Deba Prasad Mandal Assistant Professor, Dept. of Zoology, West Bengal State University. Berunanpukuria, PO Malikapur, Kolkata

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1 Deba Prasad Mandal Assistant Professor, Dept. of Zoology, West Bengal State University. Berunanpukuria, PO Malikapur, Kolkata Telephone: / dpmandal1972@gmail.com EDUCATION PhD., Bose Institute, Kolkata, India MSc in Zoology; University of Kalyani, Nadia, West Bengal, India. EMPLOYMENT till date West Bengal State University Durgapur Government College AWARDS & FELLOWSHIPS Junior Research Fellowship from UGC-JRF (NET-July 2001) Junior Research Fellowship from CSIR-JRF (NET-December 2001) Qualified GATE (2001) [AIR 301 Percentile ] RESEARCH INTERESTS Molecular Oncology, Signal Transduction, PUBLICATIONS Selected peer-reviewed publications (Five best publications in chronological order) 1. Bhattacharyya A, Mandal D, Lahiry L, Sa G, Das T. Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett. 2004; 209: Bhattacharyya A, Lahiry L, Mandal D, Sa G, Das T. Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. Int J Cancer. 2005; 117: Mandal D, Bhattacharyya A, Lahiry L, Choudhuri T, Sa G and Das T. Failure in peripheral immunosurveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor bearer. Life Sci. 2005; 77: Mandal D, Lahiry L, Bhattacharyya A, Chattopadhyay S, Siddiqi M, Sa G, Das T. Black tea protects thymocytes in tumor-bearing animals by differential regulation of

2 intracellular ROS in tumor cells and thymocytes. J Environ Pathol Toxicol Oncol. 2005; 24: Mandal D, Lahiry L, Bhattacharyya A, Bhattacharyya S, Sa G, Das T. Tumor-induced thymic involution via Inhibition of IL-7R and its JAK-STAT signaling pathway: Protection by Black Tea. Int. Immunopharmacology. 2006; 6: Mandal D, Bhattacharyya S, Lahiry L, Chattopadhyay S, Sa G and Das T. Black teainduced decrease in IL-10 and TGF- of tumor cells promotes Th1/Tc1 response in tumor-bearer. Nutrition and Cancer. 2007, 58(2); Bhattacharyya A, Mandal D, Lahiry L, Bhattacharyya S, Chattopadhyay S, Ghosh UK, Sa G, Das T. Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice. J Environ Pathol Toxicol Oncol. 2007; 26(4): Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumorinduced T-cell apoptosis through Stat-5a-mediated Bcl-2 induction. The Journal of Biological Chemistry. 2007; 282(22): Bhattacharyya S, Mandal D, Sen GS, Pal S, Benerjee S, Lahiry L, Finke JH, Tannenbaum, Sa G and Das T. Tumor-Induced Oxidative Stress Pertrubs Nuclear Factor B Activity-Augmenting Tumor Necrosis Factor- -Mediated T-Cell Death: Protection by Curcumin. Cancer Research. 2007, 67: (1). 10. Lahiry L, Saha B, Chakraborty J, Bhattacharyya S, Chattopadhyay S, Banerjee S, Choudhuri T, Mandal D, Bhattacharyya A, Sa G, Das T. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis. 2008; 13(6): Sen GS, Mohanty S, Hossain DM, Bhattacharyya S, Banerjee S, Chakraborty J, Saha S, Ray P, Bhattacharjee P, Mandal D, Bhattacharya A, Chattopadhyay S, Das T, Sa G. Curcumin enhances the efficacy of chemotherapy by tailoring p65nfκb-p300 cross-talk in favor of p53-p300 in breast cancer. The Journal of Biological Chemistry. (2011) 9; 286(49): Patra K, Bose S, Sarkar S, Rakshit J, Jana S, Mukherjee A, Roy A, Mandal DP*, Bhattacharjee S*. Amelioration of cyclophosphamide induced myelosuppression and oxidative stress by cinnamic acid. Chemico-Biological Interactions 195 (2012) Bhattacharjee S*, Mandal DP (2012). Angiogenesis modulation: the "spice effect". J Environ Pathol Toxicol Oncol; 31(3): Jana S; Patra K; Sarkar S; Jana J; Mukherjee G; Bhattacharjee S*; Mandal DP* (2014). Anti-tumorigenic Potential of Linalool is accompanied by Modulation of Oxidative Stress: An in vivo Study in Sarcoma-180 Solid Tumor Model. Nutr Cancer. 2014;66 (5): (IF- 2.7).

3 Book Chapters Lahiry L, Mandal D, Bhattacharyya A, Sa G & Das T. Cancer prevention by cancer regression and rejuvenation of host defense system: Dual role of tea.: Medicinal Properties of TEA (Eds. B Banerjee & TC Chaudhury) Oxford & IBH Publishing Co. Pvt.Ltd. New Delhi 2005: Chapter 7: Also published in Tea Therapeutics (Eds. B Banerjee & TC Chaudhury) Science Publishers Inc., New Hampshire, USA. (2005) PATENTS 1. A cancer chemotherapeutic agent/formulation, manufacture and use thereof, an international patent (PCT Int'l Appl. no. PCT/IN2013/000593) for Bose Institute, Kolkata and West Bengal State University, Barasat, 24 PGS (N). Name of Inventors : 1)DR. SUBHRANGSU CHATTERJEE 2) DR. ANIRBAN BHUNIA 3)DR. DEBA PRASAD MANDAL 4) DR. SHAMEE BHATTACHARJEE European Phase Patent Application No dated 19 th March 2015 US national Phase Patent Application No dated 17 th March 2015 Australian Phase patent Application No dated 5 th January Indian patent (1120/KOL/2012 A) entitled G-QUADRUPLEX STABILIZING AGENTS AND FORMULATIONS INVOLVING THE SAME. for Bose Institute, Kolkata and West Bengal State University, Barasat, 24 PGS (N). Name of Inventors : 1)DR. SUBHRANGSU CHATTERJEE 2) DR. ANIRBAN BHUNIA 3)DR. DEBA PRASAD MANDAL 4) DR. SHAMEE BHATTACHARJEE SEMINARS/CONFERANCES ATTENDED (National and International Conferences) 1. Black Tea as an immunological booster against immunospuppressive effects of Cancer and anti-cancer drugs. Deba Prasad Mandal, Arindam Bhattacharyya, Sreya Chattopadhyay, Gaurisankar Sa and Tanya Das. Society of Biological Chemist (India) Kolkata Branch Seminar (India) Kolkata Seminar at Santiniketan Monitoring host immune response vis-à-vis cancer development: A mechanistic Approach. Deba Prasad Mandal, Lakshmisri Lahiri, Arindam Bhattacharyya, Sreya Chattopadhay, Uttam Ghosh, Tathagata Choudhuri, Suman Pal, Gaurisankar Sa and Tanya Das. Annual Meeting of Immunology Study Group-West Bengal and Current Trends in Immunology, Bose Institute,Kolkata, November Role of black tea in countering tumor-induced thymic involution. Deba Prasad Mandal, Lakshmisri Lahiri, Arindam Bhattacharyya, Sreya Chattopadhay, Uttam Ghosh, Tathagata Choudhuri, Suman Pal, Gaurisankar Sa and Tanya Das. Annual Meeting of Immunology Study Group-West Bengal CNCRI, Kolkata, September Amelioration of tumor-induced immuneosuppression by black tea: A search for the mechanism. Deba Prasad Mandal, Lakshmisri Lahiri, Arindam Bhattacharyya, Uttam Ghosh and Tanya Das. National Seminar on Recent Advances in Stress Physiology, Toxicology and Immunology, University of Kalyani, November Black Tea prolongs the immune resistance against developing tumor countering the tumor-induced immunosuppression. Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmisri Lahiri, Sankar Bhattacharyya, Uttam Ghosh, Gaurisankar Sa and Tanya Das.

4 23 rd Annual Convention of the Indian Association for Cancer Research. Special Symposium on Anti-cancer Drug Development, ACTREC. Navi Mumbai, January Black Tea: Can it be a candidate for countering tumor-induced immunesupprrssion? Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmisri Lahiri, Sankar Bhattacharyya, Uttam Ghosh, Gaurisankar Sa and Tanya Das. Society of Biological Chemist (India) Kolkata Branch Seminar, May Black Tea: a double edged sword that induces tumor cell apoptosis and ameliorates immunosuppression of tumor-bearer. Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmisri Lahiri, Sankar Bhattacharyya, Uttam Ghosh, Tanya Das. nternational Symposium on Diet in causation and Prevention of Cancer and XXX Annual Conference of Environmental Mutagen Society of India, March UGC Sponsored State Level Seminar on Conservation of Biodiversity: Assessment & Awareness Organized by Dept. of Zoology, Hooghly Mohsin College in collaboration with Dept. of Zoology, West Bengal State University. October International Workshop on Application of Flowcytometry and Imaging Cell Biology and Nanobiotechnology th August. Centre for Nanoscience and Nanotechnology (CRNN), University of Calcutta, Kolkata, India. INVITED TALK Antitumorigenic potential of linalool: a spice principle with a promise Jana S, Patra K, Sarkar S, Jana J, Mukherjee G, Bhattacharjee S, Mandal DP. PHYSICON 2014, 19-21st December, 2014, Berhampore, Murshidabad, West Bengal. RESEARCH PROJECTS Ongoing Projects Sl. No. Title of Project 1 An Investigation into the Regulation of Nrf2 transcription factor by diosgenin and 1,8- cineole using the p53/p21 axis in lung and leukaemic cancer. Letter No. 5/13/49/10/NCD-III, dated PI/CoPI Funding Agency Co-PI Indian Council of Medical Research, Govt. of India. Amount Rs 23 lacs Date of sanction and Duration February Overcoming EGFR resistant Oral Squamous Cell Carcinomas with traditional healers of Tripura A Preclinical Study PI DBT-NER, Govt. of India (Twinning Programme ) 32.9 lakhs ( ) March 2014 Completed Projects Sl. No. Title of Project PI/CoPI Funding Agency Amount Date of completion

5 1 Investigation into the modulation of TGF signaling by capsaicin and eugenol using the p53/p21 axis in gastric carcinoma. BT/PR15116/GBD/27/327/2011 dated 09/03/ Modulation of tumor angiogenesis by the use of active ingredients of Pimpenella anisum and Coriandrum sativum in mice, a preclinical study. Sanction No. Ref No. 37(1487)/1 1/EMR-II PI Co-PI Department of Biotechnology, Govt. of India CSIR, Govt. of India 37 lacs Rs 20 lacs March 2014 May 2014 LIST OF COLLABORATORS Dr. Shamee Bhattacharjee, Department of Zoology, West Bengal State University Dr. Subhragshu Chatterjree, Department of Biophysics, Bose Institute. Dr. Utpal De, Department of Chemistry, Tripura University Dr. Gopeswar Mukherjee, Department of Pathology, Barasat District Hospital. Dr. Anirban Bhunia, Department of Biophysics, Bose Institute. Dr. Mridu Gupta, Department Dravyaguna (Medicinal plant Pharmacology), Institute of Post Graduate Ayurvedic Education and Research. PERSONAL DATA DATE OF BIRTH: 6 th September, 1972 PLACE OF BIRTH: India LANGUAGES: Bengali, English

UNIVERSITY OF CALCUTTA FACULTY ACADEMIC PROFILE/ CV

UNIVERSITY OF CALCUTTA FACULTY ACADEMIC PROFILE/ CV 1. Full name of the faculty member: SREYA CHATTOPADHYAY 2. Designation: ASSISTANT PROFESSOR DEPARTMENT OF PHYSIOLOGY 3. Specialisation : IMMUNOLOGY;