(Psidium guava Extract) -

Transcription

1 (4 ) (Psidium guava Extract) *2 1 : : 10. (STZ) mg/kg :. - :. : : : solnep2002@yahoo.com :

2 ... (Psidium guava Extract) - : ( ) ± mg/kg 60.[8 9 10] (Canada Ascensia ELITE XL metr).[8] 250..[8] 10 1 ) (..[11-13].[2 1]..[3].[4]......[5].[6]. [7] -

3 349 (4 ) ± ANOVA Repeated measure post test P<0/05...( ) ( ) 1. (P<0/001). 93/58±5/442.(118/88±9/44). ( ) (mg /dl9/76± 0/16 9 /7± 0/41).( 2 ) 9/22±0/12 2 ( ) (P<0/001) (Psidium guava) 26± [14] (Canada Ascensia ELITE XL metr) mg/kg 55 (UV 3100, Shimadzu) 25 ( %5 %95) 5 (Meredos GmbH) 30 0/1 0/00001 (MLT0380, ADInstuments).[11] (SP, ADInstruments 4)

4 ... (Psidium guava Extract) - : (P<0/01). (P<0/001).. 1/73± 0/011 0/35± 0/035 (P<0/001). 2 (P<0/01) (19/3±2/65) (12/97±1/41). (P<0/01) -1..(P< 0/001) *.(P< 0/001) (PGE) - #

5 351 (4 ) ( ) ( ) ( ) ( ) ( ) -2..(P< 0/05) *.(P< 0/05) (PGE) - #

6 ... (Psidium guava Extract) - : 352 ( ) ( ) ( ) -3 ( ). Repeated measure.(p< 0/01) *.(P<0/01) (PGE) - #.. [15] [16]..

7 353 (4 ) [11-13] Satin LS, Kinard TA. Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit? Endocrine 1998; 8(3): Taniguchi H, Okada Y, Seguchi H, Shimada C, Seki M, Tsutou A, et al. High concentration of gamma-aminobutyric acid in pancreatic beta cells. Diabetes 1979; 28 (7): Ozcelikay AT, Tay A, Guner S, Tasyaran V, Yildizoglu-Ari N, Dincer UD, Altan VM., Reversal effects of L-arginine treatment on blood pressure and vascular responsiveness of streptozotocin-diabetic rats. Pharmacol Res 2000; 41(2): [7]..[17].[18]..[3].[4] 4. Abe A, Kawasoe C, KondoY, Sato K. Enhancement of norepinephrine-induced transient contraction in aortic smooth muscle of diabetic mice. Acta Med Okayama 2003; 57(1): Keun W, Lee C, sun Lee M, Young E, Bae Sohn C, Oh H, Kim B, Ahn J. Antidiabetic effects of extracts from Psidium guajava. J Ethnopharmacolo 2005; 3(15): Chiwororo DH, Ojewole AO. Biphasic effect of Psidium guajava Linn (Myrtaceae) leaf aqueous extract on rat isolated vascular smooth muscles. Smooth Muscle Res 2008; 44(6): Altura BM, Altura BT. Magnesium and cardiovascular biology an important link between cardiovascular risk factors and atherogenesis.

8 ... (Psidium guava Extract) - : 354 Cellular and Molecular Bio Res 1995; 41(5): Soltani N, Kumar M, Glinka Y, Prud'homme GJ, Wang Q. Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Gene Ther 2007; 14(2): Müller A, Schott-Ohly P, Dohle C, Gleichmann H. Differential regulation of Th1-type and Th2- type cytokine profiles in pancreatic islets of C57BL/6 and BALB/c mice by multiple low doses of streptozotocin. Immunobiology 2002; 205(1): Sun N, Yang G, Zhao H, Savelkoul HF, An L. Multidose streptozotocin induction of diabetes in BALB/c mice induces a dominant oxidative macrophage and a conversion of TH1 to TH2 phenotypes during disease progression. Mediators Inflamm 2005; 31 (4): Soltani; N, Keshavarz; M, Sohanaki; H, Zahdi Asl; S, Dehpour; A.R: Oral magnesium sulfate prevent vascular complication STZ-diabetic rats. Life Sci 2005; 76: Soltani, N., Keshavarz, M., Sohanaki, H., Zahed Asl, S.Z., Dehpour, A.R. Relaxatory effect of magnesium on mesenteric vascular beds differs from normal and streptozotocin induced diabetic rats. Eur J Pharmacol 2005; (1-3): Farsi L, Keshavarz M, Soltani N. Relaxatory effect of GABA mediated by same pathway in diabetic and normal rat vessel. Iranian J of basic med sci 2010; 14(1): Shen SC, Cheng FC, Wu NJ. Effect of Guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. Phytother Res 2008; 22: Obatomi DK, Bikomo EO, Temple VJ. Antidiabetic properties of African mistletoe in sterptozotocin-induced diabetic rats. J Ethnopharmacol 1994; 43(1): Sunagawa M, Shimada S, Zhang Z, Oonishi A, Nakamura M, Kosugi T. Plasma insulin concentration was increased by long-term ingestion of guava juice in spontaneous noninsulin-dependent diabetes mellitus (NIDDM) rats. Journal of health Sci 2004; 50(6): Soltani N, Keshavarz M, Minaii B, Zahdi Asl S, Dehpour AR. Effect of magnesium on plasma glucose and pancreas histology in streptozotocin-diabetic rats. CEPP 2005; 32: Anetor JI, Senjobi A, Ajose OA, Agbedana EO. Decreased serum magnesium and zinc levels: atherogenic implications in type-2 diabetes mellitus in Nigerians. Nutr Health 2002; 16: