Twenty Years of Follow-Up of Aortohepatic Conduits in Liver Transplantation
|
|
- Jack Lane
- 5 years ago
- Views:
Transcription
1 LIVER TRANSPLANTATION 14: , 2008 ORIGINAL ARTICLE Twenty Years of Follow-Up of Aortohepatic s in Liver Transplantation Dmitriy Nikitin, Linda W. Jennings, Tariq Khan, Edmund Q. Sanchez, Srinath Chinnakotla, Henry B. Randall, Greg J. McKenna, Robert M. Goldstein, Marlon F. Levy, 2 and Goran B. Klintmalm 1 Transplant Services Dallas, Baylor University Medical Center, Dallas, TX; and 2 Transplant Services, Baylor All Saints Medical Center, Fort Worth, TX Arterial problems remain a formidable challenge in liver transplantation. In many situations, an aortohepatic conduit can provide a solution. No long-term results (over 5 years) have been reported. This study was designed to assess the impact of aortohepatic conduits on graft survival after liver transplantation and the safety of aortohepatic conduits and to establish the long-term results (up to 20 years) of aortohepatic conduits. Data from 2346 adult liver transplants were prospectively collected into the computerized database and analyzed. In the majority of cases, arterial conduits were constructed from the donor iliac artery obtained at the liver retrieval. Aortohepatic conduits were required in 149 (6.4%) first transplants. The long-term graft survival after liver transplantation using aortohepatic conduits was excellent and comparable to that of the control group. The graft survival was 59% with the conduit versus 67% without the conduit at 5 years of follow-up, 50% versus 52% at 10 years, and 33% versus 35% at 15 years. With up to 20 years of follow-up, there was no statistically significant difference in graft survival, patient survival, hepatic artery complications, or biliary complications. For the same time period, there was no statistically significant difference in graft survival or patient survival for the retransplants with and without aortohepatic conduits. In conclusion, in experienced hands, aortohepatic conduits can be used safely for liver transplantation with no negative impact on long-term graft survival, patient survival, hepatic artery complications, or biliary complications. Excellent long-term results can be obtained. Liver Transpl 14: , AASLD. Received January 19, 2008; accepted May 15, See Editorial on Page 1412 The aortohepatic conduit is an important tool in the armamentarium of the liver transplant surgeon. This technique has been used more frequently in more complex cases. There is considerable controversy in the assessment of the safety and indications of aortohepatic conduits. No long-term results (over 5 years) have been reported. Cases likely to need the conduit include patients with celiac trunk stenosis or occlusion, arcuate ligament syndrome, severe atherosclerotic disease (more common in older donors and older recipients), retransplants, split liver, auxiliary liver, or living-donor transplants, hepatic artery intimal dissection, stenosis or thrombosis, or hemodynamic instability. The goal of this study was to assess the impact of aortohepatic conduits on graft survival after liver transplantation and the safety of aortohepatic conduits in liver transplantation and to establish the long-term results (up to 20 years) of aortohepatic conduits. PATIENTS AND METHODS Data from 2346 adult liver transplants performed at the Baylor Regional Transplant Institute were prospectively collected into a computerized database and analyzed. Aortohepatic conduits placed at the time of the transplant were analyzed separately from retransplants. This study was approved by the Baylor University Medical Center Institutional Review Board. The aortohepatic conduit technique has been de- Abbreviations: BMI, body mass index; FHF, fulminant hepatic failure; ICU, intensive care unit; MELD, Model for End-Stage Liver Disease; OR, operating room; PRBC, packed red blood cells. Address reprint requests to Goran B. Klintmalm, M.D., Ph.D., Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX Telephone: ; FAX: ; gorank@baylorhealth.edu DOI /lt Published online in Wiley InterScience ( American Association for the Study of Liver Diseases.
2 AORTOHEPATIC CONDUITS IN LIVER TRANSPLANTATION 1487 scribed by our group in previous publications. 1 In the overwhelming majority of cases, arterial conduits are constructed from the donor iliac artery obtained during liver procurement and preserved in preservation solution. The conduits are preferentially anastomosed to the infrarenal aorta except when retroperitoneal varices make the dissection dangerous, extensive adhesions prevent safe dissection, or the aorta is severely calcified. In these instances, the conduit is anastomosed to the iliac artery. In most cases, an antepancreatic approach is used. We reflect the colon cranially and reflect the small bowel to the right. Then, at the root of the small bowel mesentery, we identify and expose the infrarenal aorta. A self-retaining retractor is used for exposure. A side biting clamp is applied to the aorta to partially occlude it. The aorta is opened with a #11 blade; 5-0 running prolene is used to create the anastomosis between the conduit and the aorta. Self-retaining clamps are applied to the conduit, and the aortic clamp is removed from the aorta. Any leaks are controlled. Then, the window is made in the mesocolon and behind the stomach to pass the conduit anterior to the pancreas, but posterior to the stomach and the colon, the duodenum stays to the right of the conduit. Then, the anastomosis is performed between the conduit and the donor hepatic artery or celiac trunk or aortic patch. After completion of the anastomosis, the clamps are removed, and the arterial flow in the liver is restored. The flow in the hepatic artery is measured by an electromagnetic method. Currently, for an adult liver transplant, a flow of 400 ml/minute or more is considered acceptable. 