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1 SVEUČILIŠTE U ZAGREBU MEDICINSKI FAKULTET Studij: Medicina (na engleskom jeziku) Izvedbeni nastavni plan predmeta Medical Chemistry and Biochemistry 2 Akademska godina 2018/2019
2 I. KOMPETENCIJE I ISHODI UČENJA II. SADRŽAJ Sati predmeta: : 29 : 41 : 40 Ukupno sati: 110 PLAN I SATNICA Datum Sat/Dvorana Grupa Vrsta :30-13:00; 13:30-15:00; :30-13:00; 13:30-15:00; :30-13:00; 13:30-15:00; :30-12:00; 10:30-12:00; 12:30-14:00; 12:30-14:00; Metabolism of Eukaryotes: an Overview. Regulation of Enzyme Activity. Types of Transport Across Membranes. Basics of Biosignaling. Metabolism of C arbohydrates: an Overview. Glycosides, C omplex C arbohydrates and Glycoconjugates: Structural Features and Metabolic Role(s). Digestion and Absorption of C arbohydrates. Glycolysis: Reactions and Regulation. Fates of Pyruvate under Aerobic and Anaerobic C onditions. Stoichiometry of ATP Production by the C omplete Oxidation of Glucose. Glycolysis: Reactions and Regulation. Fates of Pyruvate under Aerobic and Anaerobic C onditions. Stoichiometry of ATP Production by the C omplete Oxidation of Glucose. Gluconeogenesis. Regulation of Glycolysis and Guconeogenesis. Gluconeogenesis. Regulation of Glycolysis and Guconeogenesis. Pentose Phosphate Pathway; Related Pentose Phosphate Pathway; Related
3 :00-11:45; MEF Wickerhauser :30-11:15; Glycogen Metabolism: Glycogenolysis & Glycogenesis. Glycogen Storage Glycogen Metabolism: Glycogenolysis & Glycogenesis. Glycogen Storage Metabolism of Fru, Gal, GlcA, Lac. Additional Monosaccharide Interconversions; Related Metabolic Disorders. C arbohydrates. Overview of Three Stages of C ellular Respiration (Aerobic Metab.): (1) Acetyl SC oa Production; Oxidative Decarboxylation of Pyruvate; (2) C itric Acid Cycle; (3) Electron Transfer & Oxidative Phosphorylation. Metabolic Fates of Acetyl SC oa. Citric Acid Cycle as a Central Metabolic Pathway: Reactions and Regulation. Citric Acid Cycle as a Central Metabolic Pathway: Reactions and Regulation. Respiratory C hain & Oxidative Phosphorylation. Respiratory C hain & Oxidative Phosphorylation., izv. prof. dr. sc.,, izv. prof. Vukelić, dr. sc. Kristina Mlinac Jerković Transporter Systems in the Inner Mitochondrial Membrane. Shuttle Systems for Mitochondrial Oxidation of the C ytosolic NADH. Regulation of the ATP- Producing Pathways: a Summary. Simple Lipids: Reminder on C lassification, Structure and Nomenclature. Digestion and Absorption of Lipids. Triacylglycerols: Storage and Lipolysis. Overview of Fatty Acids Oxidation and Synthesis. Lipolysis. Oxidation of Fatty Acids (FA): β- oxidation of Even and Odd C-Number FAs; Very long chain FA shortening; Unsaturated FAs Oxidation; α- and ω- Oxidation. Lipolysis. Oxidation of Fatty Acids (FA): β- oxidation of Even and Odd C-Number FAs; Very long chain FA shortening; Unsaturated FAs Oxidation; α- and ω- Oxidation. Stoichiometry of ATP Production by the C omplete Oxidation of FAs. Ketone bodies Synthesis (Ketogenesis) and Oxidation
4 10:30-11:15; :45-13:15; 11:45-13:15; MEF Fiziologija I kat 12:00-15:45; 09:45-10:30; 10:45-11:30; Stoichiometry of ATP Production by the C omplete Oxidation of FAs. Ketone bodies Synthesis (Ketogenesis) and Oxidation Synthesis of saturated and unsaturated (ω-9, ω-6, ω-3 series) FAs and Eicosanoids. Role of Eicosanoids. Synthesis of saturated and unsaturated (ω-9, ω-6, ω-3 series) FAs and Eicosanoids. Role of Eicosanoids. Metabolism of C holesterol and Other Isoprenoids (Bile Acids, Steroid Hormones, Vitamins). Metabolism of C holesterol and Other Isoprenoids (Bile