Yeu-Chun Kim, Ph.D. Thesis advisor : Dr. Mark R. Prausnitz (co-advisor : Dr. Peter J Ludovice)

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1 Yeu-Chun Kim, Ph.D. Assistant Professor Department of Chemical and Biomolecular Engineering, KAIST (Korea Advanced Institute of Science and Technology), 335 Gwahang-ro, Yuseong-gu, Daejeon , KOREA Tel : dohnanyi@kaist.ac.kr EDUCATION Ph.D., School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, USA, 2007 (Minor: Management) Thesis: Transdermal drug delivery enhanced by magainin Thesis advisor : Dr. Mark R. Prausnitz (co-advisor : Dr. Peter J Ludovice) M.S., Department of Chemical and Biomolecular Engineering, KAIST (Korea Advanced Institute of Science and Technology), KOREA, 2001 Thesis: Optimization of fermentation conditions for exopolysaccharide production in Aureobasidium pullulans Thesis advisor : Dr. Ji Won Yang (co-advisor : Dr. Joon-Ki Jung at KRIBB) B.S., Department of Chemical Engineering, Yonsei University, KOREA, 1999 EXPERIENCES Post-doctoral Research Fellow, ~ Georgia Institute of Technology, Department of Chemical and Biomolecular Engineering Visiting Scholar, ~ Emory University School of Medicine, Department of Microbiology and Immunology 1

2 Research Faculty, ~ Ewha Womans University, Division of Nano Sciences, Seoul, Korea Senior Research Engineer, ~ Biotechnology Process Engineering Center, KRIBB (Korea Research Institute of Bioscience and Biotechnology), Daejeon, Korea INVITED SPEAKINGS 1. Formulation of self-administered microneedle patches for influenza vaccines (2008) IBC Formulation strategies for Protein Therapeutics conference (Anaheim, CA, USA) 2. Microneedle patches for improved influenza vaccination (2009) Medical materials and technologies conference (Greenville, SC, USA) 3. DNA delivery using coated microneedle patch IPCC (International Pachyonychia Congenita Consortium) symposium (Montreal, CANADA) 4. Self-administratable influenza vaccination using coated microneedles (2009) Korea Research Institute for Bioscience & Biotechnology (KRIBB, Daejeon, KOREA) Seminar 5. Self-administratable influenza vaccination using coated microneedles (2009) Korea Advanced Institute of Science and Technology (KAIST, Daejeon, KOREA) Young Investigator Seminar 6. Delivery system design and formulation of microneedles (2010) Short Course, 1 st International Conference on Microneedles (Atlanta, GA, USA) 7. Transdermal delivery by microneedle (2010) Handok pharmaceuticals co.(seoul, KOREA) Invited Seminar 8. Self-administratable influenza vaccination using coated microneedles (2011) Polymer Society of Korea (Kwangju, KOREA) Society's Fall Meeting 9. Self-administered influenza vaccination using coated microneedles (2011) Korea Basic Science Institute (Deajeon, KOREA) Invited Seminar 10. Self-administered influenza vaccination using coated microneedles (2011) Chungnam National University, Department of Biochemistry (Deajeon, KOREA) Invited Seminar 11. Microneedle Patches for Improved Influenza Vaccination (2011) School of Medicine, Chungnam National University (Deajeon, KOREA) Invited Seminar 12. Microneedle Patches for Improved Influenza Vaccination (2011) Yonsei University, Department of Biotechnology (Seoul, KOREA) Invited Seminar 2

3 13. Microneedle Patches for Improved Influenza Vaccination (2011) Korean Society for Biomaterials (Seould, KOREA) Presentation in Young Scientists Forum of Biomaterial Research 14. Microneedle Patches for Improved Influenza Vaccination (2011) College of Veterinary Medicine, Konkuk University (Seoul, KOREA) Invited Seminar 15. Microneedle Patches for Improved Influenza Vaccination (2011) MOGAM Biotechnology Research Institute (Gyeonggi, KOREA) Invited Seminar 16. Microneedle Patches for Improved Influenza Vaccination (2011) Korea Institute of Science and Technology (KIST, Seoul, KOREA) Invited Seminar 17. Microneedle Patches for Improved Influenza Vaccination (2011) Department of Electronic Engineering, College of Electronics and Information Engineering, Kwangwoon University (Seoul, KOREA) Invited Seminar 18. Microneedle Patches for Improved Influenza Vaccination (2012) International Vaccine Institute (Seoul, KOREA) Invited Seminar 19. Microneedle Patches for Improved Influenza Vaccination (2012) Animal, Plant, Fisheries Quarantine and Inspection Agency Seminar (Anyang, Kyungki, KOREA) Invited Seminar 20. Microneedle Patches for Improved Influenza Vaccination (2012) College of Medicine, Yonsei University (Seoul, Korea) Invited Seminar 21. Microneedle Patches for Improved Influenza Vaccination (2012) College of BioNano, Gachon University (Sungnam, Kyungki, Korea) Invited Seminar 22. Microneedle Patches for Improved Vaccination (2012) Korea Institute of Chemical Engineers (KIChE) (Jeju, KOREA) Symposium for Young Scientists 23. Microneedle Patches for Improved Influenza Vaccination (2012) Department of Chemical and Biomolecular Engineering, Yonsei University (Seoul, Korea) Invited Seminar 24. Microneedle Patches for Improved Influenza Vaccination (2012) Department of Chemistry and Nano Science, Ewha Womans University (Seoul, Korea) Invited Seminar PUBLICATIONS 1. S.J.Kim, H.J.Shin, Y.C.Kim, D.S.Lee, J.W.Yang (2000) Isolation and purification of methyl mercaptan oxidase from Rhodococcus rhodochrous for mercaptan detection, Biotechnology and Bioprocess Engineering 5 : Y.C.Kim, P.Ludovice, M.Prausnitz (2007) Transdermal delivery enhanced by magainin poreforming peptide, Journal of Controlled Release 22 :

4 3. Y.C.Kim, J.H.Park, P.Ludovice, M.Prausnitz (2008) Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol, International Journal of Pharmaceutics 352 : Y.C.Kim, P.Ludovice, M.Prausnitz (2008) Optimization of transdermal delivery using magainin pore-forming peptide, Journal of Physics and Chemistry of Solids 69 : J.H.Park, J.W.Lee, Y.C.Kim, M.R.Prausnitz (2008) The effect of heat on skin permeability International Journal of Pharmaceutics 359 : Y.C.Kim, S.Late, A.Banga, P.Ludovice, M.Prausnitz (2008) Biochemical enhancement of transdermal delivery with magainin peptide: Modification of electrostatic interactions by changing ph, International Journal of Pharmaceutics 362 : F.S.Quan, Y.C.Kim*, D.G.Yoo, R.W.Compans, M.R.Prausnitz, S.M.Kang (2009) Stabilization of influenza vaccine enhances protection by microneedle delivery in the skin, Plos ONE 4 : e Y.C.Kim, F.S.Quan, D.G.Yoo, R.W.Compans, S.M.Kang, M.R.Prausnitz (2009) Improved influenza vaccination in the skin using vaccine coated-microneedles, Vaccine 27 : Y.C.Kim, F.S.Quan, D.G.Yoo, R.W.Compans, S.M.Kang, M.R.Prausnitz (2010) Enhanced memory responses to H1N1 influenza vaccinationin the skin using vaccine coatedmicroneedles, Journal of Infectious Disease 201 : Y.C.Kim, F.S.Quan, R.W.Compans, S.M.Kang, M.R.Prausnitz (2010) Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity, Journal of Controlled Release 142 : S.O.Choi, Y.C.Kim, J.H.Park, J.Hutcheson, H.S. Gill, Y.-K. Yoon, M.R. Prausnitz, and M.G. Allen (2010) An electrically active microneedle array for electroporation, Biomedical Microdevices 12 : Y.C. Kim, F.S.Quan, J.M.Song, A.Vunnava, D.G.Yoo, K.M. Park, R.W.Compans, S. M. Kang, M. R. Prausnitz (2010) Microscale-needles immunization with stabilized H1N1 influenza virus-like particle vaccine, Procedia in Vaccinology 2: F.S.Quan, Y.C.Kim*, A. Vunnava, D.G.Yoo, J.M.Song, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Intradermal vaccination with influenza VLPs using microneedles induces superior protection to intramuscular immunization, Journal of Virology 84 : M.Pearton, S.M.Kang, J.M.Song, Y.C.Kim, F.S.Quan, M.Ivory, R.W.Compans, M.R.Prausnitz, J.C.Birchall (2010) Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin, Vaccine 28 : J.M.Song, Y.C.Kim, A.S.Lipatov, M.Pearton, C.T.Davis, K.M.Park, L.M.Chen, F.S.Quan, J.Birchall, R.O.Donis, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Microneedle 4

