Nina S. Kadan-Lottick, M.D., M.S.P.H.

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1 Nina S. Kadan-Lottick, M.D., M.S.P.H. OFFICE: Yale University Tel: Division of Pediatric Hematology-Oncology Fax: Cedar Street, LMP New Haven, CT EDUCATION: 1999 Masters of Science in Public Health, University of Colorado, Denver, CO 1993 M.D., Johns Hopkins University School of Medicine, Baltimore, MD 1989 Bachelors of Science in Biomedical Engineering and Materials Science, Johns Hopkins University, Baltimore, MD POST-GRADUATE TRAINING AND EMPLOYMENT Associate Research Scientist, Yale University, New Haven, CT Medical Director, HERO S Clinic for Childhood Cancer Survivors, Yale University, New Haven, CT Instructor, Division of Pediatric Hematology-Oncology, Blood, and Marrow Transplantation, University of Minnesota, Minneapolis, MN Research Associate, Division of Pediatric Cancer Epidemiology, Department of Pediatrics, University of Minnesota, Minneapolis, MN Post-doctoral Fellowship in Cancer Epidemiology, University of Minnesota, Minneapolis, MN Fellowship in Pediatric Hematology-Oncology, The Children s Hospital, University of Colorado Health Sciences, Denver, CO Residency, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD Internship, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland HONORS AND AWARDS: 2004 American Cancer Society Angel of Hope Award for clinical work with childhood cancer survivors Cancer Epidemiology NIH National Research Service Award Training Grant Nutrition NIH National Research Service Award Training Grant 1990 NIH medical student summer research grant 1989 Graduated from Johns Hopkins University with highest departmental and highest overall honors (designation used by institution in place of summa cum laude) 1988 Induction to Tau Beta Pi (Engineering Honor Society)

2 Recipient of Beneficial Hodson Merit Scholarship, Johns Hopkins University CERTIFICATION AND LICENSURE: 2000 Board certified in Pediatric Hematology-Oncology 1996 Board certified in Pediatrics (re-certified in 2001) Current Licensed to practice medicine in Connecticut PROFESSIONAL SOCIETIES/RESEARCH ORGANIZATION ACTIVITIES 2003-present 1999-present 1993-present 1991-present OTHER ACTIVITIES: Chair, Childrens Oncology Group Protocol #ALTE02C2 Neurobehavioral Outcomes in Childhood Acute Lymphoblastic Leukemia Chair, Childrens Oncology Group Late Effects Task Force in Psychosocial Outcomes American Society of Pediatric Hematology-Oncology Childrens Oncology Group: Member of ALL Task Force, ALL Outcomes, and Late Effects Committees Yale Cancer Center: Associate Member Eastern Society of Pediatric Research member Children s Cancer Survivor Study: Member of Genetics, Education, and Chronic Disease Committees American Academy of Pediatrics American Medical Association Member, Connecticut Radiation Response Group 2003-present Member of Yale Cancer Center Space Planning Committee BIBLIGRAPHY: Journal Articles 1. Civin CI, Trischmann T, Kadan NS, Davis J, Noga S, Cohen K, Duffy B, Groenewegen I, Wiley J, Law P, Hardwick A, Oldham F, Gee A. Highly purified CD34-positive cells reconstitute hematopoiesis. J Clin Oncol Aug; 14(8) Kadan-Lottick NS, Stork L, Ruyle SZ, Koyle M, Hunger SP, McGavran L. Cytogenetic abnormalities in a case of botryoid rhabdomyosarcoma. Med Pediatr Oncol 2000 Apr:34(4): Olson JL, May MJ, Stork L, Kadan N, Bateman JB. Acute megakaryoblastic leukemia in Down syndrome: orbital infiltration. Am J Ophthalmol July;130(1): Gurney JG, Kadan-Lottick N. Brain and other CNS tumors: incidence rates, trends, and other epidemiologic features. Curr Opin Onc July; 13:

