Section Title. Subject Index
|
|
- Griffin Tyler
- 5 years ago
- Views:
Transcription
1 Section Title Subject Index Acute kidney injury definitions hypoxia 287, 290 overview 286, 287 sublethal tubular injury adaptive responses 292, 293 combination of sublethal injuries 291, 292 detection morphology 289 resistance to further injury 292, 293 tubular necrosis 287, 288 Acute serum sickness, infection-related glomerulonephritis 154, 155 Acute tubular interstitial nephritis, see Tubular interstitial nephritis Aging, renal microvasculature injury 65, 66 Alport syndrome, collagen type IV mutations 176, 177 Amyloidosis amyloid light chain amyloidosis 241, 242 history of study renal amyloidosis diagnosis pathogenesis studies prospects for study 242, 243 Anemia, proximal tubule dysfunction 47 Angiopoietin, glomerular endothelial cell development role 60 Antineutrophil cytoplasmic autoantibodies antimyeloperoxidase induction of glomerulonephritis and vasculitis complement activation in glomerulonephritis induction 216 cytokine and infection mediation 215, 216 Fcγ receptor role 216, 217 genetic control 217, 218 immunoglobulin and lymphocyte transfer studies 213, 214 neutrophils in induction 214, 215 prospects for study 218, 219 antigen types 212 glomerulonephritis types 211 vasculitis role 211, 212 Apoptosis acute kidney injury 289 mesangial cells 16 tubular interstitial nephritis 305, 306 Apoptosis signal-regulating kinase-1, membranous nephropathy role 115, 116 Arteriosclerosis, animals 335 Asialoglycoprotein receptors, clearance of immunoglobulin A and complexes from circulation 135, 137 Atherosclerosis, hypertension association 332 BAFF, lupus nephritis role 191, 192 B cell immunoglobulin A nephropathy and turnover alterations 130 lupus nephritis and hyperactivity Bone morphogenetic protein-4, glomerular endothelial cell development role 61 Bowman s capsule, see Parietal epithelial cell Calcineurin inhibitors, tubular interstitial nephritis induction
2 Cast nephropathy, light chain-mediated tubulopathies CD89, clearance of immunoglobulin A and complexes from circulation 137 CHEB mouse, Fanconi syndrome 254, 255 Chronic tubular interstitial nephritis, see Tubular interstitial nephritis Collagen type IV genes 176 mutations Alport syndrome 176, 177 hereditary angiopathy with nephropathy, aneurysms and cramps 178 structure 176 Collapsing glomerulopathy, see also Human immunodeficiency virus-associated nephropathy models parietal epithelial cell role 28, 32 podocyte role Complement activation pathways 204 antimyeloperoxidase induction of glomerulonephritis and vasculitis role 216 co-deposits in immunoglobulin A nephropathy 138, 139 lupus nephritis role 190 membranoproliferative glomerulonephritis models with complement factor H deficiency mice pigs membranous nephropathy role C5b-9 effects on podocytes 112, 113, 117 filtration slit diaphragm effects 117, 118 overview 111, 112 CXCR3, lupus nephritis role 192 Cystinuria, proximal tubule dysfunction 44, 45 Dent s disease, proximal tubule dysfunction 42, 43 Diabetic nephropathy gene discovery in animal models differential display reverse transcriptionpolymerase chain reaction 166 DNA microarray 167 findings prospects for study 171 proteomics 167, 168 serial analysis of gene expression 166, 167 single nucleotide polymorphism-based genome-wide screening 164, 165 transcriptomics 165, 166 signaling in pathogenesis sublethal tubular injury 291, 292 Differential display reverse transcriptionpolymerase chain reaction, diabetic nephropathy gene discovery 166 DNA microarray, diabetic nephropathy gene discovery 167 DNAse I, lupus nephritis role 189 Eicosanoids, immunoglobulin A nephropathy role 141 Endocarditis, infection-related glomerulonephritis 157, 158 Endoplasmic reticulum, injury and stress in membranous nephropathy Epithelial-mesenchymal transition interstitial fibrosis proximal tubule and disease 47 tubular interstitial nephritis 304, 305 Essential hypertension, see Hypertension Extracellular matrix accumulation pathophysiology in monoclonal immunoglobulin deposition disease 227, 228 degradation in tubular interstitial nephritis 303 deposition in urinary obstruction 315 mesangium 8, 10 turnover in membranous nephropathy 119 Fanconi syndrome associated conditions 248 models endocytosis defects in mouse models light chain-associated models 252, 253 overview transgenic animal development proximal tubule dysfunction 38, 39, 247, 248 Subject Index 365
3 Fcγ receptor antimyeloperoxidase induction of glomerulonephritis and vasculitis role 216, 217 lupus nephritis role 190 Fibroblast-specific protein-1, epithelialmesenchymal transition marker in interstitial fibrosis 83, 84 Fibrosis, see Interstitial fibrosis Focal segmental glomerulosclerosis, see also Idiopathic nephrotic syndrome collapsing glomerulopathy parietal epithelial cell role 28, 30 GLEPP-1, podocyte markers 278, 279 Glomerular basement membrane expansion in membranous nephropathy 119 protein mutations in disease collagen type IV laminin 178, 179 LMX1B 179 overview 175 TREX1 179 Glomerular endothelial cell endothelial fenestrations functional overview 51, 52 glomerular development overview 53 origins 52, 53 signaling pathways in development angiopoietin 60 bone morphogenetic protein-4 61 chemokines 61 Notch 60, 61 overview 56, 57 transforming growth factor-β 59, 60 vascular endothelial growth factor Glomerulonephritis, see Antineutrophil cytoplasmic autoantibodies, Infection-related glomerulonephritis, Membranoproliferative glomerulonephritis Heavy chain deposition disease, see Monoclonal immunoglobulin deposition disease Hereditary angiopathy with nephropathy, aneurysms and cramps, collagen type IV mutations 178 Hereditary endotheliopathy with retinopathy, nephropathy and stroke, TREX1 mutation 