Block A: Membrane Biology & Biochemistry. Lipid signalling and sphingolipid function
|
|
- Alicia Carter
- 6 years ago
- Views:
Transcription
1 Block A: Membrane Biology & Biochemistry Lipid signalling and sphingolipid function Gerhild van Echten-Deckert Tel g.echten.deckert@uni-bonn.de
2 Programme of the week Monday - general discussion: cellular signalling - sphingosine-1-phosphate phosphate and neurodegeneration (Morbus Alzheimer) Tuesday - brain specific deletion of SPL and its impact on behavivour - bioactive fatty acid derivatives: endocannabinoids and eicosanoids Thursday Stefanie Herresthal: Sphingolipids: Critical Players in Alzheimer s Disease Friday Gökcen Gözüm: Targeting g sphingosine-1-phosphate p p axis in cancer
3 utline of objectives General aspects on cell signalling Signalling via: G-protein coupled receptors Receptor tyrosine kinases Nuclear receptors Signalling lipids: Fatty acids Eicosanoids Endocannabinoids Sphingolipids (S1P) Pathological implications: Neurodegeneration (Alzheimer) Inflammation Cancer References: Hagen et al. Subcellular origin of sphingosine-1-phosphate is essential for its toxic effect in lyase-deficient neurons. J. Biol. Chem. 284: (2009). Hagen et al. Sphingosine-1-phosphate links sphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell Death Differ. 18: (2011) p Walter, Jochen, van Echten-Deckert, Gerhild: Cross-talk of membrane lipids and Alzheimer-related proteins. Mol. Neurodegen. 8:34-45 (2013). van Echten-Deckert, G., Hagen-Euteneuer, N., Karaca, I., Walter, J. Sphingosine-1-phosphate: boon and bane fort he brain. Cell Physiol Biochem., 34: (2014). van Echten-Deckert t & Walter Sphingolipids: id Critical players in Alzheimer s disease Prog Lipid Res 51, (2012) Kunkel et al. Targeting g the sphingosine-1-phosphate p p axis in cancer, inflammation and beyond Nature Rev, Drug Discovery, 12: (2013). Kendall & Nicolaou Bioactive lipid mediators in skin Inflammation and immunity Prog. Lipid Res., 52: (2013).
4 Programme Introduction - Morbus Alzheimer: numbers and facts Sphingolipids: history, structure, metabolism Sphingosine-1-phosphate (S1P) boon or bane? - biological activity and mechanism of action CIMES, a synthetic sphingosine analogue S1P-lyase K and conditional K - molecular bases of S1P-induced neurotoxicity - S1P-lyase-deficiency and neurodegeneration - S1P-lyase-deficiency and synaptic plasticity Conclusion and outlook
5 1906: 37. Meeting of doctors for the insane of southwest Germany in Tübingen Alois Alzheimer reports about a peculiar affection of the cerebral cortex Auguste D. 2013: World Alzheimer Report 2013 AD most common neurodegenerative disease worldwide 36 mill. cases (2030: 77 mill. 2050: 135 mill.) Costs worldwide: 604 Bill. USD in 2010 (1% of the global GDP) 1,117 Bill USD in 2030
6 Histopathological findings reported by A. Alzheimer (1906) Miliary foci distributed all over the cortex, caused by the infiltration of a peculiar substance into the cortex Weird neurofibrillary changes, that appeared like very thick tangles filling not only the cell body but also neuronal processes Images C & D are from Holtzman et al. Sci Transl. Med. 2011, 3, 1-17
7 Key neuropathological elements of AD BAP-tists: senile (neuritic) plaques:extracellular aggregates of -amyloid TAU-ists: Neurofibrillary tangles: intracellular bundles of hyperphosphorylated tau ohcm.oxfordmedicine.com/.../graphic10017.jpeg
8 Scheme of major proteolytic processing pathways of APP A B APP S- APP S- A p3 Therapeutic approaches aimed to reduce A production/aggregation have failed! APP APP CTF APP APP CTF van Echten-Deckert & Walter, Prog Lipid Res 2012
9 Figure 3 Artistic change in an individual with Alzheimer's disease 60 years 62 years 63 years 64 years 66 years 65 years The Lancet 2001; 357:
10 Sphingolipids: History H H NH 2 Johann Ludwig Wilhelm Thudichum 1884
11 Sphingolipids - Structure H NH 2 H Sphingosine H H H H H H AcHN HC H H H AcHN H H H H H H HN H Ceramide Ganglioside GM1 H HN HN CH H 3 H 3 C N P H 3 C H Ceramide Ceramide Sphingomyelin