3 3 5. Kadan-Lottick N, Marshall JA, Barón AE, Krebs NF, Hambidge KM, Albano E. Normal bone mineral density after treatment for childhood acute lymphoblastic leukemia diagnosed between 1991 and J Pediatr 2001 June; 138 (66): Kadan-Lottick N, Neglia J. Pediatric acute lymphoblastic leukemia: redefining outcomes. Commentary in Journal of Pediatric Hematology/Oncology 2002 Feb; 24(2): Fisher PG, Kadan-Lottick NS, Korones DN. Intrathecal thiotepa: reappraisal of an established therapy. Journal of Pediatric Hematology/Oncology 2002 May; 24(4) Kadan-Lottick N, Robison L, Gurney JG, Neglia J, Yasui Y, Hayashi R, Hudson M, Greenberg M, Mertens A. Childhood cancer survivors knowledge about their past diagnosis and treatment: The Childhood Cancer Survivor Study. JAMA. 2002: 287: Kadan-Lottick N, Skluzacek M, Gurney JG. Decreasing incidence rates of primary central nervous system lymphoma. Cancer 2002 Jul 1;95(1): Gurney JG, Kadan-Lottick NS, Packer RJ, Neglia JP, Sklar CA, Punyko JA, Stovall M, Yasui Y, Nicholson HS, Wolden S, McNeil E, Mertens AC, Robison LL. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer 2003 Feb 1; 97(3): Kadan-Lottick N, Ness KK, Bhatia S, Gurney JG. Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia. JAMA 2003 Oct 15;290(15): Kadan-Lottick NS, Friedman DL, Mertens A, Whitton JA, Yusui Y, Strong LC, Robison LL. Self-reported family history of cancer: the utility of probing questions. Epidemiology Nov;14(6): Book Chapters Kadan NS, Cuervo EH, Gould RB. Formulary and Special drug topics. In: Barone MA (ed) The Harriet Lane Handbook : A Manual for Pediatric House Officers, 14 th edition, St.Louis: Mosby, Abstracts and Presentations 1. Kadan-Lottick N, Brock J, Mayer A, James K. The association between advanced parental age and the incidence of pediatric malignancy. Oral presentations at the following conferences: Colorado Public Health Association Conference (Steamboat Springs, CO, Oct 1998), University of Colorado Epidemiology Exchange (Denver, CO, November 1998), and the American Society of Clinical Oncology Meeting (Atlanta, GA, May 1999). 2. Kadan-Lottick N, Marshall JA, Baron AE, Krebs NF, Hambidge KM, Albano E. The prevalence of osteopenia and osteoporosis in survivors of acute lymphoblastic leukemia. Poster presentation at the American Society of Hematology Meeting (New Orleans, LA, December 1999). Poster presentation. 3. Kadan-Lottick N, Friedman D, Mertens A, Yusui Y, Whitton J, Robison L, Strong L. Clarification of self-reported family history data by telephone interview in the Childhood Cancer Survivor Study cohort. American Association for Cancer Research Meeting (New Orleans, LA, March 2001). Poster presentation. 4. Friedman DL, Kadan-Lottick N, Liu Y, Mertens A, Robison L, Strong L. History of cancer among first-degree relatives of childhood cancer survivors: a report from the childhood cancer survivor study. American Society of Clinical Oncology Meeting (San Francisco, CA, May, 2001). Poster presentation.

