The Muscular System. Specialized tissue that enable the body and its parts to move.

Transcription

1 The Muscular System Specialized tissue that enable the body and its parts to move.

2 Anterior View

3 Posterior View

4 TRIVIA! How many muscles are there in the human body? Answer: 640 Muscles The muscles make up about 40 % of the body mass. What is the longest muscle in the body? Answer: The Sartorius The Sartorius runs from the outside of the hip, down and across to the inside of the knee. It twists and pulls the thigh outwards. What is the smallest muscle in the body? Answer: The Stapedius The Stapedius is located deep in the ear. It is only 5mm long and thinner than cotton thread. It is involved in hearing. What is the biggest muscle in the body? Answer: The Gluteus Maximus The Gluteus Maximus is located in the buttock. It pulls the leg backwards powerfully for walking and running.

5 Functions of the Muscles Movement Maintenance of posture and muscle tone Heat production Protects the bones and internal organs.

6 Muscle Classification Functionally Voluntarily can be moved at will Involuntarily can t be moved intentionally Structurally Striated have stripes across the fiber Smooth no striations

7 The 3 Types of Muscles 3 Types of Muscles Skeletal Muscle Smooth Muscle Cardiac Muscle

8 Smooth Muscle Fibers are thin and spindle shaped. No striations Single nuclei Involuntary Contracts slowly

9 Smooth Muscle They fatigue but very slowly Found in the circulatory system Lining of the blood vessels Helps in the circulation of the blood Found in the digestive system Esophagus, stomach, intestine Controls digestion Found in the respiratory system Controls breathing Found in the urinary system Urinary bladder Controls urination

10 Cardiac Muscle Cells are branched and appear fused with one another Has striations Each cell has a central nuclei Involuntary

11 Cardiac Muscle Found ONLY in the heart Contractions of the heart muscles pump blood throughout the body and account for the heartbeat. Healthy cardiac muscle NEVER fatigues or else

12 Skeletal Muscle Fibers are long and cylindrical Has many nuclei Has striations Have alternating dark and light bands Voluntary

13 Skeletal Muscle Attached to skeleton by tendons Causes movement of bones at the joints. And yes they do fatigue Muscle fatigue activity what substance forms causing muscle fatigue??? Lactic Acid

14 Functions of Skeletal Muscle Movement muscle move bones by pulling not pushing. Synergists any movement is generally accomplished by more than one muscle. All of the muscles responsible for the movement are synergists. The one that is most responsible for the movement is the Prime Mover (agonist).

15 Functions of Skeletal Muscle Movement Antagonists muscles and muscle groups usually work in pairs example the biceps flex your arm and its partner the triceps extend your arm. The two muscles are antagonists, i.e. cause opposite actions. when one contracts the other relaxes. Levators muscle that raise a body part.

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17 Functions of Skeletal Muscle Maintenance of posture or muscle tone We are able to maintain our body position because of tonic contractions in our skeletal muscles. These contractions don t produce movement yet hold our muscles in position. Heat production contraction of muscles produces most of the heat required to maintain body temperature.

18 Structure of Skeletal Muscle Composed of striated muscle cells (=muscle fibers) and connective tissue. Most muscles attach to 2 bones that have a moveable joint between them. The attachment to the bone that does not move is the origin. The attachment to the bone that moves is the insertion. Tendons anchor muscle firmly to bones. Tendons are made of dense fibrous connective tissue. Ligaments connect bone to bone at a joint.

19 Structure of Skeletal Muscle Bursae small fluid filled sacs that lie between some tendons and the bones beneath them. They are made of connective tissue and are lined with synovial membrane that secretes synovial fluid.

20 Structure of Skeletal Muscle Contribution of the nervous system Electrochemical impulses travel from the frontal lobes of the cerebrum via motor nerves to the muscle fibers and cause them to contract. Sensation is a function of the brain impulses are integrated in the parietal lobes of the cerebrum (conscious muscle sense) and in the cerebellum (unconscious). These activities promote coordination.

21 Structure of Skeletal Muscle Microscopic anatomy Muscle cells (fibers) are grouped in a highly organized way in the muscle. The membrane that surrounds the muscle cell is called the sarcolemma. Muscle cells are filled with 2 types of fine threadlike proteins called myofilaments: myosin (thick) and actin (thin). These structures slide past each other causing the muscle cell to contract or shorten. The myofilaments are arranged in the cells in small units called sarcomeres.