179 Human immunodeficiency virus-associated nephropathy collapsing glomerulopathy models podocyte role epidemiology 271 focal segmental glomerulosclerosis models overview transgenic mice parietal epithelial cell role 28, 30, 31 pathogenesis 272, 273 pathology 271, 272 Hypertension, renal vasculature changes in essential hypertension arteriole hyalinization 329, 335 arteriosclerosis in animals 335 atherosclerosis 332 mean arterial pressure versus arterial intimal fibroplasia 330, 333, 334 preeclampsia and renal microvasculature injury 62, 63 resistance artery remodeling 327, 328 smooth muscle cell hypertrophy and proliferation 327, 328 type 2 hypertension progression 331 Hypophosphatemia, proximal tubule dysfunction 40, 41 Hypoxia acute kidney injury 287, 290, 293 tubular interstitial nephritis role 305, 307 Hypoxia-inducible factor, activation in sublethal tubular injury 290, 293 Idiopathic nephrotic syndrome cytokine profile 95, 96 minimal change nephrotic syndrome activation marker downregulation in remission 101 innate immunity in pathogenesis 100, 101 podocyte mimicry of immune cell signaling 101, 102 T cell signaling Subject Index
4 permeability factor studies 96 podocyte structure and function changes 101, 102 types 94, 95 Immunization, immunoglobulin A nephropathy role mucosal immunization 127, 129 systemic immunization 129, 130 Immunoglobulin A nephropathy clearance of immunoglobulin A and complexes from circulation asialoglycoprotein receptors 135, 137 Fc region receptors 137 mononuclear phagocytes 136 polymeric immunoglobulin receptors 137 secondary immunoglobulin A nephropathy models 135, 136 co-deposits glomerular responses and hemodynamic factors 140 immunoglobulin A affinities circulating macromolecules 134, 135 glomerular components 134 glycosylation in pathogenesis 144 physicochemical properties 133, 134 sources B cell turnover alterations 130 immunodeficiency states with autoimmunity and hypergammaglobulinemia 131, 132 mucosal immunization 127, 129 polyclonal activation and dysregulated production 130, 131 promoting factors 128 systemic immunization 129, 130 T cell regulation and cytokine polarity 132, 133 mediators eicosanoids 141 growth factors and cytokines miscellaneous mediators 143, 144 reactive oxygen and nitrogen species 141 model systems 126, 127 species differences 144, 145 treatment prospects 145 Infection-related glomerulonephritis staphylococcal disease 158, 159 streptococcal disease Interleukin-6, immunoglobulin A nephropathy role 142 Interleukin-21, lupus nephritis role 193 Interstitial fibrosis experimental models mechanisms adventitial fibroblasts 80 epithelial-mesenchymal transition extrarenal fibrocytes 80, 81 myofibroblast origins 79 overview 75, 79 resident fibroblasts 79, 80 Ischemia, renal microvasculature injury in chronic renal disease 64, 65 Kidney transplantation, glomerular endothelial cells in rejection acute antibody-mediated rejection 66, 67 chronic active antibody-mediated rejection and transplant glomerulopathy 67, 68 Laminin, mutation in Pierson syndrome 178, 179 Light chain deposition disease, see Fanconi syndrome, Light chain-mediated tubulopathies, Monoclonal immunoglobulin deposition disease Light chain-mediated tubulopathies cast nephropathy epithelial cell cytotoxicity 263 proximal tubular epithelial cell activation 263, 264 renal handling of light chains 262, 263 LMX1B, mutation in nail-patella syndrome 179 Lupus nephritis B cell hyperactivity cytokines in progression 192, 193 drug induction 184 epidemiology 183, 184 histopathology 184 models pathogenesis lessons from experimental studies and transgenic animals Subject Index 367
5 spontaneous models BXSB mouse 187 genetic dissection 187, 188 graft-versus-host disease mouse 187 MRL/Lpr mouse 186, 187 NZB/NZW mouse 185, 186 pathogenic factors 184, 185 T cell function 192 Macrophage migration inhibitory factor, immunoglobulin A nephropathy role 143 Magnetic resonance imaging, sublethal tubular injury detection 290, 291 MAMP-2, see Antineutrophil cytoplasmic autoantibodies Matrix metalloproteinases, mesangial function 11, Mean arterial pressure, see Hypertension Megalin, membranous nephropathy role 109 Membranoproliferative glomerulonephritis definition 198 models complement factor H deficiency mice pigs cryoglobulinemic models 200 experimental models 203 immunoglobulin G3 monoclonal hybridoma induction in mice 201, 202 spontaneous models 199 thymic stromal lymphopoietin transgenic mouse 200, 201 variants 198, 199 Membranous nephropathy, see also Idiopathic nephrotic syndrome apoptosis signal-regulating kinase-1 role 115, 116 complement role C5b-9 effects on podocytes 112, 113, 117 filtration slit diaphragm effects 117, 118 overview 111, 112 endoplasmic reticulum injury and stress experimental models extracellular matrix turnover and glomerular basement membrane expansion 119 nephritogenic antigens and immune deposit formation oxidative stress 115 pathogenesis 107, 108 phospholipase A 2 role 113 transcription factors and growth factor signaling 116, 117 treatment prospects 118, 120 Mesangium amyloidosis 11 cells apoptosis 16 proliferation 10, 11 types 7, 8 extracellular matrix 8, 10 function 6 glomerular interactions 16, 17 growth factor receptors 9 homeostasis regulators growth factors/cytokines matrix metalloproteinases 11, integrin function 11, 12 mesangiolysis 6 normal features 7 9 prospects for study 18, 19 proteomics 17, 18 sclerosis 11 tenascin in nodular glomerulosclerosis 12 Methicillin-resistant Staphylococcus aureus, infection-related glomerulonephritis 158 Microvasculature, see also Glomerular endothelial cell injury in renal disease aging 65, 66 ischemia in chronic renal disease 64, 65 preeclampsia 62, 63 peritubular cell endothelium 61, 62 Minimal change nephrotic syndrome, see Idiopathic nephrotic syndrome MIOX, diabetic nephropathy role 168 Mitogen-activated protein kinase, glomerular disease signaling 46, 47 Monoclonal immunoglobulin deposition disease clinical features 224, 225 extracellular matrix accumulation pathophysiology 227, 228 forms Subject Index
6 immunoglobulin chain structure heavy chain domain deletions 227 light chain structure and glycosylation 226, 227 overview 225, 226 immunohistology 223, 224 light chain-mediated damage, see Light chain-mediated tubulopathies microscopy findings electron microscopy 224 light microscopy 222, 223 overview 221, 222 therapeutic prospects Multiple myeloma, tubular interstitial nephritis association 301 Myeloperoxidase, see Antineutrophil cytoplasmic autoantibodies Nail-patella syndrome, LMX1B mutation 179 Nephrotic syndrome, see Idiopathic nephrotic syndrome Nitric oxide, mesangial function 14 Notch, glomerular endothelial cell development role 60, 61 Nuclear factor-κb, nephrotic syndrome pathophysiology 98, 99, 102 Obstructive nephropathy, see Urinary obstruction Oxidative stress diabetic nephropathy 163, 164 immunoglobulin A nephropathy 141 membranous nephropathy 115 tubular interstitial nephritis 305 Parietal epithelial cell development history of study 23 markers 25 renal injury response in disease renal progenitor niche function Peritubular cell, endothelium 61, 62 Phospholipase A 2, membranous nephropathy role 113 Pierson syndrome, laminin mutation 178, 179 Pimonidazole, sublethal tubular injury detection 289 Platelet-derived growth factor immunoglobulin A nephropathy role 141, 142 mesangial function 9 13 Podocyte C5b-9 effects in membranous nephropathy collapsing glomerulopathy role nephrotic syndrome minimal change nephrotic syndrome role 101, 102 structure and function changes 101, 102 Preeclampsia, renal microvasculature injury 62, 63 Proteinase-3, see Antineutrophil cytoplasmic autoantibodies Proteinuria, tubular interstitial nephritis 306, 307 Proximal tubule anemia and mineral-bone disorder of chronic kidney disease 47 disorders amino acid transport disorders 44, 45 chloride channel diseases 42, 43 Fanconi syndrome 38, 39, 247, 248 fluid and electrolyte transporter dysfunction 38 hypophosphatemia 40, 41 renal glucosuria 39, 40 renal tubular acidosis 43, 44 epithelial-mesenchymal transition and disease 47 function 37 glomerular disease role 46, 47 light chain-mediated damage, see Light chain-mediated tubulopathies sublethal tubular injury adaptive responses 292, 293 combination of sublethal injuries 291, 292 detection morphology 289 resistance to further injury 292, 293 tubular interstitial nephritis, see Tubular interstitial nephritis urinary obstruction changes Reactive oxygen species, see Oxidative stress Renal amyloidosis, see Amyloidosis Renal Fanconi syndrome, see Fanconi syndrome Subject Index 369
7 Renal glucosuria, proximal tubule dysfunction 39, 40 Renal interstitial fibrosis, see Interstitial fibrosis Renal progenitor cell, parietal epithelial cell niche function Renal tubular acidosis, proximal tubule dysfunction 43, 44 Sarcoidosis, tubular interstitial nephritis association 301 Scarlet fever, infection-related glomerulonephritis 153, 154 Serial analysis of gene expression, diabetic nephropathy gene discovery 166, 167 Serum amyloid A, species-specific induction 2, 3 Sjögren s syndrome, tubular interstitial nephritis association 301 Systemic lupus erythematosus genetics in animal models 187, 188 lupus nephritis, see Lupus nephritis tubular interstitial nephritis association 301 Tamm-Horsefall protein, cast nephropathy Tap1b, diabetic nephropathy role 170, 171 Tenascin, nodular glomerulosclerosis 12 T cell lupus nephritis role 192 minimal change nephrotic syndrome podocyte mimicry of immune cell signaling 101, 102 signaling overview regulation and cytokine polarity in immunoglobulin A nephropathy 132, 133 Thymic stromal lymphopoietin, transgenic mouse model of membranoproliferative glomerulonephritis 200, 201 Tim44, diabetic nephropathy role 168, 169 Toll-like receptors innate immunity in minimal change nephrotic syndrome 100, 101 lupus nephritis role 189, 192 Transforming growth factor-β epithelial-mesenchymal transition signaling 47 glomerular endothelial cell development role 59, 60 immunoglobulin A nephropathy role 143 mesangial function 9, 10, 13 Transthyretin, amyloidosis 1, 241, 242 TREX1, mutation in hereditary endotheliopathy with retinopathy, nephropathy and stroke 179 Tubular interstitial nephritis acute tubular interstitial nephritis 298, 299 apoptosis 305, 306 chronic tubular interstitial nephritis analgesic nephropathy 302, 303 associated diseases multiple myeloma 301 sarcoidosis 301 Sjögren s syndrome 301 systemic lupus erythematosus 301 calcineurin inhibitor induction 301 etiology 299, 300 pathogenesis 300 radiation nephritis 301 reflex nephropathy 300 urate nephropathy 301, 302, 306 classification 298 epithelial-mesenchymal transition 304, 305 extracellular matrix degradation 303 hypoxia role 305, 307 inflammatory cell infiltration 303, 304 obstructive nephropathy models, see Urinary obstruction overview 297, 298 oxidative stress role 305 proteinuria 306, 307 renin-angiotensin system activation 305 Tumor necrosis factor-α, immunoglobulin A nephropathy role 143 Urate nephropathy, tubular interstitial nephritis 301, 302, 306 Urinary obstruction renal function 320 renal lesions extracellular matrix deposition 315 glomerular and vascular changes 319 interstitial changes fibroblast increase 315 inflammation Subject Index