4 4 5. Gurney JG, Packer R, Punyko J, Sklar C, Kadan-Lottick N, Neglia J, Nicholson HS, Wolden S, McNeil DE, Mertens A, Robison L. Non-neurological late effects among childhood brain tumor survivors: a preliminary analysis from the Childhood Cancer Survivors Study. Oral presentation at the World Federation of Neuro-oncology Societies/Society for Neuro-Oncology Sixth Annual Meeting (Washington, DC, November 2001). 6. Kadan-Lottick N, Robison L, Gurney JG, Neglia J, Yasui Y, Hayashi R, Hudson M, Greenberg M, Mertens A,. What do childhood cancer survivors know about their past diagnosis and treatment: The Childhood Cancer Survivor Study. Presented at the American Society of Clinical Oncology Meeting (Orlando, FL, May, 2002). Poster discussion. 7. Kadan-Lottick N, Robison L, Gurney JG, Neglia J, Yasui Y, Hayashi R, Hudson M, Greenberg M, Mertens A,. What do childhood cancer survivors know about their past diagnosis and treatment: The Childhood Cancer Survivor Study. Presented at the International Conference on Long-Term Complications of Treatment of Children & Adolescents for Cancer (Niagara-on-the Lake, Canada, June, 2002). Oral presentation. 8. Kadan-Lottick N, Anderson FS, Sencer SF, Ziegler RS, Neglia JP. A pilot study of neurocognitive outcomes among patients with childhood acute lymphoblastic leukemia (ALL) randomized to prednisone to dexamethasone. To be presented at the Eastern Society for Pediatric Research (Greenwich, CT, March 2003). Oral Presentation. Also presented at the American Society of Pediatric Hematology-Oncology Annual Meeting (Seattle, WA, May 2003). Poster Presentation. Manuscripts in Progress 1. Psychosocial outcomes, including complicated grief, depression, and suicidal ideation, in surviving spouses of adult cancer patients. Collaboration with Dr. Holly Prigerson, Yale University. 2. Excess risk of cancer in twins of childhood cancer survivors. Collaboration with Dr. Louise Strong, MD Anderson, Houston, TX. 3. Excess risk of cancer in first-degree relatives of childhood cancer survivors. Collaboration with Dr. Deborah Friedman, University of Washington, Seattle, WA. 4. Risk of carcinoma as a subsequent malignancy in survivors of childhood cancer. Acting as mentor for pediatric hematology-oncology fellow, Dr. Mylene Bassal, University of Colorado, Denver, CO. 5. Neurocognitive outcomes in childhood cancer survivors (book chapter) for upcoming second edition of Survivors of Childhood Cancer: Assessment and Management. CONFERENCES Lattanzi Pearson Symposium at St. Raphael s Hospital (New Haven, CT) October 13, 2003 Survivors of Childhood Cancer: The New Generation St. Mary s Hospital Department of Pediatrics Grand Rounds (Waterbury, CT) October 22, 2003: Late Effects of Childhood Cancer Yale-New Haven Childrens Hospital Symposium on Chronic Pain and End of Life in Children (New Haven, CT) October 24, 2004: End of Life Issues in Children with Cancer Yale-New Haven Childrens Hospital Parent Support Group Symposium (New Haven, CT) October 27, 2003: Survivors of Childhood Cancer: The New Generation

5 5 Yale Cancer Center Grand Rounds (New Haven, CT) March 9, 2004: Survivors of Childhood Cancer: After the Cure Yale School of Medicine Department of Pediatrics Grand Rounds (New Haven, CT) April 7, 2004: Survivors of Childhood Cancer: What next? Leukemia Lymphoma Society Symposium (New Haven, CT) April 28, 2004: Survivors of Cancer: The Quest for High Quality Healthcare FUNDING Past: Children s Cancer Research Fund 8/01/01-7/31/02 Role: Primary Investigator $39,000, 10% effort Neuropsychological Outcomes in Survivors of Acute Lymphoblastic Leukemia The goal of this project was to study differences in neuropsychological function according to whether the patient received prednisone or dexamethasone as part of acute lymphoblastic leukemia therapy 5T32 CA Robison (PI) 11/01/99-10/31/00 NIH/NCI, Cancer Epidemiology Training Grant Postdoctoral trainee The goal was to gain postdoctoral training in conducting cancer epidemiology research Univ. of Colorado Clinical Research Center 7/01/98-7/1/99 Role: Primary Investigator $9500, 0% effort Prevalence of Osteopenia and Osteoporosis in Survivors of Acute Lymphoblastic Leukemia The goal was to determine if children treated with modern therapy for acute lymphoblastic leukemia have persistent problems with reduced bone mineral density. 5T32 DK07658 Hambidge (PI) 7/01/97-6/30/99 NIDDK, Nutrition Training Grant Postdoctoral trainee The goal was to gain postdoctoral training in nutrition-related research in childhood cancer survivors Present: American Cancer Society (PI Neglia) 7/1/03-6/30/07 Role: Co- Investigator $1,561,772, 35% effort Neuropsychological outcomes in survivors of acute lymphoblastic leukemia Lance Armstrong Foundation (PI Oeffinger) Role: Co-Investigator Feasibility Study for Project VISION: A Virtual Center for Survivors Upcoming: K12 Mentored Clinical Research Scholar Program Award 7/1/04-6/30/08 National Center for Research Resources of NIH (PI Inouye) 90% effort Psychosocial Outcomes in Children with Leukemia

Childhood Cancer Survivor Study Analysis Concept Proposal

Childhood Cancer Survivor Study Analysis Concept Proposal Title: Neurologic and Neurosensory Adverse Sequelae in Long-term Survivors of Childhood Brain Tumors: An Update and Expanded Risk Factor Analysis