C.albicans, Penicillium species and N.Niger. Antilesihmanial activity against L-donovani was also observed. 21

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1 EVIEW F LITETUE -(5-chlro-6-substituted-benzothiazol-2-yl)- -(substituted Phenyl)-[1, 3, 4] thiadiazole- 2, 5 Diamines were designed and synthesized by iddiqui. et al from substituted acetophenone. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug pheytoin sodium. All the compounds showed protections against seizures in the range % indicative of the promising nature of the compounds against seizure spread. Two compounds showed complete protection against induced seizures. 17 A novel one pot formulation of 3-(2 -hydroxy phenyl)-5-(substituted 2-purazolines) were carried out by Bibral Bajia & group using microwave irradiation with formic acid solvent free reaction afforded title compounds in 80-90% yield with high purity. ynthesized compounds were tested for their antibacterial activity using standard drug and found that four compound showed good activity against E-coli & all the compounds were inactive against gram positive.aureus &.albus. 18 Asif Hussain & coworkers synthesized a series of 1-(4-phenoxy phenyl)-3-[5-(substituted aryl)- 1, 3, 4-oxidiazol-2-yl] propane -1-one by the reaction of 3-(4-phenoxybenzoyl) propionic acid with several aryl acid hydrazides in phosphorous oxychloride. These compounds were tested for their anti-inflammatory, analgesic, minimum ulcerogenic and lipid peroxidation action. A few compounds were found to have very good anti inflammatory activity while a fair number of the compounds showed significant analgesic activity. These compounds showed very low ulcerogenic action with reduced malondialdehyde content, which is one of the byproduct of lipid peroxidation. 19 Ali M. A. et al prepared a series of -nicotinoyl-3-(4 -hydroxy-3 -methylphenyl) -5-(substituted phenyl)-2-pyrazolines by the reaction of chalcones and isoniazide. They were tested for their in vitro anti-hiv activity. Among them only one compound showed a promising anti-hiv activity in vitro against use strain (III B, D) with IC 50 of both III B 5.7 µm and D 7.0 µm [(2-arylamino-1,3,4-thiazolo)-3 -nitrophenyl]-2 -(arylsubstituted)-3 -amido-4 -thizolidinones were synthesized by Pramilla ah & co-workers. These compounds showed inhibition against the bacterial strain.aureus, E.coli, Klebsiella species, P.aeuroguisa and antifungal against

2 C.albicans, Penicillium species and.iger. Antilesihmanial activity against L-donovani was also observed. 21 Xihua Liu et al prepared eleven novel 5-methyl-2-[(un)substituted phenyl]-4-{4,5-dihydro- 3[(un)substitutedphenyl]-5-(1,2,3,4-tetrahydroisoquinoline-2-yl)pyrazol-1-yl}-oxazole derivatives. All the compounds were screened for their antiproliferative activity against PC-3 cell and A431 cell lines in vitro. The results revealed that three compounds exhibited strong inhibitory action against the PC-3 cell lines. 22 Hussain. et al synthesized 4-amino-5-pyridin-4-yl-4H-1,2,4-trizole-3-thiol by treating isonicotinic acid hydrazide successively with alcoholic KH, C 2, and hydrazine hydrate. These triazole derivatives were employed in the synthesis of 4-[substituted phenyl methylidene amino]- 5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol and -[substituted phenyl]-3pyridin-4- yl[1,2,4]triazole[3,4-b] [1,3,4] thiadizol-6-amine. ome of them were found to be potential antimicrobial agents. 23 E ajanardar 24, A iva ami eddy et al. Trimolecular condensation of -(3,5- dimethyl-4- isoxazolyl)- -arylthoureas 2 obtained from 1 by reaction with arylisothiocyanates,with aqueous formaldehyde and primary amines in toluene under reflux leads to 5-alkyl -1-(3,5- dimethyl-4-isoxazolyl)-3 aryl-hexahydro-1,3,5-triazinane-2-thiones 3 in excellent yields. Condensation of 2 with aqueous formaldehyde under similar condition provides isoxazolyl 1, 3, 5 oxadiazinane-4-thiones. 24 V K Pandey, Tusi et al 25. A series of quinolino isoquinolines 6 have been synthesized involving six synthetic steps and bioevauated for their possible antimicrobial activity againstk.pneumoniae.e.coli,p.aeruginosa,.aureus,c.albicans,c.neoformans,.schenkii,t.menta grophyte, A.flavus and C.paraplosis.

