More informationIn Vivo Models and Cell Delivery for Lung Indications NO DISCLOSURES
In Vivo Models and Cell Delivery for Lung Indications Marlowe Eldridge MD Department of Pediatrics and Biomedical Engineering University of Wisconsin School of Medicine and Public Health NO DISCLOSURES
More information-Tamara Wahbeh. -Razan Abu Rumman. Dr. Mohammed Al-Muhtaseb
-2 -Tamara Wahbeh -Razan Abu Rumman Dr. Mohammed Al-Muhtaseb I tried to include everything the doctor mentioned in both the lecture and his slides in the simplest way possible, so hopefully there would
More informationLecture 21Development of respiratory system Dr. Rehan Asad At the end of session students should able to Describe formation of lung buds Describe
Lecture 21Development of respiratory system Dr. Rehan Asad At the end of session students should able to Describe formation of lung buds Describe development of larynx, trachea and bronchi. Describe the
More informationInterstitial Lung Disease in Infants and Children
Interstitial Lung Disease in Infants and Children David A. Mong, MD SUNDAY Andrew Mong MD Beyond the interstitium (path includes airways/airspace) Radiographic diffuse disease Adult Interstitial Lung Disease
More informationFrom Buds to Branches to Tubes!
: Respiratory and Ingestive Consequences of Premature Birth 2007 ASHA KAYPentax Lecture Session 1260 JL Miller, Ph.D. National Institutes of Health jmiller@cc.nih.gov From buds to branches to tubes, the
More informationIn vivo Models of Rare Respiratory Diseases. Rare Pediatric Respiratory Diseases Conference July 7, 2017
In vivo Models of Rare Respiratory Diseases Rare Pediatric Respiratory Diseases Conference July 7, 2017 Genetic basis of pediatric lung diseases + Congenital diaphragmatic hernia Trachea-esophageal fistrula
More informationRespiration Lesson 3. Respiration Lesson 3
Respiration Lesson 3 and Airway Resistance (key factors affecting air flow) 1) What is the arterial blood pressure in a healthy 18 year old male? 2) What would his venous blood pressure be? 3) What is
More informationCongenital anomalies of the lungs. Atelectasis. Acute lung injury
Congenital anomalies of the lungs Atelectasis Acute lung injury Gábor Smuk M.D. Developmental lung diseases I.a. Bronchogenic cyst: abnormal budding of the tracheobronchial primordium of the primitive
More informationRespiratory Toxicology
Respiratory Toxicology Loch-Caruso ENVIRON 310 2017 1 Breathing Oxygen Carbon Dioxide http://www.webmd.com/lung/picture-of-the-lungs Loch-Caruso ENVIRON 310 2017 2 Breathing Enlarged view of the airways,
More informationImaging in pediatric lung diseases The roles of CT and pathology in diagnosing inherited and developmental lung diseases
Imaging in pediatric lung diseases The roles of CT and pathology in diagnosing inherited and developmental lung diseases Dr Alistair D Calder Consultant Radiologist We re not so different, you and I. Invasiveness
More informationUpdate on ChILD. R. Paul Guillerman, MD Associate Professor Department of Pediatric Radiology
Update on ChILD R. Paul Guillerman, MD Associate Professor Department of Pediatric Radiology Objectives Review recent advances in the imaging of childhood interstitial lung disease (ChILD) Diseases under-recognized,
More informationThe Anatomy and Physiology of the Respiratory System
CHAPTER 1 The Anatomy and Physiology of the Respiratory System Sagittal Section of Upper Airway Fig. 1-1. Sagittal section of upper airway. Structure of the Nose Fig. 1-2. Structure of the nose. Sagittal
More informationDevelopment of the nasal cavity :
Development of the nasal cavity : several processes contribute to the development of the nose, the nose consists of 2 cavities separated by a septum, and the nasal cavity is separated from the oral cavity
More informationGroup B: Directed self-study Group C: Anatomy lab. Lecture: Structure and function of larynx. Lecture: Dead space & compliance of lungs
Timetable Week 1 (1 st January 2018) Theme: Structure and functions of the lungs Group A: Anatomy lab Group C: Histology lab Upper Group B: Anatomy lab Group C: Anatomy lab Group A: Histology lab Upper
More informationOrgans of the Respiratory System Laboratory Exercise 52
Organs of the Respiratory System Laboratory Exercise 52 Background The organs of the respiratory system include the nose, nasal cavity, sinuses, pharynx, larynx, trachea, bronchial tree, and lungs. They
