Only BOVIPAST RSP PASTEURELLA* HAEMOLYTICA. protects against Pasteurellosis and Viral Pneumonia

Transcription

1 Only BOVIPAST PASTEURELLA* HAEMOLYTICA VIRUSES (RSV & Pi-) protects ginst Psteurellosis Virl Pneumoni

2 Bovine Respirry Disese: All cttle re t risk t every stge in ir lives Outbreks Bovine Respirry Disese (BRD) continue cuse significnt economic losses hrdship for producers. The fct is, mny contributing gents cn produce similr clinicl signs. Good niml husbry frm mngement prctices, including comprehensive herd vccintion scheme, remin st strtegy. The min risk periods Young ge: The immune systems young clves come more efficient ge, llowing for tter response when chllenged by respirry pthogens. For reson, respirry disese is more commonly dignosed during first three months life. For clves ing fed replcers, it s lso period in which wening tkes plce. Young ge Mixing: A prticulrly vulnerble time in n niml s life, especilly young clves, re dys just following introduction mixing nimls from different sources. Circultion respirry pthogens differences in immune sttus re min fcrs tht led higher incidence respirry disese. Autumn winter: Mixing In most cttle herds incidence respirry disese increses during utumn winter. During time yer clves re housed indoors risk pneumoni is higher. Trnsporttion: Autumn & winter It hs en well estblished tht loding unloding nimls cuses significnt stress m. Any sitution tht genertes stress hve negtive influence on immune system niml. Trnsporttion

3 Pneumoni pthogens: Mnnheimi* (Psteurell) hemolytic Mnnheimi (Psteurell) hemolytic Bcteri type: Grm-negtive Psteurelle fmily (formerly known s Psteurell hemolytic) Prevlence: Widespred Virulence: One most importnt bcteril pthogens, Mnnheimi (Psteurell) hemolytic cn ten prove ftl on its own even in older clves which might cpble surviving virl Pthogenic ction: Although primrily seen s secondry infection, pthogenic ction bcteri cn severe. Trigger fcrs such s wer chnges, trnsport stress or virl infection llow bcteri proliferte in nsophrynx. Inhltion bcteri from here in lungs leds colonistion. The bcteri invdes lung tissue multiplies cusing dmge (including leucoxin dmge). If left unchecked, furr dmge occurs due complement cells, cykines, neutrophils mcrophges leding fibrinous pneumoni. Clinicl signs: The clf simply finds it very difficult bre exhibits clssic signs BRD THREAT: Mnnheimi hemolytic is one most importnt bcteril pthogens. It my considered secondry invder (fter es) but it is serious pthogen worthy concerted defence. DEFENCE: Protection is st defence. Although some ntibiotics cn tret Mnnheimi (Psteurell) hemolytic infections, dmge is lredy done by time clinicl signs hve ppered. Therefore policy vccintion (where bcteri is present) is tter course ction. protection Conventionlly rered friesin-cross clves were immunised subcutneously t weeks weeks ge ml. Vccinted clves non-vccinted control group were chllenged t weeks ge M. hemolytic serotype A. All clves were scored t necropsy dys lter for consolidted lung lesions, pleuresy, bcteril counts in lung tissue, scores summed give tl disese score (TDS). The disese produced ws severe progressive, purulent bronchopneumoni. vccinted clves were solidly protected men TDS. compred. for unvccinted group. The component which protects ginst M. hemolytic hs en creted using unique Iron Regulted Protein (IRP) technology - see pge. % % % % % Totl Disee Score (TDS) Clinicl Score Vccinted M. hemolytic Disese Chllenge Result Lung Lesions Isoltion Index Disese Score Mortlity Controls vccinted Unvccinted controls weeks months

