Introduction: Developing a Global Collaboration to Study Diet and Non- Communicable Disease Prevention

Transcription

1 Introduction: Developing a Global Collaboration to Study Diet and Non- Communicable Disease Prevention Connie Weaver, Ph.D. Purdue University West Lafayette, IN weavercm@purdue.edu

2 Session- International Breast Cancer and Nutrition: A model for research, training and policy in diet, epigenetics, and chronic disease prevention Connie Weaver IBCN Ailsa Welch Diet and Breast Cancer New Approaches Nahla Hwalla Diet and Breast Cancer in the Middle East Sophie Lelièvre Nutrition and Breast Cell Biology New Tools Dorothy Teegarden Obesity and Energy Metabolism in Breast Cancer Progression

3 Sophie Lelièvre, Leader, Basic Medical Sciences Connie M. Weaver, Co-Leader, Nutrition Science Purdue University Cooperative Extension Service is an equal access/equal opportunity institution.

4 Normal Breast Cells Genetics Aggressive Breast Cancer 10 µm Environment Carcinogens/exposures Diet Exercise Purdue University Cooperative Extension Service is an equal access/equal opportunity institution. Images, courtesy from Dr. Kurt B. Hodges, IU health)

5 Nutrition is anchored in culture Lebanon Uruguay China Ghana

6 Stem/Progenitor cell theory of the origin of breast cancer subclasses: This requires measure of epigenetic changes at single cell level Specific chromatin alteration at a define loci Purdue University Cooperative Extension Service is an equal access/equal opportunity institution. Joseph Irudayaraj, Agricultural and Biological Engineering

7 IBCN NETWORK C USA GB NL SW France Lebanon QT Japan Research team Clinicians Researchers (life sciences) Researchers (social sciences) Public Health/Policy experts Nutritionists Uruguay Ghana

8 Establishing interdisciplinary teams Sophie Lelièvre Basic Medical Sciences Beatrice Wiafe Addai Breast Surgeon, Ghana Ellen Gruenbaum Anthropology Laurence Gabriel University of Rennes, France Mayor of Kumasi Purdue University Cooperative Extension Service is an equal access/equal opportunity institution.

9 Ghana Purdue University Cooperative Extension Service is an equal access/equal opportunity institution.

10 Epigenetic Changes Nutrigenomics Engineering Alterations in Gene Expression Anthropology Translational Research Economics & Behavior Studies Public Policy Dietary Compounds Technologies Communication Population Studies Type of Breast Cancer

11 International Breast Cancer and Nutrition Project-Organizational Chart EXTERNAL ADVISORY COMMITTEE ETHICS COMMITTEE PULICATION COMMITTEE Executive Committee DATA MANAGEMENT & ARCHIVES IBCN-WHO-IRAC COMMITTEE CORE COMMITTEE PR/ ADVERTISEMENT COMMITTEE Country Team Country Team Country Team Country Team Country Team Country Team Country Team Country Team Sample Acquisition Committee Communication Committee Education Committee Epigenome Task Force Nutrition Committee Advocacy Committee Physical Activity & Psychosocial Factor Committee International Liaison Committee Public Health & Policy Committee

12 Annual International Symposia on Nutrition and Breast Cancer October 16-18, 2014 at Purdue University Annual Strategic Think Tank Retreats with Country Partners

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14 Build Infrastructure Bylaws for interaction Internal Steering and External Advisory Committees Cyberinfrastructure to facilitate integration of data and workflow Establish student training reciprocity

15 Grants Keck grant NIH Conference grants Policy grants Allen Foundation grant in communication Training grants in bioethics Susan G. Komen health breast tissue biorepository

16 Publication describing collaboration: Publication describing collaboration: Lelièvre SA, Weaver CM. Global nutrition research: nutrition and breast cancer prevention as a model. Nutr Rev doi: /nure :1-11, 2013.