More informationBiochemistry of Lungs. Lecture # 35 Lecturer: Alexander Koval
Biochemistry of Lungs Lecture # 35 Lecturer: Alexander Koval Introduction Biochemistry of lungs Overview of substances produced (surfactant, mucus, collagen), inactivated (ROS, kinins, serotonin, catecholamines)
More informationThe embryonic endoderm initially is widely connected with the yolk sac. As a consequence of cephalocaudal and lateral folding, a portion of the
DIGESTIVE SYSTEM The embryonic endoderm initially is widely connected with the yolk sac. As a consequence of cephalocaudal and lateral folding, a portion of the endoderm-lined yolk sac cavity is incorporated
More information30.1 Respiratory and Circulatory Functions. KEY CONCEPT The respiratory and circulatory systems bring oxygen and nutrients to the cells.
30.1 Respiratory and Circulatory Functions KEY CONCEPT The respiratory and circulatory systems bring oxygen and nutrients to the cells. 30.1 Respiratory and Circulatory Functions The respiratory and circulatory
More informationInterstitial Apoptosis and Airway Expansion. David E. Kling, Ph.D.
Interstitial Apoptosis and Airway Expansion David E. Kling, Ph.D. Topics/Coverage Characterization of drug-sensitive cells in lung Cell differentiation protects against cytotoxicity Retinoic acid affects
More informationChapter 16. Respiratory System
Chapter 16 Respiratory System Introduction Respiration = the entire process of exchanging gases between the atmosphere and body cells 1. Ventilation 2. Gas exchange 3. Gas transport : 4. Cellular respiration
More informationBronchioles. Alveoli. Type I alveolar cells are very thin simple squamous epithelial cells and form most of the lining of an alveolus.
276 Bronchioles Bronchioles continue on to form bronchi. The primary identifying feature is the loss of hyaline cartilage. The epithelium has become simple ciliated columnar, and there is a complete ring
More informationRespiratory System. Organization of the Respiratory System
Respiratory System In addition to the provision of oxygen and elimination of carbon dioxide, the respiratory system serves other functions, as listed in (Table 15 1). Respiration has two quite different
More information#8 - Respiratory System
Page1 #8 - Objectives: Study the parts of the respiratory system Observe slides of the lung and trachea Equipment: Remember to bring photographic atlas. Figure 1. Structures of the respiratory system.
More informationLec #2 histology. Bronchioles:
Lec #2 histology. Last lecture we talked about the upper respiratory tract histology, this one is about the lower part histology. We will discuss the histology of: -bronchioles -respiratory bronchioles
More informationChronic Lung Disease Of Prematurity. Dr Jo Harrison
Chronic Lung Disease Of Prematurity Dr Jo Harrison 9.9.14 Chronic Neonatal Lung Disease Bronchopulmonary dysplasia (BPD) first described in 1967 by Northway Defined as O 2 dependence at 28 days post birth
More informationAn Overview of Bronchopulmonary Dysplasia and Chronic Lung Disease in Infancy
An Overview of Bronchopulmonary Dysplasia and Chronic Lung Disease in Infancy Housekeeping: I have no financial disclosures Learning objectives: Develop an understanding of bronchopulmonary dysplasia (BPD)
More informationThe Building Blocks of Mammalian Lung Development
a DEVELOPMENTAL DYNAMICS 240:463 476, 2011 SPECIAL ISSUE REVIEWS-A PEER REVIEWED FORUM The Building Blocks of Mammalian Lung Development Emma L. Rawlins* Progress has recently been made in identifying
More informationOrgans Histology D. Sahar AL-Sharqi. Respiratory system
Respiratory system The respiratory system provides for exchange of O2 and CO2 to and from the blood. Respiratory organs include the lungs and a branching system of bronchial tubes that link the sites of
More informationCongenital Diaphragmatic Hernia information for parents. David M Notrica MD FACS FAAP Pediatric Surgeons of Phoenix
Congenital Diaphragmatic Hernia information for parents David M Notrica MD FACS FAAP Pediatric Surgeons of Phoenix CDH Congenital absence of a portion of the diaphragm allowing abdominal contents to migrate
More information7/12/2012. Respiratory system. Respiratory Response to Toxic Injury (Lung) Ninth Industrial Toxicology and Pathology Short Course.
