Day 1 Wed April Epidemiology and extent of problem 2. Biopsychosocial model 3. ROME IV - overview of subtypes

Transcription

1 The London Neurogastroenterology Course Programme Barts and the London School of Medicine and Dentistry Queen Mary University of London April Day 1 Wed April am Intro 1. Epidemiology and extent of problem 2. Biopsychosocial model 3. ROME IV - overview of subtypes Prof Q Aziz Prof Q Aziz Prof D Dumitrascu 9:30-10:15 10:15-11:00 Problem based scenarios 1.Heartburn and belching disorders 2. Dysphagia Prof D Sifrim Dr P Woodland 11-11:30 Coffee break 11:30-12:00 12:00-12:30 12:30-1: Lunch Problem based scenarios (contd) 4. Functional Dyspepsia 5.Vomiting disorders 6.Sphincter of Oddi Syndrome 2-4 GI physiology investigations and their interpretation Rotating groups around multiple workstations Delegates to see equipment, to understand how test is performed and analysed and to work through some examples 30 mins each station a) HRM b) Reflux testing c) Small bowel manometry and breath tests d) Lower GI physiology 4-4:30 Coffee break Prof J Tack Dr M Corsetti Dr C Ainley 4:30-4:50 4:50-5:15 Special Conditions a) Ehlers-Danlos Syndrome b) Narcotic bowel syndrome 5: Keynote Lecture: Neuromodulators for functional GI disorders: from mechanisms to efficacy Dr A Fikree Dr A Farmer Prof L Van Oudenhove 6-7 Drinks reception at Wingate

2 Day 2 Thurs April :30 9: :30 10:30-11 Problem based scenarios a. Pain b. Bloating c. Diarrhoea d. Constipation 11-11:30 Coffee break Dr D Keszthelyi Dr N Zarate-Lopez Prof R Spiller Miss Emma Carrington 11:30-12 Hot topics: State of the Art Lecture: Microbiota and FGIDs Prof J Cryan 12-12:30 12: Lunch a. Enteroendocrine cells b. Diet and functional bowel disorders Dr M Peiris Prof K Whelan 2-3 Communication skills stations - Delegates will be offered tips and tricks on how to communicate neurogastroenterology concepts (eg visceral hypersensitivity, brain-gut axis, dysmotility) and will have an opportunity to practice with actors/patients: 3-3:30 Key note lecture Role of surgery in digestive motility disorders Prof C Knowles 3:30-4 Patient journey 4-4:30 Coffee break 4:30-5:30 Difficult cases: Real cases which have been submitted by the delegates will be addressed by a multidisciplinary panel 5:30 Close

3 Registration costs: Consultants and general practitioners For 2 days: 200 ( 170 early bird before 1 February 2019) For single day: 125 (Early Bird 100 before 1 Feb 2019) Trainees and allied health care professionals (will need proof of status) For 2 days: 80 ( 60 early bird before 1 Feb 2019) For single day: 40 Speakers Dr Colin Ainley He qualified at Cambridge University and trained in Gastroenterology at St Thomas s, the Middlesex Hospital and University College Hospitals. He has been a Consultant in General Medicine and Gastroenterology at Barts and the London Hospitals since His areas of interest are neurogastroenterology, inflammatory bowel disease and pancreatico-biliary disease. He has extensive experience in Endoscopy including diagnostic and therapeutic upper gastrointestinal endoscopy and colonoscopy, and also ERCP (endoscopic retrograde cholangiopancreatography). Prof Qazim Aziz After completing his undergraduate medical training in his native Pakistan he came to the UK in 1988 and completed his medical training in Manchester. He started his research career at the University of Manchester in Digestive Disorders and obtained his PhD in He is now Professor of Neurogastroenterology and Director of The Wingate Institute of Neurogastroenterology at Barts and The London School of Medicine and Dentistry at Queen Mary, University of London. He has obtained national and international awards for his research - the two most important being the British Society of Gastroenterology Research Gold Medal and the American Gastroenterology Association, Janssen Award for Basic and Clinical Research. Miss Emma Carrington She graduated from Imperial College in She became interested in academic surgery early in her career giving her first international presentation as a pre-registration house officer. She undertook a MSc in Surgical Technology also at Imperial College whilst training as a senior house officer and was appointed as an Academic Clinical Fellow in surgery shortly after. She joined the Neurogastroenterology group at Queen Mary University of London after gaining a Royal College of Surgeons one year research fellowship in 2009 and was awarded the Stefan Galeski Fellowship in Emma is now a general surgical registrar in the London deanery and is studying towards a PhD in surgery.

