CURRICULUM VITAE BABBETTE LAMARCA, PH.D.

Transcription

1 PERSONAL: Born: December 19, 1972 Jackson, Mississippi CURRICULUM VITAE BABBETTE LAMARCA, PH.D. Married: Children: Darren LaMarca Ellen LaMarca Emma LaMarca Evan Charles LaMarca ACADEMIC APPOINTMENTS: Present Professor, Department of Pharmacology & Obstretrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 2007 Present Thesis Director, ship, Department of Obstretrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi Director of Basic Science Research, Department of Obstretrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi Assistant Professor, Department of Obstretrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi Instructor, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi Postdoctoral Fellow, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi Graduate Assistant, Department of Microbiology, University of Mississippi Medical Center Laboratory Teaching Assistant, Department of Biology, Mississippi College, Clinton, Mississippi Teacher, General Biology; Anatomy and Physiology; Chemistry; and Physiological Sciences, University Christian School, Flowood, Mississippi Research Assistant, Department of Preventative Medicine, University of Mississippi Medical Center, Jackson, Mississippi Laboratory Assistant, Department of Biology, Mississippi College, Clinton, Mississippi EDUCATION: Postdoctoral Fellow, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.

2 2003 Ph.D., Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi 1995 B.S., Mississippi College, Clinton, Mississippi RESEARCH INTERESTS: Immune mechanisms causing hypertension during pregnancy PROFESSIONAL MEMBERSHIPS: American Heart Association American Society for Microbiology American Physiological Society Society for Maternal-Fetal Medicine Perinatal Research Society HONORS, AWARDS, COMMITTEES and NATIONAL SERVICE: 2015 Chair-Department of Pharmacology Promotion-Tenure Committee 2015 Bowditch Lecturer, APS APS Awards committee APSelect Selection Board Member 2015-present 2015-present Editorial Board AJP-RIC Peer Reviewer, NIH NHLBI, Special Emphasis Panel 2015 Co-Chair Department of Pharmacology Promotions and Tenure Committee, UMMC Chair, American Heart Association, Vascular endothelial biology clinical Section 2014 Peer Reviewer, NIH NHLBI, Program Project (PO1) 2014 Editorial Board of Fronteirs in Cardiovascular Medicine 2014 American Society of Hypertension, Annual Scientific Meeting Program Committee 2014 Editorial Board of Clinical and Experimental Hypertension 2013 Excellence in Research Gold Medal Award, University of Mississippi Medical Center APS STRIDE fellowship- mentor for underrepresent minority students Medical Student Research Enhancment program- mentor for medical students in research Co-Chair, American Heart Association, Vascular endothelial biology clinical Section

3 UMMC/GSHS Alumni Board 2012-present Chairperson, Fund U Team, UMMC 2012 Young Investigator Award, American Society of Hypertension 2012-present Fellow, American Heart Association 2012 Harry Goldblatt Young Investigator Award Finalist, Council for High Blood Pressure Research, American Heart Association 2012-present Full Member, Perinatal Research Society 2012 Excellence in Research Silver Medal Award, University of Mississippi Medical Center 2012-present Faculty, American Society of Hypertension Peer Reviewer, American Heart Association, Immunology Section 2012-present Peer Reviewer, NIH NHLBI, Pathway to Independence PI Awards K99/K NICHD, 1 R01 HD067541, National Institutes of Health 2011-present 2011-present 2010-present At-Large Councilor for Membership, WEH section, American Physiological Society Excellence in Research Subcommittee, University of Mississippi Medical Center Editorial Board, Hypertension Committee on Careers in Physiology, American Physiological Society 2009-present Reviewer for Hope Grants from the Preeclampsia Foundation Delta Regions Institute Advisory Committee, UMC 2009-present 2009-present Institutional Biosafety Committee, University of Mississippi Medcial Center Research Advisory Committee, University of Mississippi Medical Center 2009 Excellence in Research Bronze Medal Award, University of Mississippi Medical Center Scientist Development Grant, American Heart Association 2007-present Graduate Faculty, University of Mississippi Medical Center 2007 Merck New Investigator Award, Council for High Blood Pressure Research 2007 Travel Award, American Physiological Society Conferences, Sex and Gender Differences in Cardiorenal Physiology and Pathophysiology 2007 Young Investigator Award Finalist, Experimental Biology

4 2006 Team Captain, American Heart Walk, Jackson, Mississippi National Research Service Award (Postdoctoral), National Institutes of Health 2005 Organizer of Methodology Discussion Group and Medical Physiology Refresher Course 2005 Postdoctoral Fellowship, American Heart Association 2005 Young Investigator Award, IASH 2003 Travel Award, American Physiological Society Conference. Understanding Renal and Cardiovascular Function through Physiological Genomics 2001 McClesky Award for Outstanding Research by a Doctoral Student, American Society of Microbiologists Secretary-Treasurer, Graduate Student Body Association Vice-President, Graduate Student Body Association INVITED REVIEWER: Hypertension Research Clinical Medicine Reviews in Vascular Health Clinical and Experimental Hypertension Placenta Circulation Kidney International American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Journal of Reproductive Sciences Journal of Experimental Medicine Journal of Renin Angiotensin Aldosterone System American Journal of Reproductive Immunology American Journal of Reproductive Toxicology American Journal of Physiology TECHNICAL SKILLS: Molecular Biology

5 Cloning of DNA segments into plasmid vectors, sequencing, cycle sequencing, PCR, reverse transcription, PCR, Real Time PCR, ELISA, Mutagenesis, Expression of recombinant proteins, Thin Layer chromatography, protein column purification, RNA, DNA, Protein extraction, Southern Blot Hybridization, Northern Blot Hybridization, Western Blot hybridization Tissue Culture Bacterial cultivation, cultivation of human cell lines, BSL-2 and BSL-3 laboratory experience In Vivo (animal) models Planning and overseeing small animal protocols, surgeries and collection of samples SOURCES OF RESEARCH SUPPORT: Pending Research Support 07/01/ /30/2022 Source: NIH/NHLBI Title:Preeclampsia: Pathophysiological mechanisms and therapeutic targets. Role: Investigator of Project I, 10% Amount:$6,930, Current Research Support 07/01/11 06/30/21 Source: NIH:NICHD Title: Hypertension, kidney and immune activation. Role: LaMarca (PI); Amount: $1,520, / /2018 Source: Lumara-AMG Pharmaceuticals Title: 17-Hydroxyprogesterone Caproate Supplementation: A Novel Therapeutic for the Management of Preeclampsia? Role: LaMarca/Amaral (PI) Amount $65,000 04/01/11 03/31/17 Source: NIH/NHLBI Title: Hypertension, Kidney and Pregnancy Role: Co-Investigator, 10% Amount: $1,867, /01/09 08/31/19 Source: NIH/NHLBI Title: Hypertension and Cardiorenal Diseases Research Training Program Role: Mentor, Babbette LaMarca, Ph.D., Mentee, Mark Cunningham, Ph.D. Amount: $1,861, /01/14 12/31/19 Source: NIH/NHLBI Title: Cardiovascular dynamics and their control Project II of the proposal seeks to determine the role of angiogenic and endothelial factors in the pathophysiology of pregnancy-induced hypertension. Role: Co-Investigator of Project II, 5% Amount: $1,261, Completed Research Support: 01/01/13-4/1/16 Source: Ferring Pharmaceauticals Inhibiting AT1-AAs; potential therapeutics during preeclampsia Role: LaMarca (PI); Amount: $130,000,.00

6 02/15/2012-2/1/2014 Source: NIH/NHLBI Title: Role of CD4+ T lymphocytes inmediating hypertension in response to placental ischemia Role: Sponsor/Mentor PI/Mentee: Kedra Wallace Amount: $75, /05/14-12/31/15 Source: NIH/NHLBI Title: Hypertension, the Kidney, and Inflammation Role: Sponsor/Mentor PI/Mentee: Denise Cornelius Amount: $75,000. 7/1/2012-6/30/2014 Source: American society for reproductive medicine Title: The role of hypoxia-stimulated vasoactive peptides in the development of uterine leiomyoma Role: Author PI/Co-author:Wallace Amount: 50, /11/10 06/01/13 "Biosite Grant," Sponsored by NSA Title: Pre-Eclampsia Triage by Rapid Assay of Novel Biomarkers of Placental Function and Maternal Adaptation (PETRA) Role: PI, Amount: $83, /01/08 07/31/12 Source: American Heart Association, Scientist Development Grant N Title: The role of Agonistic Autoantibodies to the Angiotensin II type I receptor in mediating hypertension during pregnancy Role: LaMarca (PI) Amount: $308, / /2011 Source: Institutional Research Support Title: Molecular Analysis of Uterine Leiomyomas Role: LaMarca (PI) Amount:$30, / /2008 Source: NIH-National Research Service Award Title: Mechanisms of Pregnancy Induced Hypertension Role: Lamarca (PI) Amount:$153,000. TRAINEES: 1. Lyndsey Roberts, M.D Undergradraduate Summer Research, M2, M3, M4 years 2. Derrick Chandler, Ph.D M2 3. Batira Acosta, Ph.D Assistant Professor, Faculdade de Medicina Pontificia Universidade Católica do Rio Grande do Sul 4. Matt Dukes, Ph.D / Summer 5. Josh Speed, Ph.D Graduate Student 6. Sydney Roberts, Ph.D Graduate Student

7 7. Sharon Keiser, M.D Edward Veillon, M/D Marc Parrish, D.O Kiran Tam Tam, M.D Sarah Richards, M.D Nicole Lee, M.D Present 13. Pushpinder Dhillan, M.D Justin Brewer, M.D Present 15. Louissa Kipprono, M.D Present 16. Kedra Wallace, Ph.D Present Postdoctoral Fellow 17. Marie Darby, M.D present 18. Javier Castillo, M.D present 19. Rachel Morris, M.D present 20. Jeremy Scott 2011-present Undergraduate student research MS-INBRE program Summer Undergraduate Research Expereince APS STRIDE research Fellow Denise Cornelius, Ph.D present Postdoctoral Fellow 22. James Hogg AHA Medical Student Research Fellow 23. Lorena Mechado Amaral, Ph.D 2013-present Postdoctoral Fellow 24. Adrienne Page

8 Medical Research Student Program 25. Carrie Shoemaker AHA Medical Student Research Fellow 26. Mark Cunningham 2014-present Postdoctoral Fellow 27. Jamil Elfarra, M.D Ashlyn Harmon Graduate Student 29. Jessica Faulkner Graduate Student 30. Tarik Ibrahim 2014-present Graduate Student 31. Venkata Vaka Ramana 2016-present Graduate Student 32. Kristen McMasters, M.D present 33. Jesse Cotrell, M.D present PUBLICATIONS: Abstracts 1. LaMarca BB, Arceneaux JEL, Byers BR, Lundrigan MD Exochelin-Mycobactin Siderophore Mutants of Mycobacterium smegmatis Annual Meeting of the South Central Branch, American Society of Microbiologists, New Orleans, Louisiana 2. LaMarca BB, Arceneaux JEL, Byers BR, Lundrigan MD Siderophore Knockout Strains of Mycobacterium smegmatis. American Society of Microbiologist, 100 th General Meeting, Los Angeles, California. 3. LaMarca BB, Arceneaux JEL, Byers BR, Lundrigan MD Characterization of Siderophore Knockout Strains in Mycobacterium smegmatis. American Society of Microbiologists 101 st General Meeting, Orlando Florida. 4. LaMarca BB, Arceneaux JEL, Byers BR, Lundrigan MD Functional Characterization of Siderophore Synthesis in Mycobacterium smegmatis. Annual Meeting of the South Central Branch, American Society of Microbiologists, Baton Rouge, Louisiana. 5. LaMarca BB, Gu JW, Sullivan E, Granger JP TNF-alpha-induced endothelin production in HUVEC: influence of estrogen and progesterone. Council for High Blood Pressure Research in association with Council on Kidney in Cardiovascular Disease, Washington DC 6. LaMarca BB, Gu JW, Sullivan E, Granger JP Modulation of Tumor Necrosis Factor alpha induced endothelin production by estrogen and progesterone. Understanding Renal and Cardiovascular Function through Physiological Genomics, APS Conference, Augusta, Georgia.

