Curriculum vitae. Formal name change June 2003 from Arne Hensten-Pettersen to Arne Hensten

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1 Curriculum vitae Hensten, Arne Male Formal name change June 2003 from Arne Hensten-Pettersen to Arne Hensten Norwegian Overall Scientific Expertise My main research area is safety used in dentistry. This includes in vitro cell culture studies, animal studies and clinical consultation with patients and professionals who complain of adverse reactions to dental biomaterials. This has resulted in more than 200 publications in international scientific journals. Most of my research has been performed at NIOM, Nordic Institute of Dental Materials, which is a resource centre for the Departments of Health of the five Nordic countries (Denmark, Finland, Iceland,, Sweden) in all aspects of the quality, safety and efficacy of dental biomaterials. Professional experience Years employed from - to Title of position Employer name and location present Professor University of Tromsø, Faculty of Health Sciences, Institute of clinical dentistry, Tromsø, 2003 present Senior consultant NIOM AS, Nordic institute of dental materials, Oslo, Chairman of the Board of Directors Nordic Dental Certification, Haslum, Area of professional specialization Develop new dental school, plan, equip and staff a clinical training facility for 120 students International standardisation activities, especially related to biological Notified Body for used in dentistry, (Notified Body number 0510) Director NIOM, Management

2 Scandinavian institute of dental materials, Haslum, Head NIOM Certification, Haslum, Head NIOM, Biological / clinical division Scientist/ Senior scientist NIOM, Biological / clinical division 1976 Visiting scientist Department of biomaterials, University of Alabama in Birmingham, Birmingham, Alabama, USA Research associate Department of microbiology, Dental Faculty, University or Oslo, Notified Body for used in dentistry, (Notified Body number 0510) Biological Biological Biological Research on human and primate salivary proteins and mucosubstances. Other professional activities Part-time dental private practice, Oslo Part-time clinical instructor in prosthodontics, periodontics, oral diagnosis, Dental Faculty, University of Oslo, General dentist in public practice, Røsvik, Sørfold, Lieutenant/dentist, Norwegian Army & Airforce, Bardufoss, Educational background Year Degree awarded Educational institution Area of educational specialization 1965 Cand. Odont. Dental Faculty, University of Oslo, License to practice as dentist 1968 Diploma Dental Faculty, University of Oslo, 1 year formal research education in biological sciences, including

3 chemistry, cytobiology, histology, zoophysiology, anthropology, statistics, genetics, pathology, husbandry of research animals Lic. Odont. Dental Faculty, University of Oslo, 1976 Dr. odont. Dental Faculty, University of Oslo, 1998 Odont.dr.h.c. Faculty of odontology, University of Lund, Sweden Biochemistry of salivary proteins Biochemistry of human and primate salivary mucosubstances Honorary Other educational activities 1975: International Symposium on Chemical Toxicity in Man, University of Surrey, Guildford, UK 1977: Nordic Council Scientific Training Course in Toxicology, Oslo. 1985: Department of Health and Social Security (Sweden). Training seminar for resource persons for referral of patients with health problems related to dental materials. 1990: Safety, Amsterdam Training programs for developing quality assurance systems in laboratories - related to developing intramural quality system according to EN 45001: General criteria for the operation of testing laboratory, for which NIOM was accredited by Norwegian Accreditation in : CEN-Healthcare Sector Training Seminar: How to write standards, Brussels 1992: Implant Retrieval Symposium, Society for Biomaterials, St. Charles, Illinois 1992: Biological, Material and Mechanical Considerations for Joint Replacement: Current Concepts and Future Direction, Bristol-Myers Squibb/Zimmer Orthopedic Research Symposium, San Antonio, Texas. 1994: Interpreting the Medical Device Directive, Brussels ISO 9001 Course, Det norske Veritas, Oslo Activities in Scientific Advisory Bodies/Committees/Panels : Member, Scientific Committee on medicinal products and medical devices. European Commission, DG SANCO (Health and Consumer protection) 1985: Biocompatibility, Toxicity and Hypersensitivity to Alloy Systems Used in Dentistry. International Workshop. Ann Arbor, Michigan 1991: Symposium on Esthetic Restorative Materials, American Dental Association, Chicago.

