Table 3 Insecticides 1

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1 Table 3 1 I07 13 rat blood, liver, spleen anemia; hepatic inflamm.,siderosis of Kupffer cells, liver +spleen w. I07 13 dog blood erythropoiesis; hematopoiesis in spleen I dog a.ph. I rat liver periacinar hypertrophy I dog ChE RBC-ChE I mouse 3 12 ChE, liver plasma + RBC-ChE; fatty changes; weight I rat ChE brain + RBC-ChE I rat glucose, food intake I dog liver, thyroid eosinophil. bodies in hepatocytes a.ph. liver + thyroid w. I rat thyroid hypertrophy + hyperplasia of epithelial cells, weight I mouse liver weight I dog 2 20 liver bromosulphophthalein retention, bile duct hyperplasia, hypertrophy, weight I (14) I04 12 (18) rat 1.4 (0.4) dog 0.5 (0.25) 1.6 ( - ) 1 (0.5) body weight inability to constrict pupils I dog eye, liver mydriasis; ALT, a.ph. I mouse 4 8 mortality, + food I rat CNS tremor; I rat ChE plasma, RBC+ brain-che, b.w. I dog ChE plasma-che I /63 52 dog ChE plasma-che I mouse ChE plasma-che I rat ChE RBC + plasma-che I dog ChE brain + RBC-ChE I rat ChE brain + RBC-ChE I dog blood, spleen reticulocyt.; iron pigments in spleen, liver, kidney, spleen w. I rat 1 10 blood, bone, theeth anemia; fluoration of bones + theeth I mouse blood anemia, Heinz bodies, bilirub. protein I rat ChE plasma-che I (1988) 13 dog 0.03 (0.01) 0.15 (0.3) ChE plasma-che I dog ChE plasma-che (1989) (52) (0.12) (2.4) I rat ChE plasma-che I mouse ChE plasma + RBC-ChE I dog 5 15 liver pnod, cholesterol in liver; I mouse liver, urinary bladder adenoma, weight; ALAT, albumin; hyperplasia of epithel. I rat blood, urinary bladder, ovary, liver eosinoph., lymphocyt. AST, protein; hyperplasia of urinary bladder; ovary w. I dog 5 15 CNS, gastrointest. tremor, incoordination, hypersens. gait abnormality; fluid feces, b.w. I rat liver, kidney, spleen, lung aminopyrine-n-dem., SER-prolif., weight; cholest., TG, BUN; kidney, spleen, lung w.

2 Table 3 2 I mouse blood, liver anemia; liver weight; I rat 1 5 liver hypertrophy I dog 5 50 liver weight I dog liver, adrenal cellular swelling, weight; focal degeneration with inflammatory changes in cortex, lipid accumulation in zona reticul. a.ph.; I11 52 mouse liver, kidney aminopyridinedemethyl.,eosino. of hepatocytes, SER-prolif. liver + kidney w. I rat 5 25 CNS, ovary tremor; glucose; ovary w. I rat 5 15 blood anemia I dog blood, ChE anemia, plasma + RBC-ChE I rat liver weight; I dog liver hepatomegaly, weight; cholest ALAT, a.ph.; emesis, I mouse liver adenomas, weight I rat ChE plasma + RBC-ChE (8) (0.03) (0.06) I dog ChE plasma + RBC-ChE I dog ChE brain, plasma + RBC-ChE I rat ChE brain, plasma + RBC-ChE I mouse lung interstitial pneumony, weight I rat ChE plasma, RBC + brain-che I dog ChE plasma + RBC-ChE I rat ChE RBC + plasma-che I dog ChE plasma-che I mouse ChE plasma-che I rat spleen abs. +rel. weight I (1984) 13 (52) dog 7 (2.8) 14 (7) CNS, gastrointestine, liver tremor, ataxia, emesis, salivation, diarrhoea, AST I dog CNS tremor I rat liver weight; (1986) (113) (7.2) (21.3) I mouse CNS, blood, brain, kidney, liver hyperactivity; RBC-parameter, AST, ALAT, BUN; brain + kidney w. I dog body weight + food intake I mouse ChE RBC-ChE; food intake I rat ChE, kidney plasma, RBC + brain-che urine ph I dog < ChE plasma + RBC-ChE I rat ChE plasma + RBC-ChE I rat liver ALAT, AST I dog 350 no effect I rat 8 80 liver AST, ALAT I dog gastrointestine slight focal gastritis I19 52 dog liver weight I mouse liver nodular hyperplasia, adenomas, cell necrosis, bile duct + Kupffer cell proliferat, hypertrophy. I rat lymphatic system, liver ALAT, AST, OCT; hemangiomas in mesenteric nodes I rat blood, kidney anemia, BUN, + food I dog CNS.,thyroid tremor, weight; TG

3 Table 3 3 I dog CNS, gastrointest. mortality; ataxia, fluid feces, body w. I rat kidney urinary vol.; I mouse 5 20 body weight I rat CNS hypersensitivity, body weight g. I dog eye, gastrointestine diarrhoea I rat liver, kidney liver + kidney w. (1977) (26) (20) (100) I dog liver a.ph., weight I rat blood, liver, adrenal RBC; necrotic cells in liver + inflammation; adrenal w. I dog liver a.ph., ALAT, pitted surface I dog 2 10 blood, liver MHb, sulphemoglobin; macrophages and Kupffer cell siderosis I mouse blood, liver, spleen MHb, sulphemogl.; siderocytosis in Kupffer cells and in spleen I rat blood MHb, ALAT I rat < ChE, heart RBC-ChE, heart rate, temp. I dog blood Hb I25 4 rat ChE RBC + plasma-che I25 4 dog ChE plasma + RBC- ChE I rat ChE, blood RBC-ChE, anemia, reticulocyt ALAT cholest., glucose I dog ChE plasma-che I mouse ChE plasma-che, ALAT I dog CNS tonic spasm of abdominal and cheek muscle; + food I rat kidney enlarged kidney and lumbar nodes, glomerulonephritis, aneurysm, I mouse lung, ovary mortality, lung + ovary w. I rat ChE brain + plasma-che, chromadacryorrhea, lacrimation, alopecia I dog < ChE plasma-che I /86 96 mouse I / rat food intake I dog blood erythroid/myeloid ratio I rat ChE RBC + brain-che I dog ChE plasma + RBC-ChE (1985) (52) (0.1) (2.5) I mouse ChE epididyma plasma, RBC + brain-che vacuolative epididymal degenerat. I dog ChE.,blood brain, plasma +RBC-ChE, anemia, ALAT; vomiting I rat CNS, ChE, skin, liver, lung tremor; brain + plasma-che; dermatitis of tail; inflammatory changes in liver + lung I mouse ChE, testes, gastrointestine brain, plasma + RBC-ChE; epididyma degeneration; mucosal hyperplasia in duodenum I rat < 7 7 kidney a.ph., kidney w. I dog 12.5 no effect I mouse liver, blood necrotic foci, album, bilirub. leucocyt., neutroph. I rat ChE plasma + RBC-ChE

4 Table 3 4 I dog ChE RBC-ChE I dog ChE, gastrointest. RBC-ChE; diarrhoea I rat ChE brain + plasma-che I mouse ChE RBC, plasma + brain-che I dog ChE, gastrointes. plasma-che; diarrhoea I rat no effect I dog ChE brain, plasma + RBC-ChE I mouse ChE brain + plasma-che I rat ChE brain, plasma + RBC-ChE; I rat ChE ChE I dog ChE plasma + RBC-ChE I dog ChE RBC + plasma-che I rat ChE RBC + plasma-che; cholest. I mouse ChE plasma-che I dog ChE plasma + RBC-ChE I rat ChE plasma + RBC-ChE I rat ChE, liver plasma + RBC-ChE; vacuoles in hepatocytes I dog ChE RBC-ChE I36 13 rat 3 12 body weight gain I dog heart, kidney heart rate; hyperglycemia, glucosuria, adrenal effects, vomitis I rat CNS convulsion, excitable, nervous I dog CNS depression; temperature I rat 5 10 nervous system tremor, Ca2+, K+ I dog nervous system tremor, ataxia I dog CNS, blood tremor; platelets, Na+, Cl- I rat CNS tremor I mouse CNS tremor, clonic convulsion I rat 5 20 kidney weight I38 13 dog CNS, gastrointestine tremor, ataxia, incoordination, hyperaesthesia, diarrhoea, b.w. I /82 52 dog vomitis, I mouse blood, liver anemia, thrombocyt.; weight I (1981) 104 (104) rat 7.5 (5.0) 50 (50) kidney, liver BUN; liver + kidney w. I rat plasma protein, body weight I dog liver pnod, food intake I dog liver cyt.p-450; cholest., food I rat thyroid mineralisation of follicles I mouse water consumpt. I rat ChE plasma + RBC-ChE I dog ChE plasma + RBC-ChE I rat ChE plasma, RBC+ brain-che, b.w I dog < 2 2 ChE plasma + RBC-ChE I mouse ChE plasma + RBC-ChE I rat ChE plasma-che I dog ChE plasma-che I dog ChE brain, plasma + RBC-ChE I mouse < ChE brain + plasma-che

5 Table 3 5 I rat ChE brain, plasma + RBC-ChE I rat ChE plasma, RBC and brain-che; I dog ChE plasma-che I mouse ChE plasma-che I /65 52 dog ChE plasma-che I rat ChE plasma + RBC + brain-che I mouse ChE plasma-che I rat ChE plasma + RBC-ChE I dog ChE plasma-che I rat 1 25 ChE, ovary, liver, kidney, brain plasma, RBC + brain-che brain + ovary, liver, kidney w. I dog ChE plasma-che I dog 4 16 CNS, thymus gastrointestine locomotor impairment; thymus weight;, vomitis, fluid feces I mouse a.ph., ALAT; I rat bone fluor concentr.; I mouse ChE plasma-che I rat ChE plasma-che I dog ChE plasma-che I dog ChE plasma + RBC-ChE, weight I mouse ChE plasma-che I rat ChE plasma + RBC-ChE I rat 3 9 liver weight, body weight I dog CNS tremor, ataxia, mortality I rat ChE plasma-che I dog ChE plasma + RBC-ChE I mouse < ChE plasma-che I rat ChE plasma-che I dog ChE plasma-che I rat ChE RBC-ChE I dog ChE RBC-ChE I rat ChE, eye brain-che; lenticular opacity I dog water consumpt. I mouse 8 40 kidney weight; I rat ChE plasma-che I dog ChE plasma + RBC-ChE I /85 13 rat ChE blood + brain-che I /87 13 dog plasma + RBC-ChE, salivation I dog ChE, testis plasma-che; testicul. degenerat. I rat 1 5 ChE brain, plasma + RBC-ChE I mouse 3 18 ChE brain-che I rat CNS mortality, uncoordinate movement general cond.; body weight I dog CNS, gastrointestine uncoordinate movement, emesis, diarrhoea; body weight gain

substance year week species NOEL LOEL target organs symptoms at LOEL appl. Fungicides

substance year week species NOEL LOEL target organs symptoms at LOEL appl. Fungicides 1 F01 1977 13 dog 7.4 37.5 liver AST, a.ph. F01 1980 13 rat 3.5 16.2 adrenal, kidney weight; BUN F01 1980 104 rat 2.5 12.5 liver fatty infiltration, weight F01 1980 104 mouse 35.7 178.5 body weight F01

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