SIBO, LEAKY GUT & MOLD ILLNESS
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1 MSH VIP TGFb SIBO, LEAKY GUT & MOLD ILLNESS DR. SANDEEP GUPTA DR. FARSHID SAM RAHBAR
2 GET THE MOST OUT OF THIS WEBINAR Please close/minimize other browsers and browser tabs and have pen and paper ready This webinar is for general information only and not intended to diagnose, treat or cure any medical condition
3 DR. SANDEEP GUPTA Medical degree from The University of Queensland (1999) Hospital Intensive care for 5 years Private holistic practice for 10 years on Sunshine Coast, Lotus Holistic Medicine, and Sydney (3-4 times per year) Skype consults worldwide 1st non-us doctor to become certified in Shoemaker Protocol (2014) Author of Surviving Mould Down Under paper (2014) Co-author of Physicians Consensus Statement with Dr. Ackerley, Dr. Berndtson, Dr. Rapaport, Dr. McMahon and Dr. Shoemaker (2015) Website:
4 DR. FARSHID SAM RAHBAR Board certified gastroenterologist practicing in Los Angeles, CA, USA Attended University of Tehran (Iran) and completed residency at St. Mary s Hospital, Rochester, NY Fellowship Gastroenterology and nutrition, Loma Linda University, CA Certified with: American Board of Internal Medicine, American Board of Gastroenterology, American Board of Integrative Holistic Medicine, A4M and more ILADS board member and educational committee member Website:
5 WHAT IS CIRS (CHRONIC INFL AMMATORY RESPONSE SYNDROME)? Biotoxin exposure Biotoxins & inflammagens from water-damaged building or Lyme/stealth infections Immune, gene, brain Defect in antigen presentation means toxins stay in body causing chronic inflammation that leads to gene dysregulation and brain changes CIRS Multi-system, multi-symptom illness develops even if removed from WDB or infection eradicated
6 WHAT IS SIBO & LEAKY GUT (LG)? Leaky Gut (intestinal permeability) Small Intestinal Bacterial Overgrowth (SIBO) Small Intestinal Fungal Overgrowth (SIFO) SIBO/SIFO Bacteria and/or fungi, that may be normally abundant in the large intestine flow into small intestine Intestinal barrier damage - mechanisms Damage to intestinal cells (enterocytes) Damage to tight junctions Intestinal cell drop out (Extrusion) 2010 Cyrex laboratories
7 SIBO & LG SYMPTOMS/CONDITIONS Risk Factors Food poisoning Reduced stomach acid / PPI Reduced motility Altered small bowel Alcoholism Celiac disease IBD H.pylori Nerve damage Drugs (e.g. opiates) Other Iron (anemia) B12 Weight loss Malnutrition IBS Bloating after meals Nausea/vomiting Chronic diarrhea can alternate Chronic constipation GERD / reflux Gluten intolerance Lactose intolerance Multiple food sensitivities Foul gas/wind Bile reflux Immune & Neurological Restless Leg Chronic fatigue Chronic pain Joint pain Rosacea
8 SIBO & LG TESTING SIBO Breath Testing Intestinal Permeability Ghoshal, U. (2011). How to interpret hydrogen breath tests Further Gut testing Giliadin/gluten antibodies (Cyrex) Food IgG panels Occludin/Zonulin, LPS Secretory IgA Parasites / Microbiota (dysbiosis) Organic Acids CIRS testing MSH, VIP TGF-β, C4a Leptin MMP9
9 SIBO & LG WHY SO COMMON IN CIRS? Low MSH, VIP - Key anti-inflammatory, immune modulatory and antimicrobial hormones in CIRS - Low levels allow inflammation and pathogens to increase in gut - Low levels (may) reduce gut motility High TGF-β, IL-6 and other cytokines - High TGF-β plus other cytokines (IL-6) shift gut towards inflammation (Th17 : Treg balance) - Microbiota may also increase TGF-β - If high enough autoimmunity starts to develop Pro-inflammatory State - Inflammation continues to fuel the fire of CIRS - Perpetuates & exacerbates SIBO, leaky gut - Multiple food sensitivities Bauche D., Marie, JC. (2017). Transforming growth factor β: a master Regulator of the gut microbiota and immune cell interactions
10 SIBO & LG NASAL INFECTION CONNECTION MARCoNS Bacteria e.g Multiple Antibiotic Resistant Coagulase Neg Staph (MARCoNS) drip down into gut Nasal Sprays Antibiotic nasal sprays may drip down into gut and alter gut microbiota Possible alternatives: EDTA/colloidal silver XyliFos/LoxaSperse (Xylitol)
11 SIBO TREATMENTS Pharmaceutical Hydrogen predominant Rifaximin Methane predominant Rifaximin plus neomycin or tinidazole SIFO Antifungals Natural Herbs Berberine Allicin (garlic) Oregano oil Olive leaf Other Monolaurin Bioflim disruptors Artemisian Protectagen (Cat s Claw)
12 LEAKY GUT TREATMENTS Pharmaceutical & Peptides Lubriprostone Natural - activates CIC-2 - pro-kinetic BPC 157 PentaDecaPeptide - Naturally occurring peptide - Heals intestinal lining and joints Enck et al (2016). Irritable Bowel Syndrome Herbs & Stomach Berberine Quercetin Plant based antioxidants Betaine HCL Digestive Enzymes Other Restore Glutamine Zinc Carnosine Amino Acids Vitamins/minerals (IV, liposomal, liquid) Omega 3s
13 SIBO & LG MORE TREATMENTS Lifestyle Pro-kinetic agents Other Treatments Diets Exercise Stress reduction (meditation) Adequate sleep Fun activities Reglan (metoclopramide) Motilum (domperidone) Ginger Other herbs Pre/Probiotics (cautiously with SIBO) Spore probiotics Turmeric / Curcumin Low Dose Naltrexone Ozone therapy Gluten/casein free Low FODMAP Elimination Paleo (AIP) / GAPS / Elemental
14 MOLD ILLNESS MADE SIMPLE ONLINE COURSE Weekly quizzes 18 Video lectures + slides Lifetime Website Access High quality workbook for each chapter Private Facebook group
15 For the next 48 hours use the coupon B E AT S I B O For 25% off $199 now only $ (USD) Via the link below (or in replay ). Instant access via PayPal
16 Questions and Answers
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