3 Ar H 3 C Ar CH3 (1) (2) 2,4a =Ar=C 6 H 5 2,4b=Ar= C 6 -Br(p) 2,4c=Ar= C 6 - (p) 2,4d=Ar=C 6 - (p) 2,4e=Ar= C 6 -Cl(p) 3a=Ar= C 6 H 5,= 3b=Ar= C 6 -Br(p),= 3c=Ar= C 6 - (p),=ch 2 3d=Ar= C 6 - (p),=ch 2 3e=Ar= C 6 -Cl(p),=CH 2 Bahar Ahmed & Md.Yusuf 26 et al.benzyl and chlorobenzyl substituted 1,3,4-thiadiazole imine derivatives have been prepared by refluxing aromatic aldehyde imine derivatives and benzyl chloride /4- chlro benzyl chloride in ethanolic potassium hydroxide. The structures of the compounds have been determined by spectral and chemical methods. The anticonvulsant activity has been carried out using Karl Method. All the reported compounds show good anticonvulsant activity where in chlorobenzyl substituted compounds show potent anticonvulsant activity against phenytoin used as the standard reference drug. eurotoxicity has been screened through the ota rod and ethanol potentiation test. The compound did not show any neurotoxicity. (4 ) (5) Cl Anjali idhu,j harma et al 27 Condensation of malononitrile with 1-[4-(benzylideneamino)- phenyl]1-10,the compounds containing both carbon nitrogen and carbon-oxygen double bonds in equimolar ratio results in the formation of solid products, identified as 2-benzylidene

4 malononitrile and its derivatives1a-10a on basis of elemental analysis and spectral studies. The reaction of 1-10 with two moles of malononitrile also yields the same products 1a-10a by a chemo selective attack of of malononitrile on carbon nitrogen double bond only rather than on both reactive centres. The synthesized compounds 1a-10a have been evaluated for antifungal potential against Alternaria alternate, Colletotrichum capsici,fusarium, xysporum, Myrothecium roridum and Ustilago tritici. ome of the compounds have been found to possess promising antifungal potential against the test fungi. K Mogilaiah,K hiva Kumar et al 28 Potassium triiodide catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 in aqueous media to afford 1,8-nephthyridines 3 in high yields. 2 1 (6) T F Abbs Fen ej, L Manju et al 29 3-[2, 4-Bis (arylamino) thiazol-5-oyl] indoles,as the analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized from 1-(, -diarylamidino)-3- arylthioureas which provide the four [1-C2-3-C4]ring atoms for the thiazole ring construction. The remaining carbon of the thiazole is sourced from 3-(2-bromoacetyl) indole. This [4+1] hetreocyclizatoon recation provide novel 3-[2, 4-bis (arylamino) thiazole-5-oyl] indoles, which are characterized by elemental analysis I, M and FAB Mass spectral data and showed moderate antibacterial activity.

5 Me 2 H (7) Ar (8) Palle V Acharyulu,P K Dubey et al. 30 eaction of 2-(chloromethyl)-3-aryl-quinazolin -4(3H)- one 3 with -BC piperazine 4 in acetonitrile using K 2 C 3 and KI, followed by deprotection of BC group in IPA HCL, gives 3-aryl-2-( piperazin-1-yl ) quinazolin -4 (3H)-one 6.The latter on treatment with benzene /methane sulfonyl chloride in DCM in the presence of TEA at T,results in the formation of 2-(4-benzene/methane sulfonylpiperazin -1-yl-mathyl)-3-arylquinazolin -4(3H)-one 7.Alternatively 7 can also be prepared from the recation of 4-benzene /methane sulfonyl-piperazine 9 with 3,in the presence of K 2 C 3 and KI. Ashok K Yadav, Manoj Kumar et al 31 A novel one pot ecofriendly synthesis of 7- substituted/7,8-disubstituted-2,2,4-tri-substituted-1-(2,3,5 -tri-o-benzoyl-β-d ribofuranosyl)- 2,3 dihydro-1,5 benzodiazepines have been accomplished stepwise,.reacting 0- phenylenediamine and ketone in the first step followed by addition of β-d ribofuranose -1- bromo-2,3,5-tribenzoate. The ionic liquids employed are 1,3-di-n-butylimidazolium bromide [BBIM],i-butyl-3-methtlimidazolium bromide [BBIM]Br,1-butyl-3-methyl imidazolium tetrafluoroborate [BBIM]BF 4, 1-butyl-3-methyl imidazolium hexafluorophosphate[bbim] PF 6

6 and 1-methoxyethyl-3-methylimidazolium mesylate[memim]ms. The yields (72-90%) of the targeted compounds are excellent.