4 As food wter lthough generlly y continue feed. lthough generlly continue feed. RNA pneumo RNA pneumo fmily Virus type: pneumo fmilygenerlly lthough y disese continue y feed. fmily Prevlence: Widespred/Ubiquius consumption incresingly difficult, clves As disese disese food wter As disese wter As food wter come emcited. The refood round eye Widespred/Ubiquius Prevlence: Widespred/Ubiquius espred/ubiquius Virulence: Vrible sub-clinicl infections re consumption incresingly diffiincresingly cult, clves consumption diffifever cult, consumption diffidue cult, clves myincresingly gin clves common lthough explosive clinicl outbreks come emcited. re round re eye round come emcited. under eye come emcited. The The re round The eye detected. As re Vrible sub-clinicl infections re Virulence: Vrible sub-clinicl infections re ble cn sub-clinicl lso occur.infections re gin fever my gin fever mymy gin due due fever jw due throt gins brething hough explosive clinicl outbreks common lthough explosive clinicl outbreks h explosive clinicl outbreks detected. As detected. re under As re under detected. As re under incresingly lboured. ur. cn lso occur. Pthogenic ction: A er erosol trnsmission, jw throt gins throt brething jw gins more brething jw throt gins brething Eventully, s brething difficult due gins primry phse repliction in lboured. incresingly lboured. incresingly lboured. Clinicl signs: The erly signs BRSV include BovineRespirry Syncitil Virus (BRSV) incresingly emphysem, ngue protrude ction: erepilium. erosol trnsmission, Pthogenic ction: 9A er erosol trnsmission, on: A nsl era erosol trnsmission, Fever occurs - Eventully, dyseventully, er s brething rised temperture, dry cult cough cler s brething more diffi cult due nsl Eventully, s brething more diffi cult due more diffi due neck extended. At stge, preventing gins primry phse repliction in gins primry phse repliction in primry phse repliction in dischrge. Clves ffected by BRSV my show Virus type: RNA pneumo fmily exposure, infection spreding throughout emphysem, ngue protrude emphysem, ngue protrude emphysem, ngue protrude 9 9 deth isunlikely. 9 nsl Fever occurs - dys er -tree. lium. Fever occurs dys er epilium. Fever occurs -trct dys er ium. signs respirry distress distnce upper respirry bronchil neck extended. extended. At stge, preventing neck extended. At stge, preventing neck At stge, preventing th infection spreding throughout exposure, infection spreding mselves from herd, lthough generlly y Prevlence: nfection spreding throughout Syncyti, produced s Widespred/Ubiquius result throughout multinucletion deth is unlikely. deth is unlikely. deth is unlikely. THREAT: This is feed. most importnt virl bronchil upper trcttree. bronchil continue yry trct respirry bronchil tree. trct lveolr epilil cells, cusestree. bronchiole pthogens in both ef diry herds. As disese food The wter Virulence: Vrible sub-clinicl infections re duced s result multinucletion Syncyti, produced s result multinucletion ed s result multinucletion. This mucos fill mucous exudtes THREAT: isthreat: most importnt virl virl This is most importnt respirry virl THREAT: This is most importnt cuses long-term direct dmge consumption incresingly difficult, common lthough explosive clinicl outbreks nd epilil cells, cuses bronchiole lveolr epilil cells, cuses bronchiole pilil cells, cuses bronchiole pthogens in both ef diry The pthogens in bothherds. ef diry The in. both ef diry herds. The clves come emcited. Theherds. re cn lso occur. system, including reduced elsticity round incresed BRSV destroys cilited epilium pthogens. well fi ll muc usfi exudtes ll muc exudtes o. ous mucos fill muc us o exudtes cuses long-term direct dmge direct respirry cuses dmge respirry cuses long-term direct dmge respirry eyelong-term mygin due irfl ow resistnce. upper irwys, predisposing respirry trct system, including reduced elsticity system, including reduced elsticity incresed ys cilited epilium BRSV destroys cilited epilium system, fever detected. Asincresed Pthogenic ction: Aftersigns erosol trnsmission, including reduced elsticity incresed e cilited epilium furr Severe clinicl such s ow resistnce. resistnce. ow re under jwis gins Chroniclly respirry ginstrct primry phse irfl repliction in irfl ys, predisposing respirry upper irwys, predisposing trct irfl resistnce. redisposing DEFENCE: Protection throt st defence. emphysem mytrct respirry cused byow llergic brething incresingly lboured. nsl epilium. Fever occurs - s dys fter fection. Severe clinicl signs s signs furr Severe clinicl such on. Severe clinicl signs suchsuch s infected, individul nimls re thought mintin rections Eventully, s brething more difficult exposure, infection spreding throughout Protection is st st defence. DEFENCE: Protection is st defence. Chroniclly cused by llergic emphysem my cused bydefence: llergic DEFENCE: Protection is defence. Chroniclly mymy cused by llergic infection in herds, so Chroniclly policy vccintion duenimls emphysem, ngue upper respirry trct bronchil infected, individul re thought mintin infected, individul nimls re thought mintin rections infected, individul nimls re thought mintin ction. for ll clves is wise strtegy. protrude neck extended. At tree. Syncyti, produced s resultinfection in infection herds, policy vccintion in so policy vccintion so so policy herds, vccintion stge, preventing deth is unlikely. multinucletion lveolr infection epililin cells, herds, forclves ll clves is for wise strtegy. ll clves is wise strtegy. fill for ll is wise strtegy. cuses bronchiole mucos THREAT: This is one most importnt mucus exudtes. virl pthogens in both ef diry herds. The cuses long-term direct dmge BRSV destroys cilited epilium respirry system, including reduced elsticity upper irwys, predisposing respirry trct protection incresed irflow resistnce. furr Severe clinicl signs such s emphysem mycompleted cused by Clves - months ge, which hd protection protection P protection DEFENCE: Protection is st defence. llergic rections strd vccintion progrmme Chroniclly infected individul nimls re thought nths months ge, which hd completed Clves - months ge, which hd completed ge, which hd completed, were chllenged bovine RSV mintin infection in herds, so policy ccintion progrmme strd vccintion progrmme ntion progrmme vccintion. dys er initil In fce vccintion for ll clves is llenged bovine RSV, were chllenged bovine RSV nged bovine RSV hevy chllenge, conferred significnt wise strtegy. etil initil vccintion. In fce dys er initil vccintion. In fce vccintion.reducing In fce protection, temperture, nsl dischrge nge, conferred signifi cnt hevy chllenge, significnt conferred signifi cntconferred coughing. educing temperture, dischrgensl dischrge protection, reducing temperture, cing temperture, nslnsl dischrge Antibody levelshve en shown persist t g. coughing. protection high levels for t lest dys er els Antibody hve shown persist t levels hve en shown persist t hve enen shown persist t completion vccintion. orlest t lest dys er high levels for t lest dys er which hd dys er Clves - months ge, vccintion. completion vccintion. ccintion. completed strd vccintion progrmme, were chllenged Bovine RSV disese chllenge result RSV dys fer initil vccintion. Pneumoni pthogens: Bovine RSV conferred significnt protection, reducing temperture, nsl dischrge coughing. Totl Clinicl Score Totl Clinicl Score Totl Clinicl Score Score * Totl Clinicl Totl Score Clinicl Vccinted clves Vccinted clves vccinted clves Control clves (non-vccinted) Vccinted clves 9 9 Vccinted Control clves Vccinted clves clves Control clves 9 9 Control clves (Non-vccinted) Control clves Dys fter BRSV Chllenge Dys fter BRSV Chllenge *Totl Clinicl Score: Sum scores for - reduction in temperture - nsl dischrge - coughing Dys fter BRSV Chllenge Control clves Dys fter BRSV Chllenge

