The Machine Antibodies in Cells

Transcription

1 The Machine Antibodies in Cells Yi-nong Chen, version1, 2015 / 5 / 28 yilnong@qq.com Department of Physics, Xiamen University Background: The human life in the outside world confronted with lots of potentially harmful bacteria, viruses, and so on. If these viruses invade the body, but the cells in the human body cannot relative's reaction which will make people sick, even death. As early as 1796, United Kingdom doctor Jenner collected a little of cowpox virus as antigen injected into a boy's body to antagonizing the smallpox virus, and success. Later, scientists developed many virus vaccine injected into humans to fight with diseases which may be infected in the future. But it has a shelf life for some antibodies, which over time will be abated, or some antigens in humans has no effect and does not produce antibodies, others who was born or infected with HIV and the immune system does not work, could not be protected from viruses. The common way of antibody preparation is inject antigens in some other animals to get antibody, or to clone antibody. But these methods have been the antibodies may not completely effective. Theoretical foundation: With the development of electronic technology, the size of the high performance processing functions chip in constant narrowing. Each of these variants can bind to a different antigen. This enormous diversity of antibody paratopes on the antigen-binding fragments allows the immune system to recognize an equally wide variety of antigens. We developed a size of only a few tens of microns chip processor, and transplanted it into the cytoplasm. When a virus attacks cells, which have chip cell membranes exposed to signals, membranes evoked potentials and transmitted to the chip processor, the processor identified after a short time, release the corresponding electrical stimulation, these stimulate made cells division and differentiation, formation of immune cells, which destroy the virus. Because chip processing power is very strong, and can emit different kinds of stimulation, so it's not just aimed at one virus, Labs stored various viruses stimulation in the processor. So it can handle many different kinds of viruses, are no longer as in the past, and each required a different antibody. Experiments:

2 1. Controlled trials in petri dishes Select five contain the same nutrient Petri dishes, respectively named A, B, C, D, and E. A petri dish don't add anything; B petri dish add contain machine antibodies of the cells; C petri dishes to join cells containing the smallpox virus antibody; D join with hepatitis a virus antibody of the cells in a petri dish; E join contain cold virus antibody of the cells in a petri dish(table 1). Contains the tagged smallpox virus, hepatitis a virus (HAV), the cold virus mixture of the same amount of injected into five petri dishes. At set intervals,record each virus concentration in each petri dish (Figure 1). Table 1. Antibody Petri dish A B C D E Smallpox virus HAV Cold virus Note: represents perform this operation From Fig.1, we can see, the concentrations of the viruses are decrease in A petri dish (Fig.1A), because the viruses did not host cells then natural death. In B petri dish (Fig.1B), three kinds of viruses are reduced, and explain antibodies play a role in the machine, it can resist the three kinds of viruses. In C (Fig.1C), D (Fig.1D) and E (Fig.1E) petri dishes, each containing corresponding antibody virus has significantly reduced, but the rest of the two viruses did not reduce, so it can be seen that the ordinary antibody is not universal, only for single virus immune response. Fig.1 The concentration of virus in five Petri dishes. Different color represents different virus invasion

3 2. Mice s controlled trials Select 60 mice these have similar health and body shape, and divided them into five groups (A, B, C, D and E) averaged. Mice in group A were not injected any antibody; Mice in group B were injected machine antibodies; Group C s mice injected smallpox virus antibodies; Mice in group D were injected HAV antibodies; Mice in group E were injected clod antibodies. Then each group of mice were divided into four group, separately for no injection (a), injection method of smallpox virus (b), HAV (c) and cold virus (d). Observe the mice s characters at the same time, and record observations (Table 2). Table 2 Virus No virus (a) Smallpox virus HAV (c) Cold virus (d) Groups (b) Group A Group B Group C Group D Group E Comment If there are no illness symptoms in mice with, the corresponding illness symptoms with. We can be seen from Table 2, Group A as control group, those three mice were healthy which not injected any virus, but others mice which injected with the virus, there are different degree of symptoms. All the mice in group B are healthy, no disease. That s mean the machine antibodies to generate the corresponding effect in mice to kill the virus. Group C, D and E, after injection of the virus, have corresponding antibodies of mice with no illness symptoms, but illness symptoms were observed in all the mice without the corresponding antibody. Compared with group B and group C, D and E can get, machine antibodies can not only has the function of a virus, resistance to viruses have the same effect. 3. Mice with many viruses We can know from the experiment 2, when there is respectively different virus, machine antibody can effectively identify and immune cell to cell differentiation, eliminate the virus. But when multiple viruses exist at the same time, whether machine antibody can effectively work destroy all viruses? So we have the third experiment. Select 20 physical properties similar to that of healthy mice, divided into two groups. One group as control group, no antibody injection, another group of antibody of injection machine. Let the two groups of mice at the same time injected the smallpox virus, hepatitis a virus and the cold virus. Observed two groups of mice s

4 physiological traits, and recorded (Fig.2). As can be seen from the graph 3, all of the control group of mice appeared illness symptoms, and some mice appeared more than one symptoms; But other mice which injection machine antibodies, the vast majority of no illness symptoms, only a few appear condition, symptoms are not very serious. So we can come to the conclusion that machine antibodies in response to a variety of virus at the same time, still have a large effect. Fig.2 Two groups of mice injected the smallpox virus, hepatitis a virus and the cold virus. Two figure represent the number of all the physiological status of mice in each group (exist at the same time there are two kinds of disease mice) Discussion Since antibodies are applied, how to produce high quality and efficient antibody a subject of all countries in the developing, Scientists get antibody method there are two main types: 1. by cloning method; 2. Develop antibodies in animals bodies. But the yield and quality cannot be guaranteed by those ways. In order to solve this problem, we take the method of electronic chips which implanted in cells to produce antibodies. The developed degree of science and technology, can make a small chip with high computing power, we have known the surface characteristics of the virus stored in the chip, once a virus attacks cells them can stimulate the chip to distinguish of the virus, and then get a response, produce impulse current, the relative cells produce antibodies. Finally eliminate the virus. From three experiments we can see, the machine antibodies played a important role when against the virus, and the effectiveness is equal with of organism to produce the antibodies. But in the fight with a variety of virus invasion at the same time, the machine antibody effect compared with alone against the virus are not obvious, but still has great effect, and machine antibodies is a corresponding to a variety of virus, which is than single injection of each antibody, machine antibodies is convenient and efficient, another good place of machine antibody is it can be adaptive, which will not

5 be born in the body's other immune cells to attack, it provides a lot of thought to solve this some diseases. Conclusion When the virus invasion, machine antibodies may play a role to stimulate cell division and differentiation, and the virus is eliminated. But machine antibodies are still unstable, them not completely against the all of virus. So need to be done after the improvement, and then the machine antibodies play a better role. Acknowledgement Thanks for my Tech-English teacher Tien-Mo Shin giving me a deal of help, thanks for my classmates Yu-yang Chen and Si-Yu Chen to provide advice. Reference * *