2-4 The patency of the hepatic artery is assessed by ultrasound on postoperative day 1, later at 1 year, 2 years, 5 years, 10 years, 15 years, and 20 years, and when clinically indicated. If there is a suggestion of compromised arterial flow, then an angiogram is used to further delineate the arterial inflow to the liver. If there is hepatic artery stenosis, it is surgically corrected. We do not perform repeated percutaneous interventional arterial procedures and prefer to correct the arterial inflow surgically. We have not seen any pseudoaneurysms. Kinks are included in the category of stenosis and are corrected surgically as well. We have not observed stenosis at the level of inflow into the conduit. Continuous variables have been compared with the 2-sample Wilcoxon test. Categorical variables have been compared with the 2-tailed Fisher s exact test for 2-by-2 tables and with the likelihood ratio chi-square test for larger tables. Actuarial survival has been estimated by the Kaplan-Meier method with significance testing with the log-rank test. Results with a P value less than 0.05 have been considered statistically significant. All analysis has been performed with SAS RESULTS The long-term graft survival after first liver transplantation using aortohepatic conduits was excellent and comparable to that of the control group (Fig. 1 and Figure 1. First graft survival by the aortohepatic conduit. Table 1). Graft survival was 72% (102) with a conduit versus 82% (1758) without a conduit at 1 year of followup, 65% (75) versus 74% (1416) at 3 years, 59% (64) versus 67% (1092) at 5 years, 50% (40) versus 52% (545) at 10 years, 33% (18) versus 35% (158) at 15 years, and 24% (2) versus 25% (16) at 20 years. There was no statistically significant difference in graft survival, patient survival, hepatic artery complications, or biliary complications (up to 20 years of follow-up; Table 2). As indicated in Table 2, hepatic artery stenosis was observed in 3.4% of patients with a conduit and 5.2% of patients without a conduit. The difference was not statistically significant (P 0.44). Hepatic artery thrombosis was observed in 4.7% of patients with a conduit and in 2.9% of patients without a conduit. The difference was not statistically significant (P 0.21). We did not see any pseudoaneurysms. Kinks were included in the category of stenosis and were corrected surgically as well. We did not observe stenosis at the level of inflow into the conduit. No embolic complications were noted. Aortohepatic conduits were performed at the time of first liver transplant in 149 patients (6.4%). An aortohepatic conduit was more frequently used in female recipients (8.0% versus 5.1%, P ; Table 3). No statistically significant difference was found between groups with and without aortohepatic conduits in donor age, donor body mass index, donor days in intensive care unit, or donor liver function tests (Table 4). Recipients who received conduits had a smaller body mass index (median, 25.6 versus 26.5, P 0.05), a higher Model for End-Stage Liver Disease score (median, 18 versus 16, P 0.01), and a higher percentage of fulminant hepatic failure as the preoperative diagnosis (8.7 versus 3.8, P 0.009). It is a policy at our institution to use conduits in hemodynamically unstable patients as a conduit is not subject to vasoconstriction, thus securing the arterial inflow. The use of aortohepatic conduits was more frequently associated with longer operative room time (7.57 versus 6.0 hours, P ), more units of packed red blood cells transfused during transplant (5.0 versus 4.0, P ), and more units of fresh frozen plasma required at operation (6.0 versus 5.0, P ).
3 1488 NIKITIN ET AL. TABLE 1. First Graft Survival by the Aortohepatic n 1 Year 3 Years 5 Years 10 Years 15 Years 20 Years No conduit % 74% 67% 52% 35% 25% % 65% 59% 50% 33% 24% NOTE: P TABLE 2. Postoperative Complications No [n (%)] [n (%)] P Value Hepatic artery stenosis 5 (3.36) 114 (5.19) Hepatic artery thrombosis 7 (4.70) 63 (2.87) Pancreatitis 3 (2.01) 22 (1.00) Abdominal ileus 6 (4.03) 27 (1.23) Biliary stricture 4 (2.68) 110 (5.01) Biliary: anastomotic leak 10 (6.71) 94 (4.28) Respiratory failure 16 (10.74) 107 (4.87) Renal failure 11 (7.38) 54 (2.46) TABLE 3. Direct Comparison of Cohorts With and Without s No Total Value % Value % P Value Donor sex: female Donor sex: male Donor race: white Donor race: other Donor cardiac arrest: yes Donor cardiac arrest: no Recipient sex: male Recipient sex: female FHF: yes FHF: no Tumor: yes Tumor: no Abbreviations: FHF, fulminant hepatic failure. In the postoperative period, the patients with conduits were more likely to develop an ileus (4% versus 1%, P 0.016), respiratory failure (11% versus 5%, P 0.006), and renal failure (7% versus 2%, P 0.002). The incidence of postoperative renal failure was higher with the conduits. We do not perform the supraceliac aortohepatic conduit; therefore, we do not have data to compare the incidence of postoperative renal failure between the supraceliac and infrarenal conduits. A separate analysis was conducted for retransplants. Two hundred twenty-nine livers were retransplanted. s were used in 100 transplants (44%). Graft survival was 61% (61) with a conduit versus 64% (82) without a conduit at 1 year of follow-up, 54% (47) versus 52% (60) at 3 years, 48% (33) versus 47% (52) at 5 years, 34% (16) versus 36% (16) at 10 years, 23% (6) versus 27% (15) at 15 years, and 23% (2) versus 22% (4) at 20 years (Table 5). There was no statistically significant difference in graft survival (P 0.91) or patient survival (P 0.70; Fig. 2). The utilization of aortohepatic conduits increased from 2.8% in to 10.1% in DISCUSSION Our study shows that liver transplantation using an aortohepatic conduit has long-term results similar to those of standard liver transplantation. Prior reports of poor results after liver transplantation using aortohepatic conduits likely reflected additional factors (re-
