Quick Reference Table Review Conclusion**** Ingredient Name or Group Name S SQ I Z U UNS Use concentration for S conclusion

Transcription

1 1,2-butanediol 1 not in use at the time* IJT 31 (S2): , ,2-hexanediol to 10% IJT 31 (S2): , Naphthol 1 up to 3% in hair coloring products JACT 8(4):749-68, 1989 confirmed 12/06 2,3-Naphthalenediol 1 JACT 7(3):353-57, ,4-Diaminophenol 1 0.2% as the free base JACT 13(5):330-43, 1994 confirmed 06/09 2,4-Diaminophenol HCl (aka 2,4-Diaminophenol Dihydrochloride) 1 0.2% as the free base JACT 13(5):330-43, 1994 confirmed 06/09 2,4-Diaminophenoxyethanol HCl 1 up to 2% Final Amended Report 12/07 JACT 10(1):113-34, 1991 (original report) 2,4-Diaminophenoxyethanol Sulfate (amended) 1 up to 2% Final Amended Report 12/07 JACT 10(1):113-34, 1991 (original report) 2-Amino-3-Hydroxypyridine 1 Final report 09/ 2-Amino-3-Nitrophenol 1 up to 2% in hair dyes IJT 28(S3): , amino-4-hydroxyethylaminoanisole 1 should not be used in cosmetic products where N-nitroso compounds may be formed 2-amino-4-hydroxyethylaminoanisole sulfate 1 should not be used in cosmetic products where N-nitroso compounds may be formed IJT 32(S1):25-35, IJT 32(S1):25-35, 2-Amino-4-Nitrophenol 1 concentration not reported * IJT 28(S3): , Amino-4-Nitrophenol Sulfate 1 not in current use * IJT 28(S3): , Amino-5-Nitrophenol 1 not in current use * IJT 28(S3): , Amino-6-Chloro-4-Nitrophenol 1 up to 2% in hair dyes IJT 16(S1):131-43, Amino-6-Chloro-4-Nitrophenol HCl 1 up to 2% in hair dyes IJT 16(S1):131-43, Bromo-2-Nitropropane-1,3-Diol 1 0.1%; may contribute to endogenous nitrosamine formation; but should not be JACT 3(3):139-55, 1984 (Addendum) JEPT 4(4):47-61,

2 used under circumstances where its actions with amines or amides can result in the formation of nitrosamines or nitrosamides 1980 (Original report) confirmed 09/03 IJT 25(S2), Chloro-p-Phenylenediamine 1 up to 0.1% JACT 11(4): , Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4): , Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail enhancement products when skin contact is avoided; products containing this ingredient should be accompanied with directions to avoid skin contact because of the sensitizing potential of methacrylates IJT 24(S5):53-100, Methyl-5-Hydroxyethylaminophenol 1 up to 5% JACT 9(2): , 1990 confirmed 08/06 2-Methyl Resorcinol 1 up to 2% JACT 5(3): , 1986 confirmed 12/06 2-Nitro-p-Phenylenediamine 1 up to 1% JACT 4 (3): , 1985 confirmed 11/03 IJT 25(S2), Methylamino-4-Nitrophenoxyethanol 1 up to 0.15% IJT 27 (S2): 41-51, Nitro-p-Hydroxyethylaminophenol 1 up to 10% in hair coloring products (5% after dilution) IJT 28(S3): , Amino-2-Hydroxytoluene 1 up to 5% JACT 8 (4):569-87, 1989 confirmed 04/06 4-Amino-2-Nitrophenol 1 IJT 28(S3): , Amino-3-Nitrophenol 1 up to 9% in hair dyes IJT 28(S3): , Amino-m-Cresol 1 up to 0.7% in oxidative and non-oxidative hair dyes IJT 23(S2):1-22, Chloro-2-Aminophenol 1 1 Safe ase used in oxidative hair dyes, but the available data are insufficient to support the safety in non-oxidative hair dyes IJT 23(S2):1-22, Chlororesorcinol 1 1% in hair dyes JACT 15 (4): , 1996

3 4-Hydroxypropylamino-3-Nitrophenol 1 up to 2.6% in hair dyes IJT 28(S3): , Methoxy-m- Phenylenediamine 1 carcinogenicity JACT 11(4): , Methoxy-m-Phenylenediamine HCl 1 carcinogenicity JACT 11(4): , Methoxy-m-Phenylenediamine Sulfate 1 carcinogenicity JACT 11(4): , Nitro-m-Phenylenediamine 1 up to 0.2% JACT 4 (3): , 1985 confirmed 11/03 IJT 25(S2), Amino-4-Chloro-o-Cresol 1 up to 2% in oxidative and non-oxidative hair dyes IJT 23(S2):1-22, Amino-6-Chloro-o-Cresol 1 up to 2% in oxidative and non-oxidative hair dyes IJT 23(S2):1-22, Bromo-5-Nitro-1,3-Dioxane 1 0.1%; but should not be used under circumstances where its actions with amines or amides can result in the formation of nitrosamines or nitrosamides 6-Amino-m-Cresol 1 up to 2.4% in oxidative and non-oxidative hair dyes 6-Amino-o-Cresol 1 Safe as used (up to 0.7%) in oxidative hair dyes, but the available data are insufficient to support the safety in non-oxidative hair dyes JACT 9(2):279-88, 1990 IJT 23(S2):1-22, 2004 IJT 23(S2):1-22, Hydroxyindole 1 IJT 33(S3):24-35, Acacia Catechu Gum 1 IJT 24(S3):75-118, 2005 Acacia Concinna Fruit Extract 1 IJT 24(S3):75-118, 2005 Acacia Dealbata Leaf Extract 1 IJT 24(S3):75-118, 2005 Acacia Dealbata Leaf Wax 1 IJT 24(S3):75-118, 2005 Acacia Decurrens Extract 1 IJT 24(S3):75-118, 2005 Acacia Farnesiana Flower/Stem Extract 1 IJT 24 (S3):75-118, 2005 Acacia Farnesiana Flower Wax 1 IJT 24(S3):75-118, 2005 Acacia Farnesiana Gum 1 IJT 24(S3):75-118, 2005 Acacia Senegal Extract 1 IJT 24(S3):75-118, 2005

4 Acacia Senegal Gum 1 up to 9% for the gum and 0.001% for the extract IJT 24(S3:75-118, 2005 Acacia Senegal Gum Extract 1 up to 9% for the gum and 0.001% for the extract IJT 24(S3:75-118, 2005 Acetamide MEA (amended) 1 safe in the present practices of use and concentration (rinse-off products only) to be non-irritating; should not be used in cosmetic compounds may be formed Final amended report 03/12 available from CIR; JACT 12(3):225-36, 1993 (original report); IJT 30(Suppl. 2):73-127, 2011 (re-review) Acetic Acid to 0.3% IJT 31(S4): , 2012 Acetyl arginine 1 not in current use* safe for use in cosmetics when Final report 12/ Acetylated Lanolin 1 up to 7% JEPT 4(4):63-92, 1980 confirmed 02/03 IJT 24(S1):2-10, 2005 Acetylated Lanolin Alcohol 1 up to 16% JEPT 4 (4):63-92, 1980 confirmed 02/03 IJT 24(S1):2-10, 2005 Acetyl Carnitine 1 safe IJT 31(S3): , 2012 Acetyl Carnitine HCl 1 safe IJT 31(S3): , 2012 Acetyl Cysteine 1 safe for use in cosmetics when Final report 12/ Acetyl Glutamic acid 1 not in current use* safe for use in cosmetics when Final report 12/ Acetyl Glutamine 1 safe for use in cosmetics when Final report 12/ Acetyl Histidine 1 not in current use* safe for use in cosmetics when Final report 12/ Acetyl Methionine 1 safe for use in cosmetics when Final report 12/ Acetyl Proline 1 not in current use* safe for use in cosmetics when Final report 12/ Acetyl Tributyl Citrate 1 up to 7% IJT 21 (S2):1-17, 2002 Acetyl Triethyl Citrate 1 up to 7% IJT 21 (S2):1-17, 2002 Acetyl Trihexyl Citrate 1 not in current use * IJT 21(S2):1-17, 2002 Acetyl Trioctyl Citrate 1 not in current use * IJT 21(S2):1-17, 2002

5 Acetyl Tyrosine 1 safe for use for cosmetics Achillea Millefolium Extract 1 safe for use to be non-sensitizing Final report 12/ IJT 20(S2):79-84, 2001; final report 12/ available from CIR Final report 12/ Final report 12/ Achillea Millefolium Flower/Leaf/Stem Extract 1 safe for use to be non-sensitizing Achillea Millefolium Flower Extract 1 safe for use to be non-sensitizing Acid Orange % in hair dyes IJT 19 (S1):1-9, 2000 Acid Violet 43 1 safe for use in hair dye IJT 20(S3):1-6, 2001 formulations when free of impurities except for the following: <=18% volatile matter (at 135 degrees C) and chlorides and sulfates (calculated as sodium salts); <=0.4% water-insoluble matter; <=0.2% 1-hydroxy-9,10- anthracenedione; <=0.2% 1,4-dihydroxy-9,10- anthracenedione; <=0.1% p-toluidine; <=0.2% p- toluidine sulfonic acids, sodium salts; <=1% subsidiary colors; <=20 ppm lead (as Pb); <=3 ppm arsenic (as As); <=1 ppm mercury (as Hg); and >80% total color. Acrylamide/Ethyltrimonium Chloride* Acrylate/ Ethalkonium Chloride Acrylate Copolymer Acrylamidopropyl Trimonium Chloride/Acrylamide Copolymer* Acrylamidopropyl-Trimonium Chloride/Acrylates Copolymer 1 safe in the present practices of use and concentration, when 1 safe in the present practices of use and concentration, when 1 safe in the present practices of use and concentration, when IJT 31(S3): IJT 31(S3): IJT 31(S3): Acrylates/Ammonium Methacrylate Copolymer 1 safe for use when formulated to avoid irritation IJT 21(S3):1-50, 2002 Acrylates/bis-hydroxypropyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): , Acrylates/C12-13 Alkyl Methacrylates/Methoxyethyl Acrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Final report 11/2011

6 Acrylates/dimethiconol acrylate copolymer 1 up to 0.5% Final report 12/10 Acrylates/Ethylhexyl Acrylate/Glycidyl Methacrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Final report 11/2011 Acrylates/Ethylhexyl Acrylate/Styrene Copolymer 1 not in current use* Final report 09/ Acrylates/Ethylhexyl Acrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Acrylates/Hydroxyesters Acrylates Copolymer 1 safe for use when formulated to avoid irritation Acrylates/PEG-4 Dimethacrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Acrylates/PVP Copolymer 1 safe for use when formulated to avoid irritation Acrylates/Steareth-20 Methacrylate Copolymer 1 safe for use when formulated to avoid irritation Acrylates/Steareth-20 Methacrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Acrylates/Steareth-50 Acrylate Copolymer 1 safe for use when formulated to avoid irritation Acrylates/VA Copolymer 1 safe for use when formulated to avoid irritation Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Final report 11/2011 IJT 21(S3):1-50, 2002 Final report 11/2011 IJT 21(S3):1-50, 2002 IJT 21(S3):1-50, 2002 Final report 11/2011 IJT 21(S3):1-50, 2002 IJT 21(S3):1-50, 2002 Final report 11/2011 Acrylates/Vinyl Neodecanoate Crosspolymer 1 Final report 11/2011 Acrylates C10/30 Alkyl Acrylate Crosspolymer 1 1 when used as described in assessment, % data does not support use when polymerized in benzene Final report 11/2011 Acrylates Copolymer 1 safe for use when formulated to avoid irritation IJT 21(S3):1-50, 2002 Acrylates Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Final report 11/2011 Actinidia Chinensis (Kiwi) Seed Oil 1 up to 0.1% Final report 03/11 Adansonia Digitata Oil 1 up to 0.01% Final report 03/11 Adansonia Digitata Seed Oil 1 not in current use* Final report 03/11 Adansonia digitata seed oil PEG-8 esters 1 safe for use in cosmetics when

7 Adipic Acid % in leaveon; 18% in rinse- off IJT 31 (S1):5-76, 2012 Adipic acid/1,4 butanediol/terephthalate copolymer 1 not in current use* IJT 33(S3):36-47, Adipic Acid Dihydrazide 1 JACT 13(3):154-6, 1994 Alanine x 10-7 to 0.1% IJT 32(S4):41-64, Alcaligenes polysaccharides to 0.3% Final report 09/12 Alcohol Denat. denatured with Quassin or Brucine 1 IJT 27 (S1):1-43, 2008 Alcohol Denat. denatured with t-butyl Alcohol, Denatonium Benzoate, Diethyl Phthalate, or Methyl Alcohol 1 up to 99% IJT 27 (S1):1-43, 2008 Aldioxa 1 JACT 12(3):237-42, 1993 Aleurites Moluccanus Bakoly Seed Oil 1 not in current use* Final report 03/11 Aleurites Moluccanus Seed Oil to 5% Final report 03/11 Alkyl aryl sulfonate hydrotropes 1 safe for use in cosmetics when IJT 30(Suppl. 3): , 2011 Allantoin 1 up to 2% IJT 29(Suppl. 2): 84-97, 2010 Allantoin Ascorbate 1 up to 0.05% IJT 29(Suppl. 2): 84-97, 2010 Allantoin Biotin 1 not in current use * IJT 29(Suppl. 2): 84-97, 2010 Allantoin Galacturonic Acid 1 not in current use * IJT 29(Suppl. 2): 84-97, 2010 Allantoin Glycyrrhetinic Acid 1 concentration not reported * IJT 29(Suppl. 2): 84-97, 2010 Allantoin Panthenol 1 concentration not reported * IJT 29(Suppl. 2): 84-97, 2010 Allantoin Polygalacturonic Acid 1 concentration not reported * IJT 29(Suppl. 2): 84-97, 2010 Allyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Allyl Methacrylates Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Almondamide DEA 1 safe in the present practices of use and concentration to be nonirritating and when the levels of free DEA do not exceed Final report 11/2011 Final report 11/2011 IJT 32(S1):36-58,

