Malignant Mesothelioma

Transcription

1 Recent Results in Cancer Research 189 Malignant Mesothelioma Bearbeitet von Andrea Tannapfel 1. Auflage Buch. xii, 196 S. Hardcover ISBN Format (B x L): 16 x 24 cm Gewicht: 574 g Weitere Fachgebiete > Medizin > Klinische und Innere Medizin > Onkologie, Psychoonkologie Zu Leseprobe schnell und portofrei erhältlich bei Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft. Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, ebooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr als 8 Millionen Produkte.

2 1 2 Mineralogy of Asbestos Thomas A. Sporn Introduction and Historical Background Geologic and Mineralogic Features Distribution and Physicochemical Properties of Chrysotile Distribution and Physicochemical Properties of the Amphibole Species Identification and Characterization of Asbestos References Epidemiology of Mesothelioma and Historical Background J.E. Craighead Imaging of Mesothelioma Ritu R. Gill Introduction Patterns of Presentation and Imaging Features Preoperative Evaluation of MPM Postoperative Evaluation Unresectable Disease Future Directions Summary Biopsy Techniques for the Diagnosis of Mesothelioma J. Walters and Nick A. Maskell Introduction Clinical Presentation vii

3 viii Investigation of Pleural Effusion Cytology Investigation of Pleural Thickening with No Effusion Percutaneous Pleural Biopsy Techniques Abrams Needle Radiologically Guided Percutaneous Pleural Biopsy Positron Emission Tomography (PET) CT Thoracoscopy Local Anaesthetic Thoracoscopy Video-Assisted Thoracoscopic Surgery Open Biopsy Prophylactic Radiotherapy Pathohistological Diagnosis and Differential Diagnosis Iris Tischoff, Matthias Neid, Volker Neumann, and Andrea Tannapfel Introduction Malignant Mesothelioma of the Pleura Morphology Differential Diagnosis of Malignant Mesothelioma and Pleural Metastases Morphological Differences Immunohistochemistry Reactive Versus Neoplastic Mesothelial Proliferation Primary Pleural Tumours Other than Malignant Mesothelioma Peritoneal Mesothelioma Malignant Mesothelioma of Tunica Vaginalis Testis Well-Differentiated Papillary Mesothelioma Prognosis and Predictive Factors Differential Diagnosis Benign Lesions Malignant Lesions Immunohistochemistry Primary Peritoneal Carcinoma/Metastases of Serous Ovarian Cancer Versus Malignant Peritoneal Mesothelioma Mesothelioma and Analysis of Tissue Fiber Content Volker Neumann, Stefan Löseke, and Andrea Tannapfel Introduction Techniques for Analysis of Pulmonary Mineral-Fiber Content Lung Tissue Digests Methods for Mineral Fiber Analysis Light Microscopy (LM)

4 6.3.2 Electron Microscopy Comparability of Results Generated by Light or Electron Microscopy Reference Population and Background Lung Asbestos Burden Asbestos Bodies and Fiber Counting Asbestos Lung Tissue Content in Patients with Mesothelioma Light Microscopy Electron Microscopy Asbestos Content and Fiber Dimensions in Pleural Samples Discussion Asbestos Bodies and Fiber Burden of the Lung Latency Period and Mean Age at Diagnosis of Mesothelioma Clearance and Biopersistence of Asbestos Fibers Carcinogenic Potency of Asbestos Fibers Peritoneal Mesothelioma Asbestos-Associated Mesothelioma and Other Possible Causes of Malignant Mesothelioma Threshold or Cut-off Level Conclusion ix Surgical Therapy of Mesothelioma David Rice Introduction Natural History Diagnosis Video-Assisted Thoracoscopy Staging Laparoscopy Mediastinoscopy Thoracoscopy Endoscopic Staging Palliative Surgery Pleural Drainage Pleurectomy Cytoreductive Surgery Extrapleural Pneumonectomy (EPP) Pleurectomy/Decortication (P/D) Intrapleural Therapies Extrapleural Pneumonectomy Versus Pleurectomy/Decortication Does Cytoreductive Surgery Improve Survival? Summary References

5 x 8 9 Chemotherapy and Radiotherapy for Mesothelioma Xavier Dhalluin and Arnaud Scherpereel Introduction Radiotherapy Radical Radiotherapy Prophylactic Radiotherapy Systemic Therapies for Malignant Pleural Mesothelioma Systemic Chemotherapy Targeted Therapies Immunomodulators, Gene Therapy and Cell Therapy Conclusion Genetics and Molecular Biology of Mesothelioma Dean A. Fennell 9.1 Apoptosis as a Tumor Suppressor Mechanism Key Alterations in the Core Apoptosis Signaling in Mesothelioma Regulation of the Intrinsic (Mitochondrial) Apoptosis Pathway in Mesothelioma Extrinsic Apoptosis Pathway Regulation in Mesothelioma Inhibitors of Apoptosis in Mesothelioma Tumor Suppressor Loss in Mesothelioma Loss of nf2 Is Frequent in Mesothelioma NF2 Encodes the Tumor Suppressor Merlin PLZF Is a Novel Tumor Suppressor in Mesothelioma Therapeutic Inhibition of Survival Pathways PI3K/AKT/mTOR Axis in Mesothelioma HGF/cMET Pathway Is Activated in Mesothelioma WNT Pathway Activation in Mesothelioma Estrogen Receptor Beta Therapeutic Reactivation of Tumor Suppressors Epigenomic Dysregulation in Mesothelioma Targeting the Mesothelioma Epigenome via Inhibition of Histone Deacetylases Targeting the Ubiquitin Proteasome Pathway Synthetic Lethal Strategies Summary

6 10 Early Stages of Mesothelioma, Screening and Biomarkers Sonja Klebe and Douglas W. Henderson 10.1 Early-Stage Malignant Mesothelioma, Including the Concept of Mesothelioma In Situ and the Distinction from Reactive Mesothelial Hyperplasia Biomarkers for Early-Stage Epithelioid Malignant Mesothelioma Versus Reactive Mesothelial Hyperplasia Epithelial Membrane Antigen (EMA) GLUT Bcl p X-Linked Inhibitor of Apoptosis Proteins (XIAP) P-Glycoprotein (P-170) Neural Cell Adhesion Molecules (NCAMs): CD Screening for Malignant Mesothelioma and Prognostic Biomarkers: Serum Levels of Soluble Mesothelin-Related Proteins (SMRPs), Osteopontin (OPN), Megakaryocyte Potentiating Factor (MKPF) and CA Introductory Remarks on Screening for Malignant Mesothelioma Radiological Screening for MM Soluble Mesothelin-Related Proteins (SMRPs) Serum Osteopontin (OPN) Levels Megakaryocyte Potentiating Factor (MKPF) CA Summary Aquaporins and Malignant Mesothelioma References xi