Monsanto s s Pipeline for Biotech Crops. Vice President, Consumer Traits Monsanto Company

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1 Monsanto s s Pipeline for Biotech Crops David M Stark Ph D David M. Stark, Ph.D. Vice President, Consumer Traits Monsanto Company

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4 850+ million hungry grain consumption has exceeded production 7/10 years 5.6 million children >5 years age succumb to fatal hunger-related illnesses annually

5 Farmers will need to produce as much food in the next 50 years as has been produced in the previous 10,000 years. United Nations Forum On Food Improvement in efficient land use will be critical if we re going to meet every-growing demand for food and fiber without putting more pressure on our environmental resources. Dr. Jason Clay World Wildlife Fund

6 6 What can we do?

7 Our Commitment: To help farmers produce more, conserve more Double corn, soy and cotton yields by 2030, and do so using 1/3 less input per unit produced Help improve farmers quality of life, including 5 million small and subsistence growers Monsanto yield prize, wheat and rice 7

8 Today s technology makes a big difference to farmers Gallons of Ethanol Gallons of Ethanol Gallons of Ethanol 254 Pounds of Feed 1, Pounds of Feed 1, Pounds of Feed 2,400 Gallons of Ethanol 535 Pounds of Feed 3,170 HT Yield = 94 bu/ac CB Protection +HT Yield = bu/ac Soil-applied RW Protection +CB Protection +HT Yield = 150 bu/ac RW Protection +CB Protection +HT Yield = bu/ac Roundup Ready Corn 2 YieldGard Corn Borer with Roundup Ready Corn 2 YieldGard Corn Borer with Roundup Ready Corn 2 + Force insecticide YieldGard Plus with Roundup Ready Corn 2

9 and tomorrow s technology will continue to build on the promise of more using less CONTROL HYBRID (76 BU/AC) WITH GENE (94 BU/AC) Discovery Phase 1 Proof of Concept Phase 2 Early Development Phase 3 Adv. Development Phase 4 Pre-Launch Launch

10 Overcoming Insufficient Fresh Water for Cotton WITH GENE CONTROL AS PHASE 1 PROJECT, TESTING MULTIPLE GENES FOR IN-FIELD PROOF OF CONCEPT Discovery Phase 1 Proof of Concept Phase 2 Early Development Phase 3 Adv. Development Phase 4 Pre-Launch Launch

11 Nitrogen Use Efficiency COLLABORATION WITH Control Gene 1, Event 1 Gene 1, Event 2 Discovery Phase 1 Proof of Concept Phase 2 Early Development Phase 3 Adv. Development Phase 4 Pre-Launch Launch

12 Roundup Ready 2 Yield Soybeans Near-Isoline Comparisons: RR2Y vs. Roundup Ready er Roundu up rease Ove eady Yield Inc Re Percent 12% 10% 8% 6% 4% 2% 0% 11% 9% 7% 7% % 4-YEAR AVG Roundup Ready 2 Yield soybeans yield 7 to 11 percent higher than Roundup Ready soybeans based on 73 Monsanto field trials from 2004 to 2007.

13 Roundup Ready 2 Plus Yield Canola Yield (lbs/a acre) Trials 14 locations 14% 13% 11% 12% 14% Event 1 Event 2 Event 3 Event 4 Event 5 % Yield Difference vs. Control With Gene Without Gene All events = p<0.05 Error bars = LSD at 5% Discovery Phase 1 Proof of Concept Phase 2 Early Development Phase 3 Adv. Development Phase 4 Pre-Launch Launch

14 Third-Generation Herbicide Tolerance in Cotton Tolerance to three sequential dicamba applications Lewiston, NC 2007 Event 2 with gene Event 1 with gene Without gene

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A 90% reduction in saturated t fat and trans fat*.

17 A 90% reduction in saturated t fat and trans fat*. A 3.5 oz serving of French fries with 8 fewer grams of bad fat s. Saturated and Trans Fat Content French Fries 50% Trans Fat 22.5% Sat Fat 25.5% Conventional Oil French Fry ~ 48% Improved Oil French Fry <5% 17 *Versus hydrogenated oils

18 Challenge: Trans-Free Functional Fats Trans fat: 3 grams Trans fat: 5 grams Trans fat: 4.5 grams Trans fat: 2 grams 18 Data: USDA/FDA, Amount of trans fat in a serving size

19 Soybeans: A new Source of Omega 3 to Improve Heart Health Today And soon, from soybeans 19

20 20 Fruit and Vegetable e Innovations o

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22 Future Products

23 Future Soybean Products HBC OMEGA-3 HIGH STEARATE YIELD SCN DISEASE RUST DICAMBA TOLERANCE VISTIVE III 2 PROCESSING: HIGH OIL SOY 3 VISTIVE Commercialization Depends on Many Factors, Including Successful Conclusion of Regulatory Process Roundup Ready 2 Yield is not available for commercial sale or use. Monsanto Company does not sell and does not authorize the commercial sale or use of this product. Roundup Ready 2 Yield soybean seed and any product of a Roundup Ready 2 Yield soybean seed or crop can only be exported to, or used, processed or sold in countries where all necessary regulatory approvals have been granted. It is a violation of national and international law to move material containing biotech traits across boundaries into nations where import is not permitted.

24 More than 10 Years of Plant Biotechnology A DECADE+ OF COMMERCIAL EXPERIENCE ON MORE THAN 1 BILLION ACRES M. Ac. $6.9B global farm 400 income canola cotton corn soy 629M lbs, or 7.8% less pesticides 10.2M lbs less CO F SOURCE: ISAAA and Monsanto estimates

25 Seed production decisions made several years in advance of oil supply Not Just-In-Time! 2009 delivery of oil Farmers contracted by Feb. 08 Seed production contracts finalized March 07 Seed decision Sept

Breeding Soybeans with a Robust Trait Pipeline. Rick Leitz February 22, 2010 Monsanto Company

Breeding Soybeans with a Robust Trait Pipeline Rick Leitz February 22, 2010 Monsanto Company 2009 Growing Season Review The central US experienced one of the coolest and wettest summers on record White