Inpatient Consultative Dermatology and Severe Cutaneous Adverse Reactions

Transcription

1 Inpatient Consultative Dermatology and Severe Cutaneous Adverse Reactions Jeremy A. Schneider, MD Assistant Clinical Professor UC San Diego Department of Dermatology

2 Objectives Brief overview of some of the most severe dermatologic conditions encountered in the inpatient setting, with a focus on DRESS/DIHS and SJS/TEN Summarize the current data regarding the management of severe cutaneous adverse reactions

3 Nightmare Fuel* *not even close to comprehensive Infectious Necrotizing fasciitis Echthyma gangrenosum Purpura fulminans, meningoccocemia Rickettsial disease (e.g. RMSF) Toxic shock syndrome Drug reactions Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia and systemic symptoms (DRESS) Immune reactions Graft-versus-host disease Kawasaki disease (yes, even in adults) Malignancy Sezary syndrome/ctcl Erythroderma (any etiology)

4 Case 1 62 yo M with h/o PMR presented to OSH with sepsis, neutropenia started on cefepime and tobramycin; workup for neutropenia (including BMBx) revealed ALL. Transferred for further treatment and workup. Dermatology consulted for skin lesions x 2-3 weeks, began as red flat patches which then formed bullae filled with blood, then black patches with purple borders. No new lesions have developed since beginning antibiotics at OSH. All photos for this case courtesy of David Cotter, MD, PhD

5 Case 1

6 What would the best next step(s) be? A. Biopsy for H&E and tissue culture B. Collect blood cultures C. Begin broad spectrum antimicrobial treatment, including antipseudomonal agent D. Debride necrotic tissue E. Consult orthopedic surgery F. A and B G. B and C H. A, B, and C I. All of the above

7 Echthyma gangrenosum Presentation: painless red macules -> induration -> pustules and/or bullae -> gangrenous ulcers (rapid progression hours); most common sites: anogenital, axillary sites Pathophysiology: perivascular bacterial invasion of media and adventitia of arteries and veins, resulting in ischemic necrosis P. aeruginosa most common but other organisms described, including (but not limited to): P. stutzeri, Aeromonas spp, Stenotrophomonas spp, Citrobacter spp, MRSA, atypical mycobacteria, Fusarium spp, Candida spp

8 Echthyma gangrenosum Evaluation: Prompt collection of blood cultures Culture of exudates from aspirate or swab of lesions If above are negative, biopsy for tissue culture (bacterial, fungal, mycobacterial) can help exclude other etiologies Management Empiric antimicrobial coverage including agent with antipseudomonal activity; tailor to culture results Severe/extensive necrosis may require debridement +/- skin grafting

9 Case 2 42 yo M with HTN, IDDM2, gout presents to Dermatology clinic from PCP visit for rash. Initiated on allopurinol for gout 4 weeks PTA; 2 weeks PTA, developed bumps on face, then itchy pink-red rash on trunk. ROS notable for subjective fevers at home. Meds: HCTZ, lisinopril, metoprolol, spironolactone, saxagliptin, metformin, glargine, atorvastatin, allopurinol Exam: as depicted; also with facial swelling, diffuse lymphadenopathy All photos for this case courtesy of Keith Roby, MD

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11 What would be the next best step(s)? A. Check CBC with manual diff B. Check CMP including LFTs C. Pulmonary imaging (CXR or CT chest) D. EKG and echocardiogram, serum troponins E. Check a thyroid panel F. Check a CK G. Start IVIG H. Start high dose systemic corticosteroids I. All of the above except G J. All of the above except H

12 Day 3

13 Drug-induced hypersensitivity syndrome AKA Drug reaction with eosinophilia and systemic symptoms (DRESS) Rash, fever, malaise, lymphadenopathy, facial edema, hematologic abnormalities (eosinophilia, atypical lymphocytes), lymphadenopathy, liver, kidney, and/or lung involvement Long latency between exposure and onset (2-8 weeks) Strong activation of drug-specific T cells (CD8, CD4 and T-regs); role of viral reactivation unclear (cause or effect?) but frequent (HHV-6, HHV-7, EBV, CMV)

14 Score Min Max Fever>/=38.5 C No/U Yes -1 0 Enlarged lymph nodes No/U Yes 0 1 Eosinophilia if leukocytes>4000 No/U /uL >/= 1500/uL 0 2 Eosinophilia if leukocytes < % >/= 20% 0 2 Atypical lymphocytes No/U Yes 0 1 Skin involvement -2 2 Rash >50% No/U Yes Rash suggesting DRESS No U Yes Biopsy suggesting DRESS No Yes/U Organ involvement 0 2 Liver No/U Yes Kidney No/U Yes Lung No/U Yes Muscle/heart No/U Yes Pancreas No/U Yes Other organ(s) No/U Yes Resolution >/=15 days No/U Yes -1 0 Evalutation other potential causes 0 1 ANA Blood culture Serology for HAV/HBV/HCV Chlamydia-/Mycoplasma pneumoniae Other serology/pcr If none positive and 3 or more negative TOTAL SCORE -4 9 <2: no case; 2-3: possible; 4-5: probable; >5: definite Yes Table adapted from Kardaun et al

15 DIHS/DRESS Management Withdrawal of offending drug (and any nonessential medications) Without systemic involvement or LFT elevation < 3 times ULN can treat symptoms with high or super high potency topical corticosteroids Patients with severe hepatitis should be promptly referred to hepatologist as may evolve to ALF requiring transplantation Severe interstitial nephritis or interstitial pneumonia, prednisone 0.5 to 2 mg/kg per day until clinical improvement/normalization of laboratory parameters; SLOW taper over 8-12 weeks

16 Case 3 66 yo F with multiple myeloma and NHL s/p R-CHOP x 6 cycles (completed 6 months PTA) and autologous SCT (1 month PTA) admitted for cough, nausea, decreased oral intake, and fever.started treatment for CT finding of atypical PNA v aspiration. Dermatology consulted for progressive rash 1 week into admission. Patient and family report that, since admission, developed conjunctival injection followed by peeling skin on chest, shoulders, and then upper thighs. No oral or genital mucosal involvement.

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18 What is your next step? A. Create medication timeline and discontinue culprit and nonessential medications B. Check quantitative immunoglobulins and initiate IVIG therapy C. Start cyclosporine therapy D. Check quantiferon TB test and start TNF-alpha inhibitor E. Start high dose corticosteroids F. A and B G. A and C H. A and D I. A and E J. A and adjunctive therapy will depend on patient s comorbidities and relative/absolute contraindications to individual therapeutic options

19 Med timeline: Fluconazole (started 3 months prior to rash) Acyclovir (2.5 weeks prior to rash) Sulfamethoxazole-trimethoprim (2.5 weeks prior to rash) Azithromycin (3 weeks prior to rash) Vancomycin (1-3 days prior to rash) Cefepime (1-3 days prior to rash) Ciprofloxacin (1 month prior to rash) Moxifloxacin (started after rash)

20 Table from Schneider JA and Cohen PR. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Concise Review with a Comprehensive Summary of Therapeutic Interventions Emphasizing Supportive Measures

21 Lessons learned Echthyma gangrenosum, while typically associated with Pseudomonas, can be caused by multiple other infectious agents Severity of erythema may be underestimated in skin of color DRESS/DIHS may progress to exfoliative and bullous lesions, which may create diagnostic confusion SCORTEN is most accurate on hospital days 1 and 3 Evidence-based management for severe cutaneous adverse reactions continues to evolve supportive care differs from that of burn patients with same BSA adjunctive therapy should be tailored based on patient s comorbidities/risk factors

