University of Groningen. Vasoregression in incipient diabetic retinopathy Pfister, Frederick

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1 University of Groningen Vasoregression in incipient diabetic retinopathy Pfister, Frederick IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2011 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Pfister, F. (2011). Vasoregression in incipient diabetic retinopathy: Angiopoietin-2 dependency and the effect of Erythropoietin and Carnosine treatment Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 APPENDICES References Curriculum Vitae List of publications Acknowledgement 197

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8 100.! Kowluru, R.A. and P. Koppolu, Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy. Free Radic Res, (9): p ! Mohr, S., et al., Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes, (4): p ! Romeo, G., et al., Activation of nuclear factor-kappab induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes, (7): p ! Joussen, A.M., et al., Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocininduced diabetes. FASEB J, (1): p ! Park, S.H., et al., Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia, (9): p ! Abu-El-Asrar, A.M., et al., Expression of apoptosis markers in the retinas of human subjects with diabetes. Invest Ophthalmol Vis Sci, (8): p ! Kowluru, R.A., S. Chakrabarti, and S. Chen, Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NFkappaB) in the retina. Acta Diabetol, (4): p ! Lecomte, M., et al., Involvement of caspase-10 in advanced glycation end-productinduced apoptosis of bovine retinal pericytes in culture. Biochim Biophys Acta, (3): p ! Martin, P.M., et al., Death of retinal neurons in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci, (9): p ! Kowluru, R.A., Diabetic retinopathy: mitochondrial dysfunction and retinal capillary cell death. Antioxid Redox Signal, (11-12): p ! Nakanishi, Y., et al., Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinase. Exp Eye Res, (5): p ! Yatoh, S., et al., Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy. Diabetes Metab Res Rev, (1): p ! Behl, Y., et al., Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol, (5): p ! Behl, Y., et al., FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes, (4): p ! Diffley, J.M., et al., Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways. Mol Vis, : p ! Khalfaoui, T., N. Basora, and A. Ouertani-Meddeb, Apoptotic factors (Bcl-2 and Bax) and diabetic retinopathy in type 2 diabetes. J Mol Histol, (2-3): p ! Mizutani, M., T.S. Kern, and M. Lorenzi, Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest, (12): p ! Kowluru, R.A. and S. Odenbach, Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes, (12): p ! Alikhani, M., S. Roy, and D.T. Graves, FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis, : p ! Han, J.H., et al., High glucose-induced apoptosis in bovine retinal pericytes is associated with transforming growth factor beta and betaig-h3: betaig-h3 induces 203

9 apoptosis in retinal pericytes by releasing Arg-Gly-Asp peptides. Clin Experiment Ophthalmol, (6): p ! Lindblom, P., et al., Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev, (15): p ! Enge, M., et al., Endothelium-specific platelet-derived growth factor-b ablation mimics diabetic retinopathy. EMBO J, (16): p ! Hammes, H.P., Pericytes and the pathogenesis of diabetic retinopathy. Horm Metab Res, Suppl 1: p ! Uemura, A., et al., Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest, (11): p ! Hellstrom, M., et al., Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development, (14): p ! Lindahl, P., et al., Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science, (5323): p ! Wakui, S., et al., Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis. Lab Invest, (11): p ! Maisonpierre, P.C., et al., Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science, (5322): p ! Fiedler, U., et al., Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med, (2): p ! Suri, C., et al., Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell, (7): p ! Thurston, G., et al., Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med, (4): p ! Augustin, H.G., et al., Control of vascular morphogenesis and homeostasis through the angiopoietin-tie system. Nat Rev Mol Cell Biol, (3): p ! Joussen, A.M., et al., Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol, (5): p ! Asahara, T., et al., Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res, (3): p ! DeBusk, L.M., D.E. Hallahan, and P.C. Lin, Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway. Exp Cell Res, (1): p ! Hackett, S.F., et al., Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol, (3): p ! Hayes, A.J., et al., Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvasc Res, (3): p ! Hori, S., et al., A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J Neurochem, (2): p ! Yuan, H.T., S.P. Yang, and A.S. Woolf, Hypoxia up-regulates angiopoietin-2, a Tie-2 ligand, in mouse mesangial cells. Kidney Int, (5): p ! Krikun, G., et al., Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation. Biochem Biophys Res Commun, (1): p

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