8 neonates 320, 321 pathogenesis tubular changes tubular interstitial nephritis models 303, 306, 312 pathogenesis reversibility 321 Vascular endothelial growth factor epithelial-mesenchymal transition signaling 47 glomerular endothelial cell development role mesangial function 9, 14 transplant rejection role acute antibody-mediated rejection 66, 67 chronic active antibody-mediated rejection and transplant glomerulopathy 67, 68 Vasculitis, see Antineutrophil cytoplasmic autoantibodies Subject Index 371
renoprotection therapy goals 208, 209
Subject Index Aldosterone, plasminogen activator inhibitor-1 induction 163, 164, 168 Aminopeptidases angiotensin II processing 64 66, 214 diabetic expression 214, 215 Angiotensin I intrarenal compartmentalization
More informationIndex. electron microscopy, 81 immunofluorescence microscopy, 80 light microscopy, 80 Amyloidosis clinical setting, 185 etiology/pathogenesis,
A Acute antibody-mediated rejection (Acute AMR) clinical features, 203 clinicopathologic correlations, 206 pathogenesis, 205 206 204 205 light microscopy, 203 204 Acute cellular rejection (ACR) clinical
More informationHistopathology: Glomerulonephritis and other renal pathology
Histopathology: Glomerulonephritis and other renal pathology These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you
More informationGlomerular pathology in systemic disease
Glomerular pathology in systemic disease Lecture outline Lupus nephritis Diabetic nephropathy Glomerulonephritis Associated with Bacterial Endocarditis and Other Systemic Infections Henoch-Schonlein Purpura
More informationA clinical syndrome, composed mainly of:
Nephritic syndrome We will discuss: 1)Nephritic syndrome: -Acute postinfectious (poststreptococcal) GN -IgA nephropathy -Hereditary nephritis 2)Rapidly progressive GN (RPGN) A clinical syndrome, composed
More informationOverview of glomerular diseases
Overview of glomerular diseases *Endothelial cells are fenestrated each fenestra: 70-100nm in diameter Contractile, capable of proliferation, makes ECM & releases mediators *Glomerular basement membrane
More informationGlomerular diseases mostly presenting with Nephritic syndrome
Glomerular diseases mostly presenting with Nephritic syndrome 1 The Nephritic Syndrome Pathogenesis: proliferation of the cells in glomeruli & leukocytic infiltrate Injured capillary walls escape of RBCs
More informationGlomerular pathology-2 Nephritic syndrome. Dr. Nisreen Abu Shahin
Glomerular pathology-2 Nephritic syndrome Dr. Nisreen Abu Shahin 1 The Nephritic Syndrome Pathogenesis: inflammation proliferation of the cells in glomeruli & leukocytic infiltrate Injured capillary walls
More informationGlomerular Pathology- 1 Nephrotic Syndrome. Dr. Nisreen Abu Shahin
Glomerular Pathology- 1 Nephrotic Syndrome Dr. Nisreen Abu Shahin The Nephrotic Syndrome a clinical complex resulting from glomerular disease & includes the following: (1) massive proteinuria (3.5 gm /day
More informationYear 2004 Paper one: Questions supplied by Megan
QUESTION 53 Endothelial cell pathology on renal biopsy is most characteristic of which one of the following diagnoses? A. Pre-eclampsia B. Haemolytic uraemic syndrome C. Lupus nephritis D. Immunoglobulin
More informationDr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Plan of attack: Diagnostic approach to the renal biopsy Differential diagnosis of the clinical syndromes of renal disease Microscopy Step
More informationSubject Index. Bcl-2, apoptosis regulation Bone marrow, polymorphonuclear neutrophil release 24, 26
Subject Index A1, apoptosis regulation 217, 218 Adaptive immunity, polymorphonuclear neutrophil role 31 33 Angiogenesis cancer 178 endometrium remodeling 172 HIV Tat induction mechanism 176 inflammatory
More informationINTRODUCTION TO GLOMERULAR DISEASES
INTRODUCTION TO GLOMERULAR DISEASES Goal: to explain the general mechanisms leading to glomerular diseases and to analyze what is known about their relationship to morphologic and clinical manifestations
More informationInteresting case seminar: Native kidneys Case Report:
Interesting case seminar: Native kidneys Case Report: Proximal tubulopathy and light chain deposition disease presented as severe pulmonary hypertension with right-sided cardiac dysfunction and nephrotic
More informationRenal Pathology 1: Glomerulus. With many thanks to Elizabeth Angus PhD for EM photographs
Renal Pathology 1: Glomerulus With many thanks to Elizabeth Angus PhD for EM photographs Anatomy of the Kidney http://www.yalemedicalgroup.org/stw/page.asp?pageid=stw028980 The Nephron http://www.beltina.org/health-dictionary/nephron-function-kidney-definition.html
More information29 Glomerular disease: an overview
29 Glomerular : an overview Renal Extra-renal Neurological changes Clinical syndromes pressure Sore throat (streptococcal) Rash Cardiac valve lesions Hemoptysis Asymptomatic or Acute Glomerulonephritis
More informationMembranoproliferative Glomerulonephritis
Membranoproliferative Glomerulonephritis MPGN is characterizedby alterations in the GBM and mesangium and by proliferation of glomerular cells. 5% to 10% of cases of 1ry nephrotic syndrome in children
More informationApproach to Glomerular Diseases: Clinical Presentation Nephrotic Syndrome Nephritis
GLOMERULONEPHRITIDES Vivette D Agati Jai Radhakrishnan Approach to Glomerular Diseases: Clinical Presentation Nephrotic Syndrome Nephritis Heavy Proteinuria Renal failure Low serum Albumin Hypertension
More informationDr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Present the basic diagnostic features of the commonest conditions causing proteinuria & haematuria Highlight diagnostic pitfalls Nephrotic
More informationΑνάπτυξη Βιοτράπεζας για την Ανίχνευση Πρώιμων Βιοδεικτών σε Ασθενείς με Χρόνια Νεφρική Νόσο
Ανάπτυξη Βιοτράπεζας για την Ανίχνευση Πρώιμων Βιοδεικτών σε Ασθενείς με Χρόνια Νεφρική Νόσο ΔΗΜΗΤΡΙΟΣ Σ. ΓΟΥΜΕΝΟΣ Νεφρολογικό και Μεταμοσχευτικό Κέντρο Πανεπιστημιακό Νοσοκομείο Πατρών Causes of chronic
More informationFIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS
FIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS Guillermo A. Herrera MD Louisiana State University, Shreveport Fibrils in bundles 10-20 nm d Diabetic fibrillosis
More informationMOLECULAR IMMUNOLOGY Manipulation of immune response Autoimmune diseases & the pathogenic mechanism
MOLECULAR IMMUNOLOGY Manipulation of immune response Autoimmune diseases & the pathogenic mechanism SCHMAIEL SHIRDEL CONTENT 2 Introduction Autoimmune diseases Classification Involved components Autoimmune
More informationRENAL HISTOPATHOLOGY
RENAL HISTOPATHOLOGY Peter McCue, M.D. Department of Pathology, Anatomy & Cell Biology Sidney Kimmel Medical College There are no conflicts of interest. 1 Goals and Objectives! Goals Provide introduction
More informationDr Ian Roberts Oxford
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Present the basic diagnostic features of the commonest conditions causing renal failure Highlight diagnostic pitfalls. Crescentic GN: renal
More informationPATTERNS OF RENAL INJURY
PATTERNS OF RENAL INJURY Normal glomerulus podocyte Glomerular capillaries electron micrograph THE CLINICAL SYNDROMES 1. The Nephrotic Syndrome 2. The Acute Nephritic Syndrome 3. Rapidly Progressive Glomerulonephritis
More informationInterpretation of Renal Transplant Biopsy. Arthur H. Cohen Wake Forest University School of Medicine Winston-Salem, North Carolina USA
Interpretation of Renal Transplant Biopsy Arthur H. Cohen Wake Forest University School of Medicine Winston-Salem, North Carolina USA Renal Transplant Biopsies Tissue Processing Ideal world process as
More informationPodocyte Biology and clinical applications Dr. F. Ahmadi Professor Of Nephrology TUMS
Podocyte Biology and clinical applications Dr. F. Ahmadi Professor Of Nephrology TUMS Proteinuria is a major healthcare problem that affects several hundred million people worldwide. Proteinuria is a cardinal
More informationRaDaR Inclusion and Exclusion Criteria. Diagnosis Inclusion Criteria Exclusion Criteria. Alport Syndrome definite or probable
Alport Syndrome and Type IV collagenopathies APRT Deficiency Alport Syndrome definite or probable Alport carrier definite or probable Thin basement membrane nephropathy APRT Deficiency confirmed Abolished
More informationElevated Serum Creatinine, a simplified approach
Elevated Serum Creatinine, a simplified approach Primary Care Update Creighton University School of Medicine. April 27 th, 2018 Disclosure Slide I have no disclosures and have no conflicts with this presentation.
More informationCrescentic Glomerulonephritis (RPGN)
Crescentic Glomerulonephritis (RPGN) Background Rapidly progressive glomerulonephritis (RPGN) is defined as any glomerular disease characterized by extensive crescents (usually >50%) as the principal histologic
More informationRECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT. J. H. Helderman,MD,FACP,FAST
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT J. H. Helderman,MD,FACP,FAST Vanderbilt University Medical Center Professor of Medicine, Pathology and Immunology Medical Director, Vanderbilt Transplant
More informationMonoclonal Gammopathies and the Kidney. Tibor Nádasdy, MD The Ohio State University, Columbus, OH
Monoclonal Gammopathies and the Kidney Tibor Nádasdy, MD The Ohio State University, Columbus, OH Monoclonal gammopathy of renal significance (MGRS) Biopsies at OSU (n=475) between 2007 and 2016 AL or AH
More informationCHAPTER I INTRODUCTION. Nowadays chronic kidney disease (CKD) becomes one. of the most common diseases found in the population.
CHAPTER I INTRODUCTION I.1 Background Nowadays chronic kidney disease (CKD) becomes one of the most common diseases found in the population. Based on community survey that is held by PERNEFRI (Perhimpunan
More informationGlomerulonephritis. Dr Rodney Itaki Anatomical Pathology Discipline.
Glomerulonephritis Dr Rodney Itaki Anatomical Pathology Discipline. University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology Gross anatomy Ref: Goggle Images Microanatomy
More informationESRD Dialysis Prevalence - One Year Statistics
Age Group IL Other Total 00-04 12 1 13 05-09 5 2 7 10-14 15 1 16 15-19 55 2 57 20-24 170 10 180 25-29 269 14 283 30-34 381 9 390 35-39 583 14 597 40-44 871 20 891 45-49 1,119 20 1,139 50-54 1,505 35 1,540
More informationDNA vaccine, peripheral T-cell tolerance modulation 185
Subject Index Airway hyperresponsiveness (AHR) animal models 41 43 asthma inhibition 45 overview 41 mast cell modulation of T-cells 62 64 respiratory tolerance 40, 41 Tregs inhibition role 44 respiratory
More informationNephritic vs. Nephrotic Syndrome
Page 1 of 18 Nephritic vs. Nephrotic Syndrome Terminology: Glomerulus: A network of blood capillaries contained within the cuplike end (Bowman s capsule) of a nephron. Glomerular filtration rate: The rate
More informationNEPHRITIC SYNDROME. By Dr Mai inbiek
NEPHRITIC SYNDROME By Dr Mai inbiek Nephritic Syndrome The nephritic Syndrome is a clinical complex, usually of acute onset. Is caused by inflammatory lesions of glomeruli. Characterized by; 1) Hematuria
More informationDiabetic Nephropathy. Introduction/Clinical Setting. Pathologic Findings Light Microscopy. J. Charles Jennette
12 Diabetic Nephropathy J. Charles Jennette Introduction/Clinical Setting Diabetic nephropathy is a clinical syndrome in a patient with diabetes mellitus that is characterized by persistent albuminuria,
More informationCase Presentation Turki Al-Hussain, MD
Case Presentation Turki Al-Hussain, MD Director, Renal Pathology Chapter Saudi Society of Nephrology & Transplantation Consultant Nephropathologist & Urological Pathologist Department of Pathology & Laboratory
More informationDisorders of the kidney. Urine analysis. Nephrotic and nephritic syndrome.
Disorders of the kidney. Urine analysis. Nephrotic and nephritic syndrome. Azotemia and Urinary Abnormalities Disturbances in urine volume oliguria, anuria, polyuria Abnormalities of urine sediment red
More informationCase Studies: Renal and Urologic Impairments Workshop
Case Studies: Renal and Urologic Impairments Workshop Justine Lee, MD, DBIM New York Life Insurance Co. Gina Guzman, MD, DBIM, FALU, ALMI Munich Re AAIM Triennial October, 2012 The Company You Keep 1 Case
More information4. KIDNEYS AND AUTOIMMUNE DISEASE
How to Cite this article: Kidneys and Autoimmune Disease - ejifcc 20/01 2009 http://www.ifcc.org 4. KIDNEYS AND AUTOIMMUNE DISEASE Maksimiljan Gorenjak 4.1 Autoimmune diseases The human immune system limits
More informationProteinuria. Louisiana State University
Proteinuria W S A V A W C P, 2005 David F. Senior Louisiana State University The normal glomerulus is a highly selective barrier for filtration based on size (and on charge in the case of larger molecules).
More informationRaDaR Inclusion and Exclusion Criteria. Diagnosis Inclusion Criteria Exclusion Criteria. Alport Syndrome definite or probable
Alport Syndrome and Type IV collagenopathies APRT Deficiency Alport Syndrome definite or probable Alport carrier definite or probable Thin basement membrane nephropathy APRT Deficiency confirmed Abolished
More informationRECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT HISTOPATHOLOGIC DISORDERS AFFECTING THE ALLOGRAFT OTHER THAN REJECTION RECURRENT DISEASE DE NOVO DISEASE TRANSPLANT GLOMERULOPATHY Glomerular Non-glomerular
More informationvi Preface Table 2 Association of Fibrosis With Types of Injury: Representative Examples
Fibrosis or scar, defined pathologically as inappropriate repair by connective tissue, is increasingly recognized as an important feature of many chronic diseases (Table 1), and as such, represents an
More informationSurgical Pathology Report
Louisiana State University Health Sciences Center Department of Pathology Shreveport, Louisiana Accession #: Collected: Received: Reported: 6/1/2012 09:18 6/2/2012 09:02 6/2/2012 Patient Name: Med. Rec.
More information3. PODOCYTE INJURY IN GLOMERULAR DISEASES
How to Cite this article: Podocyte Injury in Glomerular Diseases - ejifcc 20/01 2009 http://www.ifcc.org 3. PODOCYTE INJURY IN GLOMERULAR DISEASES Mirjana Sabljar Matovinović Podocytes are injured in diabetic
More informationRole of Inflammatory and Progenitor Cells in Pulmonary Vascular Remodeling: Potential Role for Targeted Therapies. Traditional Hypothesis Stress
3/1/212 Role of Inflammatory and Progenitor Cells in Pulmonary Vascular Remodeling: Potential Role for Targeted Therapies K.R. Stenmark University of Colorado Denver, CO 845 Prominent Fibroproliferative
More informationHIV ASSOCIATED NEPHROPATHIES (HIVAN): 30 YEARS LATER
HIV ASSOCIATED NEPHROPATHIES (HIVAN): 30 YEARS LATER Gaston Zilleruelo M.D. Professor of Pediatrics Director of Pediatric Nephrology University of Miami/Holtz Children s Hospital Worldwide 33.2 million
More informationExpanding Spectrum of Diseases Associated with Plasma Cell Dyscrasias
Expanding Spectrum of Diseases Associated with Plasma Cell Dyscrasias Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic eva.honsova@ikem.cz Plasma cell dyscrasias Plasma
More informationRENAL PHYSIOLOGY DR.CHARUSHILA RUKADIKAR ASSISTANT PROFESSOR PHYSIOLOGY
RENAL PHYSIOLOGY DR.CHARUSHILA RUKADIKAR ASSISTANT PROFESSOR PHYSIOLOGY GROSS ANATOMY Location *Bean-shaped *Retroperitoneal *At level of T12 L1 vertebrae. *The right kidney lies slightly inferior to left
More informationMohammad Husain Department of Biotechnology, Jamia Millia Islamia New Delhi
Role of Vitamin D receptor (VDR) in HIV induced tubular injury Mohammad Husain Department of Biotechnology, Jamia Millia Islamia New Delhi 07/10/2015 INTRODUCTION Vitamin D is technically not a Vitamin;
More informationJo Abraham MD Division of Nephrology University of Utah
Jo Abraham MD Division of Nephrology University of Utah 68 year old male presented 3 weeks ago with a 3 month history of increasing fatigue He reported a 1 week history of increasing dyspnea with a productive
More informationAs outlined under External contributions (see appendix 7.1), the group of Prof. Gröne at the
3 RESULTS As outlined under External contributions (see appendix 7.1), the group of Prof. Gröne at the DKFZ in Heidelberg (Dept. of Cellular and Molecular pathology) contributed to this work by performing
More informationRenal Pathology- Transplantation. Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic
Renal Pathology- Transplantation Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic eva.honsova@ikem.cz Kidney has a limited number of tissue reactions by which the kidney
More informationClinical and pathological characteristics of patients with glomerular diseases at a university teaching hospital: 5-year prospective review
Clinical and pathological characteristics of patients with glomerular diseases at a university teaching hospital: 5-year prospective review KW Chan, TM Chan, IKP Cheng Objective. To examine the prevalence
More informationDr. Rai Muhammad Asghar Head of Paediatric Department BBH Rawalpindi
Dr. Rai Muhammad Asghar Head of Paediatric Department BBH Rawalpindi Acute Post streptococcal Glomerulonephritis Sudden onset of Gross hematuria Edema Hypertension Renal insufficiency Cause of AGN Post
More informationGlomerular diseases with organized deposits
Glomerular diseases with organized deposits Banu Sis, MD, FRCPC University of Alberta, Edmonton, AB, Canada Ulusal Patoloji Kongresi, Manavgat, Antalya 8/11/2012 What is an organized deposit? A number
More informationBiology Of Renal Tubulo-Interstitial Cells (Experimental Nephrology, 5-6)
Biology Of Renal Tubulo-Interstitial Cells (Experimental Nephrology, 5-6) If you are searched for the book Biology of Renal Tubulo- Interstitial Cells (Experimental Nephrology, 5-6) in pdf format, in that
More informationLung diseases of Vascular Origin. By: Shefaa Qa qqa
Lung diseases of Vascular Origin By: Shefaa Qa qqa Pulmonary Hypertension Pulmonary hypertension is defined as a mean pulmonary artery pressure greater than or equal to 25 mm Hg at rest. Based on underlying
More informationBiopsy Features of Kidney Allograft Rejection Banff B. Ivanyi, MD Department of Pathology, University of Szeged, Szeged, Hungary
Biopsy Features of Kidney Allograft Rejection Banff 2017 B. Ivanyi, MD Department of Pathology, University of Szeged, Szeged, Hungary Treatment of allograft dysfunction should rely on the biopsy findings
More informationThe topic of normal vascular and glomerular anatomy is introduced
Normal Vascular and Glomerular Anatomy Arthur H. Cohen Richard J. Glassock The topic of normal vascular and glomerular anatomy is introduced here to serve as a reference point for later illustrations of
More informationOrdering Physician. Collected REVISED REPORT. Performed. IgG IF, Renal MCR. Lambda IF, Renal MCR. C1q IF, Renal. MCR Albumin IF, Renal MCR
RenalPath Level IV Wet Ts IgA I Renal IgM I Renal Kappa I Renal Renal Bx Electron Microscopy IgG I Renal Lambda I Renal C1q I Renal C3 I Renal Albumin I Renal ibrinogen I Renal Mayo Clinic Dept. of Lab
More informationACUTE GLOMERULONEPHRITIS. IAP UG Teaching slides
ACUTE GLOMERULONEPHRITIS 1 Definition Etiology Pathology/pathogenesis Risk factors Clinical Presentation Investigation Differential Diagnosis Management Outcome/Prognosis Indication for Renal Biopsy Summary
More informationPathology of Complement Mediated Renal Disease
Pathology of Complement Mediated Renal Disease Mariam Priya Alexander, MD Associate Professor of Pathology GN Symposium Hong Kong Society of Nephrology July 8 th, 2017 2017 MFMER slide-1 The complement
More informationPrinciples of Adaptive Immunity
Principles of Adaptive Immunity Chapter 3 Parham Hans de Haard 17 th of May 2010 Agenda Recognition molecules of adaptive immune system Features adaptive immune system Immunoglobulins and T-cell receptors
More informationINFLAMMATION. 5. Which are the main phases of inflammation in their "sequence": 1. Initiation, promotion, progression.
INFLAMMATION 1. What is inflammation: 1. Selective anti-infective pathological reaction. 2. Pathological process, typical for vascularized tissues. 3. Self-sustained pathological condition. 4. Disease
More informationHIHIM 409 7/26/2009. Kidney and Nephron. Fermamdo Vega, M.D. 1
Function of the Kidneys Nephrology Fernando Vega, M.D. Seattle Healing Arts Center Remove Wastes Regulate Blood Pressure Regulate Blood Volume Regulates Electrolytes Converts Vitamin D to active form Produces
More informationTest Name Results Units Bio. Ref. Interval
135091662 Age 45 Years Gender Male 29/8/2017 120000AM 29/8/2017 100215AM 29/8/2017 110825AM Ref By Final RHEUMATOID AUTOIMMUNE COMREHENSIVE ANEL ANTI NUCLEAR ANTIBODY / FACTOR (ANA/ANF), SERUM ----- 20-60
More informationDiabetes. Albumin. Analyte Information
Diabetes Albumin Analyte Information -1-2014-05-02 Albumin Introduction Albumin consists of a single polypeptide chain of 585 amino acids with molecular weight of 66.5 kda. The chain is characterized by
More informationDIABETES MELLITUS. Kidney in systemic diseases. Slower the progression: Pathology: Patients with diabetes mellitus are prone to other renal diseases:
Kidney in systemic diseases Dr. Badri Paudel The kidneys may be directly involved in a number of multisystem diseases or secondarily affected by diseases of other organs. Involvement may be at a prerenal,
More informationRole of Inflammation in Pulmonary Hypertension
Role of Inflammation in Pulmonary Hypertension K. R. Stenmark University of Colorado Denver, USA Prominent Fibroproliferative Changes are Observed in the Lung Vasculature of Infants With Pulmonary Arterial
More information2014 /2018 ERA-EDTA PRD Code ERA-EDTA PRD code 1996 ERA-EDTA. SNOMED CT concept identifier Convert ERA-EDTA Primary Renal Diagnosis (PRD) Term
Convert Primary Renal Diagnosis (PRD) Term ERA_EDTA diagnosis 3380 901.1.C 90 Acute kidney injury Acute Renal Failure 14669001 Miscellaneous renal disorders 3398 901.2.C 90 Acute kidney injury due to hypovolaemia
More informationCentral tolerance. Mechanisms of Immune Tolerance. Regulation of the T cell response
Immunoregulation: A balance between activation and suppression that achieves an efficient immune response without damaging the host. Mechanisms of Immune Tolerance ACTIVATION (immunity) SUPPRESSION (tolerance)
More informationMechanisms of Immune Tolerance
Immunoregulation: A balance between activation and suppression that achieves an efficient immune response without damaging the host. ACTIVATION (immunity) SUPPRESSION (tolerance) Autoimmunity Immunodeficiency
More informationC3 GLOMERULOPATHIES. Budapest Nephrology School Zoltan Laszik
C3 GLOMERULOPATHIES Budapest Nephrology School 8.30.2018. Zoltan Laszik 1 Learning Objectives Familiarize with the pathogenetic mechanisms of glomerular diseases Learn the pathologic landscape and clinical
More informationProceedings of the 34th World Small Animal Veterinary Congress WSAVA 2009
www.ivis.org Proceedings of the 34th World Small Animal Veterinary Congress WSAVA 2009 São Paulo, Brazil - 2009 Next WSAVA Congress : Reprinted in IVIS with the permission of the Congress Organizers PROTEINURIA
More informationUrinary bladder provides a temporary storage reservoir for urine
Urinary System Organs Kidney Filters blood, allowing toxins, metabolic wastes, and excess ions to leave the body in urine Urinary bladder provides a temporary storage reservoir for urine Paired ureters
More informationIntroduction. Acute sodium overload produces renal tubulointerstitial inflammation in normal rats
Acute sodium overload produces renal tubulointerstitial inflammation in normal rats MI Roson, et al. Kidney International (2006) Introduction Present by Kanya Bunnan and Wiraporn paebua Tubular sodium
More informationMayo Clinic/ RPS Consensus Report on Classification, Diagnosis, and Reporting of Glomerulonephritis
Mayo Clinic/ RPS Consensus Report on Classification, Diagnosis, and Reporting of Glomerulonephritis Sanjeev Sethi, MD, PhD Department of Laboratory Medicine and Pathology Disclosure Relevant Financial
More informationINTRODUCTION TO GLOMERULAR DISEASES
INTRODUCTION TO GLOMERULAR DISEASES Goals: to explain the general mechanisms leading to glomerular diseases and to analyze what is known about their relationship to morphologic and clinical manifestations
More informationFamilial DDD associated with a gain-of-function mutation in complement C3.
