Less Invasive Aortic Valve Surgery
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1 Less Invasive Aortic Valve Surgery SCTS Brighton 19th March 2013 Andrew Chukwuemeka MD FRCS Consultant Cardiothoracic Surgeon Hammersmith Hospital Imperial College Healthcare NHS Trust
2 Less Invasive Aortic Valve Surgery TAVI New valves Sutureless, rapid deployment, AVR Incisions Mini-sternotomy / mini-thoracotomy Mini-CPB
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5 Aortic valve surgery in the UK
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8 Is this safe?
9 Valve Surgery in Octogenarians: A Safe Option with Good Medium-Term Results Andrew Chukwuemeka, Michael A. Borger, Joan Ivanov, Susan Armstrong, Christopher M. Feindel, Tirone E. David Division of Cardiovascular Surgery, Toronto General Hospital and Department of Surgery, University of Toronto Conclusion: Valve surgery in selected octogenarians is associated with low morbidity and mortality. The outlook after surgery is very good, and surgery should not be denied to this group on the basis of age alone. The Journal of Heart Valve Disease 2006;15:
10 Euro Heart Survey A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease. Eur Heart J 2003 Jul;24(13): in 3 patients with severe symptomatic AS did not have surgery
11 Unmet need in severe AS Charlson E et al. Decision-making and outcomes in severe symptomatic aortic stenosis. J Heart Valve Dis 2006;15: Iung B et al. A prospective survey of patients with valvular heart disease in Europe:The Euro Heart Survey on Valvular Heart Disease. European Heart Journal 2003;24: % 32% Bouma B J et al. To operate or not on elderly patients with aortic stenosis:the decision and its consequences. Heart 1999;82: %
12 Unmet need in severe AS Charlson E et al. Decision-making and outcomes in severe symptomatic aortic stenosis. J Heart Valve Dis 2006;15: Iung B et al. A prospective survey of patients with valvular heart disease in Europe:The Euro Heart Survey on Valvular Heart Disease. European Heart Journal 2003;24: % 32% Bouma B J et al. To operate or not on elderly patients with aortic stenosis:the decision and its consequences. Heart 1999;82: % TAVI is a much needed alternative to conventional AVR
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14 What is TAVI (R)?
15 Less Invasive Aortic Valve Surgery - TAVI Access routes: Transfemoral Transapical Direct aortic Subclavian (axillary) Iliac +/- conduit Depends on: patient anatomy team preference experience
16 Ann Thorac Surg May;79(5):1812-8
17 Multidisciplinary approach Heart Team
18 TAVI team Cardiac surgeons Interventional cardiologists Imaging cardiologists Radiologists Elderly care physicians Anaesthetist Critical care physicians Specialist nurses Physiotherapists Occupational therapists Rehabilitation Perfusionists Operating theatre team Psychologists
19 TAVI patient selection Anatomically suitable, inoperable or very high-risk, severe symptomatic AS Elderly (but not exclusively) Co-morbidities respiratory, renal, poor LV, hepatic ++++ Contraindication to AVR porcelain aorta, mediastinal radiation Risk score (STS >10%, EuroSCORE >20%) Frailty
20 Frailty in TAVI Frail Patients Are at Increased Risk for Mortality and Prolonged Institutional Care After Cardiac Surgery. Circulation 2010;121:973-8 Complex interaction between age and chronic illness Chronological age is not the same as biological age Subjective Parameters: gait, 5m walk speed, grip strength, ADL, biological markers (albumin, bilirubin, lung function tests), +++
21 Frailty in TAVI
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23 Risk scoring in TAVI
24 Risk scoring in TAVI
25 TAVI RESULTS PARTNER B
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27 PARTNER B - NYHA
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29
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31 PARTNER A: UPDATE 2 year results PARAVALVULAR LEAK
32 PARTNER A: UPDATE 2 year results
33 The future of TAVI? Improving patient selection ( picking the winners ) Improving technology (access, paravalvular leak, stroke) Adhering to established principles (durability etc.)
34
35 Major Dwight Harken US Army 133 consecutive survivors First series of successful open heart operations
36 Ten Commandments - Dwight Harken It must not propagate emboli It must be chemically inert and not damage blood elements It must offer no resistance to physiological flows It must close promptly It must remain closed during the appropriate phase of the cardiac cycle It must have lasting physical and geometric features It must be inserted in a physiological site It must not annoy the patient It must be capable of permanent fixation It must be technically practical to insert A A device is safe when it is safer than the condition it corrects
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38 New valve technology Sutureless AVR:
39 PERCEVAL S sutureless AVR Dedicated tools facilitate visibility at the implant site and accurate valve positioning As supplied Collapsed Ready to implant Perceval S Valve collapsing Valve collapsed to a reduced diameter (not crimped)
40 Sutureless AVR -Potential benefits Ease of implantation resulting in a shorter cross-clamp clamp and cardiopulmonary bypass time High-risk comorbidities, advanced age Concomitant cardiac procedures Adhere to established surgical principles (unlike TAVI) Annular decalcification (emboli, paravalvular leak) Direct vision
41 IMPLANTATION Ready to implant Valve deployment Implant Valve is collapsed to a reduced diameter 2-Step Deployment & Balloon Dilatation Valve is positioned in aorta
42 IMPLANTATION
43 Sutureless AVR HAMMERSMITH EXPERIENCE Total n=17 Age Range: Mean: 85.6 yrs +/- 5.9 Gender Female: 6 (35%) Male: 11 (65%) Logistic Euroscore Range: Mean: /- 13.8
44 Sutureless AVR HAMMERSMITH EXPERIENCE Procedure AVR only 12 (61%) AVR + CABG 5 (29%) Bypass Time Range: 49 77min Mean: 59.4min +/ Valve Sizes S 5 M 8 L 4 Cross-clamp Time Range: 27 58min Mean: 44.1min +/- 10.4
45 Sutureless AVR HAMMERSMITH EXPERIENCE
46 Minimally-invasive aortic surgery
47 Minimally-invasive AVR Ministernotomy versus conventional sternotomy for aortic valve replacement: A systematic review and meta-analysis. Morgan L. Brown, MD, Stephen H. McKellar, MD, Thoralf M. Sundt, MD, and Hartzell V. Schaff, MD Conclusion: Ministernotomy can be performed safely for aortic valve replacement, without increased risk of death or other major complication; however, few objective advantages have been shown. Surgeons must conduct well-designed, prospective studies of relevant, consistent clinical outcomes to determine the role of ministernotomy in cardiac surgery. Brown et al. JTCVS March 2009
48 Marginal benefit wrt mortality, ICU stay. Longer CPB and XC time Patient choice Cosmesis
49 Cardiopulmonary bypass Cardioplegic arrest in diastole Bloodless operative field Detrimental effects of extracorporeal circulation Risks vs. benefits
50 Miniature Cardiopulmonary Bypass 1. Optimise venous drainage 2. Minimise microair 3. Minimise surface contact 4. Minimise blood damage 5. Minimise haemodilution
51 Optimise Venous Drainage Controlled Kinetic Venous Drainage Smaller cannula 29 French Many draining holes Holes set into grooves Long cannula Improves Liver/ GIT drainage?
52 Minimise Microair 300ml/min 5sec 120µ filter Pump flow Active rather than Passive air removal Perthel M, El-Ayoubi L, Bendisch A, Laas J, Gerigk M. Clinical advantages of using mini-bypass systems in terms of blood product use, postoperative bleeding and air entrainment: an in vivo clinical perspective. Eur J Cardio-thorac Surg 2007;31:
53 Minimise Surface Contact Oxygenator is the largest non-physiological surface in CPB circuit 1.8m 2 Gas Exchange Surface Area 1.1m 2 Gas Exchange Surface Area
54 Minimise Blood Damage Well Managed Suction/Vent Blood ( Air Mixing and -P) Poorly Managed Suction/Vent Blood ( Air Mixing and -P)
55 Minimise Haemodilution Patient Specific Volume Strategy NOT Volume Restrictive Retrograde Autologous Prime Antegrade Autologous Prime
56 Less Invasive Aortic Valve Surgery TAVI New valves Sutureless, rapid deployment, AVR Incisions Mini-sternotomy / mini-thoracotomy Mini-CPB
57 In times of change, the learners inherit the Earth while the learned find themselves beautifully equipped to deal with a world that no longer exists.
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