9 7. LaMarca BB, Gadonski G, Cockrell K, Sullivan E, Granger JP. Endothelin type A receptor blockade attenuates TNF alpha-induced hypertension in pregnant rats. American Physiological Society, 2003, Washington D.C. 8. LaMarca BB, Cockrell K, Sullivan E, Granger JP Role of endothelin-1 in mediating TNF-alphainduced Hypertension in Pregnant Rats. Experimental Biology. Washington, D.C. 9. LaMarca BB, Chandler D, Cockrell K, Bennett W, Granger JP. Hypertension produced by chronic reductions in uterine perfusion in the pregnant rat: role of TNF alpha. IASH, 2005, Cancun, Mexico. 10. LaMarca BB, Grubbs L, Cockrell K, Bain J, Granger JP. Role of estrogen and progesterone in modulating tumor necrosis factor alpha-induced increases in blood pressure in pregnant rats. Hypertension : Llinas M, Wallukat G, Dechend R, Mueller DN, Luft FC, Alexander BT, LaMarca BB, Granger JP. Agonistic Autoantibodies to the At1 Receptor in a Rat Model of Preeclampsia Induced by Chronic Reductions in Uterine Perfusion Pressure (RUPP) Hypertension : Gutkowska J, Granger JP, Lamarca BB, Coderre L, Pelletier A, Gangal M, Jankowski M. Cardiac Hypertrophy and Cardiac Insulin Responsive Amino-Peptidase (IRAP) in the Reduced Uterine Perfusion (RUPP) Model of Preeclampsia. Hypertension : Ryan MJ, McLemore Jr. GR, Cockrell KL, LaMarca BB, Granger JP. TNF-alpha Mediated Changes in Vascular Reactivity are Attenuated by Progesterone and Estrogen in Ovariectamized Rats. Hypertension : Dechend R., M. Llinas, S. Caluwaerts,; F. Herse,, B. Lamarca,; Muller DN, Pijnenborg R, Wallukat G, Granger JP. Agonistic Autoantibodies to the AT1 Receptor in Rat Models of Preeclampsia: Induced by Chronic Reductions in Uterine Perfusion Pressure (RUPP) and Low Dose TNFalpha Infusion. Granger. Hypertension 48:(4); e35, LaMarca BB, Speed J, Fournier L, Cockrell K, Granger JP. Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: Effect of IL-6 blockade. Experimental Biology, San Fransisco, CA Costa P, LaMarca BB, Fournier L, Bisinella F, Gadonski G, Figueiredo CP, Granger JP. Maternal Plasma and Placental Cytokine Profile in Preeclampsia. Journal of Clinical Hypertension 8(5): A67, LaMarca BB, Speed J, Fournier L, Cockrell K, Chandler D, Granger JP. Angiotensin II Type I receptor blockade prevents interleukin (IL-6)-induced hypertension in the pregnant rat. Hypertension 48:(4); e47, LaMarca BB, Costa BEP, Fournier L, Hoffmann K, Gadonski G, Figueiredo CEP, Granger JP. Maternal plasma and placental cytokine profile in hypertensive preeclamptic women. Council for High Blood Pressure Research, San Antonio TX, LaMarca BB, Speed J, Fournier L, Cockrell K, Chandler D, Granger JP. The Role Angiotensin II Type I receptor activation in mediating TNF alpha-induced hypertension in the pregnant rat. Experimental Biology, Washington DC, LaMarca BB, Dechend R, Wallukat G, Llinas M. Elevated agonistic autoantibodies to the angiotensin type 1 (AT1-AA) receptor in response to placental ischemia and TNF alpha in pregnant rats. Sex and Gender in Cardiovascular-Renal Physiology and Pathophysiology, Austin TX, LaMarca BB, Speed J, Fournier L, Babcock S, Berry H, Cockrell K, Granger JP. Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: Effect of TNF alpha blockade. Council for High Blood Pressure Research, Tucson AZ, Roberts L, Dukes M, Dechend R, Wallukat G, LaMarca BB. Agonistic autoantibodies to the angiotensin II type 1 receptor increase endothelial cell sensitivity to angiotensin II. Council for High Blood Pressure Research, Tucson AZ, Roberts L, Dukes M, Fournier L, Dechend R, Wallukat G, LaMarca BB. Agonistic autoantibodies to the angiotensin II type 1 receptor increases Angiotensin II-induced ET-1 production. Experimental Biology, San Diego CA, LaMarca BB, Roberts L, Dukes M, Murphy SR, Fournier L, Speed J, Cockrell K, Granger JP. Endothelial cell activation in response to placental ischemia in pregnant rats is mediated by agonistic autoantibodies to the angiotensin type I receptor. Experimental Biology, San Diego CA, Dukes M, Roberts L, LaMarca BB, Gilbert JS, Granger JP. The ischemic placenta of pregnant rats elaborates factors that inhibit endothelial tube formation. Experimental Biology, San Diego, CA, 2008

10 26. Murphy SR, LaMarca BB, Cockrell K, Gilbert J, Granger JP. Soluble fms-like tyrosine-1 (sflt-1) in response to placental ischemia and hypoxia in the placenta of pregnant rats. Experimental Biology, San Diego, CA, LaMarca, BB, Dechend, Lillian Fournier, Sydney R. Murphy,Kathy Cockrell. Chronic elevations in agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) during pregnancy in rats increase arterial pressure and endothelin-1. Council for High Blood Pressure Research, Atlanta, GA Sydney R. Murphy, Babbette LaMarca, Kathy Cockrell, Joey P. Granger Placental Angiotension II and soluble fms-like tyrosine-1 (sflt-1) production increase in response to reductions in uterine perfusion pressure. Council for High Blood Pressure Research, Atlanta, GA Marc Parrish, Sydney R. Murphy, Ralf Dechend, Sharon Keiser, Edward Veillion, Kathy Cockrell, Lillian Fournier, James N. Martin Jr., LaMarca BB. Hypertension in response to agonistic autoantibodies to the angiotensin II type I receptor is associated with elevated circulating sflt-1. Society of Maternal Fetal Medicine, San Diego CA Edward W. Veillon, Sharon D. Keiser, William Bennett, Kathy Cockrell, Lillian Fournier, Joey P. Granger, James N Martin Jr, LaMarca BB. 17 OHP blunts the hypertensive response associated with Reductions in Uterine Perfusion Pressure in pregnant rats. Society of Maternal Fetal Medicine, San Diego CA Sharon D. Keiser, Edward W. Veillon, William Bennett, Kathy Cockrell, Lillian Fournier, Joey P. Granger, James N. Martin Jr, LaMarca BB. Administration of 17Hydroxyprogesterone attenuates Tumor Necrosis Factor alpha-induced hypertension during pregnancy Society of Maternal Fetal Medicine, San Diego CA Marcia Venegas-Pont, Porter H. Glover, LaMarca BB, Allison V. Jones, Michael J. Ryan..A Role For TNF-α in Hypertension During Systemic Lupus Erythematosus Experimental Biology, New Orleans LA Kiran Tam Tam, LaMarca BB, Sydney Murphey, Marrietta Arany, Nicole M. Lee, Lillian Fournier, Kathy Cockrell, Joey P. Granger. Hypertension in response to chronic sflt-1 excess during pregnancy: role of reactive oxygen species. Experimental Biology, New Orleans LA Joshua Speed, Lillian Fournier, Kathy Cockrell, Ralf Dechend, Joey Granger, LaMarca B.B. IL-6 induced hypertension in pregnant rats is associated with agonistic autoantibodies to the angiotensin II type I receptor. Experimental Biology, New Orleans LA Sydney R. Murphy, LaMarca BB, Joshua Speed, Sharon Keiser, Kathy Cockrell, Joey P. Granger.Soluble fms-like tyrosine-1 (sflt-1) is enhanced in response to chronic tumor necrosis factoralpha (TNF-α) excess during pregnancy. Experimental Biology, New Orleans LA LaMarca BB, Porter Glover, Marc Parrish, Lillian Fournier-Ray, Ralf Dechend, and Michael J Ryan AT1-AA induced hypertension during pregnancy is associated with renal endothelial dysfunction and endothelin (ET-1) type A receptor activation. Experimental Biology, New Orleans LA Marc R. Parrish, Sydney R. Murphy, Sharon Keiser, Lillian Fournier Ray, James N. Martin, LaMarca BB. Soluble fms-like tyrosine-1 (sflt-1) production is enhanced in response to Tumor Necrosis Factor- alpha (TNF-α) induced hypertension during pregnancy. Central Association of Obstetrics and Gynecology, Hawaii Kiran Tam Tam, Sydney Murphy, Marrietta Arany, James N. Martin, Jr., LaMarca BB, Joey P. Granger ROLE OF REACTIVE OXYGEN SPECIES DURING HYPERTENSION IN RESPONSE TO CHRONIC SFLT-1 EXCESS IN PREGNANT RATS Central Association of Obstetrics and Gynecology, Hawaii Sydney R. Murphy, LaMarca BB, Kathy Cockrell, Joey P. Granger. Hypertension in response to soluble fms-like tyrosine kinase-1 (sflt-1) during pregnancy: role of endothelin-1. Council for High Blood Pressure Research. September 23-25, 2009 Chicago Illinois. 40. LaMarca BB, Parrish MR, Ray LF, Arany M, Cockrell K, Dechlend R. Hypertension and enhanced reactive oxygen species production in response to chronic elevations in agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats. Presented to the Council for High Blood Pressure Research, September 23-25, 2009 Chicago, Illinois. 41. LaMarca BB, Murphy SR, Parrish MR, Fournier L, Cockrell K, Dechend R. Hypertension in response to agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) is associated with increased

11 sflt-1 and sendoglin in pregnant rats. Presented to the Council for High Blood Pressure Research, September 23-25, 2009 Chicago, Illinois. 42. Parrish M, Fournier L, Arany M, Weimer A, Cockrell K, Dechend R, Martin JN Jr, LaMarca BB. Hypertension in response to agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA): role of reactive oxygen species (ROS). Abstract presented at the 30 th Annual Meeting of SMFM, Feb 3-6, 2010, Chicago, IL. 43. Tam Tam KB, Wallace K, Mott K, Weimer A, Martin JN Jr, LaMarca BB. Placental ischemia triggers immune activation as leukocyte overproduction of sflt-1: a step in the pathogenesis of preeclampsia? Abstract presented as oral presentation to the 30 th Annual Meeting of SMFM, Feb 3-6, 2010, Chicago, IL. 44. Parrish MR, Brewer J, Murphy S, Ray L, Dechend R, Martin JN Jr, LaMarca BB. AT1-AA Induced hypertension during pregnancy is associated with renal endothelial dysfunction. (accepted for oral at CAOG 2010, Las Vegas, NV) 45. Richards S, Wallace K, Weimer A, Dhillon P, Wallukat G, Wenzel K, Martin JN Jr, Dechend R, LaMarca BB. Hypertension in response to placental ischemia in pregnant rats is a stimulus for the production of agonistic autoantibodies to the angiotension type 1 receptor in association with CD4+ T helper cell activation. (Accepted for oral at CAOG 2010, Las Vegas, NV) 46. Pushpinder D, Wallace K, Weimer A, Richards S, Martin J N Jr, and LaMarca BB.Hypertension in Response to Placental Ischemia is Associated with Increased Interleukin 17: Involved in the Pathogenesis of Preeclampsia? (Accepted for oral at CAOG 2010, Las Vegas, NV) 47. LaMarca BB, Kedra Wallace, Florian Herse, Gerd Wallukat, Abram Weimer, Ralf Dechend Hypertension in response to placental ischemia during pregnancy: Role of agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA). Council for High Blood Pressure Research. Oct , Washington DC 48. Kedra Wallace, Sarah Richards, Abram Weimer, James N Martin Jr, LaMarca BB CD4+ T helper cells stimulated in response to placental ischemia mediate hypertension in pregnant rats. Council for High Blood Pressure Research. Oct , Washington DC 49. Kiran B. Tam Tam, Eric George, Kathy Cockrell, Marietta Arany, Joshua Speed, James N Martin Jr., LaMarca BB, Joey P. Granger. Endothelin type A receptor antagonistattenuates uterine hypoxiainduced hypertension and uterine vascular resistence. Society for Maternal-Fetal Medicine, Feb 7-11, 2011 San Francisco CA. Am J Ob Gyn.(gray journal) , s Justin Brewer, Kedra Wallace, Lyndsay Roberts, Lillian Ray, James N Martin Jr., Gerd Wallukat 2, Ralf Dechend 2 and LaMarca BB AT1-AA increases AngII-induced ET-1 and ROS. Society for Maternal- Fetal Medicine, Feb 7-11, 2011 San Francisco CA. Am J Ob Gyn.(gray journal) , s Pushpinder Dhillon, Kedra Wallace, Sarah Richards, Abram Weimer, James N Martin Jr and LaMarca BB. Interleukin 17 increases blood pressure during pregnancy: a link between autoimmunity and preeclampsia? Society for Maternal-Fetal Medicine, Feb 7-11, 2011 San Francisco CA. Am J Ob Gyn.(gray journal) , s Sarah Richards, Kedra Wallace, Abram Weimer, Pushpinder Dhillon, Gerd Wallukat, Katrin Wenzel, James N Martin Jr, Ralf Dechend, LaMarca BB. T Lymphocyte induced AT1-AAs cause hypertension in response to placental ischemia. Society for Maternal-Fetal Medicine, Feb 7-11, 2011 San Francisco CA. Am J Ob Gyn.(gray journal) , s Kedra Wallace, Florian Herse, Gerd Wallukat, Abram Weimer, Ralf Dechend LaMarca BB Babbette LaMarca. Agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) mediate endothelial dysfunction associated with hypertension in response to placental ischemia during pregnancy Society for Maternal-Fetal Medicine, Feb 7-11, 2011 San Francisco CA. Am J Ob Gyn.(gray journal) , s LaMarca BB, Justin Brewer, Kedra Wallace, Florian Herse, Janae Moseley, Ralf Dechend Increased blood pressure sensitivity to angiotensin II in pregnant rats pretreated with agonistic autoantibodies to the angiotensin II type I receptor. Experimental Biology. April Washington DC. 55. Kedra Wallace, Pushpinder Dhillon, Sarah Richards, Abram Weimer, James N Martin Jr and LaMarca BB Interleukin 17 increases blood pressure during pregnancy: a link between autoimmunity and preeclampsia? Experimental Biology. April Washington DC.

12 56. Kedra Wallace, Sarah Richards, Abram Weimer, Pushpinder Dhillon, Gerd Wallukat, Katrin Wenzel, James N Martin Jr, Ralf Dechend, LaMarca BB Adoptive transfer of placental ischemia induced CD4+T Lymphocyte stimulate AT1-AAs and cause hypertension during pregnancy. Experimental Biology. April Washington DC. 57. Kedra Wallace, Evan Turnage, Lillian Ray, Bryan Cowan, Babbette LaMarca. Hypertension and Endothelin-1 are associated with uterine leiomyoma proliferation. Society for Gynecological Investigations, Reproductive Sciences. 2011:18(4):S98A. 58. LaMarca BB, Justin Brewer, Kedra Wallace, Florian Herse 3, Janae Moseley, Ralf Dechend 3 Gerd Wallukat 3 Ruisheng Liu 2 Agonistic autoantibodies to the angiotensin II type I receptor enhance blood pressure and renal vascular sensitivity to angiotensin II in pregnant rats. Council High Blood Pressure Research. Sept 17-24, 2011 Orlando, Fl.Hypertension 58: e. 59. Kedra Wallace, Sarah Richards Novotny, Judith Heath, Janae Moseley, James N. Martin Jr., LaMarca BB. Hypertension in response to CD4+ Tcells from RUPP rats is associated with activation of the endothelin-1 system. Council High Blood Pressure Research. Sept 17-24, 2011 Orlando, Fl.Hypertension. 58: e 60. Justin Brewer, James N. Martin Jr., Ashley Canizaro, Pamela Blake, Marie Darby, Rachael Morris, Michelle Owens, LaMarca BB, Imran Sunesara. HELLP Syndrome(s) and severe preeclampsia differentiation according to maternal outcomes: class 1 HELLP syndrome trumps all others. Society for Maternal-Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) S Luissa Fisteag-Kiprono, Kedra Wallace, Sharon Keiser, Edward Veillion, Janae Moseley, Judith Heath, James Martin Jr., LaMarca BB. Progesterone, 17-alpha Hydroxyprogesterone Caproate, Suppress Endothelin-1 and Hypertension in Response to Placental Ischemia Society for Maternal-Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) S Sarah Novotny, Kedra Wallace, Pushpinder Dhillon, Janae Moseley, Judith Heath, James N Martin Jr, LaMarca BB. Blockade of CD4+ T cells prior to placental insult, attenuates hypertension in response to placental ischemia. Society for Maternal-Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) s Justin Brewer, Ruisheng Liu, Kedra Wallace, Florian Herse, Janae Moseley, Ralf Dechend, Gerd Wallukat, LaMarca BB. AT1-AA enhances renal sensitivity and blood pressure in response to ANGII during pregnancy. Society for Maternal-Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) S Pushpinder Dhillon, Jeremy Scott, Kedra Wallace, Judith Heath, Janae Moseley, James N Martin, and LaMarca BB. Placental oxidative stress is an important mediator of IL-17 induced hypertension during pregnancy. Society for Maternal-Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) S Justin Brewer, James Martin, Amanda Armstrong, Pamela Blake, Rachael Morris, Michelle Owens, Babbette LaMarca., Posterior reversible encephalopathy sendrome (PRES) associated with eclampsia: the variable effects of therapeutic agents to accelerate safe recovery. Society for Maternal- Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) S Justin Brewer, James Martin, Amanda Armstrong, Pamela Blake, Rachael Morris, Michelle Owens, Babbette LaMarca., Eclampsia and posterior reversible encephalopathy syndrome (PRES):cause or effect or both in 47 patients? Society for Maternal-Fetal Medicine, 2012, Dallas Tx. Am J Ob Gyn.(gray journal) S Kedra Wallace, Justin Porter, Evan Turnage, Krystal Frazier, Venessia Johnson, Babbette LaMarca Hypoxia stimulates Endothelin-1 Secretion from Human Myometrium Explants; a potential link between hypertension and development of uterine leiomyomas San Diego CA., Society of Gynecological Investigations. 68. Pushpinder Dhillion, Jeremy Scott, Kedra Wallace, Judith Heath, Janae Moseley, James N Martin, and Babbette LaMarca. IL-17 mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy San Diego CA., Society of Gynecological Investigations. 69. Sarah Novotny, Kedra Wallace, Pushpinder Dhillon, Janae Moseley, Judith Heath, James N Martin Jr, and Babbette LaMarca. Blockade of CD4+ T Cells Prior to Placental Insult, Attenuates Hypertension and Placental sflt-1 in Response to Placental Ischemia San Diego CA., Society of Gynecological Investigations.

13 70. Babbette LaMarca, Sarah Richards Novotny, Kedra Wallace, Janae Moseley, Marie Darby, Judith Heath, James N Martin Jr. CD4+ T cells play a critical role in mediating hypertension in response to placental ischemia Council High Blood Pressure Research. Sept 21-23, 2012 Washington DC. Hypertension 58: e. 71. Kedra Wallace, Marie Darby, Janae Moseley, Babbette LaMarca. CD4 + T helper cell infiltration in the AV3V region and frontal cortex is associated with hypertension in response to placental ischemia in pregnant rats. Society for Neuroscience Annual Meeting Kedra Wallace, Jeremy Scott, Sarah Novotny, Judith Heath, Janae Moseley, Babbette LaMarca. Placental ischemic stimulated CD4 + T helper cells increase blood pressure and placental and renal oxidative stress during pregnancy. FASEB Journal. 2012: Kedra Wallace, Justin Porter, Evan Turnage, Krystal Frazier, Venessia Johnson, Babbette LaMarca. Hypoxia stimulates endothelin-1 secretion from human myometrium explants; A potential link between hypertension and development of uterine leiomyomas. Society for Gynecologica Investigations,Reproductive Sciences. 2012:19(3)162A. 74. Kedra Wallace, Marie Darby, Jeremy Scott, Janae Moseley, Michelle Y. Owens, Babbette LaMarca Hypertension in a rat model of HELLP syndrome is associated with T helper 1 type immune activation Council High Blood Pressure Research. Sept 21-23, 2012 Washington DC. Hypertension 58: e 75. Kedra Wallace, Marie Darby, Patrick Kyle, Rachael Morris, Janae Moseley, Krystal Frazier, Babbette LaMarca. Hypertension in a rat model of HELLP Syndrome is associated with increased TNF-alpha, IL-6 and CD4 + T cell activation. Experimental Biology; Boston, MA Kedra Wallace, Rachael Morris, Janae Moseley, Stephanie Evans, Babbette LaMarca. Cerebral white matter CD4 + T cell infiltration is associated with hypertension in a rat model of HELLP Syndrome. Experimental Biology; Boston, MA Keisa W. Mathis, Kedra Wallace, Babbette LaMarca, Michael J. Ryan. Humoral immune system activation promotes the development of hypertension. Experimental Biology, Boston, MA Denise C Cornelius, James P Hogg, Kedra Wallace, Janae Moseley, Babbette LaMarca. Blunting circulating TH17 cells decreases hypertension and oxidative stress in response to placental ischemia. Experimental Biology; Boston, MA Marie Darby, Kedra Wallace, Janae Moseley, Judith Heath, James N. Martin, Christine Purser, Rodney Baker, Michelle Owens, Babbette LaMarca. Pregnancy complicated by chronic hypertension: A state of Vitamin D Deficiency and immune activation. Society for Maternal Fetal Medicine February Luissa Kiprono, Krystal Frazier, Kedra Wallace, Janae Moseley, Margaret Wester, Jeremy Scott, James Martin, Babbette LaMarca. More Evidence Suggestive of Preeclampsia as a State of Progesterone Deficiency: Progesterone Suppresses Hypoxia-Stimulated Production of TNF-α, IL-6, IL- 17, and sflt-1. Society for Maternal Fetal Medicine Annual Meeting february Justin Brewer, Kedra Wallace, Florian Herse, Janae Moseley, Ralf Dechend, Gerd Wallukat, James N. Martin, Jr., Babbette LaMarca AT1-AA enhances ANGII induced hypertension and renal vascular sensitivity. Society for Gynecological Investigations, March 20-23, 2013, Orlando Fl. 82. Kedra Wallace, Krystal Frazier, Venessia Johnson, Jeremy Scott, Babbette LaMarca. Angiotensin type 1 receptor blockade blunts in vitro uterine leiomyoma proliferation and Endothelin-1 secretion; linking uterine fibroids with pre-hypertension in premenopausal patients. Society for Gynecological Investigation Annual Meeting, March 20-23, Orlando FL Marie Darby, MD, Kedra Wallace, PhD, Janae Moseley, Judith Heath, BS, James N Martin Jr, MD, Christine Purser, Rodney Baker, PhD, Michelle Owens, MD, and Babbette LaMarca, PhD PREGNANCY COMPLICATED BY CHRONIC HYPERTENSION: A STATE OF VITAMIN D DEFICIENCY AND IMMUNE ACTIVATION Society for Gynecological Investigation Annual Meeting, March 20-23, Orlando FL Denise C Cornelius,, Kedra Wallace,, Janae Moseley,, and Babbette LaMarca, RUPP T H 17 cell cause Hypertension during Pregnancy. Council for High Blood Pressure Research, AHA, New Orleans,LA. Sept 11-14, Lorena Amaral Machado, Denise Cornelius, Kedra Wallace, Luissa Kipprono, Janae Moseley, Florian Herse, Gerd Wallukat, James N Martin, Ralf Dechend, and Babbette LaMarca. Progesterone supplementation attenuates hypertension and AT1-AA in response to elevated IL-6 during pregnancy. Council for High Blood Pressure Research, AHA, New Orleans,LA. Sept 11-14, 2013.

14 86. Kedra Wallace, Rachael Morris, Krystal Chatman, Janae Moseley, Babbette LaMarca. Hypertension in hemolysis, elevated liver enzyme, low platelet syndrome is associated with increased Endothelin-1. Council for High Blood Pressure Research, AHA, New Orleans,LA. Sept 11-14, Javier Castillo, Justin Porter, Lorena Machado, Denise Cornelius, Kedra Wallace, Babbette LaMarca. Inhibition of AT1-AAs by interrupting lymphocyte communication or by direct binding reduces blood pressure in response to placental ischemia of pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia. AJOG; :S376. Society for Maternal Fetal Medicine, New Orleans, LA. February 3-8, Marie Darby, Kedra Wallace, Krystal Frazier, Justin Porter, Janae Moseley, Judith Heath, James N. Martin, Christine Purser, Rodney Baker, Michelle Owens, Babbette LaMarca VITAMIN D SUPPLEMENTATION decreased blood pressure in a model of CHTN DURING PREGNANCY. AJOG. 2014; 210:S166. Society for Maternal Fetal Medicine, New Orleans, LA. February 3-8, Ashlyn C. Harmon, Adrienne Paige, Denise Cornelius, Kedra Wallace, Alexia Thomas, Jeremy Scott, Janae Moseley 1, Babbette LaMarca. IL-10 supplementation suppressed hypertension and inflammation in response to placental ischemia during pregnancy. Experimental Biology, San Diego CA, April 26-30, Jeremy Scott, Kedra Wallace, Denise Cornelius, Lorena M Amaral, Janae Moseley, Krystal Chatman, Babbette LaMarca. Oxidative stress signaling in response to CD4+T cells stimulated via placental ischemia play an important role in hypertension during preeclampsia Experimental Biology, San Diego CA, April 26-30, Lorena M. Amaral, Luissa Kipprono, Kedra Wallace, Krystal Frazier, Janae Moseley, James N Martin, Babbette LaMarca. Progesterone supplementation improves blood pressure and uterine artery resistance and hypoxia-stimulated placental cytokines during pregnancy. Experimental Biology, San Diego CA, April 26-30, Janae Moseley, Javier Castillo, Lorena Machado, Denise Cornelius, Babbette LaMarca. Specific Inhibition of AT1-AAs by direct binding improves maternal and fetal outcome in response to placental ischemia during pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia. Experimental Biology, San Diego CA, April 26-30, Denise C Cornelius, Kedra Wallace, Ashlyn Harmon, Adrienne Page, Janae Moseley, and Babbette LaMarca. Normal pregnant T Regs inhibit Pathophysiology associated with hypertension in response to Reduced Uterine Perfusion Pressure (RUPP) in pregnant rats. Experimental Biology, San Diego CA, April 26-30, Denise C. Cornelius, Javier Castillo, Justin Porter, Nathan Campbell, Alexia Thomas, Lorena M. Amaral, Kedra Wallace, Janae Moseley, Babbette LaMarca Interrupting lymphocyte communication reduces RUPP T cell induced hypertension and pathophysiology during pregnancy. Council for High Blood Pressure Research, AHA, San Fransisco CA, Sept 9-12, Tarek Ibrahim, Lukasz Przybyl, Ashlyn C. Harmon, Denise Cornelius, Janae Moseley Lorena Amaral, Jessica Faulkner, Ralf Dechend and Babbette LaMarca Proliferation of endogenous T-reg cells improves the pathophysiology associated with placental ischemia of pregnancy. Council for High Blood Pressure Research, AHA, San Fransisco CA, Sept 9-12, Jessica L Faulkner, Marie M Darby, Denise C Cornelius, Janae Moseley, Florian Herse, Ralf Dechend and Babbette LaMarca. Vitamin D supplementation reduces CD4+ T cells, blood pressure and autoantibodies to the AT1 receptor (AT1-AA) in a rat model of preeclampsia. Council for High Blood Pressure Research, AHA, San Fransisco CA, Sept 9-12, Lorena M. Amaral, Denise C. Cornelius, Janae Moseley, James N Martin, Babbette LaMarca. Progesterone supplementation improves blood pressure and uterine artery resistance in response to placental ischemia during pregnancy. Council for High Blood Pressure Research, AHA, San Fransisco CA, Sept 9-12, Ashlyn C. Harmon, Denise C. Cornelius, Kedra Wallace, Janae Moseley & Babbette LaMarca. CD4 + T cells isolated from Preeclamptic Women induces a Preeclampsia-Like Phenotype in Pregnant Nude- Athymic Rats Council for High Blood Pressure Research, AHA, San Fransisco CA, Sept 9-12, Lee N, Spencer SK, LaMarca BB, Murphy S. Alterations in placental eicosanoid production contribute to impaired vascular remodeling in preeclampsia. Pregnancy Hypertens Jan;5(1): /j.preghy

15 100. Amaral LM, Cornelius DC, Moseley J, Martin JN, LaMarca B. 17-hydroxyprogesterone caproate attenuates hypertension and uterine artery resistance in response to Reduced Uterine Perfusion Pressure (RUPP) in pregnant rats. Pregnancy Hypertens Jan;5(1):28. doi: /j.preghy Epub 2015 Feb Cornelius DC, Wallace K, Scott JD, Campbell N, Thomas A, Hogg JP, Moseley J, LaMarca B. A role for TH17 cells and IL-17 in mediating the pathophysiology associated with preeclampsia. Pregnancy Hypertens Jan;5(1):17. doi: /j.preghy Epub Faulkner JL, Darby MM, Cornelius DC, Harmon AC, Amaral LM, Moseley J, Herse F, Wallukat G, Dechend R, LaMarca B Treatment with Vitamin D attenuates blood pressure and immune activation in a preeclamptic rat model. Pregnancy Hypertens Jan;5(1):17-8. doi: /j.preghy Harmon AC, Cornelius DC, Wallace K, Moseley J, LaMarca B. Placental CD4+ T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nudeathymic rats. Pregnancy Hypertens Jan;5(1): /j.preghy Nicole Lee, Shauna-Kay Spencer, Babbette LaMarca, Kedra Wallace, Sydney Murphy. Alterations in placental eicosanoids contribute to impaired vascular remodeling in preeclampsia. AJOG; :S263. Society for Maternal Fetal Medicine, San Diego, CA. February 2-7, Jose Santiago-Font, Lorena Amaral, Ellen Gillis, Janae Moseley, Babbette LaMarca, Jennifer Sasser. Serelaxin reduces mean arterial pressure (MAP) and improves fetal growth in the RUPP rat model of preeclampsia. AJOG; :S324. Society for Maternal Fetal Medicine, San Diego, CA. February 2-7, Jessica L. Faulkner, Sydney Murphy, Nicole Lee, Janae Moseley, Babbette LaMarca. Blockade of 20-HETE synthesis improves blood pressure in the RUPP rat model of preeclampsia. Experimental Biology; Boston, MA. March 28-31, Denise C. Cornelius, Kedra Wallace, Lorena Amaral, Jeremy Scott, Janae Moseley, Babbette LaMarca. Placental Ischemia-induced TH17 Cells Mediate the Pathophysiology Associated with Preeclampsia. Experimental Biology; Boston, MA. March 28-31, Mark W. Cunningham, Jessica L. Faulkner, Denise Cornelius, Lorena Amaral, Robert Kramer, Babbette LaMarca. Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance ANGII Binding on Vascular Endothelial Cells. Experimental Biology; Boston, MA. March 28-31, Lorena Amaral, Jose Santiago-Font, Ellen Gillis, Janae Moseley, Jennifer Sasser, Babbette LaMarca. Serelaxin Improves Blood Pressure and Uterine Artery Resistance in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia. Experimental Biology; Boston, MA. March 28-31, Denise C. Cornelius, D Andrea Thomas, Jamil Elfarra, Taia McAfee, Janae Moseley, and Babbette LaMarca. A Role for IL-17 to Activate Cytolytic NK cells in Response to Placental Ischemia Hypertension Council AHA, Washington DC Sept Nathan Campbell, Mark W Cunningham, Jr., Denise C Cornelius, Babbette LaMarca. Inhibition of AT1-AAs by Direct Binding Reduces Blood Pressure and Natural Killer Cells in Response to Placental Ischemia of Pregnancy; Emphasizing the Importance of Novel Drug Development in the Treatment of Preeclampsia Hypertension Council AHA, Washington DC Sept Lorena M. Amaral, Jamil Elfarra, Denise C. Cornelius, Jessica L Faulkner, Mark W. Cunningham Jr., Taia R. Mcafee, D andrea S.Thomas, Babbette LaMarca. Early administration of 17- hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sflt-1 and placental cytolytic NK cells in response to placental ischemia during pregnancy. Hypertension Council AHA, Washington DC Sept Tarek Ibrahim, Lukasz Przybyl, Ashlyn C. Harmon, Denise C. Cornelius, Janae Moseley, Lorena M. Amaral, Jessica L. Faulkner, Ralf Dechend and Babbette LaMarca. Proliferation of Endogenous T- regs Improves the Pathophysiology Associated with Placental Ischemia of Pregnancy Hypertension Council AHA, Washington DC Sept Mark W. Cunningham Jr., Jan Williams, and Babbette LaMarca. Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor enahances ANG II Induced Renal Vascular Resistance and Renal Function. Hypertension Council AHA, Washington DC Sept 2015

16 115. Jamil Elfarra, Lorena M. Amaral Denise C. Cornelius, Jessica L Faulkner, Mark W. Cunningham Jr, Taia R. Mcafee, D andrea S.Thomas, Babbette LaMarca. Administration of 17-hydroxyprogesterone caproate in mid-gestation improves fetal growth possibly by reducing sflt-1 and placental cytolytic NK cells in the Reduced Uterine Perfusion Pressure (RUPP) rat model of Preeclampsia. SMFM-the pregnancy meeting, Atlanta GA, Feb 1-6, Nicole Lee, Jessica L Faulkner, Sydney Murphy, Babbette LaMarca Blockade of 20-HETE synthesis improves blood pressure and fetal survival in the RUPP rat model of preeclampsia SMFMthe pregnancy meeting, Atlanta GA, Feb 1-6, Jose A. Santiago-font, Lorena M. Amaral, Tarik Ibrahim, Ellen Gillis, Jennifer M. Sasser, Babbette LaMarca. Serelaxin improves endothelial dysfunction and uterine artery resistance in response to placental ischemia during pregnancy SMFM-the pregnancy meeting, Atlanta GA, Feb 1-6, Venkata Ramana Vaka, Mark W. Cunningham Jr, Kristin Shirey, Tarek Ibrahim, Jonathan Hosler, Babbette LaMarca Inhibition of Angiotensin II Type I Receptor Agonistic Autoantibody Reduces Mitochondrial Mediated Oxidative Stress and Hypertension in Reduced Uterine Perfusion Pressure Rats. Experimental Biology, San Diego CA, April Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, D Andrea Thomas, Florian Herse, Ralf Dechend and Babbette LaMarca Vitamin D Inhibits Endothelial Dysfunction Markers Mediated by AT1 autoantibodies in Pregnancy. Experimental Biology, San Diego CA, April Mark W. Cunningham Jr, Javier Castillo, Frank Spradley, Jessica Faulkner, Tarek Ibrahim, Jamil Elfarra, Babbette LaMarca Angiotensin II Type 1 Receptor Agonistic Autoantibody Inhibition Improves Maternal Outcomes in Reduce Uterine Perfusion Pressure Rats Experimental Biology, San Diego CA, April Denise C. Cornelius, Maggie McCalmon, Lorena M. Amaral, Jamil Elfarra, Mark W. Cunningham, Jr., Tarek Ibrahim, Jeremy D. Scott, and Babbette LaMarca Depletion of Natural Killer Cells Activated in Response to Placental ischemia improves Hypertension and IUGR during Pregnancy. Council on Hypertesnion AHA, Orlando FL, Sept Tarek Ibrahim, Lukasz Przybyl, Ashlyn C. Harmon, Denise C. Cornelius, Mark W. Cunningham Jr., Lorena M. Amaral, Jessica L. Faulkner, Ralf Dechend and Babbette LaMarca Stimulating Endogenous T-regs Improves the Pathophysiology Associated with Placental Ischemia of Pregnancy. Council on Hypertesnion AHA, Orlando FL, Sept Lorena M. Amaral, Jamil Elfarra, Denise C. Cornelius, Mark W. Cunningham Jr., Tarek Ibrahim, Babbette LaMarca. 17-hydroxyprogesterone caproate improves blood pressures and placental cytolytic NK cells in response to placental ischemia during pregnancy. Council on Hypertesnion AHA, Orlando FL, Sept Mark W. Cunningham Jr. 1, Nadine Haase 2, Jessica L. Faulkner 1, Tarek Ibrahim 1, Venkata Ramana Vaka 1, Ralf Dechend 2, Don Foster 3, and Babbette LaMarca 1 Selective Maternal Hepatic Silencing of Angiotensinogen in Reduced Uterine Placental Perfusion Pressure (RUPP) Rats Improves Blood Pressure and Fetal Weights. Council on Hypertesnion AHA, Orlando FL, Sept Kristen McMaster, Venkata Ramana Vaka, Mark W. Cunningham Jr, Babbette LaMarca. Mitochondrial dysfunction occurs in response to placental ischemia; identifying new players in the pathology of Preeclampsia, SMFM 2017, LasVegas NVJan Jamil Elfarra 1, Lorena M Amaral 2, Maggie McCalmon 3, Ashley Gnam 2, Mark W. Cunningham, Jr. 2, Tarek Ibrahim 2, Jeremy D. Scott 2, Babbette LaMarca 1,2, Denise C Cornelius 2,3 A role for Natural Killer cells in the pathophysiology of preeclampsia SMFM 2017, LasVegas NVJan Journal Articles 1. LaMarca BB Functional Characterization of Siderophore Synthesis in Mycobacterium smegmatis: Identification of New Mycobactin Synthesis Genes (Dissertation) 2. LaMarca BB Arceneaux, JEL, Byers, BR, Lundrigan, MD. Participation of fad and mbt Genes in Synthesis of Mycobactin in Mycobacterium smegmatis J. Bacterio. 82(2): LaMarca BB, Cockrell K, Sullivan E, Bennett W, Granger JP. Role of endothelin in mediating TNF alpha-induced hypertension in pregnant rats. Hypertension July;46(1):82-6.

17 4. LaMarca BB, William A. Bennett, Barbara T. Alexander, Kathy Cockrell, and Joey P. Granger. Hypertension produced by reductions in uterine perfusion in the pregnant rat: Role of tumor necrosis factor alpha. Hypertension Oct;46(4): Roberts L, LaMarca BB, Fournier L, Bain J, Cockrell K, Granger JP. Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion. Hypertension March; 47(3) Granger JP, LaMarca BB, Cockrell K, Sedeek M, Balzi C, Chandler D, Bennett W. Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia. Methods Mol Med. 2006, 122: Gadonski G, LaMarca BB, Sullivan E, Bennett W, Chandler D, Granger JP. Hypertension produced by reductions in uterine perfusion in the pregnant rat: Role of Interleukin-6. Hypertension 2006, Oct;48(4): Granger JP, Abram S, Stec D, Chandler D, Speed J, LaMarca BB. Endothelin, the Kidney, and Hypertension. Current Hypertension Reports, 2006; 8: LaMarca BB, Ryan MJ, Granger JP. Pathophysiology of Hypertension During Preeclampsia: Role of Inflammatory Cytokines. Current Hypertension Reviews, 2007, 3; Gilbert J, Dukes M, LaMarca BB, Cockrell K, Babcock S, Granger JP. Effects of Reduced Uterine Perfusion Pressure on Blood Pressure and Metabolic Factors in Pregnant Rats. 2007, Am. J.Hypertens LaMarca BB, Chandler D, Grubbs L, Bain J, McMlemore G, Granger JP, Ryan MJ. Role of Sex Steroids in Modulating TNF alpha induced changes in Vascular Function and Blood Pressure Am. J. Hypertens. 20; Jernigan NK, LaMarca BB, Speed J, Galmiche L, Granger JP, Drummond HA. Dietary salt enhances benzamil sensitive component of myogenic constriction in mesenteric arteries. Am J Physiol Heart Circ Physiol Jan;294(1):H LaMarca BB, Ryan MJ, Gilbert J, Murphy S, Granger JP. Pathophysiology of Hypertension during Preeclampsia: Role of Inflammatory Cytokines. Current Hypertension Reports 2007 Dec; 9(6): LaMarca BB, Alexander BT, Gilbert J, Ryan MJ, Sedeek M, Murphy SR, Granger JP. Pathophysiology of Hypertension in Response to Placental Ischemia during Pregnancy: A Central Role for Endothelin? Gender Medicine (A); S133-13PMCID Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol Feb;294(2):H Epub 2007 Nov Gilbert JS, LaMarca BB, Granger JP.ACE2 and ANG-(1-7) in the gravid uterus: the new players on the block. Am J Physiol Regul Integr Comp Physiol Mar;294(3):R Epub 2008 Jan LaMarca BB, Gilbert J, Granger JP. Recent Progress Toward the Understanding of the Pathophysiology of Hypertension during Preeclampsia. Hypertension :4(2); PMCID Jernigan NL, Speed J, LaMarca B, Granger JP, Drummond HA Angiotensin II regulation of renal vascular ENaC proteins. Am J Hypertens Jun;22(6): Epub 2009 Mar Sedeek, M, Gilbert, JS, LaMarca BB, Shollok, M, Chandler, DL, Wang, Y, Granger, JP. Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant rats. Am J Hypertens. 2008;21: LaMarca BB, Speed J, Fournier L, Babcock SA, Berry H, Cockrell K, Granger JP. Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: Effect of TNF alpha blockade. Hypertension 2008;56: PMCID LaMarca BB, Wallukat G, Llinas M, Herse F, Dechend R, Granger JP. Elevated agonistic autoantibodies to the angiotensin type 1 (AT1-AA) receptor in response to placental ischemia and TNF alpha in pregnant rats. 2008Hypertension;52:7-11. PMCID Suo, Guangli Sadarangani, Anil, LaMarca BB, Cowan, Bryan and Wang, Jean Y. J. Murine Xenograft Model for Human Uterine Fibroids: An In Vivo Imaging Approach 2009, RepSciences eupub: / June Edward W. Veillon Jr., Sharon D Keiser, Marc R. Parrish, William Bennett, Kathy Cockrell, Lillian Fournier, Joey P. Granger, James N Martin Jr., LaMarca, BB.. 17 OHP blunts the hypertensive