Lung Cancer Associated with Cystic Airspaces: Don t Let This Lesion Fool You!
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1 Lung Cancer Associated with Cystic Airspaces: Don t Let This Lesion Fool You! Annemie Snoeckx Antwerp University Hospital, University of Antwerp, Belgium Head of Department: Prof. dr. Paul M. Parizel June 18-21, 2017 Boston, MA Co-authors: Pieter Reyntiens, Maarten J. Spinhoven, Laurens Carp, Paul E. Van Schil, Patrick Pauwels, Jan P. van Meerbeeck, Paul M. Parizel Thoracic Oncology UZA
2 The authors do not have any conflict of interest to disclose for this presentation
3 Overview 1. Learning objectives 2. Background 3. Imaging findings 4. Cases 5. Differential diagnosis 6. To remember 7. Suggested readings
4 1. Learning objectives - To illustrate the spectrum of imaging findings of lung cancer associated with cystic airspaces - To define key imaging features - To discuss and illustrate differential diagnoses
5 2. Background - Lung cancer is the leading cause of cancer deaths world wide - It typically presents as a mass or nodule, round or oval in shape. Recognition of these typical cases is often straightforward, whereas diagnosis of uncommon manifestations is more challenging - Lung cancer associated with cystic airspaces is an uncommon entity becoming more frequently recognized - It comprises cancer arising or abutting the wall of a pulmonary cystic airspace - These cystlike lesions have been called cysts, bullae, blebs, Mostly the generic term cystic airspaces is used: it indicates discrete thinwalled air-containing spaces in the lung regardless of the pathologic findings
6 2. Background - Patients are mostly smokers - Incidence - Represented 3.6% of screen-detected tumors in I-ELCAP lung cancer screening trial - Kaneda et al. reported an incidence in the same range: 3.5% in a group of 545 surgical cases - These cancers are generally aggressive - Possible mechanism: check-valve obstruction at the terminal bronchiolar level by an inflammatory or neoplastic process that leads to formation of the cystic airspace
7 2. Background - Histopathology - The cystic airspace can have different histologic features - Lung cancer component of the lesion can be any histology, but mainly is adenocarcinoma and squamous carcinoma to a lesser extent - Lung Cancer Screening % (5/22) of missed carcinomas in the NELSON lung cancer screening trial presented as bulla with wall thickening - Lung cancer screening (trials) will give more insight into the progression of these cancers and might help in answering questions
8 3. Imaging findings - Mascalchi et al. described 4 types of morphologic patterns on CT - Type 1: presence of a nodule extruding from the wall of the cystic airspace - Type II: nodule confined within the lumen of the cystic airspace - Type III: soft tissue density extending along the wall of the cystic airspace - Type IV: solid or nonsolid tissue intermixed within cluster of multiple cystic airspaces Type 1 Type II Type III Type IV
9 3. Imaging findings - Evolution: uniformly thin wall of the airspace, becoming thicker with increased circumferential involvement and nodule formation between 12 and 118 months after initial CT scan - No histologic features identified that suggested preexisting congenital cystic lung disease nor presence of a preexisting cavity - Associated emphysema is often present - When the solid part of the lesion increases, the diameter of the cystic airspace can decrease, increase or remain stable
10 3. Imaging findings - 18F-FDG-uptake is variable, ranging from absent or mild to moderate or marked - This is related to two facts - When the predominant tumor component presents as lepidic growth, FDG-uptake can be mild or absent. These lesions often present on CT as ground-glass - The cystic component of the lesion itself does not show 18F-FDG-uptake
11 4. Cases CASE 1 72-y-old man with a previous history of head and neck cancer who presented during follow-up with an irregular thickening of the wall of a cystic airspace in the right lower lobe. Within an extremely short time period of 3 months, the lesion had grown, filling the cystic airspace and presenting as a solid nodule. Diagnosis of primary lung cancer (squamous cell carcinoma) was confirmed after transthoracic time of diagnosis 3 months earlier 6 months earlier 5 years before
12 CASE 2 57-y-old woman who presented with a cystic airspace in the left upper lobe. In the periphery of the lesion there were two irregular nodules: one at the top and one at the bottom of the cystic airspace. Both nodules showed a high uptake on 18F-FDG-PET. Lobectomy was performed and histopathology confirmed the diagnosis of a cystic airspace with two nodular foci of adenocarcinoma.
13 CASE 3 72-y-old woman in whom as incidental finding a subpleural cystic airspace was seen in the left lower lobe. The medial wall of the cystic airspace showed a bandlike thickening. Follow-up CT 6 months later showed an increase of the exophytic component with more nodular aspect as well as a change of the internal structure of the cystic airspace. Lobectomy was performed and histopathology showed an invasive adenocarcinoma. Initial examination 6 months later
14 CASE 4 76-y-old man who presented with a subpleural nodule with associated cystic airspace in the left lower lobe. The lesion showed a very high uptake of 18F-FDG PET. Transthoracic biopsy confirmed the diagnosis of squamous cell carcinoma. Follow-up after radiotherapy treatment of the malignant lesion in the left lower lobe showed a nodule abutting the wall of a cystic airspace in the right lower lobe. Growth of this nodule was demonstrated after a second follow-up examination another 3 months later; findings were suspicious for a second primary. Initial examination 6 months later Another 3 months later
15 CASE 5 68-y-old woman who presented with numerous nodules in both lungs: large spiculated solid nodules (perihilar region right upper lobe), part-solid nodules, pure ground glass nodules as well as 3 lesions presenting as lung cancer associated with cystic airspace (blue arrows). Diagnosis of adenocarcinoma was histopathologically proven in the large spiculated solid lesion in the right upper lobe and in the cystic airspace lesion with solid component in the left lower lobe.