Ninth Industrial Toxicology and Pathology Short Course 23 27 July, 2012 Contemporary Concepts in Target Organ Toxicologic Pathology Respiratory system Respiratory Response to Toxic Injury (Lung) Eric Wheeldon
More informationThe normal lung: histology, embryology, development, aging and function
Chapter1 The normal lung: histology, embryology, development, aging and function Neil Sahasrabudhe, John R. Gosney and Philip Hasleton Introduction Knowledge of normal lung anatomy and function is important
More informationThe Evolution and Development of the Gut. Dr Mike Wride School of Natural Sciences Zoology Department
The Evolution and Development of the Gut Dr Mike Wride School of Natural Sciences Zoology Department email: wridem@tcd.ie The gut? Gut Function and Regulation (Dr. Alan Tuffery) Absorption of nutrients
More informationThe Human Respiration System
The Human Respiration System Nasal Passage Overall function is to filter, warm and moisten air as it enters the body. The nasal passages are the primary site of air movement we tend to be nose breathers.
More informationThe Respiratory System. Dr. Ali Ebneshahidi
The Respiratory System Dr. Ali Ebneshahidi Functions of The Respiratory System To allow gases from the environment to enter the bronchial tree through inspiration by expanding the thoracic volume. To allow
More informationCHAPTER 22 RESPIRATORY
pulmonary ventilation move air external respiration exchange gases transportation of gases internal respiration exchange gases CHAPTER 22 RESPIRATORY in / out lungs air - blood blood - cells cell respiration
More informationThere are four general types of congenital lung disorders:
Pediatric Pulmonology Conditions Evaluated and Treated As a parent, watching a child suffer from a respiratory disorder can be frightening and worrisome. Our respiratory specialists provide compassionate
More informationActivity 1: Respiratory System Lab
Activity 1: Respiratory System Lab Launch Human Anatomy Atlas. Navigate to Quizzes/Lab Activities, find the Respiratory Lab section. Don t have AR? Select view 1. Respiratory System. 2. Fill in the blanks.
More informationHISTOLOGY OF THE RESPIRATORY SYSTEM I. Introduction A. The respiratory system provides for gas exchange between the environment and the blood. B.
HISTOLOGY OF THE RESPIRATORY SYSTEM I. Introduction A. The respiratory system provides for gas exchange between the environment and the blood. B. The human respiratory system may be subdivided into two
More informationChronic inflammation of the airways Hyperactive bronchi Shortness of breath Tightness in chest Coughing Wheezing
Chronic inflammation of the airways Hyperactive bronchi Shortness of breath Tightness in chest Coughing Wheezing Components of the respiratory system Nasal cavity Pharynx Trachea Bronchi Bronchioles Lungs
More informationNormal Development, Anatomy, Histology and Aging of the Lung
Chapter 1 Normal Development, Anatomy, Histology and Aging of the Lung Xuchen Zhang*, and Robert J. Homer 1. Introduction The primary function of the lungs is to exchange gas between air in the external
More informationClass of We are pleased to provide support for the following new investigators who make up the Parker B. Francis Fellowship Class of 2016.