5 Pneumoni pthogens: Pi- Prinfluenz type (Pi-) Virus type: RNA prmyxo fmily Prevlence: Widespred/Ubiquius Virulence: Vrible but usully mild. Deth is rre my non-existent Pthogenic ction: Pi- minly ffects cilited cells, pneumocytes lveolr mcrophges multiplying in se cells dversely ffecting ir function. Becuse Bovine Alveolr Mcrophges (BAM) re initil cellulr defenders lungs, impirment BAM my explin pthogenesis severe bcteril pneumoni tht ten follows Pi- infection in cttle. THREAT: Although Pi- itself normlly cuses mild infection, it predisposes respirry trct secondry infection by or es or bcteri such s M. hemolytic mking mixed infection more dmging dngerous. DEFENCE: Vccintion is st defence. Although ntibiotics cn used help ddress secondry bcteril infection, only wy prevent Pi- infection from wekening clf s nturl defences is vccinte. Clinicl signs: Include fever, cough, nsl oculr dischrge, incresed respirry rte incresed breth sounds. protection In study in, young seronegtive clves were chllenged Pi- weeks fter ing vccinted twice. When group ws compred similr ged nonvccinted group, re ws significnt difference in percentge nimls tht shed Pi-. All unvccinted clves shed from dy dy fter chllenge compred mximum % for group on dy. The vccinted nimls cesed shedding by dy, while non-vccinted controls continued shed up dy. Percentge Animls Shedding Pi- % Positive Animls \\ Dys fter Pi- Virus Chllenge Vccinted Unvccinted