22 Acknowledgements

23 References Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med. 2008;14(12): Downey A, Jackson C, Harun N, Cooper A. Toxic epidermal necrolysis: review of pathogenesis and management. J Am Acad Dermatol. 2012;66: Guegan S, Bastuji-Garin S, Poszepczynska-Guigne E, Roujeau JC, Revuz J. Performance of the SCORTEN during the first five days of hospitalization to predict the prognosis of epidermal necrolysis. J Invest Dermatol. 2006;126(2): Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: Part I. Clinical perspectives. Journal of the American Academy of Dermatology May 31;68(5):693-e1. Hazin R, Ibrahimi OA, Hazin MI, Kimyai-Asadi A. Stevens-Johnson syndrome: pathogenesis diagnosis, and management. Ann Med. 2008;40: Huang YC, Li YC, Chen TJ. The efficacy of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: a systematic review and meta-analysis. Br J Dermatol Aug;167(2): Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: Part II. Management and therapeutics. Journal of the American Academy of Dermatology May 31;68(5):709-e1. Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?. British Journal of Dermatology Mar 1;156(3): Kardaun SH, Mockenhaupt M, Roujeau JC. Comments on: DRESS syndrome. Journal of the American Academy of Dermatology Nov 1;71(5): Kirchhof MG, Miliszewski MA, Sikora S, Papp A, Dutz JP. Retrospective review of Stevens-Johnson syndrome/toxic epidermal necrolysis treatment comparing intravenous immunoglobulin with cyclosporine. J Am Acad Dermatol. 2014;71(5):941. Kumar P and Kanti Das, N. Cyclosporine in toxic epidermal necrolysis: a brief review of the emerging therapeutic modality. Dermatol Online J. 2016;22(10).

24 References (continued) Lee HY, Fook-Chong S, Koh HY, Thirumoorthy T, Pang SM. Cyclosporine treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis: Retrospective analysis of a cohort treated in a specialized referral center. J Am Acad Dermatol Jan;76(1): Lee HY, Lim YL, Thirumoorthy T, Pang SM. The role of intravenous immunoglobulin in toxic epidermal necrolysis: a retrospective analysis of 64 patients managed in a specialized centre. Br J Dermatol Dec;169(6): Mayes T, Gottschlich M, Khoury J, Warner P, Kagan R. Energy requirements of pediatric patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. Nutr Clin Pract. 2008;23(5):547. Roujeau JC, Bastuji-Garin S. Systematic review of treatments for Stevens-Johnson syndrome and toxic epidermal necrolysis using the SCORTEN score as a tool for evaluating mortality. Ther Adv Drug Saf. 2011;2(3):87. Sassolas B, Haddad C, Mockenhaupt M, Dunant A, Liss Y, Bork K, Haustein UF, Vieluf D, Roujeau JC, Le Louet H. ALDEN, an algorithm for assessment of drug causality in Stevens Johnson syndrome and toxic epidermal necrolysis: comparison with case control analysis. Clinical Pharmacology&Therapeutics Jul 1;88(1):60-8. Schneck J, Fagot JP, Sekula P, Sassolas B, Roujeau JC, Mockenhaupt M. Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective study on patients included in the prospective EuroSCAR Study. J Am Acad Dermatol. 2008;58(1):33. Schneider JA, Cohen PR. Stevens-Johnson syndrome and toxic epidermal necrolysis: a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures. Advances in therapy Jun 1;34(6): Shiga S, Cartotto R. What are the fluid requirements in toxic epidermal necrolysis? J Burn Care Res. 2010;31(1): Valeyrie-Allanore L, Wolkenstein P, Brochard L, Ortonne N, Maître B, Revuz J, Bagot M, Roujeau JC. Open trial of ciclosporin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis. Br J Dermatol. 2010;163(4):847. Wojtkiewicz A, Wysocki M, Fortuna J, Chrupek M, Matczuk M, Koltan A. Beneficial and rapid effect of infliximab on the course of toxic epidermal necrolysis. Acta Derm Venereol. 2008;88(4): Zárate-Correa LC, Carrillo-Gómez DC, Ramírez-Escobar AF, Serrano-Reyes C. Toxic epidermal necrolysis successfully treated with infliximab.