UNIVERSITY OF CALCUTTA

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1 UNIVERSITY OF CALCUTTA FACULTY ACADEMIC PROFILE/ CV Full name of the faculty member: ANINDITA UKIL Designation: Assistant Professor (stage 2) Specialisation : Cell Biology, Immunology Contact information : Udayan, Flat A 10, 25/2B/1 Jheel Road, Dhakuria, Kolkata Mobile: , aninditau@yahoo.com Academic qualifications: College/ university from which the degree was obtained University of Calcutta Jadavpur University Abbreviation of the degree M.Sc (Biochemistry) Ph.D Positions held/ holding : Research Associate, Senior Research Fellow and Junior Research Fellow Research interests: To study host pathogen interaction in macrophage using visceral leishmaniasis as a model macrophage associated disease. Research guidance:

2 Number of researchers awarded M.Phil/ Ph.D degrees : One Number of researchers pursuing M.Phil/ Ph.D : Six Projects: Completed projects: Specific innate immune mechanism pathways during intracellular protozoa Leishmania donovani infection: from molecular mechanisms to therapeutic benefits using herbal immunomodulator, sanctioned under the SERC Fast-Track Proposals for Young Scientists Scheme, Department of Science and Technology ( , amount 15 lakh). Elucidating the novel role of MAP kinase directed phosphatases in Toll like receptor signaling mediated protective Th1 type immunity, sanctioned under the Basic Research in Modern Biology, Department of Biotechnology ( , amount 76 lakh). Current projects: "The roles of IL-17 and IL-23 in the protection against leishmania infection" has been selected for funding jointly by The Israel Science Foundation (ISF) and the University Grant Commission (UGC). Role of lipid mediator in modulation of host defence by the protozoan parasite Leishmania donovani sanctioned by the Department of Science and Technology, 2013, amount 37 lakh. Role of anti-apoptotic protein Mcl-1 in Leishmania donovani-induced cytoprotection of infected macrophages sanctioned as Department of Science and Technology as SERB Women Excellence Award in recognition of NASI young women scientist, 2013, amount 18 lakh. Role of Inflammasome mediated IL-1β dependent Host Response during Infection by the Protozoan Parasite Leishmania donovani, has been sanctioned by Government of West Bengal, Department of Biotechnology, 2015, amount lakh. 11. Select list of publications: a) Journals: Giri J, Srivastav S, Basu M, Palit S, Gupta P and Ukil A. Leishmania donovani exploits myeloid cell leukemia 1 (MCL-1) protein to prevent mitochondria dependent host cell apoptosis (2016) J. Biol Chem. (In press) (Impact factor 4.6) Srivastav S, Saha A, Barua J, Ukil A, Das PK. IRAK-M regulates the inhibition of TLR-mediated macrophage immune response late during in vitro Leishmania donovani infection. (2015) Eur. J. Immunol. (In Press). (Impact factor 4.511)

3 Gupta, P., Das, P.K. and Ukil, A. Antileishmanial Effect of 18β-Glycyrrhetinic Acid is Mediated by TLR Dependent Canonical and Noncanonical p38 Activation. (2015). Antimicrob Agents Chemother. 59: (Impact factor 4.5) Saha A, Biswas A, Srivastav, S. Mukherjee M, Das PK, and Ukil A. Prostaglandin E 2 Negatively Regulates the Production of Th1/Th17 Cytokines and Proinflammatory Chemokines in Visceral Leishmaniasis (2014) J. Immunol. 193 : Gupta, P., Giri, J., Srivastav, S., Chande, A.G., Mukhopadhyaya, R., Das, P.K. and Ukil, A. Leishmania donovani Negatively Regulates TLR4 Mediated Host Response by Preventing Ubiquitination Dependent Degradation of TRAF3. (2014) FASEB J. 28: Srivastav S, Basu Ball W, Gupta P, Giri J, Ukil A, and Das PK. Leishmania donovani prevents oxidative burst mediated apoptosis of host macrophages through selective induction of supressors of cytokine signalling (SOCS) proteins. J. Biol Chem. 2014; 289(2): Ghosh K, Sharma G, Saha A, Kar S, Das PK, and Ukil A. Successful therapy of visceral leishmaniasis with curdlan involves T-helper 17 Cytokines J. infec. Dis.2013; 207: Ukil A, Kar S, Srivastav,S, Ghosh K and Das PK. Curative effect of 18glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatasedependent modulation of cellular MAP kinases. PLos ONE, 2011 ; (6) : e29062 Kar S, Ukil A and Das PK. Cystatin cures visceral leishmaniasis by NF-kB mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-tpl2-erk pathway. Eur. J. Immunol. 2011; ;41(1): Kar S, Ukil A, Sharma G and Das PK. MAPK directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J Leukoc Biol. 2010; 88(1):9-20. *Kar S, *Ukil A and Das PK. Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-?B and JAK/STAT pathways.. Eur. J. Immunol. 2009; 39: (*Equal contribution).