6 Only contins IRP (Iron Regulted Protein) technology Bckground Iron is essentil for bcteril growth out iron, bcteri find it difficult multiply or survive. Bcteri do not sre iron refore need bsorb it from host. Iron Regulted Proteins Iron Regulted Proteins re nturl components on surfce bcteril cells. These IRP s bsorb iron from host reby denying bcteri such s M. hemolytic iron y need survive. IRP Antigens in is only cttle vccine tht contins IRP ntigens. Following vccintion, ntibodies re produced ginst IRP s. These ntibodies bind bcteri, preventing m from bsorbing iron. When M. hemolytic cnnot bsorb iron, it is unble cuse disese. IRP technology mkes highly effective vccine for prevention pthology relted M.hemolytic. The sme IRP ntigens exist in or bcteril serotypes, vccine hs lso en shown provide cross protection tween serotypes A A. All vccines stimulte body produce ntibodies, which circulte in bloodstrem. Antibodies n ttck bcteri by binding sites on ir surfce. IRP vccines re unique in tht y stimulte body produce extr, IRP ntibodies (shown in blue). These IRP ntibodies re ble bind bcteri in mny more sites thn trditionl vccine, producing more effective immune response tht works erlier in

7 Bovilis : Prt your integrted BRD control strtegy The multi-fcril nture BRD complex dems n integrted control strtegy. The three min pillrs strtegy re: Vccintion: Animls nefiting from strtegic vccintion progrm enjoy n enhnced bility overcome chllenges by respirry pthogens. Moreover, cuse vccintion reduces shedding trgeted pthogens, it contributes reduction infectious pressure on frm. Strt erly, choose right Initition vccintion t young ge is key in BRD control progrms ensure tht young clves re protected during highest risk period. Bovilis cn sfely dministered from weeks ge, it is dvisble vccinte ll nimls in herd in order minimise infectious potentil. Environment control: Adequte ventiltion temperture control re essentil elements in controlling BRD. Inspection by specilist cn help you identify problem res contributes improved housing conditions. Minimise stress: During its life clf exposed different unfvorble conditions tht cn trigger stress. These include wening, mixing, feeding chnges more. Mngement prctices should im t ensuring tht stress ssocited se prctices is reduced minimum. Comptible Bovilis IBR Mrker Live Vccintion Bovilis IBR Mrker Live t sme time s Bovilis my required s prt n erdiction progrm or cuse respirry disese IBR involvement hs en detected on frm. The comptibility Bovilis Bovilis IBR Mrker Live hs en proven in severl chllenge studies,. Bovilis vccintion progrms Birth weeks weeks Young clves weeks fore weeks fore Wenlings wening Arrivl Fttening clves Slughter weeks

