Outbreaks and control of swine influenza viruses in Korea

Transcription

1 Inception meeting of the OIE/JTF Project for Controlling Zoonoses in Asia under One Health Concept Outbreaks and control of swine influenza viruses in Korea Tokyo, Japan, 19-20, December 2013 Yeun-Kyung Shin, QIA, Korea Seong-Hee Kim, QIA, Korea

2 CONTENTS Pig Industry in Korea Swine Influenza in Korea National Surveillance of swine influenza Control and prevention strategies in Korea Ongoing activities in animal influenza control Challenges and constraints in SI control

3 Pig Industry in Korea Cattle No. Animals * 3,079 3,352 3,354 3,479 3,465 Beef 2,635 2,922 2,950 3,059 3,043 Dairy No. Farms Beef Dairy Pigs No. Animals * 9,585 9,881 8,171 9,916 10,188 Sows No. Farms Chicken No. Animals * 138, , , , ,721 Layers 62,967 61,691 62,425 61,344 62,674 Broiler 67,194 77,871 76,435 76,130 64,505 Breeding 8,607 9,638 10,652 9,362 9,542 No. Farms 3,539 3,604 3,403 3,144 2,958 * Unit : 1000 animals; + Unit : 1000 farms No. Animals per farm : Beef cattle (23.1/farm), Diary cattle (72/farm), Pigs (1,722/farm), Chicken (46,221/farm)

4 Swine Influenza in Korea Influenza A virus isolates in pigs Year Subtype REF 1997 H1N1 VI Kwon at al, Korean J Vet Res (1997) 2002 H1N1 Antigen & RNA detection Jung et al, Vet Pathol (2002) 1998 H3N2 VI, human like Song et al, J Vet Diag Invest (2003) 2003 H1N2 VI Jung et al, Arch Virol (2004) 2004 H9N2 Seo et al (NCBI Genbank) 2005 H1N1 VI, US like Song et al, Virus Research (2007) 2006 H3N1 VI, novel H3N1 Shin et al, J Clin Microbiol (2006) 2008 H5N2 VI, Eurasian Avian like Lee et al, JVI (2009) 2012 vh3n2 VI, (ph1n1+h3n2) Kim et al, Arch Virol (2013) 2013 H1N2 VI, Eurasian Avian like Pascua et al, Genomea (2013)

5 Swine Influenza in Korea Seroprevalence of influenza in pigs Area Gyeonggi Gangwon Incheon 40 - Chungbuk Chungnam Jeonbuk Jeonnam Gyeongbuk Gyeongnam Jeju Total 3,815 3,282 1,199 GG CN JB JN JJ GW CB GB GN

6 Swine Influenza in Korea Seroprevalence of influenza in pigs Total Pandemic H1 H

7 National surveillance of SI Launched since the outbreak of pandemic H1N1 in 2009 Noticeable disease agents : pandemic H1N1 & H3N2v Period: September to December every year Subject: Commercial farms, breeding farms & AI centers Sample: nasal swabs (18 samples per farm) Test method: RT-PCR, virus isolation, genome analysis

8 National surveillance of SIV Procedure of surveillance testing Collection of nasal swab RT-PCR negative Finishing of test positive Virus isolation(cell & egg) negative Finishing of test positive Analysis of gene negative Finishing of test Positive(variant) Notice & control action

9 National surveillance of SIV The number of pig farms of surveillance testing Year No. of Pig farms (pigs) Breeding pig farm Commercial pig farm Total No. of positive cases (3,366) 2,829(48,153) 3,027(51,519) (5,818) 1,489(25,156) 1,821(30,974) (2,984) 968(17,379) 1,135(20,363) (3,412) 809(14,538) 997(17,950) (3,744) 792(14,256) 1000(18,000)* 3

10 Swine Influenza in Korea Positive cases in surveillance since 2009 Year Subtype H1N1 H1N2 H3N2 ph1n1 H3N2v Total Total

11 National surveillance of SIV Geographical distribution of pig farms affected with ph1n1 since (17) 2010(8) 2011(5) 2012(3)

12 National surveillance of SIV Geographical distribution of pig farms affected with H3N2v 2011(2) 2012(1)

13 Genome variation screening program for SIV QIA Data analysis KAHIS Samples Info. Data analyzed Regional Vet Lab KAHIS : Korea Animal Health Information System

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15 Swine Influenza in Korea Phylogenetic analysis of SIV isolates H1 HA M

16 Swine Influenza in Korea Phylogenetic analysis of SIV isolates H3 HA M

17 Control and prevention strategies of SI Movement restriction on confirmed pig farm Re-testing at one-week interval Testing individual pigs before slaughter Epidemiological survey KAHIS: Disease Information gathering and analysis Automatically informed to KCDC Epidemiology survey on confirmed farm-related people by KCDC

18 Ongoing activities in animal influenza control Farms Equine Farms AI centers SI Slaughter houses Feline Mammalian Animals Canine Wild birds AI LBM Breeding Animal Disease Diagnositc Farms Zoo Animals Viral Disease Avian Disease Breeding Farms Total 18,000 samples Total 229,906 samples

19 Challenges and constraints in SI control SI : not infectious disease designated by law and required to report Only pandemic 2009 and H3N2v Public awareness

20 Influenza A virus monitoring: Human-Animal Interface 1. Influenza A viruses DB from human and animals 2. Web-based DB analysis and genome analysis 3. Nation level influenza A virus monitoring infrastructure

21 Thank you for your attention.