KRANSKA GORA (SLOVENIA), TH SEPTEMBER Agenda CLOSED SESSION OF THE STANDING TECHNICAL COMMITTEE

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1 KRANSKA GORA (SLOVENIA), TH SEPTEMBER 2009 Agenda CLOSED SESSION OF THE STANDING TECHNICAL COMMITTEE

2 Objective Develop immediate and longer term (2-4 year) action plans to address the issues/priorities identified at the 38 th Session; Review progress of research studies commissioned/ongoing since the Closed Session, 2008; Provide guidance/recommendations to EuFMD on issues arising from project activities or planned in the new 4 year program. Priorities for At the General Session of the EuFMD Commission, April 2009, the CVOs decided that the priorities of the Research Group in should be: 1. To continue the FMD genome sequencing and related epidemiology studies in Turkey/Iran; 2. To develop a procedure for decisions on new antigens for (European and national) vaccine banks and endemic regions; 3. To set up guidelines for surveillance to meet objectives of Stages 1, 2, 3 of the Progressive Control Pathway (PCP); 4. To support validation of FMD spread models developed in various member countries to support their contingency plans (for national ministries of agriculture); 5. The socio -economic evaluation of FMD control programmes; 6. Validation/guidance on pen-side and other diagnostic tests for FMD. Note from the Chairman: below are issues from previous Research Group sessions that may need to be addressed: 1. Role of sheep in maintaining or spreading FD in a temperate European climate with mixed sheep and cattle farms (UK, 2001); 2. Paper on the risk of spread from wild boar in the Israeli circumstances; 3. Report on the use of thermal imaging camera for use in extensively kept cattle for the purpose of detection of febrile animals. With the above in mind, the 3 day Closed Session is structured to allow maximum time to work in subgroups to make action plans/propose solutions to address priorities 2 (specialists on antigenic matching), 3 (epidemiologists) and 6 (specialists in laboratory diagnostics). The other issues should be at least be discussed on the last day, in making up the action plan. The groups will be responsible to make longer term plans for actions/ studies to address the issues over the next 2 years; some of these studies may require additional funding, through concept notes/commissioned research. 2

3 Proposed timetable Wednesday 23 Session AM1 (15 min per subject) Chair: Aldo Dekker Introduction, Objectives, Plan of Session; Subgroups Chairs to introduce their plans for subgroup work (Emiliana Brocchi, David Paton, Keith Sumption); Where do we deal with planning vaccine batch trials (for NSP, bulk sera, SP responses); Outcomes of the EuFMD General Session; Outcome of the Global FMD conference (Paraguay); Progressive Control Pathway (PCP) and relevance to RG topics. Session AM2 Progress Reports on contracted studies/research (15 min presentation; 5 min discussion) Chair: Kris De Clercq Full-length sequencing (David Paton: IAH/SAP); Optimizing FMDV transfection (Graham Belsham: Lindholm); Carrier status of Asiatic buffaloes (David Paton: IAH); Risk-based surveillance for FMDV in Pakistan/Afghanistan; approach and initial findings (Giancarlo Ferrari: FAO Central Asia project); TransCaucasus/Regional FMD Vaccination database (Carsten Potzsch: EuFMD/FLI); Antigenic cartography paper. Session PM1 Subgroup work session 3 working groups for priority 2, 3 and 6. Session PM2 Continued/brief feedback at the end of the day to chairman, vice chairman and secretariat. Thursday 24 Note: progress reports/offered papers could be fitted in Session AM1 or AM2 of Thursday SESSION AM1 Plenary session (15 min presentation; 5 min discussion) Chair: Bernd Haas Report WRL on FMD status world-wide including Priority European FMD vaccine bank; Sero-surveillance results TransCaucasus 2009 (Emiliana Brocchi, Carsten Potzsch); Discussion on improving threat detection for FMDV circulating in the African proximity including the role of transborder movement in endemic areas (Adel Ben Youssef); Progress report on Real-Time training exercises (ETC) (Naci Bulut, Nadia Rumich); Introduction action plan RG; proposed subjects (Aldo Dekker); Discussion on NSP induction by vaccines used in Iran(Keith Sumption). 3

4 Proposed timetable (cont.) SESSION AM2 Plenary session (15 min presentation; 5 min discussion) Chair: Donal Sammin FMD spread models: update on recent published/developed models (Antonello di Nardo: IAH, with comments from Kris de Clercq on planned validation under DISCONVAC); Changing the legislation on outbreaks diagnosed without evidence of spread of the disease (e.g. carrier detection by probang) (introduced by Aldo Dekker); Modelling population immunity paper by Arnaud Le Menach (reviewed by Fernando Boinas). SESSION PM1 Subgroup work sessions continued. SESSION PM2 Plenary feedback from subgroup 1. Friday 25 SESSION AM1 Plenary Session Feedback from subgroup 2. SESSION AM2 Plenary Session Feedback from subgroup 3. SESSION PM1 Plenary SESSION Other issues Chair: Aldo Dekker Consolidated Plan of Action/ Recommendations Election of Chairperson and Officers for the coming year Chair: Keith Sumption SESSION PM2 Free social event/explore Kranska Gora. 4

5 Group work Group 1 To develop a procedure for decision on advising new antigens for (European and national) vaccine banks and endemic regions Issues that can be addressed are: Priority setting procedure for the WRL list - can we introduce risk of introduction (from FMDV pools, Turkey, etc), and how? The relevance of using Asia-1 Shamir as the standard vaccine for Asia-1 (Query from Israel); Set up a subgroup addressing the problems with SAT type vaccines in Africa and study the relevance for the EU vaccine bank; The need to update the commercial vaccine to the changing situation in the field; Use of new antigenic cartography techniques in FMD antigenic matching. Important are the validity of the currently used r-value technique and the possible shortcomings of the r-value. How should these shortcomings be overcome, are more standard sera needed? Which research is already performed, what is needed? How can vaccine quality be proven at the time of production as well as at the end of the shelf life? Group 2 Surveillance group To 1) develop guidelines for surveillance to meet objectives of Stages 1,2,3 of the Progressive Control Pathway (PCP); and 2) to give guidance to the EuFMD Commission on procedure and objectives for Phase II support to African laboratories to improve FMDV surveillance for threat identification. This Group may be split to address each topic. Group 3 Group work: it will be decided on Day 1 of the session. Topics: leaders of each group should identify the key issues/ priorities, and group outputs should be a clear course of action and/or recommendation Validation/guidance on pen-side and other diagnostic tests for FMD Issues that can be addressed are: Evaluate papers on validation of other tests; How important is sensitivity in relation to specificity and robustness? Training in real-time rtpcr and other confirmation methods, for middleeast and north African countries: proposed tests to be used, course coverage (Stefan/AFFSA, Adel BenYoussef); Would pen-side test for NSP antibodies help in the diagnosis? What is the minimum level of proficiency needed for these test? How can proficiency be controlled? 5

6 Group work (cont.) Possible working groups (all groups open to additional experts) Group 1 Priority setting antigens David Paton, Bernd Haas, Kris de Clercq, Hagai Yadin, Donal Sammin Group 2 Surveillance Keith Sumption, Giancarlo Ferrari, Carsten Potzsch, Aldo Dekker, Adel Ben Youssef, Fernando Boinas Group 3 Diagnostics/Pen-side testing Emiliana Brocchi, Yanmin Li, Naci Bulut, Stephan Zientara, Georgi Georgiev, Helen Hondrokouki 6