8 those considered safe int the CIR safety assessment of DEA and its salts; should not be used in cosmetic compounds may be formed Almondamidopropyl betaine 1 safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Almondamidopropyl dimethylamine 1 not in current use* safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Almond oil PEG-6 esters 1 safe for use in cosmetics when Almond oil PEG-8 Esters 1 safe for use in cosmetics when Almond Oil Propylene Glycol Esters* 1 safe IJT 31(S1):77-111, 2012 Final report 06/ Final report 12/ Aloe Andongensis Extract 1 IJT 26(S2):1-50, 2007 Aloe Andongensis Leaf Juice 1 IJT 26(S2):1-50, 2007 Aloe Arborescens Leaf Extract 1 IJT 26(S2):1-50, 2007 Aloe Arborescens Leaf Juice 1 IJT 26(S2):1-50, 2007 Aloe Arborescens Leaf Protoplasts 1 IJT 26(S2):1-50, 2007 Aloe Barbadensis Flower Extract 1 safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. Aloe Barbadensis Leaf 1 safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. Aloe Barbadensis Leaf Extract 1 safe as cosmetic ingredients in the practices of use IJT 26(S2):1-50, 2007 IJT 26(S2):1-50, 2007 IJT 26(S2):1-50, 2007

9 and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. Aloe Barbadensis Leaf Juice 1 safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. Aloe Barbadensis Leaf Water 1 safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. Aloe Barbadensis Polysaccharides 1 safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. IJT 26(S2):1-50, 2007 IJT 26(S2):1-50, 2007 IJT 26(S2):1-50, 2007 Aloe Ferox Leaf Extract 1 IJT 26(S2):1-50, 2007 Aloe Ferox Leaf Juice 1 IJT 26(S2):1-50, 2007 Aloe Ferox Leaf Juice Extract 1 IJT 26(S2):1-50, 2007 Alpha Hydroxy Acids (e.g. Glycolic and Lactic Acid, and their salts and esters) (see CIR report of the same name) Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations <=10%, at final formulation ph >=3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations <=30%, at final formulation ph >=3.0, in products designed for brief, discontinuous use followed by thorough rinsing IJT 17(S1):1-242, 1998

10 from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Alumina 1 Final report 12/ Alumina Magnesium Metasilicate 1 up to 0.01% Final Report 09/09 Aluminum Calcium Sodium Silicate 1 up to 6% Final Report 09/09 Aluminum Citrate 1 concentration not reported * IJT 33 (S2): 16-46, Aluminum Dimyristate (amended) 1 up to 3% IJT 29(S3) : ,2010 Aluminum Distearate 1 up to 5% JACT 1(2):143-77, 1982 confirmed 11/01 IJT 22(S1):1-35, 2003 Aluminum Hydroxide 1 Final report 12/ Aluminum Iron Silicates 1 not in current use* Final Report 09/09 Aluminum Isostearates/Myristates 1 not in current use * IJT 29(S3) : ,2010 Aluminum Myristate 1 up to 1% IJT 29(S3) : ,2010 Aluminum Myristates/Palmitates 1 up to 6% IJT 29(S3) : ,2010 Aluminum Silicate 1 up to 37% in dentifrices; up to 3% in other uses IJT 22(S1):37-102, 2003 Aluminum Starch Octenylsuccinate 1 safe as used provided that established limitations imposed on heavy metal concentrations are not exceeded IJT 21(S1):1-7, 2002 Aluminum Stearate 1 up to 8% JACT 1(2):143-77, 1982 confirmed 11/01 IJT 22(S1):1-35, 2003 Aluminum Tristearate 1 up to 10% JACT 1(2):143-77, 1982 confirmed 11/01 IJT 22(S1):1-35, 2003 Amaranthus Hypochondriacus Seed Oil 1 not in current use* Final report 03/11 Amino Bispropyl Dimethicone 1 not in current use * IJT 22(S2):11-35, 2003

11 Aminoethyl Propanediol 1 Final report 09/ Aminomethyl Propanediol (amended) 1 up to 2% IJT 28 (S2): JACT 9(2):203-28, 1990 (original report); final report 09/ Aminomethyl Propanol (amended) 1 up to 7% IJT 28 (S2): JACT 9(2):203-28, 1990 (original report) Aminopropyl Dimethicone 1 not in current use * IJT 22(S2):11-35, 2003 Ammonium Acrylates Copolymer 1 safe for use when formulated to avoid irritation IJT 21(S3):1-50, 2002 Ammonium Bisulfite 1 up to 32% IJT 22(S2):63-88, 2003 Ammonium C12-15 Pareth Sulfate 1 safe in the present practices of use and concentration when Ammonium Capryleth Sulfate, 1 safe in the present practices of use and concentration when IJT 29(Suppl. 3) : ,2010 IJT 29(Suppl. 3) : ,2010 Ammonium Cocomonoglyceride Sulfate (amended) 1 not in current use * IJT 30(S1):5S-16S Ammonium Coco-Sulfate 1 not in current use * IJT 29(S2): , 2010 Ammonium Cocoyl Isethionate 1 safe for use in cosmetics when Final report 09/ Ammonium Cocoyl Sarcosinate 1 safe as used in rinse-off products; but 5% in leaveon products. Should not be used in products where N- nitroso compounds may be formed. Insufficient data to determine safety in products where these ingredients are likely to be inhaled. IJT 20(S1):1-14, 2001 Ammonium Cumenesulfonate 1 not in current use * IJT 30(S3): , 2011 Ammonium Dinonyl Sulfosuccinate 1 not in current use* safe for use in cosmetics when Final report 09/ Ammonium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics when IJT 29 (S4) , 2010 Ammonium Glycolate 1 safe for use in cosmetic products at concentrations <=10%, at final formulation ph >=3.5, IJT 17(S1):1-242, 1998