12 Glycosphingolipids form cell type specific profiles ligodendrocyte Neuron GalCer GlcCer Myelin Sheath Sulfatide LacCer Axon Astrocyte Endothelial Cells Gbose 3 Cer Gbose 4 Cer Neuron Muscle Fiber van Echten-Deckert & Herget, BBA 2006 Microglia G M3 G M2 G M1 G D3 G D1a G D1b G T1b
13 NH 2 NH 2 H serine H + (CH 2 ) 14/16 CSCoA palmitoyl/stearoyl-coa SPT (+PLP) Sphingolipids: Main metabolic pathways H CH3 3-ketosphinganine 3KSR (+NADPH) De novo formation NH 2 Sulfatide H H sphinganine CerS1 (+stearoyl-coa) Degradation Recycling HN GalCer H H dihydroceramide DES H HN SMS H 3C N P HN H ceramide SMase H sphingomyelin CerS1 Cerase(acid) GlcCer H NH 2 H sphingosine LacCer NH 2 SPP SK2 P H sphingosine-1-phosphate Gangliosides SPL (+PLP) phosphoethanolamine + hexa/octadecenal van Echten-Deckert & Walter, Prog Lipid Res 2012
14 Biosynthesis of major brain gangliosides Glc-T Gal-T I SAT I SAT II β 1,1 β 1,4 α 2,3 α 2,8 Cer GlcCer LacCer GM3 GD3 GalNAc-T β 1,4 GlcCer GalCer Sulfatide LacCer GM2 Gal-T II β 1,3 GD2 GM1a SAT IV α 2,3 GD1b GM3 GM2 GM1 GD1a SAT V α 2,8 GT1b GD3 GD1a GD1b GT1b GT1a GQ1b ligo Astro Neuro a-series b-series Glucose (Glc) Galactose (Gal) N-Acetylgalactosamine (GalNAc) Sialic Acid van Echten-Deckert & Walter, Prog Lipid Res 2012
15 Degradation pathways of selected glycosphingolipids affected in lysosomal storage disorders GM1- Gangliosidosis GM1 GM1- -galactosidase GM2-activator, SAP-B GM2 Tay-Sachs Sandhoff -hexosaminidasea,b GM2-activator Sialidosis GM3 sialidase SAP-B Glucose (Glc) Galactose (Gal) LacCer N-Acetylgalactosamine (GalNAc) Sialic Acid Phosphocholine van Echten-Deckert & Walter, Prog Lipid Res 2012 GlcCer Gaucher GlcCerase SAP-C acid SMase Cer Niemann-Pick A,B Farber acid Cerase SAP-C, SAP-D Sph SM
16 Physiological/clinical relevance of bioactive sphingolipids Ser + FA-CoA apoptosis p Sphingomyelin DHCer differentiation inflammation insulin resistance Ceramide C1P inflammation senescence stress response MDR glucose tolerance brain function morphogenesis tumour genesis GlcCer GSL Sa So S1P anti-apoptosis proliferation migration inflammation i angiogenesis wound healing
17 Dual Action of S1P: Extracellular Ligand and Intracellular Second Messenger growth factor S1P S1P 1-5 trimeric G-proteins sphingosine Sphingosine kinase S1P adenylate- monomeric cyclase PLC G-proteins intracellular targets? proliferation Ca 2+ homeostasis anti-apoptosis survival differentiation motility cytoskeleton rearrangements inflammation angiogenesis
18 The subcellular origin of S1P is essential for its neurotoxic effect S1P cimes Sph PM S1P Sph SK1 (LPP?) SK2 cimesp apoptotic ti SPP ER SK2 S1P S1P apoptotic Hagen et al, JBC 2009
19 Summary cimes extracellular intracellular Z-LEHD-FMK cimes SK2 Caspase-12 Caspase-9 Caspase-3 cimesp MDL ER ER-stress Ca 2+ Calpain S1P MDL SPP SK2 Sph p35 p25 CDK5 Rb P neuronal apoptosis cell cycle reactivation tau P S1P Hagen et al, Cell Death Differ, 2011
20 Conclusions Sphingosine-1-phosphate (S1P) is a neuronal death signal, when generated by SK2 and impaired degradation Calpain is an essential mediator of S1P-induced neurotoxicity n cellular and molecular level S1P neurotoxicity parallels that of A S1P-lyase expression is correlated with neuronal death S1P-lyase deficiency is correlated with Alzheimer characteristics: Hyperphosphorylation h of tau Impaired APP-processing Elevated levels of cholesteryl-ester S1P stimulates BACE1, the rate-limiting enzyme for A production (Takasugi et al., 2011, J. Neurosci.) Conditional knockout mouse: neuron specific Conditional knockout mouse: neuron-specific inactivation ofs1p-lyase
Block A: Membrane Biology & Biochemistry. Lipid signalling and sphingolipid function
Block A: Membrane Biology & Biochemistry Lipid signalling and sphingolipid function 02.-06.11.2015 Gerhild van Echten-Deckert Tel. 73 2703 E-mail: g.echten.deckert@uni-bonn.de Sphingolipids: History H
More informationnumber Done by Corrected by Doctor
number 26 Done by حسام أبو عوض Corrected by Zaid Emad Doctor فيصل الخطيب 1 P a g e A small note about phosphatidyl inositol-4,5-bisphosphate (PIP2) before moving on: This molecule is found in the membrane
More informationAbdallah Q& Razi. Faisal
27 & Ahmad Attari م ح م د ي وس ف Abdallah Q& Razi Faisal Sphingophospolipids - The backbone of sphingophospholipids is sphingosine, unlike glycerophospholipids with a glycerol as the backbone. Which contains
More informationMetabolism of acylglycerols and sphingolipids. Martina Srbová
Metabolism of acylglycerols and sphingolipids Martina Srbová Types of glycerolipids and sphingolipids 1. Triacylglycerols function as energy reserves adipose tissue (storage of triacylglycerol), lipoproteins
More informationSphingosine-1-phosphate signaling and cardiac fibrosis. Department of Physiology, Kanazawa University School of Medicine, Kanazawa, Japan
96 Special Issue: Cellular and Molecular Bases for Fibrotic Diseases Review Article Sphingosine-1-phosphate signaling and cardiac fibrosis Noriko Takuwa 1, 2, ), Yasuo Okamoto 1), Kazuaki Yoshioka 1) and
More informationMETABOLISM OF ACYLGLYCEROLS AND SPHINGOLIPDS. Ben S. Ashok MSc.,FAGE.,PhD., Dept. of Biochemistry
METABOLISM OF ACYLGLYCEROLS AND SPHINGOLIPDS Ben S. Ashok MSc.,FAGE.,PhD., Dept. of Biochemistry STORAGE AND MEMBRANE LIPIDS STORAGE LIPIDS Mainly as triacylglycerols (triglycerides) in adipose cells Constitute
More informationMEMBRANE LIPIDS I and II: GLYCEROPHOSPHOLIPIDS AND SPHINGOLIPIDS
December 6, 2011 Lecturer: Eileen M. Lafer MEMBRANE LIPIDS I and II: GLYCEROPHOSPHOLIPIDS AND SPHINGOLIPIDS Reading: Stryer Edition 6: Chapter 26 Images: All images in these notes were taken from Lehninger,
More informationThe role of the laboratory in diagnosing lysosomal disorders
The role of the laboratory in diagnosing lysosomal disorders Dr Guy Besley, formerly Willink Biochemical Genetics Unit, Manchester Children s Hospital, Manchester M27 4HA, UK. Lysosomal disorders What
More informationThe Role of Sphingolipids in Alzheimer s Disease, Parkinson s Disease and Lewy Body Dementia: A Common Pathway?
The Role of Sphingolipids in Alzheimer s Disease, Parkinson s Disease and Lewy Body Dementia: A Common Pathway? Michelle M. Mielke, PhD Professor of Epidemiology and Neurology Center for Healthy Brain
More informationPhospholipids Metabolism
Chapter VI: Phospholipids Metabolism Dr. Sameh Sarray Hlaoui Phospholipids Features: Amphipatic: - Hydrophobic head: fatty acids - Hydropholic head: P group+ alcohol Composed of alcohol attached by a phosphodiester
More informationSphingolipid de novo synthesis: its relevance to metabolic diseases and cell polarity
Sphingolipid de novo synthesis: its relevance to metabolic diseases and cell polarity Xian-Cheng Jiang (shian-chen chiang) SUNY Downstate Medical Center Cell plasma membrane Lipid rafts Sphingolipid =
More informationChapter 26 Biochemistry 5th edition. phospholipids. Sphingolipids. Cholesterol. db=books&itool=toolbar
http://www.ncbi.nlm.nih.gov/sites/entrez? db=books&itool=toolbar 1 The surface of a soap bubble is a bilayer formed by detergent molecules 2 Chapter 26 Biochemistry 5th edition phospholipids Sphingolipids
More informationRole of Toll-like Receptors in the Activation
Role of Toll-like Receptors in the Activation of Natural Killer T (NKT) lymphocytes HOST PATHOGEN CROSS TALK Annecy, Les Pensières September 24-26, 2007 Institut Pasteur de Lille Inserm 547 (Prof M. Capron)
More informationI. Structure and Properties of Lipids
I. Structure and Properties of Lipids Lipids: A diverse group of compounds characterized by their low solubility in water and a high solubility in organic solvents such as chloroform and methanol. Nonpolar
More informationTechNotes. Gangliosides. 1. Applications
TechNotes Gangliosides Gangliosides are a large group of sialylated glycosphingolipids that are widely expressed in mammalian tissues. Gangliosides are found in most tissues of the body, but they are particularly
More information3-keto-Dihydrosphingosine is an Important Early Metabolite of Sphingolipid Biosynthesis
H C 2 H H H H H H H C 2 H H H H H H H H H H NHAc C 2 H H H H C 2 H H H H H H C 17 H 35 NH H N E W S L E T T E R F R G LY C / S P H I N G L I P I D R E S E A R C H N V E M B E R 2 0 1 8 3-keto-Dihydrosphingosine
More informationDiabetes Mellitus and Dementia. Andrea Shelton & Adena Zadourian
Diabetes Mellitus and Dementia Andrea Shelton & Adena Zadourian Abstract Diabetes mellitus increases the risk for developing dementia...but there is inconsistency with the subtypes of dementia Diabetes
More informationTUESDAY, MARCH 28, 2017 WEDNESDAY, MARCH 29, 2017 WELCOME RECEPTION (VIENNA CITY HALL)
KEY: PRE CONFERENCE SYMPOSIUM SPONSORED SYMPOSIUM SYMPOSIUM PLENARY LECTURE FORUM OTHER EVENT *PRE-REGISTRATION IS REQUIRED FOR THE INFORMAL NETWORKING WITH PROFESSOR LUNCH SESSION TUESDAY, MARCH 28, 2017
More informationRare metabolic diseases: the miglustat experience. Fran Platt Department of Pharmacology University of Oxford
Rare metabolic diseases: the miglustat experience Fran Platt Department of Pharmacology University of Oxford The lysosome is an organelle involved in degrading and recycling macromolecules Christian de
More informationUNIVERSITA DEGLI STUDI DI MILANO
UNIVERSITA DEGLI STUDI DI MILANO SCUOLA DI DOTTORATO DI RICERCA IN SCIENZE BIOCHIMICHE, NUTRIZIONALI E METABOLICHE DOTTORATO DI RICERCA IN BIOCHIMICA CICLO XXIII BIO/10 TESI DI DOTTORATO DI RICERCA PLASMA
More informationClassification, functions and structure
Classification, functions and structure Elena Rivneac PhD, Associate Professor Department of Biochemistry and Clinical Biochemistry State University of Medicine and Pharmacy "Nicolae Testemitanu" Lipids
More informationTUESDAY, MARCH 26, 2019 WEDNESDAY, MARCH 27, 2019
KEY: PRE CONFERENCE SYMPOSIUM SPONSORED SYMPOSIUM SYMPOSIUM PLENARY LECTURE FORUM OTHER EVENT *PRE-REGISTRATION IS REQUIRED FOR THE INFORMAL NETWORKING WITH PROFESSOR LUNCH SESSION TUESDAY, MARCH 26, 2019
More informationTUESDAY, MARCH 26, 2019 WEDNESDAY, MARCH 27, 2019
KEY: PRE CONFERENCE SYMPOSIUM SPONSORED SYMPOSIUM SYMPOSIUM PLENARY LECTURE FORUM OTHER EVENT *PRE-REGISTRATION IS REQUIRED FOR THE INFORMAL NETWORKING WITH PROFESSOR LUNCH SESSION TUESDAY, MARCH 26, 2019
More informationNutrition and Age-Associated Inflammation :Role of Nutritional Intervention Simin Nikbin Meydani, DVM, PhD.
Nutrition and Age-Associated Inflammation :Role of Nutritional Intervention Simin Nikbin Meydani, DVM, PhD simin.meydani@tufts.edu Outline 1) Role of immune and inflammatory responses in age-related diseases
More informationReview Article Ganglioside Biochemistry
International Scholarly Research Network ISRN Biochemistry Volume 2012, Article ID 506160, 36 pages doi:10.5402/2012/506160 Review Article Ganglioside Biochemistry Thomas Kolter Program Unit Membrane Biology
More information9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. 9.01 Recitation (R02)
More informationLipids and Membranes
Lipids and Membranes Presented by Dr. Mohammad Saadeh The requirements for the Pharmaceutical Biochemistry I Philadelphia University Faculty of pharmacy Membrane transport D. Endocytosis and Exocytosis
More informationSphingolipids (and precursor fatty acyl-coa s) M. Cameron Sullards
LIPID MAPS Lipidomics Workshop April 28, 2007 www.lipidmaps.org Sphingolipids (and precursor fatty acyl-coa s) M. Cameron Sullards Schools of Chemistry, Biochemistry and Biology & Petit Institute for Bioengineering
More informationDevelopment of Sphingosine Kinase Selective Inhibitors for Cancer Therapy
Development of Sphingosine Kinase Selective Inhibitors for Cancer Therapy Zuping Xia College of Pharmacy Washington State University Sphingolipids, similar to phospholipids, are composed of a polar head
More informationTechnical Report. Structural Analysis of Glycosphingolipids by LC-IT-TOF-MS. Abstract:
C146-E268 Technical Report Structural Analysis of Glycosphingolipids by LC-T-TF-MS Akemi Suzuki 1, Jin-ichi nokuchi 2, Masakazu Nagafuku 2, Hideshi Fujiwake 3, Yoshikatsu Umemura 3 Abstract: A method for
More informationGANGLIOSIDES for Neuroscience Research
GANGLIOSIDES for Neuroscience Research STANDARDS & MONOCLONAL ANTIBODIES Gangliosides GANGLIOSIDE AND GLYCOLIPID STANDARDS purified PURIFIED NATURAL GANGLIOSIDES Cat. # Description Size GANGLIOSIDE A PATH
More informationContents 1 Metabolism and Roles of Eicosanoids in Brain
Contents 1 Metabolism and Roles of Eicosanoids in Brain... 1 1.1 Introduction... 1 1.2 Multiplicity of Cyclooxygenases, Lipoxygenases, and Epoxygenases in the Brain... 4 1.2.1 Cyclooxygenases (COXs)...
More informationSphingolipids (and precursor fatty acyl-coa s) M. Cameron Sullards
LIPID MAPS Lipidomics Workshop April 28, 2007 www.lipidmaps.org Sphingolipids (and precursor fatty acyl-coa s) M. Cameron Sullards Schools of Chemistry, Biochemistry and Biology & Petit Institute for Bioengineering
More informationCellular Physiology (PHSI3009) Contents:
Cellular Physiology (PHSI3009) Contents: Cell membranes and communication 2 nd messenger systems G-coupled protein signalling Calcium signalling Small G-protein signalling o RAS o MAPK o PI3K RHO GTPases
More informationSphingolipids: Regulators of the Crosstalk between Apoptosis and Autophagy
Sphingolipids: Regulators of the Crosstalk between Apoptosis and Autophagy Megan M. Young 1, Mark Kester 1 and Hong-Gang Wang 1, * 1 Department of Pharmacology and Penn State Hershey Cancer Institute,
More informationQuantitation of Sphingolipids in Tissue Extracts by LC/MS/MS
Quantitation of Sphingolipids in Tissue Extracts by LC/MS/MS Alexei Belenky CASSS, Meritage Resort, Napa 2008 Outline Role of lipid analysis in drug discovery and disease diagnostics Analytical tools and
More informationneurons Gemma Triola, Gemma Fabrias, Mihaela Dragusin, Lars Niederhausen, Roland Broere,
Molecular Pharmacology Fast Forward. Published on September 15, 2004 as doi:10.1124/mol.104.003681 MOL 003681 1 Specificity of the dihydroceramide desaturase inhibitor GT11 in primary cultured cerebellar
More informationOptimising. membranes
Optimising Neuronal membranes Lipids are classified as 1. Simple lipids oils and fats 2. Complex lipids a) Phospholipids b) Glycosphingolipids containing a fatty acid, sphingosine and a CHO c) Lipoproteins
More informationLecture 15. Signal Transduction Pathways - Introduction
Lecture 15 Signal Transduction Pathways - Introduction So far.. Regulation of mrna synthesis Regulation of rrna synthesis Regulation of trna & 5S rrna synthesis Regulation of gene expression by signals
More informationBiochemistry. Metabolism
Biochemistry Metabolism 07.11.2017 27.11.2017 Gluconeogenesis Gerhild van Echten-Deckert Tel. 73 2703 E-mail: g.echten.deckert@uni-bonn.de www.limes-institut-bonn.de Gluconeogenesis Glycolysis 7 glycolytic
More informationLipids and Biological Membranes
Lipids and Biological Membranes Lipids: Found in all living organisms Especially important as components of biological membranes Defined functionally, not structurally, as compounds that are totally or
More informationChapter 15: Signal transduction
Chapter 15: Signal transduction Know the terminology: Enzyme-linked receptor, G-protein linked receptor, nuclear hormone receptor, G-protein, adaptor protein, scaffolding protein, SH2 domain, MAPK, Ras,
More informationPhospholipids, Triglycerids. Léránt István
Phospholipids, Triglycerids Léránt István Membran lipids Phosphatidic acids COMMON INTERMEDIER IN Biosynthesis of Glycerol Fatty acid Fatty acid Fatty acid Glycerol Fatty acid Fatty acid P Alcohol phospholipids
More informationLipids. Lipids. Jiří Jonák and Lenka Fialová Institute of Medical Biochemistry, 1st Medical Faculty of the Charles University, Prague
Lipids Jiří Jonák and Lenka Fialová Institute of Medical Biochemistry, 1st Medical Faculty of the Charles University, Prague Lipids 1. General introduction 2. Nomenclature of fatty acids 3. Degradation
More informationPlasma Phospholipids Identify Antecedent Memory Impairment in Older Adults. Madeline Haff, Bikem Sonmezler, & Rosie Chu
Plasma Phospholipids Identify Antecedent Memory Impairment in Older Adults Madeline Haff, Bikem Sonmezler, & Rosie Chu So what exactly is Alzheimer s Disease? A progressive form of dementia that causes
More informationSphingolipids and gangliosides of the nervous system in membrane function and dysfunction
FEBS Letters 584 (2010) 1748 1759 journal homepage: www.febsletters.org Review Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction Elena Posse de Chaves *, Simonetta
More informationTest Bank for Lehninger Principles of Biochemistry 5th Edition by Nelson
Test Bank for Lehninger Principles of Biochemistry 5th Edition by Nelson Link download full: http://testbankair.com/download/test-bank-forlehninger-principles-of-biochemistry-5th-edition-by-nelson/ Chapter
More informationSphingolipids: regulators of crosstalk between apoptosis and autophagy. Megan M. Young, Mark Kester, and Hong-Gang Wang 1
review Sphingolipids: regulators of crosstalk between apoptosis and autophagy Megan M. Young, Mark Kester, and Hong-Gang Wang 1 Department of Pharmacology and Penn State Hershey Cancer Institute, Pennsylvania
More informationLipid Chemistry. Presented By. Ayman Elsamanoudy Salwa Abo El-khair
Lipid Chemistry Presented By Ayman Elsamanoudy Salwa Abo El-khair 4 Objectives: 1. By the end of this chapter the student should be able to: define lipids. describe the biological importance of lipids.
More informationThematic Review Series: Lipids and Lipid Metabolism in the Eye. Regulating survival and development in the retina: key roles for simple sphingolipids
thematic review Thematic Review Series: Lipids and Lipid Metabolism in the Eye Regulating survival and development in the retina: key roles for simple sphingolipids Nora P. Rotstein, 1 Gisela E. Miranda,
More informationSCIRF Award #2016 I-03 PI: Azizul Haque, PhD Grant Title: Neuron-specific Enolase and SCI
SCIRF Award #2016 I-03 PI: Azizul Haque, PhD Grant Title: Neuron-specific Enolase and SCI 10-month Technical Progress Report Enolase is a multifunctional glycolytic enzyme involved in growth control, hypoxia,
More informationANSC (NUTR) 618 LIPIDS & LIPID METABOLISM Membrane Lipids and Sphingolipidsd
ANSC (NUTR) 618 LIPIDS & LIPID METABOLISM Membrane Lipids and Sphingolipidsd I. Classes of membrane lipids A. Glycerolipids (quantitatively the most important of the three membrane lipids) B. Shingolipids
More informationGlycoproteins and Mucins. B.Sopko
Glycoproteins and Mucins B.Sopko Content Glycoproteins: Structures and Linkages Interconversions and activation of dietary sugars Other pathways of sugar nucleotide metabolism Biosynthesis of oligosaccharides
More informationBiochemistry. Metabolic pathways
Biochemistry Metabolic pathways 07.11.2017 01.12.2017 Gerhild van Echten-Deckert Tel. 73 2703 E-mail: g.echten.deckert@uni-bonn.de www.limes-institut-bonn.de Objectives of the course: Energy metabolism
More informationKA Toulis, K. Dovas, M. Tsolaki. The endocrine facets of Alzheimer s disease and dementia-related disorders
KA Toulis, K. Dovas, M. Tsolaki The endocrine facets of Alzheimer s disease and dementia-related disorders Sex hormones Calcium metabolism GH/IGF-I Thyroid axis Metabolic hormones + dementia Sex hormones
More informationCell regulatory function of glycosphingolipids: Carbohydrate recognition and biosignaling
ure & Appl, Chem., Vol. 70, No. 1, pp. 49-53, 1998. rinted in Great Britain. Q 1998 UAC Cell regulatory function of glycosphingolipids: Carbohydrate recognition and biosignaling Yoshitaka Nagai Mitsubishi
More informationAlzheimer s disease: the state of play
Alzheimer s disease: the state of play 30 th May 2012 Dr Eric Karran Director of Research ARUK Scope of presentation An overview of research into the causes of dementia, with an emphasis on Alzheimer s
More informationPrinciples of Genetics and Molecular Biology
Cell signaling Dr. Diala Abu-Hassan, DDS, PhD School of Medicine Dr.abuhassand@gmail.com Principles of Genetics and Molecular Biology www.cs.montana.edu Modes of cell signaling Direct interaction of a
More informationTABLE OF CONTENTS TABLE OF
TABLE F CNTENTS TABLE F CNTENTS...ii Technical Service...iv Natural Products...iv Storage...iv Package Weight...iv Matreya s Mission...iv Lysosomal Storage Disorders Pathways Chart...v Sphingoid Bases,
More informationFigure S2
Figure S1 Figure S2 Figure S3 Figure S4 Figure S5 Figure S6 SUPPLEMENTARY FIGURE LEGENDS Figure S1 Biosynthetic pathway for gangliosides showing activity of GalNAcT and GD3s and the structures of the major
More informationTGF-ß1 pathway as a new pharmacological target for neuroprotection in AD. Filippo Caraci
Department of Clinical and Molecular Biomedicine Section of Pharmacology and Biochemistry Department of Educational Sciences University of Catania TGF-ß1 pathway as a new pharmacological target for neuroprotection
More informationCell Signaling part 2
15 Cell Signaling part 2 Functions of Cell Surface Receptors Other cell surface receptors are directly linked to intracellular enzymes. The largest family of these is the receptor protein tyrosine kinases,
More informationCholesterol and Sphingolipids in Non-Alcoholic fatty liver disease.
Cholesterol and Sphingolipids in Non-Alcoholic fatty liver disease. José C. Fernández-Checa Liver Unit, Hospital Clinic CIBEK and IDIBAPS Instituto Investigaciones Biomédicas Barcelona Consejo Superior
More informationWnt Signaling Pathway and AD
Center for Cell Regulation and Pathology Joaquín V. Luco (CRCP), Millennium Institute (MIFAB) Center for Aging and Regeneration (CARE). Wnt Signaling Pathway and AD Nibaldo C. Inestrosa European Union
More informationAlzheimer's Disease A mind in darkness awaiting the drink of a gentle color.
Alzheimer's Disease A mind in darkness awaiting the drink of a gentle color. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD Gabriel García Márquez One Hundred Years of Solitude Alois Alzheimer
More informationCompanion to Biosynthesis of Ketones & Cholesterols, Regulation of Lipid Metabolism Lecture Notes
Companion to Biosynthesis of Ketones & Cholesterols, Regulation of Lipid Metabolism Lecture Notes The major site of acetoacetate and 3-hydorxybutyrate production is in the liver. 3-hydorxybutyrate is the
More information11/8/16. Cell Signaling Mechanisms. Dr. Abercrombie 11/8/2016. Principal Parts of Neurons A Signal Processing Computer
Cell Signaling Mechanisms Dr. Abercrombie 11/8/2016 Principal Parts of Neurons A Signal Processing Computer A Multitude of Synapses and Synaptic Actions Summation/Synaptic Integration 1 The Synapse Signal
More informationDepartment of Biochemistry and Molecular Biology. Medical University of South Carolina. Charleston, South Carolina, 29425
Bioactive Sphingolipids: Metabolism and Function Authors: Nana Bartke and Yusuf A. Hannun 1 Institution: Department of Biochemistry and Molecular Biology Medical University of South Carolina 173 Ashley
More informationSphingoid Bases, Sphingolipids and Glycosphingolipids
Sphingoid Bases, Sphingolipids and Glycosphingolipids Sphingoid bases such as sphingosine are the characteristic structural unit of the sphingolipids. The bases are long chain aliphatic amines, containing
More informationsphingolipids Nora P. Rotstein*, Gisela E. Miranda, Carolina E. Abrahan and O. Lorena German
Regulating survival and development in the retina: key roles for simple sphingolipids Nora P. Rotstein*, Gisela E. Miranda, Carolina E. Abrahan and O. Lorena German Instituto de Investigaciones Bioquímicas
More informationOverview on the identification of different classes of. lipids by HPTLC (High Performance Thin Layer. Chromatography) and ITLC (Immuno Thin Layer
Overview on the identification of different classes of lipids by HPTLC (High Performance Thin Layer Chromatography) and ITLC (Immuno Thin Layer Chromatography) Iuliana Popa 1, Marie-Jeanne David 2, Daniel
More informationGlycans linked to lipids and lipid precursors
Glycobiology BCMB 8130 Clinical Correlations! -sign up for 1st and 2nd choice (1/2)! *********************************! Glycosylation in Diabetes! O-Mannosylation in Human Pathophysiology! Glycoconjugate
More informationRole of Ganglioside Metabolism in the Pathogenesis of Alzheimer s Disease---A Review
Role of Ganglioside Metabolism in the Pathogenesis of Alzheimer s Disease---A Review Toshio Ariga 1, Michael P. McDonald 2, and Robert K. Yu 1* 1 Institute of Molecular Medicine and Genetics Medical College
More informationLIPIDS TAG, PL and SL metabolism. Marek Vecka
LIPIDS TAG, PL and SL metabolism Marek Vecka BIOSYNTHESIS OF TAG TWO BIOSYNTHETIC PATHWAYS IN MAMMALS liver, adipose tissue - use mainly phosphatidate pathway ( Kennedy pathway ) intestine - monoacylglycerol
More informationBy: Dr Hadi Mozafari 1
Biological lipids are a chemically diverse group of compounds, the common and defining feature of which is their insolubility in water. By: Dr Hadi Mozafari 1 Fats and oils are the principal stored forms
More informationThe elements of G protein-coupled receptor systems
The elements of G protein-coupled receptor systems Prostaglandines Sphingosine 1-phosphate a receptor that contains 7 membrane-spanning domains a coupled trimeric G protein which functions as a switch
More informationChapter 20. Cell - Cell Signaling: Hormones and Receptors. Three general types of extracellular signaling. endocrine signaling. paracrine signaling
Chapter 20 Cell - Cell Signaling: Hormones and Receptors Three general types of extracellular signaling endocrine signaling paracrine signaling autocrine signaling Endocrine Signaling - signaling molecules
More informationHuman Complex Milk Lipids: Concentrations, benefits and the implications for Paediatric Nutrition
Human Complex Milk Lipids: Concentrations, benefits and the implications for Paediatric Nutrition Alastair MacGibbon, Bertram Fong, Angela Rowan and Paul McJarrow Fonterra Research and Development Centre,
More informationRealising the potential of MILK PHOSPHOLIPIDS as an ingredient to improve cognitive function
Realising the potential of MILK PHOSPHOLIPIDS as an ingredient to improve cognitive function Professor Louise Dye Human Appetite Research Unit, Institute of Psychological Sciences Leeds University NUTRITION
More informationReview My journey into the world of sphingolipids and sphingolipidoses
554 Proc. Jpn. Acad., Ser. B 88 (2012) [Vol. 88, Review My journey into the world of sphingolipids and sphingolipidoses By Konrad SANDHFF *1, (Communicated by Kunihiko SUZUKI, M.J.A.) Abstract: Analysis
More informationChapter 8. Functions of Lipids. Structural Nature of Lipids. BCH 4053 Spring 2001 Chapter 8 Lecture Notes. Slide 1. Slide 2.
BCH 4053 Spring 2001 Chapter 8 Lecture Notes 1 Chapter 8 Lipids 2 Functions of Lipids Energy Storage Thermal Insulation Structural Components of Membranes Protective Coatings of Plants and Insects Hormonal
More informationDFG-SPP. Sphingolipids - Signals and Disease. Meeting 2009
DFG-SPP Sphingolipids - Signals and Disease Meeting 2009 University Hospital Essen Hörsaal - Operatives Zentrum II Friday, September 4, 2009 9.00 am Welcome Reception I) MEMBRANES, ENZYMES AND INHIBITORS
More informationIrene Yu, class of 2019
Irene Yu, class of 2019 Nerve Cells and Glia Overview What is the brain made of - types of cells What do neurons do; How are they specialized to do it? CONCEPTS communication via signalling changeability
More informationApolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer s disease and cardiovascular disease
FEATURE REVIEW (2006) 11, 721 736 & 2006 Nature Publishing Group All rights reserved 1359-4184/06 $30.00 www.nature.com/mp Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk
More informationTEST BANK FOR LEHNINGER PRINCIPLES OF BIOCHEMISTRY 6TH EDITION BY NELSON
Link full download: https://testbankservice.com/download/testbank-for-lehninger-principles-of-biochemistry-6th-edition-bynelson TEST BANK FOR LEHNINGER PRINCIPLES OF BIOCHEMISTRY 6TH EDITION BY NELSON
More informationMicroglia, Inflammation, and FTD
FTD Minicourse April, 2009 Microglia, Inflammation, and FTD Li Gan, Ph.D Gladstone Institute of Neurological Disease University of California, San Francisco Outline Why study inflammation in neurodegeneration?
More informationSignal Transduction: Information Metabolism. Chem 454: Regulatory Mechanisms in Biochemistry University of Wisconsin-Eau Claire
Signal Transduction: Information Metabolism Chem 454: Regulatory Mechanisms in Biochemistry University of Wisconsin-Eau Claire Introduction Information Metabolism How cells receive, process and respond
More informationBiological role of lipids
Lipids Lipids Organic compounds present in living organisms, insoluble in water but able to be extracted by organic solvents such as: chloroform, acetone, benzene. Extraction = the action of taking out
More informationCell Communication. Chapter 11. Biology Eighth Edition Neil Campbell and Jane Reece. PowerPoint Lecture Presentations for
Chapter 11 Cell Communication PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from Joan Sharp
More informationThematic Review Series: Genetics of Human Lipid Diseases. Multi-system disorders of glycosphingolipid and ganglioside metabolism
thematic review Thematic Review Series: Genetics of Human Lipid Diseases Multi-system disorders of glycosphingolipid and ganglioside metabolism You-Hai Xu, 2 Sonya Barnes, 2 Ying Sun, 2 and Gregory A.
More informationNovel Targets of disease modifying therapy for Parkinson disease. David G. Standaert, MD, PhD John N. Whitaker Professor and Chair of Neurology
Novel Targets of disease modifying therapy for Parkinson disease David G. Standaert, MD, PhD John N. Whitaker Professor and Chair of Neurology Disclosures Dr. Standaert has served as a paid consultant
More informationChapter 17. Lecture and Animation Outline
Chapter 17 Lecture and Animation Outline To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn audio/text on or off. Please Note: Once you have
More informationChapt. 10 Cell Biology and Biochemistry. The cell: Student Learning Outcomes: Describe basic features of typical human cell
Chapt. 10 Cell Biology and Biochemistry Cell Chapt. 10 Cell Biology and Biochemistry The cell: Lipid bilayer membrane Student Learning Outcomes: Describe basic features of typical human cell Integral transport
More informationReview. Yaron Ilan. Gastroenterology and Liver Units, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Review Am J Physiol Gastrointest Liver Physiol 310: G1102 G1117, 2016. First published May 12, 2016; doi:10.1152/ajpgi.00095.2016. Compounds of the sphingomyelin-ceramide-glycosphingolipid pathways as
More informationSphingolipids. Sphingolipids are an additional type of membrane lipids, after glycerophospholipids, galactolipids and sulfolipids
Lipids 2 Steven E. Massey, Ph.D. Assistant Professor of Bioinformatics Department of Biology and Environmental Sciences University of Puerto Rico Río Piedras Office & Lab: Bioinformatics Lab NCN#343B Tel:
More informationAtrophy. Dystrophy. II. practical training 2 rd year Dentistry. Lucie Tučková
Atrophy. Dystrophy. II. practical training 2 rd year Dentistry Lucie Tučková Atrophy Decrease in size of the cell or organ Reduction in cell size and/or cell number, or both Atrophic cells may have diminished
More informationDementia and Healthy Ageing : is the pathology any different?
Dementia and Healthy Ageing : is the pathology any different? Professor David Mann, Professor of Neuropathology, University of Manchester, Hope Hospital, Salford DEMENTIA Loss of connectivity within association
More informationMol Bio Biochem 694:407 &115: 511 Second Hourly, Deis
Mol Bio Biochem 694:407 &115: 511 Second Hourly, Deis Tuesday, Oct. 31, 2006 Name Row Letter Seat Number This exam consists of two parts. Part I is multiple choice. Each of these 25 questions is worth
More informationPropagation of the Signal
OpenStax-CNX module: m44452 1 Propagation of the Signal OpenStax College This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of this section,
More information