4 1991: Effects and Side Effects of Dental Restorative materials. National Institute of Health (USA): Technology Assessment Conference at National Institute of Dental Research, Bethesda, Maryland. 1995: Alternatives to the Animal Testing of Medical Devices. ECVAM Workshop 17, Copenhagen. ECVAM - European Centre for the Validation of Alternative Methods : Delegate from Notified Body Meeting Group as expert in EEA ad hoc working group on the dental amalgam. A Draft report was presented in : Dental Filling Materials: Hazards to patients and the environment? Central European Division/Scandinavian Division Symposium, Berlin. 1997: Expert delegate to World Health Organization (WHO) Consultation on "Dental Amalgam and its Alternatives", Geneva. Developed a revised WHO consensus statement International Conference on Human Health Effects of Mercury Exposure. Torshavn, Faeroe Islands. 1998: Invited expert at the Swedish Research Council seminar series: Dental amalgam and health risks 1999: International Agency for Research on Cancer (IARC, Lyon): Invited as expert and leader of working group for IARC Monograph # 74: Surgical implants and other foreign bodies 2000: Carious lesions. Management alternatives. Medical University of South Carolina, College of Dental Medicine : Expert member of working group for SCENIHR s Opinion on the safety of dental amalgam and alternative dental restoration materials for patients and users : Expert member for the Swedish Board of Health in developing guidelines for dental treatment modalities Membership in professional organisations International Association for Dental Research (IADR) Norwegian Dental Association (NTF) Norwegian Society for Pharmacology and Toxicology (NSFT)

5 Scandinavian Society for Immunology (SSI) Society for Biomaterials (SFB) Member of editorial board Journal of biomedical materials research Activities in international standardisation I participate in the standardization activities of CEN/TC 55, Dentistry and CEN/TC 206, Biocompatibility of, and in the international counterparts: ISO/TC 106 Dentistry and ISO/TC 194: Biological. I am convenor of ISO/TC 194, Working Group 10, which is responsible for developing the standard ISO : Biological. Part 6. Tests for local effects after implantation. I am convenor of CEN/TC 55/Working Group 4, which, together with ISO/TC 106/WG 10, has developed ISO 7405 (1997): Pre-clinical medical devices used in dentistry. I have been national delegate to the CEN ABHS (Advisory Board for Heathcare Standards) since it started in 2006, and am at present convenor of ABHS Task Force 9: Traceability of. Selected publications Kallus T, Hensten-Pettersen A & Mjör IA. Tissue response to allergenic leachables from dental materials. J Biomed Mater Res 1983, 17, Brune D, Kjærheim Å, Hensten-Pettersen A. & Marion L. Corrosion of dental alloys studied by implantation and nuclear tracer technique. Acta Odontol Scand 1983, 41, Hensten-Pettersen, A., Ørstavik, D. & Wennberg, A. Allergenic potential of endodontic sealers. Endod Dent Traumatol 1985, 1, 61-5 Syrjänen S, Hensten-Pettersen A. & Nilner K. In vitro testing of dental materials by means of macrophage cultures. II: Effects of particulate dental amalgams and their constituent phases on cultured macrophages. J Biomed Mater Res 1986, 20, Hensten-Pettersen, A.: Replacement of restorations based on material allergies, In: Quality Evaluation of Dental Restorations. Criteria for Placement and Replacement K.J. Anusavice, ed., Quintessence Publ. Co., Inc. 1989, Chicago, London, Berlin, Sao Paulo, Hong Kong, and Tokyo, pp Kerosuo H, Kullaa, A, Kerosuo E, Kanerva L, Hensten-Pettersen A: Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears, Amer J Orthodont Dentofac Orthop, 1996, 109,

6 Schedle A, Örtengren UT, Eidler N, Gabauer M, Hensten A. Do adverse effects of dental materials exist? What are the consequences, and how can they be diagnosed and treated? Clinical Oral Implants Research 2007,

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