4 Mukherjee S, Ukil A and Das PK. Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, using leishmaniasis as model macrophage disease. Antimicrob. Agents Chemother. 2007; 51: Ukil A, Maity S and Das PK. Protection from experimental colitis by theaflavin- 3,3'-digallate correlates with inhibition of IKK and NF-kappaB activation. Br. J. Pharmacol : *Ukil A, *Maity S, and Das PK. Biodistribution and pharmacokinetics of theaflavin-3,3`-digallate, the major antioxidant of black tea, in mice. Int. J. Pharmacol. 2006; 2: (* Equal contribution) Karmakar S, Ukil A, Mukherjee S and Das PK.. Regulation of guanylyl cyclase by intracellular Ca2+ in relation to the infectivity of the protozoan parasite, Leishmania donovani. Int. J. Biochem. Cel. Biol. 2006; 38: Ukil A, Biswas A, Das T and Das PK. 18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappaB. J. Immunol. 2005; 175: Maity S, Ukil A, Karmakar S, Datta N, Chaudhuri T, Vedasiromoni JR, Ganguly DK and Das PK. Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Eur. J. Pharmacol. 2003; 470: Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR and Das PK. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br. J. Pharmacol. 2003; 139: b) Books/ book chapters : Srivastav, S., Ukil, A. and Das, P.K. (2015). Elucidating the strategies of immune evasion by Leishmania in: Leishmania: Current Biology and Control, Chapter 6, pp , Eds. Drs. S. Adak and R. Datta, Caister Academic Press, UK.

5 Membership of Learned Societies: Society of Biological Chemists, India Molecular Immunology Forum, India Invited lectures delivered : Invited lecture delivered at Dinabandhu Mahavidyalaya, Bongaon, on 27 th August, Motivational lecture delivered at DST-INSPIRE Internship Science Camp, organized by Jagadis Bose National Science Talent Search (JBNSTS), on 24 th July, Professor B.K. Bachhawat Young Scientist Award Lecture (NASI) delivered on 26 th March, 2015 at the Bose Institute, Kolkata. Invited lecture delivered at Molecular Immunology Forum on 16 th Institute of Life Sciences, Bhubaneswar. January, 2015 in the Invited lecture delivered at Molecular Immunology Forum on 9 th January, 2014 in Bose Institute, Kolkata. Delivered invited plenary talk at IMMUNOCON 2013, organized by Indian Immunological Society in Delhi from November 15-17, 2013 on Leishmania donovani Negatively Regulates TLR4 Mediated Host Response by Preventing Ubiquitination Dependent Degradation of TRAF3. Attended one day Group Monitoring Workshop organized by DST in Bhubaneswar and presented lecture on Specific innate immune signaling pathways during intracellular protozoa Leishmania donovani infection: from molecular mechanisms to therapeutic benefits using herbal immunomodulator on 18 th January, Arranged an one day seminar entitled Research Impact of Thrust Areas identified under CAS programme of Biochemistry on 7 th march, 2012 in the department of Biochemistry, Calcutta University. Invited lecture on The Emerging World of RNA: Paradigm Shift in Modern Biology in Ramkrishna Mission Vidyamandira, Belur, on 29 th September, Invited lecture on Macrophage signaling in host defense: a pivotal regulator of immunity and pathogenesis in St. Xavier s college on 6 th October, 2010.

6 Awards : Received Young Scientist Award 2010 in Biomedical Sciences by National Academy of Sciences, India. Received SERB Women Excellence Award 2013, by Science and Engineering Research Board (SERB), Department of Science and Technology. Received Prof. B.K. Bachhawat Memorial Young Scientist Lecture 2014 by National Academy of Sciences, Allahabad (NASI), India. Other notable activities : 2016 Research proposal entitled: "The roles of IL-17 and IL-23 in the protection against leishmania infection" has been selected for funding jointly by The Israel Science Foundation (ISF) and the University Grant Commission (UGC).