22 Structure of Skeletal Muscle Neuromuscular junction Spot where the axon of a motor nerve nears the muscle fiber. The axon terminal does not touch the muscle but comes close. The space between the axon and the muscle cell is called the synapse. Within the terminal end of the axon are small sacs filled with a neurotransmitter called acetylcholine.

23 Muscle Contraction Sequence Electrical impulse travels down a motor neuron. When it reaches the end, acetylcholine (chemical) is released into the synapse. Acetylcholine bind to special receptors on the muscle cell and causes an electrical impulse to spread over the cell. The sarcomeres shorten and the muscle cell contracts.

24 Naming Skeletal Muscles Location of the muscle Shape of the muscle Relative Size of the muscle Direction/Orientation of the muscle fibers/cells Number of Origins Location of the Attachments Action of the muscle

25 Muscles Named by Location Location: frontalis frontal bone lateralis lateral or on the side tibialis anterior front of tibia fibularis longus near fibula supra above infra below sub - underneath

26 Muscles Named by Shape Shape: deltoid triangle Latissimus wide teres - round trapezius trapezoid serratus saw-tooth orbicularis circular

27 Naming Skeletal Muscles Shape: Trapezius Deltoid Serratus anterior Rhomboideus major

28 Muscles Named by Size Maximus largest Minimis smallest Longus longest Brevis short Major large Minor small Psoas minor Psoas major

29 Muscles Named by Direction of Fibers Direction/Orientation: Rectus (straight) - parallel to the muscle s long axis ex: rectus abdominis Transversus (transverse) at right angles to the muscle s long axis Oblique diagonal

30 Muscles Named by Direction of Fibers Rectus abdominis External oblique

31 Muscles Named for Number of Origins Biceps 2 Biceps brachii Triceps 3 Quadriceps 4

32 Muscles Named for Origin and Insertion Sternocleidomastoid originates from sternum and clavicle and inserts on mastoid process of temporal bone insertion origins

33 Origin and Insertion: sterno = sternum Muscles Named for Origin and Insertion Points cleiodo = clavicle mastoid = location on the temporal bone sternocleiodomastoid muscle

34 Muscles Named for Action Flexor carpi radialis (extensor carpi radialis) flexes wrist Abductor pollicis brevis (adductor pollicis) flexes thumb Abductor magnus abducts thigh Extensor digitorum extends fingers Adductor magnus

35 Arrangement of Fascicles Parallel - strap-like ex: sartorius Fusiform - spindle shaped ex: biceps femoris

36 Pennate "feather shaped Unipennate one Feather ex: extensor digitorum longus Bipennate Two Feahers ex: rectus femoris Multipennate Many Feathers ex: deltoid Arrangement of Fascicles

37 Arrangement of Fascicles Convergent Coming together ex: pectoralis major Circular - Round Called sphincters ex: orbicularis oris

38 There are about 60 muscles in the face. Smiling is easier than frowning. It takes 20 muscles to smile and over 40 to frown. Smile and make someone happy.

39 Anatomy of the Muscular System Origin Insertion Action Muscle attachment that remains fixed Muscle attachment that moves What joint movement a muscle produces i.e. flexion, extension, abduction, etc.

40 For muscles to create a movement, they can only pull, not push Muscles in the body rarely work alone, & are usually arranged in groups surrounding a joint A muscle that contracts to create the desired action is known as an agonist or prime mover A muscle that helps the agonist is a synergist A muscle that opposes the action of the agonist, therefore undoing the desired action is an antagonist

41 Anatomy of skeletal muscles tendon epimysium perimysium Muscle Fascicle Surrounded by perimysium Skeletal muscle Surrounded by epimysium endomysium Skeletal muscle fiber (cell) Surrounded by endomysium

42 Microanatomy of a Muscle Fiber (cell)

43 Microanatomy of a Muscle Fiber (Cell) transverse (T) tubules sarcoplasmic reticulum terminal cisternae sarcolemma myoglobin mitochondria thick myofilament thin myofilament myofibril nuclei triad Play IP Anatomy of Skeletal muscles (IP p. 7)

44 Muscle fiber Myofibril Z-line sarcomere Sarcomere Thin filaments Thin myofilament Myosin molecule of thick myofilament Thick filaments

45 Thin Myofilament (myosin binding site)

46 Thick myofilament (has ATP & actin binding site)

47 Sarcomere Z line A band H zone Z line Thin myofilaments I band Zone of overlap Thick myofilaments M line Zone of overlap

48 Sliding Filament Theory Myosin heads attach to actin molecules (at binding (active) site) Myosin pulls on actin, causing thin myofilaments to slide across thick myofilaments, towards the center of the sarcomere Sarcomere shortens, I bands get smaller, H zone gets smaller, & zone of overlap increases

49 As sarcomeres shorten, myofibril shortens. As myofibrils shorten, so does muscle fiber Once a muscle fiber begins to contract, it will contract maximally This is known as the all or none principle

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51 Sarcomere Z A Z A Z I Z Z Z

52 Physiology of skeletal muscle contraction Skeletal muscles require stimulation from the nervous system in order to contract Motor neurons are the cells that cause muscle fibers to contract cell body dendrites axon hillock axon telodendria Synaptic terminals (synaptic end bulbs) (motor neuron)

53 Neuromuscular junction telodendria Synaptic terminal (end bulb) Synaptic vessicles containing Ach Neuromuscular junction Motor end plate of sarcolemma Synaptic cleft

54 Overview of Events at the neuromuscular junction An action potential (AP), an electrical impulse, travels down the axon of the motor neuron to the end bulbs (synaptic terminals) The AP causes the synaptic vesicles to fuse with the end bulb membrane, resulting in the release of Acetylcholine (Ach) into the synaptic cleft Ach diffuses across the synaptic cleft & binds to Ach receptors on the motor end plate The binding of Ach to its receptors causes a new AP to be generated along the muscle cell membrane Immediately after it binds to its receptors, Ach will be broken down by Acetylcholinesterase (AchE) an enzyme present in the synaptic cleft

55 Arrival of an action potential at the synaptic terminal Arriving action potential Action potential Synaptic terminal Axon Sarcolemma Synaptic cleft Sarcolemma of motor end plate Vesicles ACh AChE molecules ACh receptor site Muscle fiber An action potential (AP), an electrical impulse, travels down the axon of the motor neuron to the end bulbs (synaptic terminals) Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 7-4(b-c) 2 of 5

56 Arrival of an action potential at the synaptic terminal Arriving action potential Action potential Synaptic terminal Axon Sarcolemma Synaptic cleft Sarcolemma of motor end plate Vesicles ACh AChE molecules ACh receptor site Muscle fiber Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. The AP causes the synaptic vesicles to fuse with the end bulb membrane, resulting in the release of Acetylcholine (Ach) into the synaptic cleft Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 7-4(b-c) 3 of 5

57 Arrival of an action potential at the synaptic terminal Arriving action potential Action potential Synaptic terminal Axon Sarcolemma Synaptic cleft Sarcolemma of motor end plate Vesicles ACh AChE molecules ACh receptor site Muscle fiber Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. ACh binding at the motor and plate The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Na + Ach diffuses across the synaptic cleft & binds to Ach receptors on the motor end plate Na + Na + Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 7-4(b-c) 4 of 5

58 The binding of Ach to its receptors causes a new AP to be generated along the muscle cell membrane Immediately after it binds to its receptors, Ach will be broken down by Acetylcholinesterase (AchE) an enzyme present in the synaptic cleft

59 Physiology of Skeletal Muscle Contraction Table 7-1 Once an action potential (AP) is generated at the motor end plate it will spread like an electrical current along the sarcolemma of the muscle fiber The AP will also spread into the T-tubules, exciting the terminal cisternae of the sarcoplasmic reticula This will cause Calcium (Ca +2 ) gates in the SR to open, allowing Ca +2 to diffuse into the sarcoplasm Calcium will bind to troponin (on the thin myofilament), causing it to change its shape. This then pulls tropomyosin away from the active sites of actin molecules. The exposure of the active sites allow the sliding of the filaments

60 Physiology of skeletal muscle contraction events at the myofilaments Resting sarcomere Active-site exposure ADP + P Troponin Myosin head ADP + P Sarcoplasm Ca 2+ Tropomyosin Actin ADP P + Active site ADP P + Ca 2+ Calcium (Ca +2 ) gates in the SR open, allowing Ca +2 to diffuse into the sarcoplasm Calcium will bind to troponin (on the thin myofilament), causing it to change its shape. This then pulls tropomyosin away from the active sites of actin molecules. Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure of 7

61 Physiology of skeletal muscle contraction events at the myofilaments Resting sarcomere Active-site exposure Cross-bridge formation ADP + P Troponin Myosin head ADP + P Sarcoplasm ADP + P Ca 2+ Ca 2+ Tropomyosin Actin ADP P + Active site ADP P + Ca 2+ ADP + P Ca 2+ Myosin heads are energized by the presence of ADP + PO 4 3- at the ATP binding site (energy is released as phosphate bond of ATP breaks) Once the active sites are exposed, the energized myosin heads hook into actin molecules forming cross-bridges Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure of 7

62 Physiology of skeletal muscle contraction events at the myofilaments Resting sarcomere Active-site exposure Cross-bridge formation ADP + P Troponin Myosin head ADP + P Sarcoplasm ADP + P Ca 2+ Ca 2+ Tropomyosin Actin ADP P + Active site ADP P + Ca 2+ ADP + P Ca 2+ Using the stored energy, the attached myosin heads pivot toward the center of the sarcomere The ADP & phosphate group are released from the myosin head Pivoting of myosin head ADP + P Ca 2+ Ca 2+ ADP + P Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure of 7

63 Physiology of skeletal muscle contraction events at the myofilaments Resting sarcomere Active-site exposure Cross-bridge formation ADP + P Troponin Myosin head ADP + P Sarcoplasm ADP + P Ca 2+ Ca 2+ Tropomyosin Actin ADP P + Active site ADP P + Ca 2+ ADP + P Ca 2+ A new molecule of ATP binds to the myosin head, causing the cross bridge to detach from the actin strand The myosin head will get re-energized as the ATP ADP+P Cross bridge detachment ATP Ca 2+ Ca 2+ ATP Pivoting of myosin head ADP + P Ca 2+ Ca 2+ ADP + P As long as the active sites are still exposed, the myosin head can bind again to the next active site

64 Physiology of skeletal muscle contraction events at the myofilaments Resting sarcomere Active-site exposure Cross-bridge formation ADP + P Troponin Myosin head ADP + P Sarcoplasm ADP + P Ca 2+ Ca 2+ Tropomyosin Actin ADP P + Active site ADP P + Ca 2+ ADP + P Ca 2+ Myosin reactivation Cross bridge detachment Pivoting of myosin head ADP + P ATP ADP + P Ca 2+ Ca 2+ Ca 2+ Ca 2+ ADP P + Ca 2+ ATP Ca 2+ ADP + P - animation animation with Taylor Swift song

65 Physiology of Skeletal Muscle Contraction Table 7-1 If there are no longer APs generated on the motor neuron, no more Ach will be released AchE will remove Ach from the motor end plate, and AP transmission on the muscle fiber will end Ca +2 gates in the SR will close & Ca +2 will be actively transported back into the SR With Ca +2 removed from the sarcoplasm (& from troponin), tropomyosin will re-cover the active sites of actin No more cross-bridge interactions can form Thin myofilaments slide back to their resting state

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67 Muscle Fiber Contraction These physiological processes describe what happen at the cellular level how skeletal muscle fibers contract But what about at the organ level? How do skeletal muscles (like your biceps brachii) contract to create useful movement?

68 Muscle Fiber Contraction Skeletal muscles are made up of thousands of muscle fibers A single motor neuron may directly control a few fibers within a muscle, or hundreds to thousands of muscle fibers All of the muscle fibers controlled by a single motor neuron constitute a motor unit

69 The size of the motor unit determines how fine the control of movement can be small motor units precise control (e.g. eye muscles large motor units gross control (e.g. leg muscles)

70 Recruitment is the ability to activate more motor units as more force (tension) needs to be generated Hypertrophy stressing a muscle (i.e. exercise) causes more myofilaments/myofibrils to be produced within muscle fibers; allows for more cross bridges resulting in more force (strength) as well as larger size There are always some motor units active, even when at rest. This creates a resting tension known as muscle tone, which helps stabilize bones & joints, & prevents atrophy PLAY Play IP Contraction of motor units p. 3-7

71 MUSCLE MYOFIBRIL MUSCLE FIBER SARCOMERE

72 Movement of skeletal muscle These muscles move when the brain sends messages to the muscle Always work in pairs 2 movements of skeletal muscle Contraction (shorten) Extension (lengthen)

73 Categories of skeletal muscle actions Categories Actions Extensor Increases the angle at a joint Flexor Decreases the angle at a joint Abductor Moves limb away from long axis of body Adductor Moves limb toward long axis of body Levator Moves insertion upward Depressor Moves insertion downward Rotator Rotates a bone along its axis Sphincter Constricts an opening

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