12 to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations <=30%, at final formulation ph >=3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Ammonium Glycyrrhizate 1 up to 5% IJT 26 (S2):79-112, 2007 Ammonium Lactate 1 safe for use in cosmetic products at concentrations <=10%, at final formulation ph >=3.5, to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations <=30%, at final formulation ph >=3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Ammonium Laureth Sulfate 1 safe in the present practices of use and concentration when Ammonium Lauroyl Sarcosinate 1 safe as used in rinse-off products; but 5% in leaveon products. Should not be used in products where N- nitroso compounds may be IJT 17(S1):1-242, 1998 JACT 2(5):1-34, 1983 confirmed 11/02 IJT 24(S1):85-89, 2005; IJT 29(Suppl. 3) : ,2010 IJT 20(S1):1-14, 2001

13 formed. Insufficient data to determine safety in products where these ingredients are likely to be inhaled. Ammonium Lauryl Sulfate 1 safe for use in rinse-off products; but 1% for leave-on Ammonium Myreth Sulfate 1 not in current use * safe in the present practices of use and concentration when JACT 2(7):127-81, 1983 confirmed 06/02 IJT 24(S1):89-98, 2005 IJT 29(S3) : ,2010 Ammonium Myristyl Sulfate 1 not in current use * IJT 29(S2): , 2010 Ammonium Persulfate 1 safe as oxidizing agents in hair colorants and IJT 20(S3):7-21, 2001 lighteners designed for brief, discontinuous use followed by thorough rinsing from hair and skin Ammonium Polyacrylate 1 safe for use when formulated to avoid irritation IJT 21(S3):1-50, 2002 Ammonium Stearate 1 up to 10% JACT 1(2):143-77, 1982 confirmed 11/01 IJT 22(S1):1-35, 2003 Ammonium Styrene/Acrylates Copolymer 1 safe for use when formulated to avoid irritation IJT 21(S3):1-50, 2002 Ammonium Sulfite 1 not in current use * IJT 22 (S2):63-88, 2003 Ammonium Tallate 1 not in current use * IJT 28(S3): , 2009 Ammonium Thioglycolate (amended) 1 in hair straighteners, permanent waves, tonics, dressings, etc., wave sets, other non-coloring hair products, and hair dyes and colors; safe at 15.2% (as thioglycolic acid); hairdressers should avoid skin contact and minimize consumer skin exposure Ammonium VA/Acrylates Copolymer 1 safe for use when formulated to avoid irritation IJT 28(S3):68-133, 2009 JACT 10(1):135-92, 1991 (original report) IJT 21(S3):1-50, 2002 Ammonium Xylenesulfonate 1 up to 3% IJT 30 (S3): , 2011 Amodimethicone 1 up to 3% IJT 22(S2):11-35, 2003

14 Amodimethicone Hydroxystearate 1 not in current use * IJT 22(S2):11-35, 2003 AMP-Acrylates Copolymer 1 safe for use when formulated to avoid irritation IJT 21(S3):1-50, 2002 Amyl Acetate 1 up to 10% JACT 7(6):705-19, 1988 Amyl Benzoate 1 not in current use * IJT 31 (S3): Anacardium Occidentale (Cashew) Seed Oil to 1% Final report 03/11 Anthemis nobilis flower extract 1 safe for use in cosmetics to be non-sensitizing Final report 12/ Anthemis nobilis flower oil 1 safe for use in cosmetics to be non-sensitizing Anthemis nobilis flower powder 1 safe for use in cosmetics to be non-sensitizing Anthemis nobilis flower water 1 safe for use in cosmetics to be non-sensitizing Apricotamide DEA 1 safe in the present practices of use and concentration to be nonirritating and when the levels of free DEA do not exceed those considered safe int the CIR safety assessment of DEA and its salts; should not be used in cosmetic compounds may be formed Apricotamidopropyl betaine 1 safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Final report 12/ Final report 12/ Final report 12/ IJT 32(S1):36-58, IJT 31(S1):77-111, 2012 Apricot Kernel Amino Acids 1 not in current use * IJT 33(S4):5-12, Apricot Kernel Oil PEG-40 esters 1 safe for use in cosmetics when Apricot Kernel Oil PEG-6 esters 1 safe for use in cosmetics when Apricot Kernel Oil PEG-8 esters 1 safe for use in cosmetics when Apricot Kernel Oil Propylene Glycol Esters* 1 safe Final report 12/

15 Arachideth-20 1 safe in cosmetics as long as they are formulated Arachidonic Acid 1 JACT 12(5): , 1993 Arachidyl behenate 1 safe for use in cosmetics when Final report 03/ arachidyl erucate 1 not in current use* safe for use in cosmetics when Final report 03/ Arachidyl Glucoside 1 safe in cosmetics IJT 32 (S3): 22-48, Arachidyl Glycol 1 not in use at the time* IJT 31 (S2): , 2012 Arachidyl Propionate 1 up to 10% safe in cosmetics as long as they are formulated JACT 9(2):143-52, 1990 confirmed 06/06; Final report 03/ available from CIR Arctium Lappa Seed Oil 1 not in use at the time* Final report 03/11 Argania Spinosa Kernel Oil to 10% Final report 03/11 Argan oil PEG-8 esters 1 safe for use in cosmetics when Arginine to 18% IJT 32(S4):41-64, Arginine HCl to 0.02% IJT 32(S4):41-64, Arnica Montana 1 IJT 20(S2):1-11, 2001 Arnica Montana Extract 1 IJT 20(S2):1-11, 2001 Ascorbyl Dipalmitate 1 not in current use * IJT 18(S3):1-26, 1999 Ascorbyl Palmitate 1 up to 0.2% IJT 18(S3):1-26, 1999 Ascorbyl Stearate 1 not in current use * IJT 18(S3):1-26, 1999 Ascorbyl tocopheryl acetate 1 not in current use * Final report 03/ Ascorbyl tocopheryl maleate 1 Final report 03/ Asparagine 1 concentration not reported IJT 32(S4):41-64, Aspartic Acid to 1% IJT 32(S4):41-64,

16 Astragalus Gummifer Gum 1 up to 3% JACT 6(1):1-22, 1987 confirmed 09/04 Astrocaryum Murumuru Seed Butter to 7% Final report 03/11 Attapulgite 1 up to 8% IJT 22(S1):37-102, 2003 Avena Sativa (oat) bran 1 safe to be non-sensitizing Final report 12/ Avena Sativa (oat) bran extract 1 safe to be non-sensitizing Final report 12/ Avena Sativa (oat) Flower/leaf/stem Juice* 1 safe to be non-sensitizing Final report 12/ Avena Sativa (oat) Kernel Extract 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Kernel Flour 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Kernel Meal 1 safe to be non- sensitizing Final report 12/ Avena Sativa (Oat) Kernel Oil to 3% Final report 03/11 Avena Sativa (oat) Kernel Protein 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Leaf/stalk Extract* 1 safe to be non-sensitizing Final report 12/ Avena Sativa (oat) Leaf/stem Extract* 1 safe to be non-sensitizing Final report 12/ Avena Sativa (oat) Leaf Extract 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Meal Extract 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Meristem Cell Extract 1 Final report 12/ Avena Sativa (oat) Peptide 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Protein Extract 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Seed Extract* 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Seed Water* 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Sprout Oil* 1 safe to be non- sensitizing Final report 12/ Avena Sativa (oat) Straw Extract 1 safe to be non- sensitizing Final report 12/ Avocadamide DEA 1 safe in the present practices of use and concentration IJT 32(S1):36-58,

17 to be nonirritating and when the levels of free DEA do not exceed those considered safe int the CIR safety assessment of DEA and its salts; should not be used in cosmetic compounds may be formed Avocadamidopropyl betaine 1 safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Avocadamidopropyl dimethylamine 1 not in current use * safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment IJT 31(S1):77-111, 2012 Final report 06/ Avocado Oil to 98% JEPT 4(4):93-103, 1980 confirmed 06/01 IJT 22(S1):1-35, 2003 Avocado oil PEG-11 esters 1 safe for use in cosmetics when Avocado oil PEG-8 esters 1 safe for use in cosmetics when Avocado Oil Propylene Glycol Esters* 1 safe Final report 12/ Azelaic acid 1 up to 0.3% in leave-on; up to 10% in rinse- off IJT 31 (S1):5-76, 2012 Azelamide MEA 1 safe in the present practices of use and concentration (rinse-off products only) to be non-irritating; should not be used in cosmetic compounds may be formed Final amended report 03/12 available from CIR Azulene 1 IJT 18(S3):27-32, 1999 Babassu Acid 1 not in current use* Final report 03/11 Babassuamide DEA 1 safe in the present practices of use and concentration to be nonirritating and when the levels of free DEA do not exceed IJT 32(S1):36-58,

18 those considered safe int the CIR safety assessment of DEA and its salts; should not be used in cosmetic compounds may be formed Babassuamide MEA 1 safe in the present practices of use and concentration (rinse-off products only) to be non-irritating; should not be used in cosmetic compounds may be formed Babassuamidopropyl betaine 1 safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Babussuamidopropyl dimethylamine 1 not in current use* safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Barium Sulfate 1 safe in cosmetics as long as they are formulated Final amended report 03/12 available from CIR IJT 31(S1):77-111, 2012 Final report 06/ Final report 06/ Basic Blue 99 1 up to 2% IJT 26(S2):51-63, 2007 Basic Violet 1 1 IJT 28(S3): Basic Violet 3 1 IJT 28(S3): Basic Violet 4 1 IJT 28(S3): Bassia Butyracea Seed Butter 1 not in current use* Final report 03/11 Bassia Latifolia Seed Butter to 2% Final report 03/11 Batyl Alcohol to 3% IJT 32 (S3): 5-21, Batyl Isostearate 1 not in current use* safe for use in cosmetics when Final report 03/ Batyl Stearate 1 not in current use* safe for use in cosmetics when Final report 03/ Beeswax 1 up to 56% JACT 3(3):1-41, 1984 confirmed

19 Behenamide DEA 1 safe in the present practices of use and concentration to be nonirritating and when the levels of free DEA do not exceed those considered safe int the CIR safety assessment of DEA and its salts; should not be used in cosmetic compounds may be formed Behenamide MEA 1 safe in the present practices of use and concentration (rinse-off products only) to be non-irritating; should not be used in cosmetic compounds may be formed Behenamidopropyl betaine 1 safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Behenamidopropyl dimethylamine 1 safe in cosmetics as long as they are formulated to be non-sensitizing, which may be based on a quantitative risk assessment Beheneth-10 1 safe in cosmetics as long as they are formulated Beheneth-15 1 safe in cosmetics as long as they are formulated Beheneth-2 1 safe in cosmetics as long as they are formulated Beheneth-20 1 safe in cosmetics as long as they are formulated Beheneth-25 1 safe in cosmetics as long as they are formulated 06/03 IJT 24(S1):48-52, 2005 IJT 32(S1):36-58, Final amended report 03/12 available from CIR IJT 31(S1):77-111, 2012 Final report 06/

20 Beheneth-30 1 safe in cosmetics as long as they are formulated Beheneth-5 1 safe in cosmetics as long as they are formulated Behenoxy Dimethicone 1 IJT 22(S2):11-35, 2003; Final report 12/ available from CIR Behenoxy PEG-10 Dimethicone* 1 Final report 12/ Behentrimonium chloride 1 safe IJT 31(S3): Behentrimonium methosulfate 1 safe IJT 31(S3): Behenyl/Isostearyl Beeswax 1 safe for use in cosmetics when Final report 03/ Behenyl Alcohol 1 up to 50% JACT 7(3): , 1988 confirmed 12/05 Behenyl Beeswax 1 safe for use in cosmetics when Final report 03/ Behenyl Behenate 1 safe for use in cosmetics when Final report 03/ Behenyl Benzoate 1 not in current use* IJT 31 (S3): Behenyl Betaine 1 Up to 8.4% safe for use in cosmetics when Final report 03/ Behenyl dimethicone/bis-vinyldimethicone crosspolymer to 10% IJT 33 (S2): , Behenyl Erucate 1 safe for use in cosmetics when Final report 03/ Behenyl Isostearate 1 not in current use* safe for use in cosmetics when Final report 03/ Behenyl Olivate 1 safe for use in cosmetics when Final report 03/ Bentonite % in mud packs; up to 8% for other uses IJT 22(S1):37-102, 2003 Benzaldehyde 1 up to 0.5% IJT 25(S1):11-27 Benzalkonium Chloride 1 0.1% free active ingredient JACT 8(4): , 1989 confirmed 06/06 Benzethonium Chloride 1 0.5% skin; 0.02% eye area JACT 4(5):65-106, 1985 confirmed 03/04 IJT 25(S2), 2006

21 Benzoic Acid to 5% Final amended report 10/11; original IJT 20(S3):23-50, 2001 Benzophenone-1 1 up to 2% JACT 2(5):35-77, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-11 1 up to 0.2% JACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-2 1 up to 6% JACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-3 1 up to 7% JACT 2(5):35-77, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-4 1 up to 2.5% JACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-5 1 up to 0.3% JACT 2(5):35-77, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-6 1 up to 0.3% JACT 2(5):35-77, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-8 1 up to 0.2% JACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzophenone-9 1 up to 0.4% JACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005 Benzoxiquine 1 IJT 16(S1):117-22,1997 Benzyl Alcohol (amended) to 10% amended report 10/11 IJT 20(S3):23-50, 2001 (original report) Benzyl Benzoate to 4% Final report 10/11 Benzylparaben (amended) 1 up to 0.4% if used alone; parabens mixture up to 0.8% IJT 27(S4): 1-82, 2008 JACT 5

22 (5): , 1986 (original report) Bertholletia Excelsa Seed Oil to 0.5% Final report 03/11 bertholletia excelsa seed oil PEG-8 esters 1 safe for use in cosmetics when Beta-glucan to 0.1% Final report 09/12 Beta-glucan hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12 Beta-glucan palmitate 1 not in current use* Final report 09/12 Betaine to 8.7% safe for use in cosmetics when Final report 03/ Beta-sitosterol 1 Final report 12/ Beta-sitosteryl acetate 1 Final report 12/ BHA 1 up to 0.2% JACT 3(5):83-146, 1984 BHT 1 up to 0.5% IJT 21(S2):19-94, 2002 Biosaccharide gum to 6% Final report 09/12 Biosaccharide gum-2 1 1% Final report 09/12 Biosaccharide gum-3 1 not in current use* Final report 09/12 Biosaccharide gum to 5% Final report 09/12 Biosaccharide gum-5 1 not in current use* Final report 09/12 Biotin 1 up to 1% IJT 20(S4):1-12, 2001 Bis (tripeptide-1) copper acetate 1 not in current use* Final report 06/ Bisabolol 1 up to 1% IJT 18(S3):33-40, 1999 Bis-cetyl/PEG-8 Cetyl PEG-8 Dimethicone* 1 Final report 12/ Bis-diglyceryl Polyacyladipate to 10% IJT 32(S3):56-64, Bis-diglyceryl Polyacyladipate to 36% IJT 32(S3):56-64, Bis-hydroxyethoxypropyl Dimethicone 1 Final report 12/

23 Bis-isobutyl PEG/PPG-10/7/dimethicone Copolymer* 1 Final report 12/ Bis-isobutyl PEG-13/dimethicone Copolymer* 1 Final report 12/ Bis-isobutyl PEG-24/PPG-7/dimethicone Copolymer* 1 Final report 12/ Bis-PEG/PPG-14/14 Dimethicone 1 Final report 12/ Bis-PEG/PPG-15/5 Dimethicone* 1 Final report 12/ Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone 1 Final report 12/ Bis-PEG/PPG-18/6 Dimethicone* 1 Final report 12/ Bis-PEG/PPG-20/20 Dimethicone 1 Final report 12/ Bis-PEG/PPG-20/5 PEG/PPG-20/5 Dimethicone* 1 Final report 12/ Bis-PEG-10 Dimethicone* 1 Final report 12/ Bis-PEG-12 Dimethicone 1 Final report 12/ Bis-PEG-12 Dimethicone Beeswax 1 Final report 12/ Bis-PEG-12 Dimethicone Candelillate 1 Final report 12/ Bis-PEG-15 Methyl Ether Dimethicone 1 Final report 12/ Bis-PEG-1 Dimethicone* 1 Final report 12/ Bis-PEG-20 Dimethicone* 1 Final report 12/ Bis-PEG-4 Dimethicone 1 Final report 12/ Bis-PEG-8 Dimethicone* 1 Final report 12/ Bis-PEG-8 PEG-8 Dimethicone* 1 Final report 12/ Bis-phenylisopropyl phenylisopropyl dimethicone/vinyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): , Bis-stearoxy Dimethicone* 1 Final report 12/ Bis-stearoxyethyl Dimethicone* 1 Final report 12/ Bis-vinyldimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): ,

24 Bis-vinyldimethicone/ PEG-10 dimethicone crosspolymer 1 not in current use* IJT 33 (S2): , Bis-vinyldimethicone/PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): , Bis-vinyldimethicone crosspolymer 1 not in current use* IJT 33 (S2): , Borage Seed Oil PEG-8 esters 1 safe for use in cosmetics when Borago Officinalis Seed Oil to 1% Final report 03/11 Boric Acid 1 5%; but not safe for use on infant or injured skin JACT 2(7):87-125, 1983 confirmed 06/03 Boron Nitride 1 Final report 06/13 Brassica Campestris (Rapeseed) Sterols 1 Final report 12/ Brassica Campestris (Rapeseeed) Oil Unsaponifiables 1 not in current use* Final report 03/11 Brassica Campestris (Rapeseeed) Seed Oil to 17% Final report 03/11 Brassicamidopropyl dimethylamine 1 safe for use in cosmetics to be nonirritating, which may be based on a quantatitive risk assessment (QRA) Final report 06/ Brassica Napus Seed Oil 1 not in current use* Final report 03/11 Brassica Oleracea Acephala Seed Oil 1 not in current use* Final report 03/11 Brassica Oleracea Italica (Broccoli) Seed Oil to 3% Final report 03/11 Brucine (denaturant) 1 IJT 27 (S1):1-43, 2008 Brucine Sulfate (denaturant) 1 IJT 27 (S1):1-43, 2008 Butoxyethanol 1 up to 10% in hair and nail products JACT 15(6): , 1996 confirmed 02/02 IJT 24(S1):18-20, 2005 Butoxyethyl Acetate 1 not in use at the time* IJT 31(S1): , 2012 Butyl Acetate 1 up to 72% JACT 8(4): , 1989 confirmed 08/06 Butyl Acrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices of use and concentration when not polymerized in benzene Final report 11/2011

25 Butyl acrylate/styrene copolymer 1 Final report 09/ Butylated Hydroxyanisole (now BHA) 0 up to 0.2% JACT 3(5):83-146, 1984 confirmed 09/03 IJT 25(S2), 2006 Butylated Hydroxytoluene (now BHT) 0 up to 0.5% IJT 21(S2):19-94, 2002 Butyl Avocadate 1 safe for use in cosmetics when Final report 03/ Butyl Babassuate 1 not in current use* safe for use in cosmetics when Final report 03/ Butyl Benzoate 1 not in use at the time* IJT 31(S3): Butyl Benzyl Phthalate 1 less than 1% JACT 11 (1):1-23, 1992; IJT 30(S2):73-127, 2011 Butyldimethicone methacrylate/methyl methacrylate crosspolymer 1 not in current use* IJT 33 (S2): , Butylene/ethylene/styrene copolymer 1 Final report 09/ Butylene Glycol to 89% JACT 4(5):223-48, 1985 confirmed 02/04 IJT 25(S2), 2006 Butylene Glycol Cocoate 1 up to 2% IJT 30 (S1):5S-16S, 2011 Butylene Glycol Diisononanoate 1 17% IJT 30 (S3): , 2011 Butyl Ester of PVM/MA Copolymer 1 up to 14% Amended Final Report 06/09 JACT 12(3):243-56, 1993 (original report) Butyl Glucoside 1 safe for use in cosmetics when IJT 32 (S3): 22-48, Butyl Glycolate 1 safe for use in cosmetic products at concentrations <=10%, at final formulation ph >=3.5, to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations <=30%, at final formulation ph >=3.0, IJT 17(S1):1-242, 1998

26 in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Butyl Isostearate 1 not in current use* safe for use in cosmetics when Butyl Lactate 1 safe for use in cosmetic products at concentrations <=10%, at final formulation ph >=3.5, to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations <=30%, at final formulation ph >=3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Butyl Methacrylate 1 safe in nail enhancement products when skin contact is avoided; products containing this ingredient should be accompanied with directions to avoid skin contact because of the sensitizing potential of methacrylates Butyl Myristate (amended) 1 safe for use in cosmetics when Butyloctyl Beeswax 1 not in current use* safe for use in cosmetics when Butyloctyl Behenate 1 not in current use* safe for use in cosmetics when Final report 03/ IJT 17(S1):1-242, 1998 IJT 24(S5):53-100, 2005 amended IJT 29(S3): , 2010; original JACT 9(2):247-58, 1990; final report 03/ Final report 03/ Final report 03/

27 Butyloctyl Benzoate 1 not in use at the time* IJT 31(S3): Butyloctyl Candelillate 1 not in current use* safe for use in cosmetics when Final report 03/ Butyloctyl Cetearate 1 not in current use* safe for use in cosmetics when Final report 03/ Butyloctyl Oleate 1 not in current use* safe for use in cosmetics when Final report 03/ Butyloctyl Palmitate 1 not in current use* safe for use in cosmetics when Final report 03/ Butyloctyl Salicylate 1 safe to IJT 22(3):1-108 avoid irritation and to avoid increasing sun sensitivity, or when increased sun sensitivity would be expected, directions for use include the daily use of sun protection. Butyl Oleate 1 safe for use in cosmetics Final report 03/ Butylparaben (amended) 1 up to 0.4% if used alone; parabens mixture up to 0.8% Butyl Stearate 1 up to 9% safe for use in cosmetics when Butyl Thioglycolate 1 in hair straighteners, permanent waves, tonics, dressings, etc., wave sets, other non-coloring hair products, and hair dyes and colors; safe at 15.2% (as thioglycolic acid); hairdressers should avoid skin contact and minimize consumer skin exposure IJT 27(S4): 1-82, 2008 JACT 3(5): , 1984 (original report) JACT 4(5):107-46, 1985 confirmed 06/03 IJT 24(S1):21-25, 2005; final report 03/ IJT 28(S3):68-133, 2009 Butyrospermum Parkii (Shea) Butter to 60% Final report 03/11 Butyrospermum Parkii (Shea) Butter Unsaponifiables to 3% Final report 03/11 Butyrospermum Parkii (Shea) Oil to 15% Final report 03/11 C10-11 isoparaffin 1 safe IJT 31(S3):

28 C10-12 isoparaffin 1 safe IJT 31(S3): C10-13 isoparaffin 1 safe IJT 31(S3): C10-16 Alkyl Glucoside 1 safe for use in cosmetics when IJT 32 (S3): 22-48, C10-16 Pareth-1 1 safe for use in cosmetics when C10-16 Pareth-2 1 safe for use in cosmetics when C10-40 Isoalkyl acid Octododecanol Esters 1 not in current use* safe as used in cosmetics Final report 03/ C10-40 Isoalkyl acid phytosterol esters 1 Final report 12/ C11-12 isoparaffin 1 safe IJT 31(S3): C11-13 isoparaffin 1 safe IJT 31(S3): C11-13 Pareth-10 1 safe for use in cosmetics when C11-13 Pareth-6 1 safe for use in cosmetics when C11-13 Pareth-9 1 safe for use in cosmetics when C11-14 isoparaffin 1 safe IJT 31(S3): C11-15 Pareth-12 1 safe for use in cosmetics when C11-15 Pareth-15 1 safe for use in cosmetics when C11-15 Pareth-20 1 safe for use in cosmetics when C11-15 Pareth-3 1 safe for use in cosmetics when C11-15 Pareth-30 1 safe for use in cosmetics when C11-15 Pareth-40 1 safe for use in cosmetics when C11-15 Pareth-5 1 safe for use in cosmetics when C11-15 Pareth-7 1 safe for use in cosmetics when C11-15 Pareth-9 1 safe for use in cosmetics when C11-15 Sec-Pareth-12 1 safe for use in cosmetics when, 2012

29 C11-21 Pareth-10 1 safe for use in cosmetics when C11-21 Pareth-3 1 safe for use in cosmetics when C12-13 alkyl ethylhexanoate 1 safe for use in cosmetics when C12-13 Pareth-1 1 safe for use in cosmetics when C12-13 Pareth-10 1 safe for use in cosmetics when C12-13 Pareth-15 1 safe for use in cosmetics when C12-13 Pareth-2 1 safe for use in cosmetics when C12-13 Pareth-23 1 safe for use in cosmetics when C12-13 Pareth-3 1 safe for use in cosmetics when C12-13 Pareth-4 1 safe for use in cosmetics when C12-13 Pareth-5 1 safe for use in cosmetics when C12-13 Pareth-6 1 safe for use in cosmetics when C12-13 Pareth-7 1 safe for use in cosmetics when C12-13 Pareth-9 1 safe for use in cosmetics when C12-14 isoparaffin 1 safe C12-14 Pareth-12 1 safe for use in cosmetics when C12-14 Pareth-3 1 safe for use in cosmetics when C12-14 Pareth-5 1 safe for use in cosmetics when C12-14 Pareth-7 1 safe for use in cosmetics when C12-14 Pareth-9 1 safe for use in cosmetics when C12-14 Sec-Pareth-12 1 safe for use in cosmetics when C12-14 Sec-Pareth-15 1 safe for use in cosmetics when C12-14 Sec-Pareth-20 1 safe for use in cosmetics when Final report 03/ IJT 31(S3): , 2012, 2012, 2012

30 C12-14 Sec-Pareth-3 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-30 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-40 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-5 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-50 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-7 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-8 1 safe for use in cosmetics when, 2012 C12-14 Sec-Pareth-9 1 safe for use in cosmetics when, 2012 C12-15 Alkyl Benzoate to 59% IJT 31 (3): C12-15 alkyl ethylhexanoate 1 safe for use in cosmetics when Final report 03/ C12-15 Alkyl Salicylate 1 safe to IJT 22(3):1-108 avoid irritation and to avoid increasing sun sensitivity, or when increased sun sensitivity would be expected, directions for use include the daily use of sun protection. C12-15 Pareth-10 1 safe for use in cosmetics when C12-15 Pareth-11 1 safe for use in cosmetics when C12-15 Pareth-12 1 safe for use in cosmetics when C12-15 Pareth-2 1 safe for use in cosmetics when C12-15 Pareth-3 1 safe for use in cosmetics when C12-15 Pareth-5 1 safe for use in cosmetics when C12-15 Pareth-7 1 safe for use in cosmetics when C12-15 Pareth-9 1 safe for use in cosmetics when C12-16 Pareth-5 1 safe for use in cosmetics when C12-16 Pareth-7 1 safe for use in cosmetics when

31 C12-16 Pareth-9 1 safe for use in cosmetics when C12-18 Alkyl Glucoside 1 safe for use in cosmetics when IJT 32 (S3): 22-48, C12-20 Alkyl Glucoside 1 safe for use in cosmetics when IJT 32 (S3): 22-48, C12-20 isoparaffin 1 safe IJT 31(S3): C13-14 isoparaffin 1 safe IJT 31(S3): C13-15 Pareth-21 1 safe for use in cosmetics when C13-16 isoparaffin 1 safe IJT 31(S3): C14-15 Pareth-11 1 safe for use in cosmetics when C14-15 Pareth-12 1 safe for use in cosmetics when C14-15 Pareth-13 1 safe for use in cosmetics when C14-15 Pareth-4 1 safe for use in cosmetics when C14-15 Pareth-7 1 safe for use in cosmetics when C14-15 Pareth-8 1 safe for use in cosmetics when C14-18 alkyl ethylhexanoate 1 not in current use * safe for use in cosmetics when Final report 03/ C14-18 glycol 1 not in use at the time* IJT 31 (S2): , 2012 C14-30 Alkyl Beeswax 1 not in current use * safe for use in cosmetics when Final report 03/ C15-18 glycol 1 concentration not reported* IJT 31 (S2): , C15-35 isoparaffin/isoalkylcycloalkanes 1 safe IJT 31(S3): C16-17 Alkyl Benzoate 1 not in current use * IJT 31(3): C16-22 Acid Amide MEA 1 safe in the present practices of use and concentration (rinse-off products only) to be non-irritating; should not be used in cosmetic compounds may be formed Final amended report 03/12 available from CIR

32 C16-36 alkyl stearate 1 not in current use* safe for use in cosmetics when Final report 03/ C18-22 hydroxyalkyl hydroxypropyl guar 1 not in current use* Final report 03/12 C18-30 glycol 1 not in use at the time* IJT 31 (S2): , C18-38 Alkyl Beeswax 1 not in current use* safe for use in cosmetics when Final report 03/ C18-38 Alkyl C24-54 Acid Ester 1 not in current use* safe for use in cosmetics when Final report 03/ C18-70 isoparaffin 1 safe IJT 31(S3): C20-22 Alkyl Glucoside 1 safe for use in cosmetics when IJT 32 (S3): 22-48, C20-22 Alkyl phosphate 1 safe for use in cosmetics when Final report 09/ C20-30 glycol 1 not in use at the time* IJT 31 (S2): , 2015 C20-40 Alkyl Behenate 1 not in current use* safe for use in cosmetics when Final report 03/ C20-40 Alkyl Stearate 1 safe for use in cosmetics when Final report 03/ C20-40 isoparaffin 1 safe IJT 31(S3): C20-40 Pareth-95 1 safe for use in cosmetics when C22-24 Pareth-33 1 safe for use in cosmetics when C24-28 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35, 2003 C30-45 alkyl cetearyl dimethicone crosspolymer to 4% IJT 33 (S2): , C30-45 Alkyl Dimethicone 1 2% IJT 22(S2):11-35, 2003 C30-45 alkyl dimethicone/ polycyclohexene oxide crosspolymer 1 concentration not reported * IJT 33 (S2): , C30-45 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35, 2003 C30-50 Alkyl Beeswax 1 safe for use in cosmetics when Final report 03/ C30-50 Alkyl Stearate 1 safe for use in cosmetics when Final report 03/ C30-50 Pareth-10 1 safe for use in cosmetics when C30-50 Pareth-3 1 safe for use in cosmetics when

33 C30-50 Pareth-40 1 safe for use in cosmetics when C32-36 Isoalkyl Stearate 1 safe for use in cosmetics when Final report 03/ C40-60 Alkyl Stearate 1 safe for use in cosmetics when Final report 03/ C40-60 Pareth-10 1 safe for use in cosmetics when C40-60 Pareth-3 and safe for use in cosmetics when C4-24 alkyl dimethicone/ divinyldimethicone crosspolymer 1 2% IJT 33 (S2): , C4-5 Isoalkyl Cocoate 1 safe for use in cosmetics when Final report 03/ C4-6 Olefin/styrene copolymer 1 not in current use* Final report 09/ C5-6 Olefin/styrene copolymer 1 not in current use* Final report 09/ C7-8 isoparaffin 1 safe IJT 31(S3): C8-10 alkyl ethyl phosphate 1 not in current use * safe for use in cosmetics when Final report 09/ C8-22 Alkyl Acrylates/Methacrylic Acid Crosspolymer 1 safe in the present practices of use and concentration when Final report 11/2011 not polymerized in benzene C8-9 isoparaffin 1 safe IJT 31(S3): C9-11 isoparaffin 1 safe IJT 31(S3): C9-11 Pareth-3 1 safe for use in cosmetics C9-11 Pareth-4 1 safe for use in cosmetics C9-11 Pareth-6 1 safe for use in cosmetics C9-11 Pareth-8 1 safe for use in cosmetics C9-12 isoparaffin 1 safe C9-13 isoparaffin 1 safe C9-14 isoparaffin 1 safe IJT 31(S3): IJT 31(S3): IJT 31(S3):

34 C9-15 alkyl phosphate 1 safe for use in cosmetics when Final report 09/ C9-15 Pareth-8 1 safe for use in cosmetics C9-16 isoparaffin 1 safe IJT 31(S3): Caesalpinia spinosa gum to 0.5% Fina report 03/12 Caesalpinia spinosa hydroxypropyltrimonium chloride 1 not in current use * Final report 03/12 Calcium/Sodium PVM/MA Copolymer (amended) 1 concentration not reported * Amended Final Report 06/09 JACT 12(3):243-56, 1993 (original report) Calcium Acetate 1 concentration not reported * IJT 31(S1): , 2012 Calcium Aluminum Borosilicate to 33% IJT 32(S3): 65-72, Calcium Ascorbate 1 not in current use * IJT 24(2):51-111, 2005 Calcium Aspartate 1 not in current use * IJT 32(S4):41-64, Calcium Benzoate to 0.004% Amended final report 09/11 available from CIR Calcium Carboxymethyl Cellulose 1 not in use at the time* IJT 5 (3): 1-59, 1986 (original report); Amended safety assessment 03/09 - Calcium citrate 1 not in use at the time* IJT 33 (S2): 16-46, Calcium Disodium EDTA 1 not in current use * IJT 21(S2):95-142, 2002 Calcium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics when IJT 29 (S4) , 2010 Calcium Gluconate 1 Final report 03/ Calcium Glycinate 1 3% IJT 32(S4):41-64, Calcium Glycolate 1 Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations <=10%, at final formulation ph >=3.5, when IJT 17(S1):1-242, 1998