4 AORTOHEPATIC CONDUITS IN LIVER TRANSPLANTATION 1489 TABLE 4. Direct Comparison of Cohorts With and Without s No n Mean n Mean P Value Donor age (years) Donor BMI (kg/m 2 ) Donor days in ICU Recipient age (years) Recipient BMI (kg/m 2 ) MELD score Cold ischemia time (hours) Warm ischemia time (hours) OR time (hours) PRBC: intraoperative total (units) Abbreviations: BMI, body mass index; ICU, intensive care unit; MELD, Model for End-Stage Liver Disease; OR, operating room; PRBC, packed red blood cells. TABLE 5. Retransplant Graft Survival by the Aortohepatic n 1 Year 3 Years 5 Years 10 Years 15 Years 20 Years No conduit % 52% 47% 36% 27% 22% % 54% 48% 34% 23% 23% NOTE: P Figure 2. conduit. Retransplant graft survival by the aortohepatic transplants, placement of the conduit after the hepatic artery thrombosis, and patients with a hypercoagulable state). 5-8 When the influence of the confounding factors is minimized, the results of liver transplantation using aortohepatic conduits become very close to those of the control group. The trend of lower graft survival in the first 5 years and the higher incidence of postoperative renal failure may be related to a sicker recipient population (a higher Model for End-Stage Liver Disease score, more patients with fulminant hepatic failure, more hemodynamically unstable patients, and a higher rate of respiratory failure). Excellent long-term results prove the longevity of aortohepatic conduits using the iliac artery of the donor. Thrombosis of the hepatic artery and the conduit remains the major problem We believe that meticulous surgical technique, aggressive surveillance, and early intervention are very important in preventing and treating this complication. We also by policy place such recipients on salicylic acid (80 mg once daily) as prophylaxis. This study is important because this is the first report in the literature on the long-term results (up to 20 years) of aortohepatic conduits. It is based on extensive information from a single center, and this provides consistency in management and technique. The results of this study may also be applicable to other fields of surgery (the use of biological conduits for vascular reconstruction). Our study has a number of limitations. It is a retrospective analysis of a prospectively maintained database and is subject to selection bias, observer bias, and bias of the confounding factors. In conclusion, in experienced hands, aortohepatic conduits can be used safely for liver transplantation with no negative impact on long-term graft survival, patient survival, hepatic artery complications, or biliary complications. Excellent long-term results can be obtained. REFERENCES 1. Goldstein RM, Secrest CL, Klintmalm GB, Husberg BS. Problematic vascular reconstruction in liver transplantation. Part I. Arterial. Surgery 1990;107:
5 1490 NIKITIN ET AL. 2. Molmenti EP, Levy MF, Molmenti H, Casey D, Fasola CG, Hamilton WM, et al. Correlation between intraoperative blood flows and hepatic artery strictures in liver transplantation. Liver Transpl 2002;8: Molmenti EP, Casey D, Coke C, Jennings L, Brooks B, Marubashi S, et al. Correlation between intraoperative flows and hepatic artery strictures in liver transplantation. Transplant Proc 2001;33: Abbasoglu O, Levy MF, Testa G, Obiekwe S, Brkic BS, Jennings LW, et al. Does intraoperative hepatic artery flow predict arterial complications after liver transplantation? Transplantation 1998;66: Shaked AA, Takiff H, Busuttil RW. The use of the supraceliac aorta for hepatic arterial revascularization in transplantation of the liver. Surg Gynecol Obstet 1991;173: Zamboni F, Franchello A, Ricchiuti A, Fop F, Rizzetto M, Salizzoni M. Use of arterial conduit as an alternative technique in arterial revascularization during orthotopic liver transplantation. Dig Liver Dis 2002;34: Muralidharan V, Imber C, Leelaudomlipi S, Gunson BK, Buckels JA, Mirza DF, et al. Arterial conduits for hepatic artery revascularisation in adult liver transplantation. Transpl Int 2004;17: Liu T, Dilworth P, Sosef M, Wang C, Crawford M, Gallagher J, Verran D. Arterial vascular conduits in adult orthotopic liver transplant recipients. ANZ J Surg 2006;76: Secrest CL, Goldstein RM, Klintmalm GB, Paulsen WA, Nery JR, Husberg BS, Poplawski SC. Arterial grafts for revascularization of liver transplants. Transplant Proc 1989;21(pt 2): Abbasoglu O, Levy MF, Vodapally MS, Goldstein RM, Husberg BS, Gonwa TA, Klintmalm GB. Hepatic artery stenosis after liver transplantation incidence, presentation, treatment, and long term outcome. Transplantation 1997; 63: Loupatatzis C, Stoupis C, Seiler C, Candinas D, Do DD, Triller J. Use of a mechanical thrombectomy device to recanalize a subacutely occluded aortohepatic bypass after orthotopic liver transplantation. J Endovasc Ther 2005;12: Oh CK, Pelletier SJ, Sawyer RG, Dacus AR, McCullough CS, Pruett TL, Sanfey HA. Uni- and multi-variate analysis of risk factors for early and late hepatic artery thrombosis after liver transplantation. Transplantation 2001;71: Yedlicka JW Jr, Halloran J, Payne WD, Hunter DW, Castaneda-Zuniga WR, Amplatz K, Letourneau JG. Angiogenesis after hepatic arterial occlusion in liver transplant patients. J Vasc Interv Radiol 1991;2:
Successful Application of Supraceliac Aortohepatic Conduit Using Saphenous Venous Graft in Right Lobe Living Donor Liver Transplantation
LETTERS FROM THE FRONTLINE Successful Application of Supraceliac Aortohepatic Conduit Using Saphenous Venous Graft in Right Lobe Living Donor Liver Transplantation TO THE EDITOR: Hepatic artery (HA) reconstruction
More informationHepatorenal Syndrome: a Proposal for Kidney After Liver Transplantation (KALT)
LIVER TRANSPLANTATION 13:838-843, 2007 ORIGINAL ARTICLE Hepatorenal Syndrome: a Proposal for Kidney After Liver Transplantation (KALT) Richard Ruiz, Yousri M. Barri, Linda W. Jennings, Srinath Chinnakotla,
More informationSurgical Injuries of Postmortem Donor Livers: Incidence and Impact on Outcome After Adult Liver Transplantation
LIVER TRANSPLANTATION 12:1365-1370, 2006 ORIGINAL ARTICLE Surgical Injuries of Postmortem Donor Livers: Incidence and Impact on Outcome After Adult Liver Transplantation Danielle M. Nijkamp, 1 Maarten
More informationDonor Hypernatremia Influences Outcomes Following Pediatric Liver Transplantation
8 Original Article Donor Hypernatremia Influences Outcomes Following Pediatric Liver Transplantation Neema Kaseje 1 Samuel Lüthold 2 Gilles Mentha 3 Christian Toso 3 Dominique Belli 2 Valérie McLin 2 Barbara
More informationLong-Term Deleterious Effects of Aortohepatic Conduits in Primary Liver Transplantation: Proceed With Caution
LIVER TRANSPLANTATION 19:916 925, 2013 ORIGINAL ARTICLE Long-Term Deleterious Effects of Aortohepatic s in Primary Liver Transplantation: Proceed With Caution Taizo Hibi, 1,2 Seigo Nishida, 1,5 David M.