16 CASE 6 74-y-old man who presented with a large cystic airspace surrounded and interspersed with ground glass. The lesion remained stable during a 3 month period of follow-up making an infectious lesion unlikely and the morphology of the lesion was found to be suspicious for lung cancer. 18F-FDG-PET showed only very minor uptake. Lobectomy was performed. Histopathology confirmed the diagnosis of lung cancer and showed a NSCLC with predominant lepidic pattern. These findings are consistent on imaging with the ground glass aspect of the abnormalities and are an explanation for the very low 18F-FDG-uptake on PET.
17 CASE 7 78-y-old man who presented with a persistent triangular area of cystic changes surrounded by an area of consolidation. Over time the area changed in morphology with decrease of the cystic airspaces and increase of the consolidation. Lobectomy was performed and histopathology showed an invasive adenocarcinoma. Initial examination 6 months later Another 6 months later
18 CASE 8 Area of consolidation with central foci of cystic airspaces in the right lower lobe in a 69-year-old man. During follow-up the lesion showed an increase in size and density. Diagnosis of adenocarcinoma was confirmed on histopathology. Initial examination 6 months later
19 5. Differential diagnosis - Depends on the type (I-IV) of lung cancer associated with cystic airspace - Differential diagnosis is broad and includes a variety of solitary cavitary lung lesions: tumor, infection, granulomatous disease, bronchogenic cyst,... - Entities that may mimic type IV are diffuse centrilobular emphysema with superimposed ground glass or consolidation, large pulmonary infarct,... - Look for associated findings to narrow down a differential diagnosis list - Clinical information, evolution and previous medical history are crucial for assessing the right diagnosis
20 Old tuberculous cavern with small fungus ball (Candida) Infected bronchogenic cyst Cavitated lung infarct Squamous cell arcinoma
21 Emphysema with superimposed infectious consolidation Large pulmonary infarct Adenosquamous carcinoma
22 6. To remember - Lung cancer associated with cystic airspaces is a relative new entity, getting more attention - Closely look at the wall of cystic airspaces, especially when they are new - Nodules, consolidation or ground-glass surrounding or abutting cystic airspaces should be closely monitored - Early recognition is important to avoid delay in diagnosis and treatment - Lots of questions remain and further research is needed When to consider malignancy? What regimen of follow-up? Are all 4 types of the same concern?
23 You only see what you look for and you only look for what you know Don t forget to think about lung cancer associated with cystic airspaces when you read chest CT s
24 7. Suggested readings 1. Farooqi AO, Cham M, Zhang L, Beasley MB, Austin JHM, Miller A, et al. Lung cancer associated with cystic airspaces. AJR Am J Roentgenol Oct;199(4): Mascalchi M, Attinà D, Bertelli E, Falchini M, Vella A, Pegna AL, et al. Lung cancer associated with cystic airspaces. J Comput Assist Tomogr Jan;39(1): Maki D, Takahashi M, Murata K, Sawai S, Fujino S, Inoue S. Computed tomography appearances of bronchogenic carcinoma associated with bullous lung disease. J Comput Assist Tomogr May;30(3): Kaneda M, Tarukawa T, Watanabe F, Adachi K, Sakai T, Nakabayashi H. Clinical features of primary lung cancer adjoining pulmonary bulla. Interactive CardioVascular and Thoracic Surgery May 17;10(6): Rampinelli C, Calloni SF, Minotti M, Bellomi M. Spectrum of early lung cancer presentation in low-dose screening CT: a pictorial review. Insights into Imaging. Insights into Imaging; 2016 May 14;: Scholten ET, Horeweg N, de Koning HJ, Vliegenthart R, Oudkerk M, Mali WPTM, et al. Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening. Eur Radiol Sep 4;25(1): Devaraj A. Missed cancers in lung cancer screening--more than meets the eye. Eur Radiol Jan;25(1): Yoshida T, Harada T, Fuke S, Konishi J, Yamazaki K, Kaji M, et al. Lung adenocarcinoma presenting with enlarged and multiloculated cystic lesions over 2 years. Respir Care Dec;49(12): Guo J, Liang C, Sun Y, Zhou N, Liu Y, Chu X. Lung cancer presenting as thin-walled cysts: An analysis of 15 cases and review of literature. Asia-Pac J Clin Oncol Dec 19;12(1):e
25 Author contact information Annemie Snoeckx, MD Antwerp University Hospital Radiology Department Wilrijkstraat Edegem, Belgium
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