Acids, Steroid Hormones, Vitamins). Lipoproteins: Metabolism and Role(s); Related Lipoproteins: Metabolism and Role(s); Related C omplex Lipids: Reminder on C lassification, Structure and Nomenclature. Overview of the Metabolism and Roles as Membrane C omponents & Second Messengers. Metabolism and Role of Ester- and Ether- Linked Phospholipids; Related Disorders. Metabolism and Role of Ester- and Ether- Linked Phospholipids; Related Disorders. Sphingolipids: Metabolism and Metabolic Disorders, Roles. Lipids in Signal Transduction. Sphingolipids: Metabolism and Metabolic Disorders, Roles. Lipids in Signal Transduction. Lipids. Acid-Base and Mineral Status of Human Body. Protein Digestion and Absorption Proteins: Posttranslational Modifications, Targeting (Traffic and Sorting) and Degradation.,, izv. prof. dr. sc.,, izv. Daria Pašalić, izv. prof. dr. sc.,, dr. sc. Dragana
5 :00-10:30; 09:00-10:30; :00-11:45; MEF Biološka :00-10:45; 10:00-10:45; :30-17:15; SVI Exam 1st C ontrol Test Selected Methods of Separation and Detection of Biomolecules Derived from Biological Materials. Metabolism of Amino Acids and Proteins: an Overview. Catabolism of Proteins and of Amino Acid Nitrogen. Fates of Amino Groups. Urea C ycle. Related Disorders. Catabolism of Proteins and of Amino Acid Nitrogen. Fates of Amino Groups. Urea C ycle. Related Disorders. Catabolism of the Carbon Skeleton of Catabolism of the Carbon Skeleton of Urine Analysis. Synthesis of Nutritionally Nonessential Synthesis of Nutritionally Nonessential Biomolecules Derived from Amino Acids: Porphyrins and Bile Pigments; C reatine Phosphate and C reatinine; Glutathione; Biological Amines (Neurotransmitters); Nitric Oxide; C arnitine. Biomolecules Derived from Amino Acids: Porphyrins and Bile Pigments; C reatine Phosphate and C reatinine; Glutathione; Biological Amines (Neurotransmitters); Nitric Oxide; C arnitine. Porphyrins, Hemoglobin and Bile Pigments. Metabolism of Purine and Pyrimidine Nucleotides. Metabolism of Purine and Pyrimidine Nucleotides.,, izv. prof. dr. sc.,,, izv. prof. dr. sc.,, izv. Željka Vukelić,, dr. sc. Dragana, izv. Daria Pašalić
6 :30-20:15; lab Podrum Nucleotides and Nucleic Acids. Nucleotides and Nucleic Acids. Metabolic Pathways Interrelationships & Integration of Metabolism. Enzymes in Medicine 16:30-20:15; 10:30-12:00; :30-12:00; 09:30-11:00; :30-12:15; 14:30-15:15; :00-11:45; MEF Biološka :30-12:45; MEF Biološka :00-14:00; 12:00-15:00; 13:00-16:00; Enzymes in Medicine Hormones: Synthesis, a Way of Action, and Effects. Hormones: Synthesis, a Way of Action, and Effects. The Feeding-Fasting C ycle. Metabolism in Starvation. Glucose Homeostasis. Metabolism in Diabetes. Nutritional Requirements and Principles. Nutritional Requirements and Principles. The Tissue Division of Labor. The Tissue Division of Labor. SVI Exam 2nd C ontrol Test Regulation of the Cell Cycle. Oncogenes, Tumor Suppressor Genes and Apoptosis. (Malignant Transformations.) Regulation of the Cell Cycle. Oncogenes, Tumor Suppressor Genes and Apoptosis. (Malignant Transformations.), izv. Daria Pašalić, izv. prof. dr. sc., dr. sc. Dragana, izv. Željka dr. sc.,, izv. prof. dr. sc., izv. Daria Pašalić, prof. dr. sc. Svjetlana Kalanj
7 :00-14:00; MEF Č ačković III. LITERATURA IV. DODATNA LITERATURA V./I. POPIS NASTAVNIKA I SURADNIKA U NASTAVI doc. dr. sc. Igor Picek 7. doc. dr. sc. Ivana Karmelić 8. dr. sc. Danijela Cvijanović 9. dr. sc. Vladimir Damjanović V./II VANJSKI SURADNICI: V./III NASTAVNICI U NASLOVNIM ZVANJIMA: VI. OBLICI NASTAVE VII. NAČIN PROVJERE
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