8 Bovilis. The one for ll. Here s why: Unique combintion virl bcteril ntigens Double djuvnt system IRP technology Erly vccintion (from weeks ge) Efficcious in presence MDA Sfe in pregnnt lctting nimls Comptibility Bovilis IBR Mrker Live Bovilis contins per ml dose inctivted: BRS-Virus, strin EV9.. TCID ; Prinfluenz- -Virus, strin SF- Reisinger.. TCID ; Mnnheimi (Psteurell) hemolytic A, strin M/ 9 x 9 cells. Indicted for use in cttle for ctive immunistion ginst Prinfluenz--Virus, Bovine Respirry Syncytil Virus, Mnnheimi (Psteurell) hemolytic. Contrindictions, wrnings precutions: Do not vccinte nimls tht hve intercurrent disese, hevy prsitic infesttion or re in poor generl condition, since stisfcry immune response only obtined in helthy immuno-competent nimls. The bsic immunistion should strted in time, so tht immunity hs fully developed by ginning period risk. The bsic immunistion clves should completed prior housing or should performed in housing unit under qurntine. It is dvisble vccinte ll nimls in herd in order minimise infectious potentil unless re is contrindiction. Filure vccinte individul nimls my promote trnsmission pthogens development disese. The mgnitude ntibody response my reduced by mternlly derived ntibodies in clves up six weeks ge. However, ccording results chllenge experiments, significnt protection ginst infection by BRS-Virus is still provided three weeks fter bsic vccintion course, significnt protection ginst PI--Virus Mnnheimi (Psteurell) hemolytic serotype A is still provided six weeks fter bsic vccintion course. The results chllenge experiments in clves mternlly derived ntibodies furr indicte tht onset cross protective immunity A serotype is weeks fter completion vccintion course. Cross protective immunity is provided up six weeks fter bsic vccintion course s demonstrted by serologicl tests. Respirry infections in clves re ten ssocited poor hygiene. Thus, generl improvements in hygiene re importnt support effect vccintion. User wrnings: In cse ccidentl self-injection seek medicl dvice immeditely show pckge insert or ll physicin. Adverse rections: Immunistion my result in temporry ings t injection site (in extreme cses nrrow ings up cm long my occur). Typiclly, se ings completely dispper or reduce in size negligible smll lump in weeks fter vccintion, though in individul nimls very smll rections cn found for up months. Additionlly, trnsient slight rise in body temperture, lsting mximum dys, my occur fter vccintion t sme time slight reluctnce move my found. Occsionl hypersensitivity rections my occur. Pregnncy, lcttion: The vccine proved sfe during use in pregnncy lcttion. Interctions: Sfety efficcy dt re vilble which demonstrte tht vccine cn dministered on sme dy but not mixed Bovilis IBR Mrker Live vccine (where product is uthorised) in cttle from weeks ge onwrds. No informtion is vilble on sfety efficcy vccine when used ny or veterinry medicinl product except product mentioned bove. A decision use vccine fore or fter ny or veterinry medicinl product refore needs mde on cse by cse bsis. Immunosuppressive drugs should generlly not used directly fore or fter vccintion, since stisfcry immune response only obtined in immuno-competent nimls. Overdose: Accidentl overdosge is unlikely cuse ny rection or thn descrid under dverse rections, however ing my lrger temperture rise my higher. Incomptibilities: Do not mix ny or vccine or immunologicl product. Srge: Sre in refrigerr ( C - C). Protect from light frost. Withdrwl period: Zero dys. Ech ml dose reconstituted Bovilis IBR Mrker Live vccine contins: BHV-, strin GK/D (ge - ):. -. TCID. Legl ctegory for Bovilis Bovilis IBR Mrker Live: ROI POM(E) NI POM-V Use Medicines Responsibly References:. Donchie W., (), The development vccines contining iron-regulted proteins (IRP s) Mnnheimi (Psteurell) hemolytic for control psteurellosis in cttle. Proceedings WBC, Hnnover.. Burrows M.R. ors (99), The efficcy bovine respirry vccine (Bovigrip New/ ) ginst BRSV Pi experimentl infection in clves. HRVet IAH.. Mkoschey B. ors (), Comprehensive protection ginst ll importnt primry pthogens in bovine respirry disese complex by combintion two vccines. Der Prktische Tierrzt, 9-.. Donnchie W. ors (), Protection fforded by Bovilis Bovigrip/ ginst chllenge Mnnheimi hemolytic A. Proceedings WBC, Nice.. Mkoschey B. ors (), Field efficcy combintion vccines ginst bovine respirry pthogens in clves. Act Veterinri Hungric (), pp.-9. R- Furr informtion is vilble from your prescrir or: MSD Animl Helth, Red Ok North, South County Business Prk, Leoprdswn, Dublin, Irel Tel: +()-9 E-Mil: vet-support.ie@merck.com Web: