Leadless pacing. P.E. Vardas Professor of Cardiology University of Crete, Greece
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1 Leadless pacing P.E. Vardas Professor of Cardiology University of Crete, Greece
2 DISCLOSURES Small teaching fees from: Bayer/J&J, Boeringer, Menarini Small consulting fees from: Medtronic
3 1957: First External Pacemaker
4 1958: First implanted pacemaker Elmquist Senning Larsson First implantable (Engineer) (Cardiologist) (Patient) pacemaker
5 Pacemakers ( ) Activitrax MicroMinix Thera EnPulse EnRhythm MRI First External Pacemaker Pediatric Asynchronous Pulse Generator Rate response Radically smaller size First Microprocessor-based, Mode switching Full automaticity MRI safe First Implantable MDT Pacemaker Chardack-Greatbatch Byrel Dual chamber rate response Synergist Elite Rate response via activity & minute ventilation Kappa MVP, Full automaticity Adapta MVP, Full automaticity, MRI safe Advisa MRI
6 54 years after cardiac pacing is the only effective treatment for syncope due to symptomatic bradycardia
7 Milestones in Pacing 1960 s Durable permanent implants VVI and VAT modes Lithium-iodine battery cell 1970 s VDD and DDD pacing modes Rate-responsiveness 1980 s Microprocessors introduced Improved reliability of IPGs Steroid elution First ICD implant 1990 s-2000 s IS-1 connector standard Stored electrograms Biventricular pacing Transvenous implants ICD
8 Conventional sites of pacing leads Pacing from RA appendage Pacing from RV apex easy feasibility chronically stable mechanical positions stable stimulation thresholds
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10 System proposed by Spickler in 1970
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13 Questions that arise
14 Problems accompanying endocardial pacing
15 Leadless pacing technologies EBR technology Energy transfer from an ultrasound transmitter to a receiver electrode to achieve cardiac stimulation Induction technology Magnetic field generated from a transmitter unit to the receiver coil in the heart and converted directly into voltage pulses for stimulation Wireless electrical stimulation An implantable RF rechargeable bion microstimulator transmits command signals to the coil that generates direct electrical stimulation
16 Investigational stimulation system an ultrasound generator with an externally applied ultrasound transmission transducer a catheter incorporating a receiver electrode into the distal tip a data collection and display system Feasibility and safety of pacing using ultrasound energy JACC 2007
17 Induction technology The stimulation system consists basically of two components a transmitter unit (primary coil) implanted under the skin or the major pectoralmuscle just above the heart a small receiver unit (secondary coil) implanted in the right or left chamber of the heart The subcutaneous coil generates an alternating magnetic field and the receiver coil in the heart converts some fraction of the energy of this magnetic field directly into voltage pulses for stimulation Induction technology represents an energy transmission with an outstanding characteristic: very low energy loss Screw-equipped receiver unit without external connection Wieneke H et al, PACE 2009
18 Induction technology The complete control of the electrical pulse is in the transmitter unit The device can be programmed like a conventional pacemaker by telemetry pulse amplitude pulse duration frequency number of pulses Receiver unit mounted on an EP catheter positioned in the RV Receiver unit without external connection in the RV. The transmitter unit is placed on the outer thoracic wall directly beyond the receiver unit. Bottom: ECG tracing during wireless pacing
19 WiSE-CRT Study Wireless Stimulation Endocardially for CRT, 100 pts. Purpose: To evaluate the safety and performance of the WiCS-LV System in patients with indications for CRT. Primary Outcome Measures: Safety: Procedure and device-related adverse events Bi-ventricular pacing capture Inclusion Criteria: Patients with standard indication for CRT based upon the most recent guidelines AND meeting criteria for one of these three categories: PM and ICD upgrades LV lead failures Non responders
20 Leadless Pacing: Acoustic Energy WiSE Device: Receiver: 9 mm plus small lead, 0.05 cc Transmitter: implanted over the apex, connected to battery implanted in the abdomen
21 Leadless Pacemaker: Intracardiac Intracardiac VVIR pacemaker ~20F, ~24 mm length, 7-10 yr longevity Steerable Catheter +
22 Leadless Pacemaker: Intracardiac
23 Leadless pacing Comments Advantages Percutaneous catheter-based endovascular implant Precise placement in many locations True multisite ventricular stimulation Epicardial placement Possible endocardial left heart placement Reduced infection Reduced vascular occlusion Disadvantages Recharging energy source Compliance Travel Stability/embolization Complexity of follow up and programming
24 Novel technologies Biological pacemakers An approach to create a pacemaker in a cell that previously had little or no pacemaker function These approaches modify the electric signals generated by cardiac myocytes and/or specialized conducting cells to transform them into dominant pacemakers
25 Strategies to generate biological pacemakers Gene therapy overexpress a gene that will increase pacemaker rate in cardiac myocytes (by increasing inward current) knock out the function of a gene that would otherwise decrease pacemaker rate (and decrease outward current) Stem cell therapy Human embryonic stem cells-hescs Human mesenchymal stem cells-hmscs
26 Limitations for development of biological pacemaker Gene therapy-viral vectors Adenoviruses lead to only transient improvement in pacemaker function potential inflammatory responses Retroviruses risk of carcinogenicity and infectivity Stem cell therapy immunogenicity of cell potential for neoplasia proper engineering of pure cardiac lineages spatial non uniformity of implants need for an optimal cell mass and optimal cell-cell coupling for long term normal function
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