Paraplegia in endovascular repair of TAA and in TEVAR: Incidence, prevention and therapy. Johannes Lammer Medical University Vienna, Austria

Transcription

1 Paraplegia in endovascular repair of TAA and in TEVAR: Incidence, prevention and therapy Johannes Lammer Medical University Vienna, Austria

2 Conflict of interests: none

3 68y, male, PAU in coral reef aorta, distal embolization; paraplegia 24h after intervention

4

5 Spinal Cord Ischaemia in Endovascular Thoracic and Thoraco-abdominal Aortic Repair: Review of Preventive Strategies. Dijkstra ML, Vainas T, Zeebregts CJ, Hooft L, van der Laan MJ. Eur J Vasc Endovasc Surg Mar studies (7168 patients). Transient SCI in 5.7% (450/7,168) Permanent SCI in 2.2% (232/7,168)

6 Incidence of Spinal Cord Ischemia (SCI) after TEVAR of TAA, TAAA, and Acute Dissection TEVAR OSR N % N % p All paraplegia, paraparesis 46/1, /1, ** Permanent paraplegia 9/ / ** *Contemporary spinal cord protection during thoracic and thoracoabdominal aortic surgery and endovascular aortic repair: a position paper of the vascular domain of the European Association for Cardio-Thoracic Surgery. Etz CD, et al. Eur J Cardiothorac Surg Jun;47(6): **Endovascular aortic repair versus open surgical repair for descending thoracic aortic disease a systematic review and meta-analysis of comparative studies. Cheng D, et al. J Am Coll Cardiol Mar 9;55(10):

7 Anatomy of spinal cord arterial supply 4 levels of supply: Subclavian arteries Intercostal arteries Lumbo-sacral arteries Hypogastric arteries

8 Imaging of anterior spinal artery (ASA) ASA detectability was at 80-83% using CTA and 90-93% with time resolved MRA. Use of both CTA and MRA provided detection rates of 97%. MR angiography and CT angiography of the artery of Adamkiewicz: state of the art. Yoshioka K, et al. Radiographics Oct;26 Suppl 1:S Identifying the Adamkiewicz artery using 3-T time-resolved magnetic resonance angiography: its role in addition to multidetector computed tomography angiography. Takagi H, et al. Jpn J Radiol Dec;33(12):

9 Risk factors for SCI after TEVAR of TAA, TAAA, and Acute B-Dissection Previous aortic surgery (destruction of collateral arterial network). Length of covering the aorta. Occlusion of > 1 level of arterial supply: i.e. additional occlusion of left subclavian occlusion of hypogastric arteries. Post-OP hypotension (mean arterial pressure < 80mmHg). High cerebro-spinal fluid (CSF) pressure (>10mmHg). Patient age. Renal insufficiency.

10 Strategies to prevent spinal cord ischemia Arterial procedures: Imaging of arteria Adamkiewicz and spinal arterial supply. In case of subclavian artery coverage, revascularization by bypass, transposition, or stentgraft with side branch. In case of bilateral hypogastric artery occlusion, use of distally branched stentgraft. Early removal of iliac artery flow blocking sheath. Staged stenting: delayed connection of one side branch to maintain sack perfusion for collateral artery development. MISACE - minimal invasive spinal artery coil embolization before stentgraft procedure to induce collateral artery development.

11 Strategies to prevent spinal cord ischemia Medical precautions Cerebro-spinal fluid (CSF) drain 24 hours before endovascular procedure to enable heparinization without risk for epidural hematoma IMC/ICU stay for min. 48 hours (SCI detection after 0-72 hours, mean 10 h). Post-OP mean arterial pressure >80mmHg, to prevent spinal hypoperfusion. Cerebro-spinal fluid (CSF) pressure 10mmHg (spinal cord ischemia may cause oedematous swelling and CSF hypersecretion). Neurologic monitoring for min. 48 hours.

12 Strategies to treat spinal cord ischemia CSF drainage pressure initially < 7mmHg, output not > 20ml/h. Systolic arterial pressure mmHg, mean arterial pressure > 80mmHg. Dexametasone, Mannitol 20% Systemic hypothermia (35 C)

13 Conclusion Incidence: 3.4% - 5.7% Prevention: preoperative protection of collateral flow CSF catheter ICU monitoring (RR, neurology, CSF pressure) Treatment: CSF drainage RR increase Dexametasone, Mannitol 20%