More informationVisceral aneurysm. Diagnosis and Interventions M.NEDEVSKA
Visceral aneurysm Diagnosis and Interventions M.NEDEVSKA History 1953 De Bakeyand Cooley Visceral aneurysm VAAs rare, reported incidence of 0.01 to 0.2% on routine autopsies. Clinically important Potentially
More informationOPERATIVE TECHNIQUES AND HAZARDS
OPERATIVE TECHNIQUES AND HAZARDS CHRIS O SULLIVAN MD FRCSI CONSULTANT HBP AND LIVER TRANSPLANT SURGEON FREEMAN HOSPITAL, N-UPON-TYNE CAVAL RECONSTRUCTION IN ORTHOTOPIC LIVER TRANSPLANTATION RESECTION OF
More informationLiver Transplantation in Children: Techniques and What the Surgeon Wants to Know from Imaging
Liver Transplantation in Children: Techniques and What the Surgeon Wants to Know from Imaging Jaimie D. Nathan, MD Associate Professor of Surgery and Pediatrics Associate Surgical Director, Liver Transplant
More informationCHALLENGING ILIAC ACCESSES AND THROMBOSIS PREVENTION
CHALLENGING ILIAC ACCESSES AND THROMBOSIS PREVENTION ARMANDO MANSILHA MD, PhD, FEBVS UNIVERSITY HOSPITAL - PORTO Disclosure of Interest Speaker name: ARMANDO MANSILHA I have the following potential conflicts
More informationAsymptomatic celiac and superior mesenteric artery stenoses are more prevalent among patients with unsuspected renal artery stenoses
Asymptomatic celiac and superior mesenteric artery stenoses are more prevalent among patients with unsuspected renal artery stenoses R. James Valentine, MD, John D. Martin, MD, Smart I. Myers, MD, Matthew
More informationFree Esophageal Perforation Following Hybrid Visceral Debranching and Distal Endograft Extension to Repair a Ruptured Thoracoabdominal Aortic
Free Esophageal Perforation Following Hybrid Visceral Debranching and Distal Endograft Extension to Repair a Ruptured Thoracoabdominal Aortic Aneurysm History A 56-year-old gentleman, who had been referred
More informationFEVAR FIFTEEN YEARS OF EFFICIENCY E.DUCASSE MD PHD FEBVS CHU DE BORDEAUX
FEVAR FIFTEEN YEARS OF EFFICIENCY E.DUCASSE MD PHD FEBVS CHU DE BORDEAUX 2018 A BIT OF HISTORY First use of F-EVAR : 1990s Park et al. J Vasc Interv Radiol. 1996;7:819-823. Faruqi et al. J Endovasc Surg.
More informationPancreas After Islet Transplantation: A First Report of the International Pancreas Transplant Registry
American Journal of Transplantation 2016; 16: 688 693 Wiley Periodicals Inc. Brief Communication Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons doi:
More informationHepatic Artery Stenosis After Liver Transplantation: Is Endovascular Treatment Always Necessary?
LIVER TRANSPLANTATION 21:162 168, 2015 ORIGINAL ARTICLE Hepatic Artery Stenosis After Liver Transplantation: Is Endovascular Treatment Always Necessary? Carlo Pulitano, 1,2 David Joseph, 1 Charbel Sandroussi,
More informationKey words: celiac occlusive disease, pancreaticoduodenectomy, abdominal aorta-celiac bypass
Key words: celiac occlusive disease, pancreaticoduodenectomy, abdominal aorta-celiac bypass 51(2023) Table 1 Laboratory data on admission Fig. 2 Percutaneous transhepatic cholangiogram shows tapering obstruction
More informationTechniques for Safe Organ Recovery After Endovascular Aortic and Bariatric Operations
LIVER TRANSPLANTATION 20:619 623, 2014 LETTER FROM THE FRONTLINE Techniques for Safe Organ Recovery After Endovascular Aortic and Bariatric Operations Received January 14, 2014; accepted January 23, 2014.
More informationPeripheral Vascular Disease
Peripheral artery disease (PAD) results from the buildup of plaque (atherosclerosis) in the arteries of the legs. For people with PAD, symptoms may be mild, requiring no treatment except modification of
More informationDIFFICULT ACCESS REMAINS A CONTRAINDICATION FOR EVAR APOSTOLOS K. TASSIOPOULOS, MD, FACS PROFESSOR AND CHIEF DIVISION OF VASCULAR SURGERY
DIFFICULT ACCESS REMAINS A CONTRAINDICATION FOR EVAR APOSTOLOS K. TASSIOPOULOS, MD, FACS PROFESSOR AND CHIEF DIVISION OF VASCULAR SURGERY Disclosures Speaker Bureau: - Medtronic - Cook Medical - Bolton
More informationClinical Outcomes From Hepatic Artery Stenting in Liver Transplantation
LIVER TRANSPLANTATION 12:422-427, 2006 ORIGINAL ARTICLE Clinical Outcomes From Hepatic Artery Stenting in Liver Transplantation Takehisa Ueno, 1 Greg Jones, 2 Adrian Martin, 1 Toru Ikegami, 1 Edmund Q.
More informationAccepted Manuscript. Perioperative renal function and thoracoabdominal aneurysm repair: Where do we go from here? Leonard N. Girardi, M.D.