5 delivery of virus-like particles to the skin induces long-lasting protective immunity against H5N1 influenza virus, Clinical and Vaccine Immunology 17 : Y.C.Kim, P.Ludovice, M.Prausnitz (2010) Transdermal delivery enhanced by antimicrobial peptides, Journal of Biomedical Nanotechnology, 6 : Y.C.Kim, F.S.Quan, R.W.Compans, S.M.Kang, M.R.Prausnitz (2010) Fomulation of microneedles coated withvirus-like particle influenza vaccine, AAPS PharmSciTech, 11 : F.S.Quan, Y.C.Kim*, R.W.Compans, M.R.Prausnitz, S.M.Kang (2010) Dose sparing microneedles vaccination with H1 influenza VLPs, Journal of Controlled Release, 147 : J.M.Song, Y.C.Kim, P.G.Barlow, M.J.Hossain, K.M.Park, R.O.Donis, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Improved protection against avian influenza H5N1 virus by a single vaccinationwith virus-like particles in skin using microneedles, Antiviral Research, 88 : Y.C.Kim, F.S.Quan, R.W.Compans, S.M.Kang, M.R.Prausnitz (2011) Long-term storage and stability kinetics of influenza vaccines using coated microneedle, Pharmaceutical Research, 28 : Y.C.Kim, M.R.Prausnitz (2011) Enabling skin vaccination using new delivery technologies, Drug Delivery and Translational Research, 1: Y.Hiraishi, S.Nandakumar, S.O.Choi, J.W.Lee, Y.C.Kim, J.E.Posey, S.B.Sable, M.R. Prausnitz (2011) Bacillus Calmette-Guérin (BCG) vaccination using a microneedle patch, Vaccine, 29 : E.G.González, Y.C.Kim, T.J.Speaker, R.P.Hickerson, R.Spitler, J.C.Birchall, M.F.Lara, R.Hu, Y.Liang, N.K.Smith, M.R.Prausnitz, C.H.Contag, L.M.Milstone, R.L.Kaspar (2011) Visualization of plasmid delivery to keratinocytes in mouse and human epidermis, Scientific Reports, 1: Y.C.Kim, D.Zehrung, J.Courtney, S.Mitragotri, M.R.Prausnitz (2012) Delivery systems for intradermal vaccination, Current Topics in Microbiology and Immunology, 351 : S.O.Choi, Y.C.Kim, J.W.Lee, J.H.Park, M.R.Prausnitz, M.G.Allen (2012) Intracellular protein delivery and gene transfection by electroporation using a microneedle electrode array, Small, 8 : S.M.Kang, J.M.Song, Y.C.Kim (2012) Microneedle and mucosal delivery of influenza vaccines, Expert Review of Vaccines, in press. 27. Y.C.Kim, J.H.Park, M.R.Prausnitz (2012) Microneedles for drug and vaccine delivery, Advanced Drug Delivery Review, in press. 5

6 28. Y.C.Kim, J.M.Song, A.S.Lipatov, S.O.Choi, J.W.Lee, R.O.Donis, R.W.Compans, S.M.Kang, M.R.Prausnitz (2012) Increased immunogenicity of avian influenza DNA vaccine delivered to the skin using a microneedle patch, European Journal of Pharmaceutics and Biopharmaceutics, in press. 29. J.M.Song, Y.C.Kim*, R.W.Compans, M.R.Prausnitz, S.M.Kang (2012) Influenza H1 DNA vaccine coating on microneedles and immune responses, Molecular Therapy, in press. * Equally contribution. Co-first author. Corresponding author. 6