Monday, November 27 th

Transcription

1 Monday, November 27 th Arrival and registration Opening and Welcome Address CFATG president Mathias FAURE Dean of the Faculty of Medicine of University Paris Descartes Gérard FRIEDLANDER Local committee coordinator Audrey ESCLATINE Session I REGULATION AND SIGNALING Chair: Patrice CODOGNO (Institut Necker-Enfants Malades, Paris) Keynote lecture Alfred MEIJER (University of Amsterdam, Amsterdam, The Netherlands) Amino acid regulation of Autophagy Chairs: Etienne MOREL (Institut Necker-Enfants Malades, Paris); Carine JOFFRE (Centre de Recherches en Cancérologie de Toulouse, Toulouse) Maria MORIEL-CARRETERO* (Institut de Génétique Humaine, Montpellier) Control of Genome Stability by Dietary Interventions Caroline MAUVEZIN* (Bellvitge Biomedical Research Institute, Spain) Impact of lysosomal acidification and intracellular localization on autopha gosome-lysosome fusion Ganna PANASUYK (Institut Necker-Enfants Malades, INEM, Paris) Class III PI3K acts upstream of mitochondria function to control adaptation to fasting Coffee Break Chair: Etienne MOREL (Institut Necker-Enfants Malades, Paris) Keynote lecture Patrice CODOGNO (INEM, University Paris Descartes, Paris) Dynamics and versatility in Autophagy: Lessons from cell biology and physiology 13

2 Chairs: Etienne MOREL (Institut Necker-Enfants Malades, Paris); Carine JOFFRE (Centre de Recherches en Cancérologie de Toulouse, Toulouse) Franck OURY (Institut Necker-Enfants Malades, INEM, Paris) Autophagy controls memory acquisition and reverse age-related memory decline Frédéric CHECLER (IPMC UMR 7275 CNRS-UNS, Labex DistAlz, Valbonne) Presenilins at the crossroad of an interplay between Parkin and Pink-1 in neurodegenerative diseases Manish Kumar SINGH* (Institut Curie, Paris) An imaging approach to study the relationship between spatial-temporal localization of autophagosomes and direction of cell migration Flash Talks Session I Chair: Sophie PATTINGRE (Institut de Recherche en Cancérologie de Montpellier, Montpellier) Pierre VIGIÉ* (Institut de biochimie et génétique cellulaires, Bordeaux) Study of the contribution of phosphatidylethanolamine pools in yeast mitophagy induction Laury LESCAT* (UMR1419 Nutrition Métabolisme Aquaculture NuMeA, Aquapôle INRA, Saint Pée sur Nivelle) LAMP2A in the light of evolution Marine JACQUET* (UMR1098 Inserm, Besancon) GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells Petra PAUL* (University of Zürich, Zürich, Switzerland) The role of macroautophagy in the lung epithelium during Influenza A infections Presentation of the European Autophagy Network (TRANSAUTOPHAGY Cost Action) James MURRAY (University of Dublin, Ireland) Chair of the COST action; Cecile VINDIS (I2MC, Inserm UMR1048, Toulouse), Vice-chair of the COST action Dinner finger food and open bar Poster Session I (even numbers) Tuesday, November 28 th Session II PATHOPHYSIOLOGY Chair: Sophie PATTINGRE (Institut de Recherche en Cancérologie de Montpellier, IRCM, Montpellier) Keynote lecture Beth LEVINE (HHMI, Dallas, USA) Molecular Regulation, Biological Functions and Therapeutic Applications of Beclin 1-Dependent Autophagy

3 Chairs: Valerie PIERREFITE-CARLE (E4320 CEA, Centre Antoine Lacassagne, Nice); Sophie PATTINGRE (Institut de Recherche en Cancérologie de Montpellier, IRCM, Montpellier) Matias SIMONS* (Institut Imagine, Paris) Mutations in ATP6AP2 cause autophagic liver disease in humans Nicolas DUPONT (Institut Necker-Enfants Malades, INEM, Paris) Non-cell autonomous autophagy regulates kidney epithelium homeostasis Stéphanie GAYRAL (Inserm UMR 1048, I2MC, EQ5 Toulouse) Targeting phosphoinositide 3-kinase CIIα impairs the interplay between primary cilium and autophagy in endothelial cell: a role in atherosclerosis development Coffee Break Manon MOULIS* (Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Toulouse) Role of mitochondria-associated membranes as a sub-cellular hub for the regulation of cell death and mitophagy in vascular smooth muscle cell Emmanuel WEISS* (Centre de recherche sur l'inflammation CRI UMR 1149, Paris) LC3-associated phagocytosis as a protective pathway against systemic inflammation in patients with cirrhosis Ana NEGULESCU* (Institut du Cerveau et de la Moelle épinière, Paris) Impaired TBK1 kinase activity can lead to ALS disease due to defective autophagy Flash Talks Session II Chair: Marion LUSSIGNOL (Institut de Biologie Intégrative de la Cellule, I2BC, Gif-sur-Yvette) Jennifer BEAUVARLET* (Université de Bordeaux, Inserm U1218, Bordeaux) Inhibition of autophagy and ATM in cancer cells switch senescence to apoptosis in response to a G-quadruplex ligand Cecily LUCAS* (M2iSH, UMR 1071 Inserm, Clermont-Ferrand) Autophagy inhibits protumoral effects induced by colibactin-producing colorectal cancer-associated Escherichia coli. Olivia LENOIR (Paris-Centre de Recherche Cardiovasculaire, PARCC, Paris) Angiotensin II-modulated autophagy in hypertensive nephropathy Edor KABASHI (Institut du Cerveau et de la Moelle épinière, Paris) Deciphering the function and mechanisms of C9ORF72 in amyotrophic lateral sclerosis Lunch Break Poster Session II (odd numbers) Chairs: Renaud LEGOUIS (Institut de Biologie Intégrative de la Cellule, I2BC, Gif-sur- Yvette) Keynote lecture Malene HANSEN (Sanford-Burnham Med Res Institute, La Jolla, USA) Cellular recycling: role of autophagy in aging and disease Chairs: Renaud LEGOUIS (Institut de Biologie Intégrative de la Cellule, I2BC, Gif-sur-Yvette); Mojgan DJAVAHERI-MERGNY (Université de Bordeaux, Inserm U1218, Bordeaux) Coralie TRENTESAUX* (Institut Cochin, Paris) Role of autophagy in intestinal stem cell homeostasis Program 15

4 Mario TSCHAN (Institute of Pathology, Division of Experimental Pathology, Berne, Switzerland) Inverse regulation of Chaperone-Mediated Autophagy and non-canonical macroautophagy during retinoic acid therapy of acute myeloid leukemia cells Fengjuan WANG* (Université de Strasbourg, UPR 3572 Immunopathologie et chimie thérapeutique, Strasbourg) Targeting autophagy and lysosomal function for autoimmune diseases Coffee Break Chair: Sylviane MULLER (Institut de Biologie Moléculaire et Cellulaire, IBMC, Strasbourg) Keynote lecture Ana-Maria CUERVO (A. Einstein College, New York, USA) Chaperone-mediated autophagy, beyond cellular cleaning Annual General CFATG Meeting (CFATG Members only) Gala Dinner at restaurant (Bouillon Racine 53 rue Racine Paris, see map p. XX) Wednesday, November 29 th Session III CANCER Chair: Beth LEVINE (HHMI, Dallas, USA) Keynote lecture Guido KROEMER (IGR, University Paris Descartes, Villejuif) Autophagy induction for combating age-associated diseases Chairs: Svetlana DOKUDOVSKAYA (Institut Gustave Roussy, Villejuif); Patrick AUBERGER (Université de Nice Sophia Antipolis, Nice) Stéphane ROCCHI (Centre Méditérannéen de Médecine Moléculaire, Nice) New anti-melanoma compounds targeting endoplasmic reticulum stress and autophagy Lucie BRISSON* (Nutrition, croissance et cancer, UMR 1069 Inserm, Tours) Lactate dehydrogenase B controls lysosome activity and autophagy in cancer Arnaud BESSON (Centre de Recherches en Cancérologie de Toulouse, CRCT, Toulouse) Control of Ragulator and mtor activity by p27 in amino acid deprivationinduced autophagy Alix DUBOIS (Centre Méditérannéen de Médecine Moléculaire, Nice) LAMP2 expression dictates azacytidine response and prognosis in MDS/ AML Coffee Break

5 Session IV INFECTION AND IMMUNITY Chairs: Lucile ESPERT (Institut de Recherche en Infectiologie à Montpellier, IRIM, Montpellier); Pierre LAPAQUETTE (Université de Bourgogne Franche Comté, UMR A PAM, Dijon) Arnaud MORIS (Centre d Immunologie et Maladies Infectieuses CIMI, Paris) Autophagy receptors in the presentation of viral antigens by MHC-II molecules Laure-Anne LIGEON* (University of Zürich, Zürich, Switzerland) Molecular mechanisms of LC3-associated phagocytosis during MHC class II presentation Anaïs LARABI* (M2iSH, UMR 1071 Inserm, Clermont-Ferrand) Exosomes released from intestinal epithelial cells infected with Crohn's disease-associated adherent-invasive E. coli transfer mirnas into recipient cells to inhibit autophagy Lunch Break Poster Session III Chairs: Lucile ESPERT (Institut de Recherche en Infectiologie à Montpellier, IRIM, Montpellier); Pierre LAPAQUETTE (Université de Bourgogne Franche Comté, UMR A PAM, Dijon) Franck LAFONT (Institut Pasteur, Lille) Involvement of LC3 in the cell response to internal membrane damage Marianne DORE HANSEN* (Faculty of Medicine and Health Sciences, Trondheim, Norway) Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M Mathieu CLAVIÈRE* (Centre International de Recherche en Infectiologie, CIRI, Lyon) Escapement of bacteria from autophagy in virus co-infected cells Elena MUSCOLINO* (Heinrich Pette Institute, Hamburg, Germany) Murine cytomegalovirus recruits the retromer complex to promote NEMO degradation by autophagy Coffee Break Chair: Mathias FAURE (Centre International de Recherche en Infectiologie, CIRI, Lyon) Keynote lecture Christian MÜNZ (University of Zürich, Switzerland) Autophagy proteins in endocytosis and exocytosis Closing ceremony and final remarks Awards: best short talk, best poster and best flash talk End of meeting Program * He/she is eligible for short talk/flash talk awards 17