7 Participants (RG members) Members of the Research Group of the Standing Technical Committee EuFMD Dr Aldo DEKKER (Chairman) Senior Scientist Laboratory Vesicular Diseases Central Institute for Animal Disease Control PO Box AB Lelystad The Netherlands Dr Bernd HAAS Head of National FMD Reference Laboratory Friedrich-Loeffler-Institut Federal Research Institute for Animal Health Boddenblick 5 a Greifswald-Insel Riems GERMANY Tel.: Fax: bernd.haas@fli.bund.de Dr Dónal SAMMIN Senior Research Officer Regional Veterinary Laboratory Department of Agriculture, Fisheries and Food, Leggetsrath, Hebron Rd., Kilkenny, IRELAND Tel.: donal.sammin@agriculture.gov.ie Dr Emiliana BROCCHI Head, National Reference Laboratory for Vesicular Diseases Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna Via A. Bianchi, 7/ Brescia ITALY emiliana.brocchi@bs.izs.it Dr Hagai YADIN Head of Virology Division and FMD Laboratory Kimron Veterinary Institute c/o Ministry of Agriculture PO Box 12 Beit-Dagan ISRAEL hagaiy@moag.gov.il Dr Naci BULUT Expert, Head of Diagnosis Department SAP Institute Eskisehir Yolu 7 Kilometre Ankara, TURKEY Tel. Lab: nacib@sap.gov.tr Dr Stephan ZIENTARA Head of Afssa virology Unit, Deputy- Head of the Research unit Afssa/INRA/ ENVA AFSSA Alfort, UMR1161(Afssa/INRA/ ENVA), 23 avenue du Général de Gaulle, BP 63, Maisons-Alfort Cédex FRANCE s.zientara@afssa.fr Dr Kris DE CLERCQ (vice chair) Head Department of Virology Section Epizootic Diseases CODA-CERVA-VAR Groeselenberg 99 B-1180 Ukkel BELGIUM Kris.De.Clercq@var.fgov.be Dr David PATON Pirbright Laboratory Institute for Animal Health Ash Road Pirbright, Surrey GU24 0NF UK Tel.:+44 (0) Fax:+44 (0) david.paton@bbsrc.ac.uk Dr Georgi Kirilov GEORGIEV Head, Department of Exotic and Emerging Diseases National Diagnostic and Research Veterinary Medical Institute 1606 Sofia, P. Slaveikov Blvd N.15 BULGARIA Tel.: Tel.: georgivet2@yahoo.com Dr Helen HONDROKOUKI Neapolfos 25, Ag. Paroskevi, Athens GREECE fmdi@otenet.gr Dr. Fernando BOINAS Laboratório de Doenças Infecciosas CIISA Faculdade de Medicina Veterinária Polo Universitário do Alto da Ajuda Av Universidade Técnica Lisboa PORTUGAL Phone: Fax: fboinas@fmv.utl.pt 7

8 Participants (RG members) (cont.) Observers Dr Yanmin LI Institute for Animal Health Ash Road, Pirbright, Surrey GU24 0NF, UK Tel/Fax: / yanmin.li@bbsrc.ac.uk Dr Graham BELSHAM National Veterinary Institute Technical University of Denmark Lindholm 4771 Kalvehave, Denmark Tel.: grbe@vet.dtu.dk Dr Labib BAKKALI-KASSIMI Agence française de sécurité sanitaire des aliments, UMR AFSSA/INRA/ ENVA, 23 Avenue du Général de Gaulle, Maisons-Alfort, France lbakkali@vet-alfort.fr Antonello DI NARDO (DVM, MSc) FMD Epidemiologist Institute for Animal Health Pirbright Laboratory Ash Road Pirbright, GU24 0NF United Kingdom Tel.: +44 (0) Fax::+44 (0) antonello.di-nardo@bbsrc.ac.uk Haj Ammar HENI Direction Générale des Services Vétérinaires Ministère de l Agriculture et des Ressources Hydrauliques 30 Rue Alain SAVARY Tunis Tel.: ; post: 3081 Fax: heni_hah@yahoo.fr Dr. Yaser WAZER Syria Dr Yasser Gadou Govs-Egypt Egypt yaser_gov@yahoo.com Dr Malik Jamal Morocco malikjamal7@hotmail.com Dr Mehdi El Harrak Morocco Dr Heni Haj Ammar Direction Générale des Services Vétérinaires Ministère de l Agriculture et des Ressources Hydrauliques 30 Rue Alain SAVARY-1002-Tunis Tel.: ; post: 3081; Mob: heni_hah@yahoo.fr Dr Nabih Ghaouch CVO, Lebanon EuFMD Keith SUMPTION Secretary, EuFMD Animal Health Service Animal Production and Health Division FAO HQs Viale delle Terme di Caracalla Rome, Italy Tel.: keith.sumption@fao.org Adel Ben YOUSSEF Animal Health Service Animal Production and Health Division FAO HQs Viale delle Terme di Caracalla Rome, Italy Tel.: Adel.BenYoussef@fao.org Carsten POTZSCH EuFMD consultant FMD Surveillance and Control in the Transcaucasus (Armenia, Azerbaijan and Georgia) Tbilisi carsten.potzsch@fao.org Enrique ANTON EuFMD Secretariat Animal Health Service Animal Production and Health Division FAO HQs Viale delle Terme di Caracalla Rome, Italy Tel.: enrique.anton@fao.org Nadia RUMICH EuFMD Secretariat Animal Health Service Animal Production and Health Division FAO HQs Viale delle Terme di Caracalla Rome, Italy Tel.: nadia.rumich@fao.org 8

Keith Sumption Secretary, European FMD Control Commission (EuFMD) FAO, Rome

Foot and mouth disease situation and control strategies in Europe the current situation Keith Sumption Secretary, European FMD Control Commission (EuFMD) FAO, Rome The European neighborhood wider group