4 Dr Maura Corsetti She obtained her Specialization (2000) and PhD (2004) at the "Universita' degli Studi di Milano", Italy. During her PhD she worked for two years ( ) as a research fellow in the Gastrointestinal Motility and Sensitivity Research Group of the Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Belgium, acquiring the expertise in the study of gastrointestinal motility and sensitivity in functional bowel disorders. For eight years ( ), she was the clinical and scientific referral consultant for functional gastrointestinal disorders at the San Raffaele University Hospital, Milan, Italy. Then she moved to TARGID, University of Leuven, Belgium where she worked for four years ( ) as Senior Research Supervisor responsible for the development of the colonic high-resolution manometry. She is now a Clinical Associate Professor in Gastroenterology at the University of Nottingham where her research focuses on the role of altered motility in the pathophysiology of symptoms of functional disorders of the lower GI tract. Prof John Cryan He received a B.Sc. (Hons) and PhD from the National University of Ireland, Galway, Ireland. He was a visiting fellow at the Dept Psychiatry, University of Melbourne, Australia ( ), which was followed by postdoctoral fellowships at the University of Pennsylvania, Philadelphia, USA and The Scripps Research Institute, La Jolla, California. He spent four years at the Novartis Institutes for BioMedical Research in Basel Switzerland, as a LabHead, Behavioural Pharmacology prior to joining UCC in 2005 where he was a Senior Lecturer in Pharmacology in the School of Pharmacy and in the Dept. Pharmacology & Therapeutics UCC. He is now Professor & Chair, Dept. of Anatomy & Neuroscience, University College Cork. He received the inaugural University College Cork Researcher of the Year Award in 2012 and has also been honoured with the European College of Neuropsychopharmacology (ECNP) Fellowship Award, the Wyeth Psychopharmacology Award from British Association of Psychopharmacology and the Young Scientist Award from the European Behavioural Pharmacology Society. He has received commercialisation awards from UCC in 2012 and Further, in 2013 he received the University of Utrecht Award for Excellence in Pharmaceutical Research Prof Dan Dumitrascu He graduated from the medical school in Cluj, Romania in He worked as Research Associate in Cluj and Bucharest before starting a university career after the political changes in his country 20 years ago. Currently, he is Professor of Medicine at the University of Medicine and Pharmacy, Iuliu Hatieganu, Cluj, Romania, and Head, 2nd Medical Department. He is also Consultant of Gastroenterology and Internal Medicine at the County Emergency Hospital, where he also leads the laboratory for functional GI investigations. He has been interested in gastroenterological motility and functional disorders for over 20 years. He was recipient of a Young Clinician Award by the World Congress of Gastroenterology (WCOG) in Los Angeles in 1994, a travel award of the Functional Brain-Gut Research Group (FBG) in San Diego 2000 and of the American Psychosomatic Society (APS) in Orlando 2003 as well as a research award of the International Foundation for Functional Gastrointestinal Disorders (IFFGD) in Milwaukee 2003.