Accepted Manuscript Perioperative renal function and thoracoabdominal aneurysm repair: Where do we go from here? Leonard N. Girardi, M.D. PII: S0022-5223(18)31804-X DOI: 10.1016/j.jtcvs.2018.06.057 Reference:
More informationTHORACOABDOMINAL AORTIC ANEURYSMS HYBRID REPAIR
Update on Open and Endovascular Therapeutic Option for Aortic Repair CENTRE CARDIO-TORACIQUE DE MONACO Friday November 7 th, 2014 THORACOABDOMINAL AORTIC ANEURYSMS HYBRID REPAIR Roberto Chiesa Vascular
More informationLAPAROSCOPIC AORTO-ILIAC SURGERY
LAPAROSCOPIC AORTOILIAC SURGERY J QUANIERS UNIVERSITY HOSPITAL OF LIEGE OCCLUSIVE AORTIC DISEASE Purpose : This article describes an original laparoscopic technique that allows performance of aortobifemoral
More informationImportance of the third arterial graft in multiple arterial grafting strategies
Research Highlight Importance of the third arterial graft in multiple arterial grafting strategies David Glineur Department of Cardiovascular Surgery, Cliniques St Luc, Bouge and the Department of Cardiovascular
More informationHeart Transplantation for Patients with a Fontan Procedure
Heart Transplantation for Patients with a Fontan Procedure Kirk R. Kanter MD Professor of Surgery Pediatric Cardiac Surgery Emory University School of Medicine Children s Healthcare of Atlanta Atlanta,
More informationCoral Reef Aorta- Treatment Options?
Chronic mesenteric ischemia (CMI) Coral Reef Aorta- Treatment Options? Bala Ramanan Vascular Fellow, UCSF CMI is a life-threatening problem that can result in death from inanition or bowel infarction Incidence
More informationWhat Is the Real Gain After Liver Transplantation?
LIVER TRANSPLANTATION 15:S1-S5, 9 AASLD/ILTS SYLLABUS What Is the Real Gain After Liver Transplantation? James Neuberger Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom;
More informationVascular Imaging in the Pediatric Abdomen. Jonathan Swanson, MD
Vascular Imaging in the Pediatric Abdomen Jonathan Swanson, MD Goals and Objectives To understand the imaging approach, appearance, and clinical manifestations of the common pediatric abdominal vascular
More informationORIGINAL ARTICLE. Summary
Transplant International ISSN 0934-0874 ORIGINAL ARTICLE Thrombotic and nonthrombotic hepatic artery complications in adults and children following primary liver transplantation with long-term follow-up
More informationPedal Bypass With Deep Venous Arterialization:
Pedal Bypass With Deep Venous Arterialization: Long Term Result For Critical Limb Ischemia With Unreconstructable Distal Arteries Pramook Mutirangura Professor of Vascular Surgery Faculty of Medicine Siriraj
More informationRecords. Adult Kidney Pancreas Transplant Recipient Registration Worksheet. Recipient Information. Provider Information.
Records Adult Kidney Pancreas Transplant Recipient Registration Worksheet FORM APPROVED: O.M.B. NO. 0915 0157 Expiration Date: 07/31/2020 Note: These worksheets are provided to function as a guide to what
More informationUse of polytetrafluoroethylene renal bypass
Use of polytetrafluoroethylene renal bypass grafts for P. Lagneau, M.D., J. B. Michel, M.D., and J. M. Charrat, M.D., Paris, France Fifty-six revascularizations of the renal arteries were performed in
More informationPossible graft-related complications in visceral debranching for hybrid B dissection repair
Featured Article Possible graft-related complications in visceral debranching for hybrid B dissection repair Roberto Chiesa, Yamume Tshomba, Davide Logaldo, Andrea Kahlberg, Domenico Baccellieri, Luca
More informationOpen fenestration for complicated acute aortic B dissection
Art of Operative Techniques Open fenestration for complicated acute aortic B dissection Santi Trimarchi 1, Sara Segreti 1, Viviana Grassi 1, Chiara Lomazzi 1, Marta Cova 1, Gabriele Piffaretti 2, Vincenzo
More informationNeurological Complications of TEVAR. Frank J Criado, MD. Union Memorial-MedStar Health Baltimore, MD USA
ISES Online Neurological Complications of Frank J Criado, MD TEVAR Union Memorial-MedStar Health Baltimore, MD USA frank.criado@medstar.net Paraplegia Incidence is 0-4% after surgical Rx of TAAs confined
More informationInduction Immunosuppression With Rabbit Antithymocyte Globulin in Pediatric Liver Transplantation
LIVER TRANSPLANTATION 12:1210-1214, 2006 ORIGINAL ARTICLE Induction Immunosuppression With Rabbit Antithymocyte Globulin in Pediatric Liver Transplantation Ashesh Shah, 1 Avinash Agarwal, 1 Richard Mangus,
More informationAn early experience of liver transplantation in portal vein thrombosis
C a s e R e p o r t Singapore Med J 2008; 49(2) : e37 An early experience of liver transplantation in portal vein thrombosis Shelat V G, Diddapur R K Abstract Portal vein thrombosis (PVT) is a recognised
More informationPOST TRANSPLANT OUTCOMES IN PSC
POST TRANSPLANT OUTCOMES IN PSC Kidist K. Yimam, MD Medical Director, Autoimmune Liver Disease Program Division of Hepatology and Liver Transplantation California Pacific Medical Center (CPMC) PSC Partners
More informationRepair of type IV thoracoabdominal aneurysm with a combined endovascular and surgical approach
Repair of type IV thoracoabdominal aneurysm with a combined endovascular and surgical approach William J. Quiñones-Baldrich, MD, Thomas F. Panetta, MD, Candace L. Vescera, RN, and Vikram S. Kashyap, MD,
More informationPerioperative Events in Living and Deceased Donor Liver Transplant Recipients: A Case Control Study
