Functional Dyspepsia. Norbert Welkovics Heine van der Walt

Transcription

1 Norbert Welkovics Heine van der Walt

2 Characteristics: Central abdomen Pain or discomfort Not associated with bowel movements No structural or biochemical abnormalty Definition Part of Gastroduodenal disorders (Rome II)

3 Fx Gastro-intstinal disorders A. Esophagial disorders E. Billiary disorders Rome II (1999) A1. Globus E1. Gallbladder dysfunction A2. Rumination Syndrome E2. Sphincter of Odi dysfunction A3. Functional chest pain of presumed oesophageal origin A4. Functional heartburn A5. Functional dysphagia A6. Unspecified oesophageal disorder B. Gastroduodenal disorders F. Anorectal disorders B1. Functional dyspepsia F1. Functional faecal incontinence B1a. Ulcer like dyspepsia F2. Functional anorectal pain B1b. Dysmotility like dyspepsia F2a. Levator ani syndrome B1c. Non-specific dyspepsia F2b. Proctalgia fugax B2. Aerophagia B3. Functional vomiting C. Bowel disorders C1. Irritable bowel syndrome C2. Functional abdominal bloating C3. Functional constipation C4. Functional diarrhoea C5. Unspecified functional bowel disorder D. Functional abdominal pain D1. Functional abdominal pain syndrome D2. Unspecified functional abdominal pain

4 Organic dyspepsia Classification PUD, GERD, Pancreatico-billiry disease Functional dyspepsia Ulcer-like dyspepsiea Pain Dysmotility-like dyspepsia Discomort; nausea, vomiting, postprandial fullness and upper abdominal bloating Reflux-like dyspepsia Heartburn but not the predominant symptom

5 Epidemiology Common complaint (15 25%) On upper GIT endoscopy: Peptic ulcer disease 22% Esophagitis 10% Cancer 1% Functional dyspepsia 67% Comparable to asymptomatics

6 Aetiology Cause and effect difficult to establish 1. Symptoms experienced are intermittent and changing 2. High placebo response rate (30%) 3. No specific findings in all patients present 4. Findings present in asymptomatic patients as well 5. Symptoms and findings often do not correlate 6. There is no universal effective treatment 7. The response to treatment is difficult to predict

7 Aetiology Postulates Ulcer-like like Dyspepsia Dysmotility-like like Dyspepsia Helicobacter pylori Gastritis / Duodenitis Missed PUD Acid sensitivity Occult GERD Gastroparesis Abnormal relaxation Visceral hypersensitivity Brain-gut disorder Psychological disorder

8 Aetiology Helicobacter pylori Controversial: Background infection rates increase with age H.pylori gastritis equal in asymptomatics Possible CagA+ strain For treatment WHO declared HP carcinogen Response to treatment 20% at 1 year

9 Aetiology Helicobacter pylori Against treatment Response to PPI not to antibiotics Low background infection rate in 1 st world countries MAASTRICHT CONSENSUS Test and treat approach in uninvestigated dyspepsia in patients younger than 45 in the absence of: 1. Alarm symptoms 2. NSAID use 3. Predominant reflux symptoms 4. Family history of gastric carcinoma

10 Aetiology Gastritis NSAID gastropathy and functional dyspepsia can occur simultaniously Stop NSAID If symptoms don t improve, treat as functional dyspepsia

11 Aetiology Duodenitis Presence of past PUD diagnosis Manage as PUD even if endoscopy normal Missed PUD? Absence of past history Treat as functional dyspepsia

12 Aetiology Acid sensitivity Normal acid secretion Acid sensitivity increased 20% incidence in functional dyspepsia Decreased acid clearance by duodenum? H 2 treatment response 20% above placebo rate

13 Aetiology Occult GERD Reflux s a normal phenominon High positive predictive value If dominant symptom = GERD Might form part of functional dyspepsia