5 Dr Adam Farmer Dr Adam Farmer was educated at Stonyhurst College in Lancashire and undertook his medical training at University College London, qualifying with the degrees of MB BS BSc (Hons) in He became a member of the Royal College of Physicians in Subsequently, he undertook his specialist training in gastroenterology and general medicine in the West Midlands before moving to the Wingate Institute of Neurogastroenterology, Barts and the Royal London School of Medicine, where he undertook a body of research funded by the Medical Research Council. He currently works as a Consultant Gastroenterologist at the University Hospitals of North Midlands where he is clinical lead for gastroenterology. He also has academic positions at the Wingate Institute of Neurogastroenterology, Keele University and Aalborg University in Denmark. He is considered to be an international expert in his field having been awarded prestigious prizes from the American Society of Neurogastroenterology and Motility and the United European Gastroenterology Federation. With Professor Aziz, he was the first to comprehensively described the association between EDS and gastrointestinal symptoms. Dr Asma Fikree She trained in Cambridge and Oxford Universities and graduated with a BMBCh in Following completion of basic medical training in Bristol and London, she gained Membership of the Royal College of Physicians of the United Kingdom in That same year, she was appointed to the Higher Specialist Training Programme in Gastroenterology and General Internal Medicine in London. In 2009 she was appointed as a clinical research fellow working with Professor Aziz at Barts and the London School of Medicine and Dentistry, Queen Mary University of London where she undertook a considerable body of research which systematically confirmed the association between EDS and functional gastrointestinal disorders. After she was awarded her PhD in 2013 she was appointed as a Clinical Lecturer in Gastroenterology at Barts and the London and continued to be actively involved in research on EDS. She completed her gastroenterology training and entered the Specialist Register in She currently works as a Gastroenterology Consultant at the Royal London Hospital in London, subspecialising in Neurogastroenterology. Dr Daniel Keszthelyi Dr Keszthelyi is a consultant gastroenterologist at Maastricht, UMC, Netherlands. He completed his PhD in 2012 at Maastricht University. His research interests focus on understanding visceral hypersensitivity in IBS including the role of the brain-gut axis, serotonin, ion channels and diet. Prof Charles Knowles He qualified from the University of Cambridge and undertook general surgical training and a PhD in London before being awarded a HEFCE clinical senior lectureship ( ). He is Professor of Surgery at Queen Mary University of London and Consultant Colorectal surgeon at Barts Health NHS Trust. In addition he is Deputy Director of the Blizard Institute within Barts School of Medicine and Dentistry and Honorary Professor of Experimental Therapeutics at UCL. He is also Director of the National Bowel Research Centre. His main clinical interests are the surgical management of benign coloproctological and pelvic floor conditions. His main research interests are (1) the evaluation of new technologies for the treatment of chronic GI diseases (especially neuromodulation and cell therapies); (2) the development of GI diagnostics for deeper phenotyping and treatment stratification; (3) the pathogenesis and management of gastrointestinal

6 neuromuscular diseases and (4) development of new trial methodology for evaluation of complex interventions (including surgery). Dr Madusha Peiris She completed her BSc (Hons) at the University of Queensland, Australia in 2002, majoring in Biomedical Science and Genetics. Her honours thesis, Investigation of RNA interference as a molecular tool for identification of P.falciparum gene function. was carried out at the Queensland Institute of Medical Research and majored in Parasitology and Molecular Biology. In 2004, she began reading for her PhD entitled Functional Roles of Peroxisome Proliferator-Activated Receptor β/δ in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis at the School of Pharmacy, University of Queensland. Following completion of her PhD in 2008, Madusha joined the Wingate Institute of Neurogastroenterology in the same year where she studies cellular mechanisms driving enteroendocrine cell functions driving appetite, the influence of the microbiome on these mechanisms and the molecular pathways involved in visceral pain. Prof Daniel Sifrim He is a Gastroenterologist, trained in Argentina and Belgium, with both clinical and scientific interest in oesophageal benign disorders. He contributed to the development of diagnostic techniques for oesophageal motility disorders and gastro-oesophageal reflux disease (high resolution manometry, oesophageal impedance and salivary pepsin measurements). He is Professor of Gastrointestinal Physiology at Barts and the London School of Medicine and Dentistry, Queen Mary University of London. His research focuses on pathophysiology of GORD, including gastric motility, transient lower oesophageal sphincter relaxations, types of refluxate measured with impedance-phmetry and more recently, oesophageal mucosal permeability and its role in hypersensitivity. Prof Robin Spiller He was educated at Cambridge University and University College Hospital London. He is Professor of Gastroenterology in the NIHR Nottingham Biomedical Research Centre at the University of Nottingham. His main research interest is the pathophysiology of irritable bowel syndrome (IBS), particularly the role of infection, inflammation, diet and alterations in the microbiome as well as a long standing collaboration with the Sir Peter Mansfield Imaging Centre pioneering the use of MRI to image the underlying mechanisms in functional bowel diseases. Current work includes an EME funded multicentre trial of ondansetron in IBS with diarrhoea, a MRC funded study of colonic motility using MRI and High resolution manometry and a Newton grant examining the effect of fibre of intestinal physiology in IBS. Prof Jan Tack He graduated summa cum laude in 1987 from the University of Leuven and specialized in internal medicine and gastroenterology at the same institution. A research fellow at the Department of Physiology at the Ohio State University, Columbus, Ohio, USA from 1989 to 1990, he has been conducting research at Leuven University since Professor Tack s scientific interest focuses

7 on neurogastroenterology and motility, and includes diverse topics such as the pathophysiology and management of gastrointestinal functional and motor disorders (including GERD, globus, dysphagia, FD, gastroparesis, dumping syndrome, chronic constipation, IBS and opioid-induced bowel dysfunction), the physiology and pharmacology of the enteric nervous system, GI hormones and the control of satiation and food intake. He is currently a Head of Clinic in the Department of Gastroenterology, a Professor in Internal Medicine and head of the Department of Clinical and Experimental medicine at the University of Leuven, and a principal researcher in TARGID (the Translational Research Center for Gastrointestinal Disorders) at the University of Leuven.He has won several awards for Basic and Clinical Research in GI Science. Prof Lucas Van Oudenhove He graduated as a Medical Doctor at the KU Leuven, Belgium, in During his specialist training in psychiatry at the Onze-Lieve-Vrouw Hospital Aalst and at the University Hospitals Leuven, he was granted a PhD-fellowship of the Research Foundation Flanders. This allowed him to perform doctoral research from October 2004 until the end of his psychiatry training in September From 2009 until 2012, he worked as a postdoctoral fellow of the Research Foundation Flanders at the Translational Research Center for Gastrointestinal Diseases (TARGID) of the KU Leuven. In October 2012, he was appointed assistant research professor funded by the KU Leuven Special Research Fund, which allowed him to establish his own group within TARGID, the Laboratory for Brain-Gut Axis Studies (LaBGAS). The highly collaborative research lines of his group cover various aspects of gut-brain interactions, including psychobiological mechanisms underlying gastrointestinal symptom perception as well as the control of appetite and food intake in health and disease and, most recently, the influence of (subliminal) gut-brain signals on psychological processes and their neural basis. He also won several international research awards: a Young Scholar Award and MacLean Scholar Award from the American Psychosomatic Society in 2006 & 2010, respectively, a Young Investigator Award from the Functional Brain-Gut Research Group in 2008 and a Fellow Abstract Prize from the American Gastroenterological Association in In 2012, he was chosen as Rising Star by United European Gastroenterology and in 2013, he won the Junior Clinical Researcher Award of the International Foundation for Functional Gastrointestinal Disorders. Prof Kevin Whelan Following a BSc in Biochemistry, he completed an MSc in Nutrition and Dietetics (awarded with Distinction) and worked as a clinical dietitian specialising in the management of patients with gastrointestinal disease requiring nutritional support. This was followed by completion of a PhD at King s College London investigating prebiotics and the gut microbiome. He is now the Professor of Dietetics and Head of Department of Nutritional Sciences at King s College London, United Kingdom. He has undertaken extensive research on probiotics, prebiotics, fibre and dietary interventions in gastrointestinal health and disease, funded through national agencies such as the Medical Research Council and National Institute of Health Research and charities such as Crohn s and Colitis UK and the Kenneth Rainin Foundation. He has twice received the College Teaching Excellence Award and in 2007 was awarded a College Teaching Fellowship. In 2012 he was awarded the Nutrition Society Sir David Cuthbertson Medal in recognition of research that has advanced clinical nutrition and impacted on patient care, and in 2017 was appointed a Fellow of the British Dietetic Association.

8 Dr Philip Woodland Dr Woodland trained at University College London Medical School and was awarded a PhD in 2010 for his research into gastro-oesophageal reflux disease. He is a Consultant Gastroenterologist and Honorary Senior Lecturer at the Royal London Hospital. He serves on the British Society of Gastroenterology Neurogastroenterology Committee, is a member of the editorial board for the Neurogastroenterology & Motility Journal, and peer reviews research proposals for the Bowel and Cancer Research Grants committee and the National Institute of Health Research. Dr Natalia Zarate-Lopez She specialized in gastroenterology in Spain. After completing a post-cct fellowship in Neurogastroenterology at Hospital Vall d Hebron, Barcelona, she obtained a fellowship at MacMaster University, Canada at the Intestinal Disease Research Programme where she studied the role of interstitial cells of Cajal in human motor disorders. She achieved her PhD in 2008 with a project integrating basic science and clinical research leading to ground-breaking investigation of the pacemakers of the gut. After moving to London, she obtained further training and expertise in lower GI physiology and pelvic floor disorders at the Centre for Academic Surgery at The Royal London Hospital. In 2018, she was appointed a Consultant Gastroenterologist in GI physiology at UCLH and is one of the clinical leads of the GI Physiology Unit. Her clinical activity is turned to gut functional, motility and pelvic floor disorders. In addition, she is a member of the gastroenterology adolescent service, focusing on the management of adolescent and young adults with functional and motility disorders transitioned from GOSH. She is actively involved in clinical research including developing novel techniques for the investigation of gut sensorimotor disorders and is passionate about promoting a better training in the Neurogastroenterology subspeciality among gastro trainees. Supported By:

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