8 The Open Transplantation Journal, 2011, 5, 8-14 Open Access Perioperative Events in Living and Deceased Donor Liver Transplant Recipients: A Case Control Study Bhargavi Gali *,1, David J. Plevak 1, David
More informationThe pediatric end-stage liver disease (PELD) score
Selection of Pediatric Candidates Under the PELD System Sue V. McDiarmid, 1 Robert M. Merion, 2 Dawn M. Dykstra, 2 and Ann M. Harper 3 Key Points 1. The PELD score accurately predicts the 3 month probability
More informationClinical trial and real-world outcomes of an endovascular iliac aneurysm repair with the GORE Iliac Branch Endoprosthesis (IBE)
Clinical trial and real-world outcomes of an endovascular iliac aneurysm repair with the GORE Iliac Branch Endoprosthesis (IBE) Jan MM Heyligers, PhD, FEBVS Consultant Vascular Surgeon The Netherlands
More informationIncreased Flexibility of AneuRx Stent-Graft Reduces Need for Secondary Intervention Following Endovascular Aneurysm Repair
583 Increased Flexibility of AneuRx Stent-Graft Reduces Need for Secondary Intervention Following Endovascular Aneurysm Repair Frank R. Arko, MD; W. Anthony Lee, MD; Bradley B. Hill, MD; Paul Cipriano,
More informationLong-term Outcomes After Third Liver Transplant
ArtıcLe Long-term Outcomes After Third Liver Transplant C. Burcin Taner, 1 Deniz Balci, 1 Darrin L. Willingham, 1 Andrew P. Keaveny, 1 Barry G. Rosser, 1 Juan M. Canabal, 1 Timothy S. J. Shine, 2 Denise
More informationSingle-lung transplantation in the setting of aborted bilateral lung transplantation
Washington University School of Medicine Digital Commons@Becker Open Access Publications 2011 Single-lung transplantation in the setting of aborted bilateral lung transplantation Varun Puri Tracey Guthrie
More informationRobert F. Cuff, MD FACS SHMG Vascular Surgery
Robert F. Cuff, MD FACS SHMG Vascular Surgery Objectives To become familiar with the commercially available fenestrated EVAR graft Discuss techniques to increase success Review available data to determine
More informationErratum to: Int J Hematol (2014) 99: DOI /s
Int J Hematol (216) 13:725 729 DOI 1.17/s12185-16-1987-1 ERRATUM Erratum to: Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history
More informationDisclosure. I do not have any potential conflict of interest
Endovascular repair of ruptured abdominal aortic aneurysms is superior to open repair in risk stratified patients: a look at the United States experience through the SVS Vascular Quality Initiative 2003
More informationHow to manage TAVI related vascular complications. Paul TL Chiam MBBS, FRCP, FESC, FACC, FSCAI
How to manage TAVI related vascular complications Paul TL Chiam MBBS, FRCP, FESC, FACC, FSCAI Definition VARC-2 consensus statement Complications caused by: Wire Catheter Anything related to vascular access
More informationComplex Thoracic and Abdominal Aortic Repair Using Hybrid Techniques
Complex Thoracic and Abdominal Aortic Repair Using Hybrid Techniques Tariq Almerey MD, January Moore BA, Houssam Farres MD, Richard Agnew MD, W. Andrew Oldenburg MD, Albert Hakaim MD Department of Vascular
More informationHow to Determine Tolerance for Branch Vessel Coverage
How to Determine Tolerance for Branch Vessel Coverage Venita Chandra, MD Clinical Assistant Professor of Surgery Division of Stanford Medical School, Stanford, CA PNEC May 25 th, 2017 DISCLOSURES Venita
More informationSubclavian artery Stenting
Subclavian artery Stenting Etiology Atherosclerosis Takayasu s arteritis Fibromuscular dysplasia Giant Cell Arteritis Radiation-induced Vascular Injury Thoracic Outlet Syndrome Neurofibromatosis Incidence
More informationLate Surgical Complications Following Liver Transplantation
LIVER TRANSPLANTATION 15:S12-S18, 2009 AASLD/ILTS SYLLABUS Late Surgical Complications Following Liver Transplantation Paige M. Porrett, John Hsu, and Abraham Shaked Division of Transplantation, Department
More informationPeri-operative challenges and long-term outcomes in liver transplantation for polycystic liver disease
DOI:10.1111/j.1477-2574.2012.00579.x HPB ORIGINAL ARTICLE Peri-operative challenges and long-term outcomes in liver transplantation for polycystic liver disease Roberto Gedaly, Paige Guidry, Daniel Davenport,
More informationHepatic artery thrombosis following pediatric liver transplantation: Assessment of blood flow measuremen,t in allografts
Hepatic artery thrombosis following pediatric liver transplantation: Assessment of blood flow measuremen,t in allografts Yanaga K, Makowka L, Shimada M, Esquivel CO, Bowman JS, Todo S, Tzakis AG, Starzl
More informationArcuate ligament compression as a cause of early-onset thrombosis of the hepatic artery after liver transplantation
88 CASE REPORT January-March, Vol. 10 No.1, 2011: 88-92 Arcuate ligament compression as a cause of early-onset thrombosis of the hepatic artery after liver transplantation Mario Vilatobá,* Daniel Zamora-Valdés,**
More informationObesity is perhaps the most significant public health problem
Obesity and Its Effect on Survival in Patients Undergoing Orthotopic Liver Transplantation in the United States Satheesh Nair, 1 Sumita Verma, 2 and Paul J. Thuluvath 2 Studies assessing morbidity and
More informationCombined Endovascular and Surgical Repair of Thoracoabdominal Aortic Pathology: Hybrid TEVAR
Combined Endovascular and Surgical Repair of Thoracoabdominal Aortic Pathology: Hybrid TEVAR William J. Quinones-Baldrich MD Professor of Surgery Director UCLA Aortic Center UCLA Medical Center Los Angeles,
More informationManagement of the persistent sciatic artery with coexistent aortoiliac aneurysms; endovascular and open techniques.
ISPUB.COM The Internet Journal of Thoracic and Cardiovascular Surgery Volume 14 Number 2 Management of the persistent sciatic artery with coexistent aortoiliac aneurysms; endovascular and open A Rodriguez-Rivera,
More informationCUAJ Techniques in Urology Techniques: Orthotopic kidney transplantation
Techniques Orthotopic kidney transplantation in patients with diseased inferior vena cavas E. Chan 1 ; Alp Sener 1,2 ; Vivian C. McAlister 1,2, Patrick P. Luke 1,2 1 Western University Schulich School
More informationAxillobrachial artery bypass grafting with in situ cephalic vein for axillary artery occlusion: A case report
CASE REPORTS Axillobrachial artery bypass grafting with in situ cephalic vein for axillary artery occlusion: A case report Evan S. Cohen,/VII), Robert B. Holtzman, MD, and George W. Johnson, Jr., MD, Houston,
More informationVasile Goldiş Western University of Arad Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
ENDOVASCULAR TREATMENT FOR VASCULAR GRAFT RESTENOSIS Bogdan Totolici 1, Francisca Blanca Călinescu 1*, Ionel Droc 2, Carmen Neamţu 1 1 Vasile Goldiş Western University of Arad Faculty of Medicine, Pharmacy
More informationUseful? Definition of High-risk? Pre-OP/Intra-OP/Post-OP? Complication vs Benefit? Mortality? Morbidity?
Preoperative intraaortic balloon counterpulsation in high-risk CABG Stefan Klotz, M.D. Preoperative IABP in high-risk CABG Questions?? Useful? Definition of High-risk? Pre-OP/Intra-OP/Post-OP? Complication
More informationHybrid Repair of a Complex Thoracoabdominal Aortic Aneurysm
Hybrid Repair of a Complex Thoracoabdominal Aortic Aneurysm Virendra I. Patel MD MPH Assistant Professor of Surgery Massachusetts General Hospital Division of Vascular and Endovascular Surgery Disclosure
More informationThe role for contrast-enhanced ultrasonography outside of focal liver lesions
The role for contrast-enhanced ultrasonography outside of focal liver lesions Paul S. Sidhu King s College Hospital, London, UK Introduction Contrast-enhanced ultrasonography (US) of focal liver lesions
More informationDeliberate Renal Ischemia
Deliberate Renal Ischemia A Valuable and Safe Adjunct During Operations upon the Abdominal Aorta Robert K. Brawley, M.D., R. Darryl Fisher, M.D., Tom R. DeMeester, M.D., and Ronald C. Elkins, M.D. ABSTRACT
More informationSuccessful aortic surgery aftcr renal transplantation without protection of the transplanted lddncy
Successful aortic surgery aftcr renal transplantation without protection of the transplanted lddncy John Preston Harris, M.S., F.R.C.S., F.RoA.C.S., and James May, M.S., F.R.A.C,S., Sydney, Australia When
More informationSupplementary Online Content
Supplementary Online Content Smith D, Chudgar A, Daly B, Cooper M. Evaluation of potential renal transplant recipients with computed tomography angiography. Arch Intern Med. doi: 10.1001/archsurg.2012.1466.
More informationThe Journal of Thoracic and Cardiovascular Surgery
Accepted Manuscript Commentary: NO FLOW? QUICK, RE-SEW Ross M. Bremner, MD, PhD PII: S0022-5223(19)30560-4 DOI: https://doi.org/10.1016/j.jtcvs.2019.02.092 Reference: YMTC 14240 To appear in: The Journal
More informationIn-situ v Normothermic Regional Perfusion for Abdominal Organs
In-situ v Normothermic Regional Perfusion for Abdominal Organs ANGEL RUIZ M.D. DONATION AND TRANSPLNAT COORDINATION UNIT MEDICAL DIRECTION HOSPITAL CLÍNIC DE BARCELONA Introduction Donation after circulatory
More informationLiving Donor Liver Transplantation for Hepatocellular Carcinoma: It Is All about Donors?
Original Article Living Donor Liver Transplantation for Hepatocellular Carcinoma: It Is All about Donors? R. F. Saidi 1 *, Y. Li 2, S. A. Shah 2, N. Jabbour 2 1 Division of Organ Transplantation, Department
More informationAbdominal Aortic Aneurysms. A Surgeons Perspective Dr. Derek D. Muehrcke
Abdominal Aortic Aneurysms A Surgeons Perspective Dr. Derek D. Muehrcke Aneurysm Definition The abnormal enlargement or bulging of an artery caused by an injury or weakness in the blood vessel wall A localized
More informationAb H. Boontje, M.D., Ph.D., Groningen, Holland
Aneurysm formation in human umbilical vein grafts used as arterial substitutes Ab H. Boontje, M.D., Ph.D., Groningen, Holland A series of 257 human umbilical vein grafts for femoropopliteal bypass in 203
More informationSurgical Options for revascularisation P E T E R S U B R A M A N I A M
Surgical Options for revascularisation P E T E R S U B R A M A N I A M The goal Treat pain Heal ulcer Preserve limb Preserve life The options Conservative Endovascular Surgical bypass Primary amputation
More informationLiver retransplantation for adult recipients
Korean J Hepatobiliary Pancreat Surg 2013;17:1-7 Review Article Liver retransplantation for adult recipients Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung,
More informationOpen Repair of RAAA is always possible -is it always better? No disclosures!! Lazar B. Davidovic MD, PhD, FETCS
Open Repair of RAAA is always possible -is it always better? Lazar B. Davidovic MD, PhD, FETCS Professor of Surgery School of Medicine, University of Belgrade Head of the Clinic for Vascular and Endovascular
More informationIs EVAS a proper choice in women?
