OIE Reference Laboratory Reports Activities

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1 OIE Reference Laboratory Reports Activities Activities in 2017 This report has been submitted : :23:14 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Swine influenza Address of laboratory: New Haw, Addlestone Surrey KT15 3NB Weybridge UNITED KINGDOM Tel.: Fax: address: ian.brown@apha.gsi.gov.uk Website: Name (including Title) of Head of Laboratory (Responsible Official): Mr Christopher Hadkiss, Chief Executive Name (including Title and Position) of OIE Reference Expert: Professor Ian Brown Director of EU/OIE/FAO International Reference Laboratory for Avian Influenza, Newcastle Disease and Swine Influenza Which of the following defines your laboratory? Check all that apply: Governmental OIE Reference Laboratory Reports Activities,

2 ToR 1: To use, promote and disseminate diagnostic methods validated according to OIE Standards 1. Did your laboratory perform diagnostic tests for the specified disease/topic for purposes such as disease diagnosis, screening of animals for export, surveillance, etc.? (t for quality control, proficiency testing or staff training) Diagnostic Test Indicated in OIE Manual (/) Total number of test performed last year Indirect diagnostic tests Nationally Internationally HI Direct diagnostic tests Nationally Internationally Real-time RT-PCR M gene Real-time RT-PCR ph1n ToR 2: To develop reference material in accordance with OIE requirements, and implement and promote the application of OIE Standards. To store and distribute to national laboratories biological reference products and any other reagents used in the diagnosis and control of the designated pathogens or disease. 2. Did your laboratory produce or supply imported standard reference reagents officially recognised by the OIE? 3. Did your laboratory supply standard reference reagents (non OIE-approved) and/or other diagnostic reagents to OIE Member Countries? 4. Did your laboratory produce vaccines? 5. Did your laboratory supply vaccines to OIE Member Countries? 2 OIE Reference Laboratory Reports Activities, 2017

3 ToR 3: To develop, standardise and validate, according to OIE Standards, new procedures for diagnosis and control of the designated pathogens or diseases 6. Did your laboratory develop new diagnostic methods validated according to OIE Standards for the designated pathogen or disease? 7. Did your laboratory develop new vaccines according to OIE Standards for the designated pathogen or disease? ToR 4: To provide diagnostic testing facilities, and, where appropriate, scientific and technical advice on disease control measures to OIE Member Countries 8. Did your laboratory carry out diagnostic testing for other OIE Member Countries? Name of OIE Member Country seeking assistance Date (month). samples received for provision of diagnostic support. samples received for provision of confirmatory diagnoses GHANA 12/17 awaiting samples 0 SPAIN 04/ THE NETHERLANDS 06/ ITALY 12/17 awaiting samples 0 COLOMBIA 12/17 awaiting samples 0 FRANCE 05/17 0 UNITED STATES OF AMERICA 09/17 0 Panel for advanced diagnostics Panel for advanced diagnostics 9. Did your laboratory provide expert advice in technical consultancies on the request of an OIE Member Country? OIE Reference Laboratory Reports Activities,

4 Name of the OIE Member Country receiving a technical consultancy Purpose How the advice was provided UNITED KINGDOM Request for swine influenza isolates - interested in obtaining a recent European H1N1, H3N2 and H1N2 GHANA Request for diagnostic support, protocols, sampling and for emergency full virus characterisation of influenza A virus positive samples through OIE/FAO SPAIN Advanced antigenic and genetic analyses ITALY Advanced antigenic and genetic analyses THE NETHERLANDS Advanced antigenic and genetic analyses ToR 5: To carry out and/or coordinate scientific and technical studies in collaboration with other laboratories, centres or organisations 10. Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? Title of the study Duration Purpose of the study Partners (Institutions) OIE Member Countries involved other than your country Swine pandemic risk assessment pipeline to 2021 Funded by NIH through the CEIRS network programme (Centres of Excellent in Influenza Research and Surveillance Led by USDA-ARS and University of Cambridge, global partners in the CEIRS network including APHA UNITED STATES OF AMERICA ToR 6: To collect, process, analyse, publish and disseminate epizootiological data relevant to the designated pathogens or diseases 11. Did your Laboratory collect epizootiological data relevant to international disease control? 12. Did your laboratory disseminate epizootiological data that had been processed and analysed? 4 OIE Reference Laboratory Reports Activities, 2017

5 13. What method of dissemination of information is most often used by your laboratory? (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: 3 Sookhoo, J.R., Brown-Jordan, A., Blake, L., Holder, R.B., Brookes, S.M., Essen, S., Carrington, C.V., Brown, I.H. and Oura, C.A., Seroprevalence of economically important viral pathogens in swine populations of Trinidad and Tobago, West Indies. Tropical Animal Health and Production, pp Anderson TK; Macken CA; Lewis NS; Scheuermann RH; Van Reeth K; BROWN IH; Swenson SL; Simon G; Saito T; Berhane Y; Ciacci-Zanella J; Pereda A; Davis CT; Donis RO; Webby RJ; Vincent AL 2016 A phylogeny-based global nomenclature system and automated annotation tool for H1 hemagglutinin genes from swine influenza A viruses. msphere 1 (6) e Kate A. Harris, Gudrun S. Freidl, Olga S. Munoz, Sophie von Dobschuetz, Marco De Nardi, Barbara Wieland, Marion P. G. Koopmans, Katharina D. C. Stärk, Kristien van Reeth, Gwen Dauphin, Adam Meijer, Erwin de Bruin, Ilaria Capua, Andy A. Hill, Rowena Kosmider, Jill Banks, Kim Stevens, Sylvie van der Werf, Vincent Enouf, Karen van der Meulen, Ian H. Brown, Dennis J. Alexander, Andrew C. Breed, the FLURISK Consortium. Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers. EcoHealth, June 2017, Volume 14, Issue 2, pp b) International conferences: 2 Scott M. Reid, Helen Everett, Vivien Coward, Naomi Smallcalder, Sharon M. Brookes. Development of a real-time RT-PCR for differential detection of reassortant H1N2 (rh1n2) swine influenza virus. 18th International Symposium of WAVLD, Sorrento, June 2017 Scott M. Reid, Christine Russell, Jayne Cooper, Vivien Coward, Helen Everett, Susanna Williamson, Sharon M. Brookes, Ian H. Brown Adoption and validation of real-time RT-PCR protocols for sub-typing European swine influenza viruses in the United Kingdom. 18th International Symposium of WAVLD, Sorrento, June 2017 c) National conferences: 0 d) Other: (Provide website address or link to appropriate information) 1 ToR 7: To provide scientific and technical training for personnel from OIE Member Countries To recommend the prescribed and alternative tests or vaccines as OIE Standards 14. Did your laboratory provide scientific and technical training to laboratory personnel from other OIE Member Countries? a) Technical visits: 0 b) Seminars: 20 c) Hands-on training courses: 20 d) Internships (>1 month): 0 OIE Reference Laboratory Reports Activities,

6 Type of technical training provided (a, b, c or d) Country of origin of the expert(s) provided with training. participants from the corresponding country B and C Amy Vincent (USA), Ariel Pereda (Argentina), Clement Meseko (Nigeria), Frank Wong (Australia), Janice Ciacci Zanella (Brazil), John Pasick (Canada), Kristien Van Reeth (Belgium), Marie Culhane (USA), Richard Webby (USA), Todd Davis (USA), Sabrina Swenson (USA), Peter Daniels (Australia), Taki Saito (Japan), Tung Nguyen (Vietnam), Young Ki Choi (Rep. Korea), Gaelle Simon (France), Gounalan Pavade (OIE), Lidewij Wiersma (FAO), Gwenaelle Dauphin (FAO), Sophie VonDobschuetz (FAO). Amy Vincent (USA), Ariel Pereda (Argentina), Clement Meseko (Nigeria), Frank Wong (Australia), Janice Ciacci Zanella (Brazil), John Pasick (Canada), Kristien Van Reeth (Belgium), Marie Culhane (USA), Richard Webby (USA), Todd Davis (USA), Sabrina Swenson (USA), Peter Daniels (Australia), Taki Saito (Japan), Tung Nguyen (Vietnam), Young Ki Choi (Rep. Korea), Gaelle Simon (France), Gounalan Pavade (OIE), Lidewij Wiersma (FAO), Gwenaelle Dauphin (FAO), Sophie VonDobschuetz (FAO). ToR 8: To maintain a system of quality assurance, biosafety and biosecurity relevant for the pathogen and the disease concerned 15. Does your laboratory have a Quality Management System certified according to an International Standard? Quality management system adopted ISO17025 Certificate scan (PDF, JPG, PNG format) UKAS certificate.pdf 16. Is your laboratory accredited by an international accreditation body? Test for which your laboratory is accredited Haemagglutination Inhibition test Matrix (M)-gene PCR Accreditation body UKAS UKAS H1-118 (pdm09) real-time PCR UKAS Virus isolation in SPF eggs UKAS 17. Does your laboratory maintain a biorisk management system for the pathogen and the disease concerned? (See Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, Chapter 1.1.4) 6 OIE Reference Laboratory Reports Activities, 2017

7 ToR 9: To organise and participate in scientific meetings on behalf of the OIE 18. Did your laboratory organise scientific meetings on behalf of the OIE? 19. Did your laboratory participate in scientific meetings on behalf of the OIE? Title of event Date (mm/yy) Location Role (speaker, presenting poster, short communications) Title of the work presented OFFLU Steering Committee 03/17 Rome Speaker Swine Influenza Update OFFLU SIV Group 03/17 Rome Speaker Europe SI update, Antigenic risk assessment for human pandemic preparedness and global antigenic diversity of swine IAV and participation in human risk assessment pipeline, H3 clade classification discussion ToR 10: To establish and maintain a network with other OIE Reference Laboratories designated for the same pathogen or disease and organise regular inter-laboratory proficiency testing to ensure comparability of results 20. Did your laboratory exchange information with other OIE Reference Laboratories designated for the same pathogen or disease? 21. Was your laboratory involved in maintaining a network with OIE Reference Laboratories designated for the same pathogen or disease by organising or participating in proficiency tests? 22. Did your laboratory collaborate with other OIE Reference Laboratories for the same disease on scientific research projects for the diagnosis or control of the pathogen of interest? OIE Reference Laboratory Reports Activities,

8 ToR 11: To organise inter-laboratory proficiency testing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results 23. Did your laboratory organise or participate in inter-laboratory proficiency tests with laboratories other than OIE Reference Laboratories for the same disease? te: See Interlaboratory test comparisons in: Laboratory Proficiency Testing at: see point 1.3 ToR 12: To place expert consultants at the disposal of the OIE 24. Did your laboratory place expert consultants at the disposal of the OIE? 25. Additional comments regarding your report: 8 OIE Reference Laboratory Reports Activities, 2017

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