Familial DDD associated with a gain-of-function mutation in complement C3. Santiago Rodríguez de Córdoba, Centro de investigaciones Biológicas, Madrid Valdés Cañedo F. and Vázquez- Martul E., Complejo
More informationDiabetes, Obesity and Heavy Proteinuria
Diabetes, Obesity and Heavy Proteinuria Clinical Case 41 yo Black woman with heavy proteinuria History 2014: noted to have proteinuria on routine lab testing (1.1g/g). 1+ edema. Blood pressure has been
More informationCase # 2 3/27/2017. Disclosure of Relevant Financial Relationships. Clinical history. Clinical history. Laboratory findings
Case # 2 Christopher Larsen, MD Arkana Laboratories Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence or control the content
More informationCHAPTER 2. Primary Glomerulonephritis
2nd Report of the PRIMARY GLOMERULONEPHRITIS CHAPTER 2 Primary Glomerulonephritis Sunita Bavanandan Lee Han Wei Lim Soo Kun 21 PRIMARY GLOMERULONEPHRITIS 2nd Report of the 2.1 Introduction This chapter
More informationGeneral introduction. General introduction
General introduction 1 Chapter 1 Proteinuria is the excretion of proteins into the urine. Presence of abnormal proteinuria, the urinary excretion of abnormal amounts of serum proteins (briefly called proteinuria),
More informationManagement of Rejection
Management of Rejection I have no disclosures Disclosures (relevant or otherwise) Deborah B Adey, MD Professor of Medicine University of California, San Francisco Kidney and Pancreas Transplant Center
More information29th Annual Meeting of the Glomerular Disease Collaborative Network
29th Annual Meeting of the Glomerular Disease Collaborative Network Updates on the Pathogenesis IgA Nephropathy and IgA Vasculitis (HSP) J. Charles Jennette, M.D. Brinkhous Distinguished Professor and
More informationRENAL EVENING SPECIALTY CONFERENCE
RENAL EVENING SPECIALTY CONFERENCE Harsharan K. Singh, MD The University of North Carolina at Chapel Hill Disclosure of Relevant Financial Relationships No conflicts of interest to disclose. CLINICAL HISTORY
More informationDiseases of Immunity 2017 CL Davis General Pathology. Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc.
Diseases of Immunity 2017 CL Davis General Pathology Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc. Autoimmunity Reflects a loss of immunologic tolerance Mechanisms Auto-antibodies
More informationDiabetic Nephropathy
Diabetic Nephropathy Objectives: Know what Diabetic Nephropathy means. Know how common is Diabetic nephropathy in Saudi Arabia and to appreciate how bad are this complications. Know the risk factors of
More informationInnate immunity. Abul K. Abbas University of California San Francisco. FOCiS
1 Innate immunity Abul K. Abbas University of California San Francisco FOCiS 2 Lecture outline Components of innate immunity Recognition of microbes and dead cells Toll Like Receptors NOD Like Receptors/Inflammasome
More informationPharmaceutical pathology
Pharmaceutical pathology Livia Vida 2018 1. Necrosis, types, examples. Apoptosis. 2. Adaptations I. Degeneration, atrophy. 3. Adaptations II. Hypertrophy, hyperplasia. 4. Pigments. Calcification. 5. Inflammation
More informationHLA and antigen presentation. Department of Immunology Charles University, 2nd Medical School University Hospital Motol
HLA and antigen presentation Department of Immunology Charles University, 2nd Medical School University Hospital Motol MHC in adaptive immunity Characteristics Specificity Innate For structures shared
More informationDiabetic Nephropathy in Spontaneously Diabetic Torii (SDT) Rats
The Open Diabetes Journal, 2011, 4, 45-49 45 Diabetic Nephropathy in Spontaneously Diabetic Torii (SDT) Rats Takeshi Ohta * and Tomohiko Sasase Open Access Biological/Pharmacological Research Laboratories,
More informationMon, Wed, Fri 11:00 AM-12:00 PM. Owen, Judy, Jenni Punt, and Sharon Stranford Kuby-Immunology, 7th. Edition. W.H. Freeman and Co., New York.
Course Title: Course Number: Immunology Biol-341/541 Semester: Fall 2013 Location: HS 268 Time: Instructor: 8:00-9:30 AM Tue/Thur Dr. Colleen M. McDermott Office: Nursing Ed 101 (424-1217) E-mail*: mcdermot@uwosh.edu
More informationTarek ElBaz, MD. Prof. Internal Medicine Chief, Division of Renal Medicine Al Azhar University President, ESNT
The Kidney in Multiple Myeloma Tarek ElBaz, MD. Prof. Internal Medicine Chief, Division of Renal Medicine Al Azhar University President, ESNT Normal Cell Plasma cells produce antibodies that bind to antigens,
More informationAnalysis on the mechanism of reduced nephron number and the pathological progression of chronic renal failure in Astrin deficient rats
Analysis on the mechanism of reduced nephron number and the pathological progression of chronic renal failure in Astrin deficient rats Summary of Doctoral Thesis Hidenori Yasuda Graduate School of Veterinary
More information