The Parker B. Francis Fellowship Program provides career development support to M.D. and Ph.D. scientists embarking on careers in clinical, laboratory or translational science related to Pulmonary, Critical
More information6/25/2013. Pulmonary Hypoplasia in Congenital Defects. Joshua E. Petrikin, MD Assistant Professor Pediatrics June 28 th, 2013
Pulmonary Hypoplasia in Congenital Defects Joshua E. Petrikin, MD Assistant Professor Pediatrics June 28 th, 2013 I have no financial conflicts of interest to disclose Case 1 39 wk infant with born via
More informationGAS EXCHANGE IB TOPIC 6.4 CARDIOPULMONARY SYSTEM CARDIOPULMONARY SYSTEM. Terminal bronchiole Nasal cavity. Pharynx Left lung Alveoli.
IB TOPIC 6.4 GAS EXCHANGE CARDIOPULMONARY SYSTEM CARDIOPULMONARY SYSTEM Branch from the pulmonary artery (oxygen-poor blood) Branch from the pulmonary vein (oxygen-rich blood) Terminal bronchiole Nasal
More informationIB TOPIC 6.4 GAS EXCHANGE
IB TOPIC 6.4 GAS EXCHANGE CARDIOPULMONARY SYSTEM CARDIOPULMONARY SYSTEM Branch from the pulmonary artery (oxygen-poor blood) Branch from the pulmonary vein (oxygen-rich blood) Terminal bronchiole Nasal
More informationRespiratory System. BSC 2086 A&P 2 Professor Tcherina Duncombe Palm Beach State College
Respiratory System BSC 2086 A&P 2 Professor Tcherina Duncombe Palm Beach State College Respiration Ventilation of lungs Gas exchange between air/bld and bld/tissue Use of oxygen in cellular respiration
More informationHome Pulse Oximetry for Infants and Children
Last Review Date: April 21, 2017 Number: MG.MM.DM.12aC2v2 Medical Guideline Disclaimer Property of EmblemHealth. All rights reserved. The treating physician or primary care provider must submit to EmblemHealth
More information10.1 The Pulmonary-Circulatory System
pulmonary system breathing lungs pneumonia suffocation asthma circulatory system atrium ventricle artery capillary vein heart attack stroke heart The Pulmonary System Our pulmonary system contains tissues
More informationTissue repair. (3&4 of 4)
Tissue repair (3&4 of 4) What will we discuss today: Regeneration in tissue repair Scar formation Cutaneous wound healing Pathologic aspects of repair Regeneration in tissue repair Labile tissues rapid
More informationThe Respiratory System
The Respiratory System Cells continually use O2 & release CO2 Respiratory system designed for gas exchange Cardiovascular system transports gases in blood Failure of either system rapid cell death from
More informationThe Respiratory System
PowerPoint Lecture Slide Presentation by Vince Austin Human Anatomy & Physiology FIFTH EDITION Elaine N. Marieb The Respiratory System Dr Nabil Khouri. MD, Ph.D Respiratory System Consists of a conducting
More informationSupplementary Materials for
advances.sciencemag.org/cgi/content/full/3/8/e1700521/dc1 Supplementary Materials for Functional vascularized lung grafts for lung bioengineering N. Valerio Dorrello, Brandon A. Guenthart, John D. O Neill,
More informationTests Your Pulmonologist Might Order. Center For Cardiac Fitness Pulmonary Rehab Program The Miriam Hospital
Tests Your Pulmonologist Might Order Center For Cardiac Fitness Pulmonary Rehab Program The Miriam Hospital BASIC ANATOMY OF THE LUNGS Lobes of Lung 3 lobes on the Right lung 2 lobes on the Left Blood
More informationTHE RESPIRATORY SYSTEM
THE RESPIRATORY SYSTEM Functions of the Respiratory System Provides extensive gas exchange surface area between air and circulating blood Moves air to and from exchange surfaces of lungs Protects respiratory
More informationLUNGS. Requirements of a Respiratory System
Respiratory System Requirements of a Respiratory System Gas exchange is the physical method that organisms use to obtain oxygen from their surroundings and remove carbon dioxide. Oxygen is needed for aerobic
More informationImmunological Lung Diseases
Emphysema and Fibrosis Universitätsklinik für Pneumologie Prof. Thomas Geiser Head Div. of Pulmonary Medicine and Laboratory of Lung Research, MU50 thomas.geiser@insel.ch The healthy lung: The pathway
More informationRespiratory System Embryology
Respiratory System Embryology Development of the nose and Palate Development of the nose At the end of the fourth week, facial prominences consisting primarily of neural crest-derived mesenchyme and formed
More informationChest and cardiovascular
Module 1 Chest and cardiovascular A. Doss and M. J. Bull 1. Regarding the imaging modalities of the chest: High resolution computed tomography (HRCT) uses a slice thickness of 4 6 mm to identify mass lesions
More informationRestrictive lung diseases
Restrictive lung diseases Restrictive lung diseases are diseases that affect the interstitium of the lung. Interstitium of the lung is the very thin walls surrounding the alveoli, it s formed of epithelium
More information3/13/2009. Bronchopulmonary Dysplasia (BPD) Congenital Diaphragmatic Hernia. Congenital Heart Disease. Connective Tissue Disease.
Pulmonary vascular alterations in chronic lung disease: The clinical problem Fetal circulation-gas exchange occurs in the placenta David N. Cornfield, M.D. Anne T. and Robert M. Bass Professor of Pulmonary
More informationRespiratory Physiology
Respiratory Physiology Dr. Aida Korish Associate Prof. Physiology KSU The main goal of respiration is to 1-Provide oxygen to tissues 2- Remove CO2 from the body. Respiratory system consists of: Passages
More informationThe labyrinth of neonatal and pediatric ILD
The labyrinth of neonatal and pediatric ILD Matthias Griese München child-eu Register and biobank child-eu Register and biobank 4-2014 until 7-2017 439 cases entered 378 peer-reviewed and diagnosed into
More informationCARDIOVASCULAR AND RESPIRATORY SYSTEMS
CARDIOVASCULAR AND RESPIRATORY SYSTEMS KEY TERMS: Cardiovascular System, cardio, vascular, blood vessels, valves, arteries, capillaries, veins, systemic circulation, pulmonary circulation Your Cardiovascular
More informationGrowth Factor Circuitry in Vascular Morphogenesis. Lung Development
Growth Factor Circuitry in Vascular Morphogenesis Margaret Schwarz, MD Associate Professor Lung Development PECAM-1 Vascular Mediators VEGF ECM Adhesion molecules Anti-angiogenic Factors Fate Specification
More information8/14/2017. Objective: correlate radiographic findings of common lung diseases to actual lung pathologic features
What is that lung disease? Pulmonary Patterns & Correlated Pathology Dr. Russell Tucker, DACVR Objective: correlate radiographic findings of common lung diseases to actual lung pathologic features Improved
More informationRespiratory System. Functional Anatomy of the Respiratory System
Respiratory System Overview of the Respiratory System s Job Major Duty Respiration Other important aspects ph control Vocalization Processing incoming air Protection Metabolism (ACE) What structures allow
More informationFour Types of Vertebrate Tissue
BIO 121 Molecular Cell Biology Lecture Section IV A. Cells in the Context of Tissue, Organ and Organismal Architecture B. Wound Healing Four Types of Vertebrate Tissue 1.Epithelium 2.Connective Tissue
More informationRespiratory System. December 20, 2011
Respiratory System December 20, 2011 Nasal Cavity: Contains cilia (hair cells) to prevent particles from entering the respiratory tract Mucus does the same, in addition to warming and moistening the air
More informationEffect of Fgf10 deficiency on mouse lung development and in a mouse model of bronchopulmonary dysplasia
Effect of Fgf10 deficiency on mouse lung development and in a mouse model of bronchopulmonary dysplasia Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfillment of the requirements
More informationClass of We are pleased to provide support for the following new investigators who make up the Parker B. Francis Fellowship
The Parker B. Francis Fellowship Program provides career development support to M.D. and Ph.D. scientists embarking on careers in clinical, laboratory or translational science related to Pulmonary, Critical
More informationA New Treatment Paradigm Outside-In
A New Treatment Paradigm Outside-In 2 2013 Mercator MedSystems OneMedForum Jan 8, 2013 Outside-In Response: Signal Amplification Signal convection Signal amplification Modified from Michel 2007, ATVB 3
More information3. Which statement is false about anatomical dead space?
Respiratory MCQs 1. Which of these statements is correct? a. Regular bronchioles are the most distal part of the respiratory tract to contain glands. b. Larynx do contain significant amounts of smooth
More informationSPR 2017 General Pediatric Radiology Categorical Course: Chest II and IR May 17, 2017 SAM References
SPR 2017 General Pediatric Radiology Categorical Course: Chest II and IR May 17, 2017 SAM s Lateral Chest: Underused and Overlooked Alan S. Brody, MD 1. Adding an upright lateral view is most likely to
More informationJournal of the COPD Foundation Stem Cell Therapy for COPD: Where are we?
148 Journal Club: Stem Cell Therapy Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation Stem Cell Therapy for COPD: Where are we? Ron Balkissoon, MD, MSc, DIH, FRCPC 1 Abbreviations:
More informationNotes to complete gas exchange in mammals
Notes to complete gas exchange in mammals Mass flow of air to respiratory surface this is achieved through the mechanics of ventilation (breathing). This ensures a regular supply of air into and out of
More informationLate pulmonary hypertension in preterm infants How to sort things out? V.Gournay, FCPC, La Martinique, Nov 23,2015
Late pulmonary hypertension in preterm infants How to sort things out? V.Gournay, FCPC, La Martinique, Nov 23,2015 Epidemiology Incidence of extreme prematurity (
More informationImaging of the Lung in Children
Imaging of the Lung in Children Imaging methods X-Ray of the Lung (Anteroposterior, ) CT, HRCT MRI USG Congenital developmental defects of the lungs Agenesis, aplasia, hypoplasia Tension pulmonary anomalies
More informationDevelopment of Blood Vessels and Fetal Circulation *
OpenStax-CNX module: m46610 1 Development of Blood Vessels and Fetal Circulation * OpenStax This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the
More informationCBPH 852 Experimental Physiology of Human Health and Disease (Formerly PHYI 702; Fall 2016)
CBPH 852 Experimental Physiology of Human Health and Disease (Formerly PHYI 702; Fall 2016) M,W,F, 9-10:30 AM, 7002 Marsico Hall (7 th floor conference room) This course is ideal for first or second-year
More informationRespiratory System Functions. Respiratory System Organization. Respiratory System Organization
Respiratory System Functions Functions of Respiratory System Gas exchange between blood and air Move air to and from exchange surfaces Protect exchange surfaces from environmental variations and pathogens
More informationVascular Lung Diseases
Vascular Lung Diseases SESSION SPECIFIC OBJECTIVES List the major types of vascular lung disease Recognize and describe the pathology of vascular lung disease: Pulmonary embolism, thrombosis, hypertension,
More informationSignaling Vascular Morphogenesis and Maintenance
Signaling Vascular Morphogenesis and Maintenance Douglas Hanahan Science 277: 48-50, in Perspectives (1997) Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive vascular
More informationChapter 23 The Respiratory System
Chapter 23 The Respiratory System Cells continually use O 2 & release CO 2 Respiratory System designed for gas exchange Cardiovascular system transports gases in blood Failure of either system rapid cell
More informationDISEASES OF THE RESPIRATORY SYSTEM 2017 DR HEYAM AWAD LECTURE 1: RESPIRATORY DISTRESS SYNDROMES
DISEASES OF THE RESPIRATORY SYSTEM 2017 DR HEYAM AWAD LECTURE 1: RESPIRATORY DISTRESS SYNDROMES This lecture covers two topics: neonatal respiratory distress syndrome (neonatal RDS) and adult respiratory
More informationBio 322 Human Anatomy Objectives for the laboratory exercise Respiratory System
Bio 322 Human Anatomy Objectives for the laboratory exercise Respiratory System Required reading before beginning this lab: Saladin, KS: Human Anatomy 5 th ed (2017) Chapter 23 For this lab you will use
More informationChapter 10 Lecture Outline
Chapter 10 Lecture Outline See separate PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright 2016 McGraw-Hill Education. Permission required for reproduction
More informationPULMONARY FGF-18 GENE EXPRESSION IS DOWNREGULATED DURING THE CANALICULAR-SACCULAR STAGES IN NITROFEN-INDUCED HYPOPLASTIC LUNGS
PULMONARY FGF-18 GENE EXPRESSION IS DOWNREGULATED DURING THE CANALICULAR-SACCULAR STAGES IN NITROFEN-INDUCED HYPOPLASTIC LUNGS Hiromizu Takahashi 1,2, Florian Friedmacher 1, Naho Fujiwara 1, Alejandro
More informationHeart Development. Robert G. Kelly Developmental Biology Institute of Marseilles - Luminy
ESC CBCS Summer School on Cardiovascular Sciences 15th June 2011 Heart Development Robert G. Kelly Developmental Biology Institute of Marseilles - Luminy Animal models of heart development Tinman/Nkx2.5
More informationCase Based Fetal Lung Masses
Case Based Fetal Lung Masses Advances in Fetal and Neonatal Imaging Course Orlando, Florida, January 28, 2017 Leann E. Linam, MD Associate Professor Radiology University of Arkansas for Medical Sciences/
More informationCongenital Lung Malformations: Radiologic-Pathologic Correlation
Acta Radiológica Portuguesa, Vol.XVIII, nº 70, pág. 51-60, Abr.-Jun., 2006 Congenital Lung Malformations: Radiologic-Pathologic Correlation Marilyn J. Siegel Mallinckrodt Institute of Radiology, Washington
More informationRespiration. Chapter 37. Mader: Biology 8 th Ed.
Respiration Chapter 37 Gas Exchange Surfaces Respiration is the sequence of events that results in gas exchange between the body s cells and the environment. Ventilation External Respiration Internal Respiration
More informationViral infections in airway remodeling
Viral infections in airway remodeling Nikos Papadopoulos As. Proffesor,Head, Allergy Dpt, 2 nd Pediatric Clinic, University of Athens Overview Acute events may have long term consequences Remodeling appears
More informationRespiratory Management and Outcome of Preterm Infants
Respiratory Management and Outcome of Preterm Infants 6 th Annual Care Of The Sick Newborn Conference Shu Wu, MD. Department of Pediatrics Division of Neonatology University of Miami School of Medicine
More informationCambridge International Examinations Cambridge International Advanced Subsidiary and Advanced Level
Cambridge International Examinations Cambridge International Advanced Subsidiary and Advanced Level *9074709121* BIOLOGY 9700/22 Paper 2 AS Level Structured Questions May/June 2017 1 hour 15 minutes Candidates
More informationPulmonology Elective PL-1 Residents
PL-1 Residents The Pulmonary elective is available to first year residents in either a 2 or 4 week block rotation. The experience will include performing inpatient consultations, attending outpatient clinics
More informationTissues. tissue = many cells w/ same structure and function. cell shape aids function tissue shape aids function. Histology = study of tissues
Tissues tissue = many cells w/ same structure and function cell shape aids function tissue shape aids function Histology = study of tissues 4 types of tissues Epithelial coverings contact openings Connective
More informationCHAPTER 7.1 STRUCTURES OF THE RESPIRATORY SYSTEM
CHAPTER 7.1 STRUCTURES OF THE RESPIRATORY SYSTEM Pages 244-247 DO NOW What structures, do you think, are active participating in the breathing process? 2 WHAT ARE WE DOING IN TODAY S CLASS Finishing Digestion
More informationChapter 10. The Respiratory System Exchange of Gases. Copyright 2009 Pearson Education, Inc.
Chapter 10 The Respiratory System Exchange of Gases http://www.encognitive.com/images/respiratory-system.jpg Human Respiratory System UPPER RESPIRATORY TRACT LOWER RESPIRATORY TRACT Nose Passageway for
More information