Antigenic diversity and evolution of swine influenza viruses: an update! OFFLU swine influenza virus group, Rome 2013! Department of Zoology
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1 Antigenic diversity and evolution of swine influenza viruses: an update! OFFLU swine influenza virus group, Rome 2013! Department of Zoology
2 Initial OFFLU SIV antigenic cartography aim -> global antigenic map of H1 in swine Characterise the antigenic diversity and evolution of H1 viruses dataset = , viruses from USA, Canada, EU, Hong Kong, genetic evolution - global molecular basis for antigenic differences rates of antigenic evolution H1 and H3 Providing up to date global characterisation of antigenic diversity Examining relationship where relevant to human flu strains. 2
3 Within-host antigenic evolution: Where are we now? Swine influenza (H3N2) viruses North America
4
5 SI-87! BE-92! N145K! Be-89! WU-95! N145K, N156K, K189E! WU-95! SY-97! Y159H, H155Y, H158G, R189E! N145K, N156K! K189R! N145K Y159N! swine=ferret! NE/2012 dropped to Vacc 1,2,3
6 Genetic clade Antigenic Cluster AF268128_A/swine/Colorado/23619/ K H Q K Y S AY531035_A/Moscow/10/1999_(H3N2) K H Q K Y S CY039079_A/Sydney/5/1997_(H3N2)_ K H Q K Y S CY095675_A/swine/Texas/4199-2/19 K H K E Y S CY112821_A/Wuhan/359/1995(H3N2)_ K H K E Y S JX422575_A/swine/Nebraska/A01241 K H K N Y R JQ739697_A/swine/Iowa/A / K H K N Y E JX092535_A/swine/Indiana/A N Y H G H E JX422557_A/swine/Illinois/A01241 N H N N Y R JX092555_A/swine/Iowa/A / N H N N Y R JN652493_A/swine/Iowa/A / N H N N Y R JN652507_A/swine/Texas/A N H N N Y R CY099035_A/swine/Minnesota/01146 N H N N Y R CY099027_A/swine/Iowa/01700/2007 N H N D Y R A/swine/Illinois/02970/2009_C4-T N T N D Y R CY099103_A/swine/Minnesota/02782 N H S N Y R JX092307_A/swine/Iowa/A / N H N N Y K JX092542_A/swine/Iowa/A / N H N N Y K CY107066_A/swine/Illinois/A01201 N Y N N Y K JX657030_A/swine/Minnesota/A0130 N Y N N Y K JX657018_A/swine/Iowa/A / N Y N N Y K JX422521_A/swine/Minnesota/A0132 N Y N N Y K JF263535_A/swine/Pennsylvania/62 N Y N N Y K JX442056_A/swine/Michigan/A01259 N Y N N Y K JN638733_A/Indiana/08/2011_(H3N2 N Y N N Y K JX422497_A/swine/Illinois/A01241 N Y N N Y K JN940422_A/swine/New_York/A01104 N Y N N Y K JX534982_A/swine/Indiana/A N Y N N Y K JX422257_A/swine/Minnesota/A0112 K Y N N N K
7 Initial OFFLU SIV antigenic cartography aim -> global antigenic map of H1 in swine Characterise the antigenic diversity and evolution of H3 swine influenza viruses dataset = United States, EU (ESNIP3...under way), any other partners? genetic evolution - global phylogenetic tree, significant phylogenetic diversity - not all clades represented antigenically molecular basis for antigenic differences -> analyses under way rates of antigenic evolution 7
8 Swine influenza A H1 viruses North America ->2012 Lorusso,, Vincent, Harland, Alt, Bayles, Swenson, Gramer, Lager, and Lewis USDA/ARS/NADC, USDA/APHIS/NVSL, University of Minnesota, University of Cambridge. J Gen Virol 92:
9
10 Phylogenetically very diverse
11 Swine influenza A H1 viruses globally Key: Red = USA, Green = Canada, Gold = Hong Kong Pink = Europe. Black = human viruses 11
12 Avian-like alpha/beta/ gamma/ conventional / TRIG Pdm Eurasian England/80-like- from 1994 onwards deltas 12
13 Geographic spatial diversity ? 13
14 The future Aim to have globally representative antigenic data from all possible geographic regions through 2012 and beyond. Include integration of human flu data where relevant. Informing WHO/OIE/FAO with latest:?through OFFLU or?whocc VCM system for antigenic cartography EU - more Eurasian H1 s? drift variants, recent avian-like H1 s, HK? later than 2009?, Add Argentinian data,? Canadian 26 isolates , other partners with potential antigenic variants H3 s...eu to be added to USA. Other collaborators Re-run global SIV phylogenetic trees and finalise genetic basis for differences among clusters. Calculate rates of evolution (antigenic and genetic) Publication? - OFFLU output for this year 14
15 Viroscience, Department of Virology, Erasmus Medical Center Rotterdam (NL) Ron Fouchier Josanne Verhagen Miranda de Graaf Pascal Lexmond Oanh Vuong Theo Bestebroer Bjorn Koel Kim Westgeest Walter Beyer Ruud van Beek Monique Spronken Chantal Baas Pascal Lexmond Jan de Jong Guus Rimmelzwaan Ab Osterhaus St Jude Children s Research Hospital (USA) Robert Webster, Scott Krauss, Richard Webby HKU (Hong Kong) and Duke University, Singapore Malik Peiris, Gavin Smith, Vijay Dhanasekaran, Justin Bahl AHVLA (UK) Ian Brown, Jill Banks, Sharon Brookes, Scott Reid,, swine strains also contributed by Chris Olsen WHO Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases and Centre for Pathogen Evolution, University of Cambridge Derek Smith Colin Russell David Burke Eugene Skepner Terry Jones Dan Horton (& AHVLA) Ana Mosterin Judy Fonville Leah Katzelnick Gene Selkov ESNIP 3 consortium partners DTU: Lars Larsen, Ramona Trebbien USDA/ARS/NADC Amy Vincent Alessio Lorusso Michelle L. Harland, David Alt, Darrell O. Bayles, Kelly Lager USDA/APHIS/NVSL Sabrina L. Swenson University of Minnesota Marie R. Culhane Canadian Food Inspection Agency John Pasick Charles Nfon Funding support of USDA- ARS and APHIS, USA, ESNIP3:FP7#
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