Is EVAS a proper choice in women? CACVS 2018 Jan MM Heyligers, PhD, FEBVS Consultant Vascular Surgeon Elisabeth TweeSteden Hospital Tilburg The Netherlands Disclosures Consultant for Endologix DEVASS =Dutch
More informationDamage Control in Abdominal and Pelvic Injuries
Damage Control in Abdominal and Pelvic Injuries Raul Coimbra, MD, PhD, FACS The Monroe E. Trout Professor of Surgery Surgeon-in Chief UCSD Medical Center Hillcrest Campus Executive Vice-Chairman Department
More informationRemoving Patients from the Liver Transplant Wait List: A Survey of US Liver Transplant Programs
LIVER TRANSPLANTATION 14:303-307, 2008 ORIGINAL ARTICLE Removing Patients from the Liver Transplant Wait List: A Survey of US Liver Transplant Programs Kevin P. Charpentier 1 and Arun Mavanur 2 1 Rhode
More informationArthroplasty after previous surgery: previous vascular problems
Arthroplasty after previous surgery: previous vascular problems Jacques Menetrey & Victoria B. Duthon Centre de médecine de l appareil locomoteur et du sport Swiss Olympic medical Center Unité d Orthopédie
More informationEndovascular Should Be Considered First Line Therapy
Revascularization of Patients with Critical Limb Ischemia Endovascular Should Be Considered First Line Therapy Michael Conte David Dawson David L. Dawson, MD Revised Presentation Title A Selective Approach
More informationEtiology and Management of Hepatic Artery Thrombosis After Adult Liver Transplantation
LIVER TRANSPLANTATION 20:713 723, 2014 ORIGINAL ARTICLE Etiology and Management of Hepatic Artery Thrombosis After Adult Liver Transplantation Moustafa Mabrouk Mourad, 1 Christos Liossis, 1 Bridget K.
More informationThe Role of US in Chronic Mesenteric Ischemia. Sagar S. Gandhi, MD Vascular Health Alliance Greenville Health System
The Role of US in Chronic Mesenteric Ischemia Sagar S. Gandhi, MD Vascular Health Alliance Greenville Health System No Disclosures Mesenteric Ischemia Anatomy Presentation Diagnostic tools Treatment Celiac
More informationMesenteric vascular insufficiency and claudication following acute dissecting thoracic aortic aneurysm
Mesenteric vascular insufficiency and claudication following acute dissecting thoracic aortic aneurysm Thomas H. Cogbill, M.D., A. Erik Gundersen, M.D., and Renato TraveUi, M.D., La Crosse, Wisc. Mesenteric
More informationTreatment of choice for end stage renal disease Imaging to establish baseline and diagnosis of potential complications Review common surgical
Treatment of choice for end stage renal disease Imaging to establish baseline and diagnosis of potential complications Review common surgical techniques Review normal appearance Discuss US diagnosis of
More informationEarly and One-year Outcomes of Aortic Root Surgery in Marfan Syndrome Patients
Early and One-year Outcomes of Aortic Root Surgery in Marfan Syndrome Patients A Prospective, Multi-Center, Comparative Study Joseph S. Coselli, Irina V. Volguina, Scott A. LeMaire, Thoralf M. Sundt, Elizabeth
More informationRecommendations for Follow-up After Vascular Surgery Arterial Procedures SVS Practice Guidelines
Recommendations for Follow-up After Vascular Surgery Arterial Procedures 2018 SVS Practice Guidelines vsweb.org/svsguidelines About the guidelines Published in the July 2018 issue of Journal of Vascular
More informationTechnical Considerations in Liver Transplantation. Luis S. Marsano, MD Professor of Medicine U. of Louisville & Louisville VAMC
Technical Considerations in Liver Transplantation Luis S. Marsano, MD Professor of Medicine U. of Louisville & Louisville VAMC Types OLTX: Orthotopic liver Tx; placed in the anatomically correct position
More informationThe Management and Treatment of Ruptured Abdominal Aortic Aneurysm (RAAA)
The Management and Treatment of Ruptured Abdominal Aortic Aneurysm (RAAA) Disclosure Speaker name: Ren Wei, Li Zhui, Li Fenghe, Zhao Yu Department of Vascular Surgery, The First Affiliated Hospital of
More informationTHE CRITICAL COMPLCATIONS AND MANAGEMENTS AFTER PANCREATIC SURGERY 2013/12/21
THE CRITICAL COMPLCATIONS AND MANAGEMENTS AFTER PANCREATIC SURGERY Tsann-Long Hwang, MD, FACS Department of Surgery Chang Gung Memorial Hospital Chang Gung University Taipei, TAIWAN 2013/12/21 THE DIFFICULTY
More informationDaniela Branzan MD, Department of Vascular Surgery and Department of Interventional Angiology University Hospital Leipzig
Ischemic Preconditioning with Minimally Invasive Segmental Artery Coil Embolization (MISACE) prior to Endovascular TAAA Repair: Clinical Experience in 50+ Patients Daniela Branzan MD, Department of Vascular
More informationSurgical Aspects of Kidney and Pancreas Transplant. Hannah Choate, MD
Surgical Aspects of Kidney and Pancreas Transplant Hannah Choate, MD I have no financial disclosures or conflicts of interest Kidney transplantation Indications ESRD or advancing CKD with GFR less than
More informationBC Vascular Day. Contents. November 3, Abdominal Aortic Aneurysm 2 3. Peripheral Arterial Disease 4 6. Deep Venous Thrombosis 7 8
BC Vascular Day Contents Abdominal Aortic Aneurysm 2 3 November 3, 2018 Peripheral Arterial Disease 4 6 Deep Venous Thrombosis 7 8 Abdominal Aortic Aneurysm Conservative Management Risk factor modification
More informationEndovascular and Hybrid Treatment of TASC C & D Aortoiliac Occlusive Disease
Endovascular and Hybrid Treatment of TASC C & D Aortoiliac Occlusive Disease Arash Bornak, MD FACS Vascular & Endovascular Surgery University of Miami Miller School of Medicine No disclosure BACKGROUND
More informationThe Second Best Arterial Graft:
The Second Best Arterial Graft: A Propensity Analysis of the Radial Artery Versus the Right Internal Thoracic Artery to Bypass the Circumflex Coronary Artery American Association for Thoracic Surgery,
More informationOPCAB IS NOT BETTER THAN CONVENTIONAL CABG
OPCAB IS NOT BETTER THAN CONVENTIONAL CABG Harold L. Lazar, M.D. Harold L. Lazar, M.D. Professor of Cardiothoracic Surgery Boston Medical Center and the Boston University School of Medicine Boston, MA
More informationPACT module High risk surgical patient. Intensive Care Training Program Radboud University Medical Centre Nijmegen
PACT module High risk surgical patient Intensive Care Training Program Radboud University Medical Centre Nijmegen Intravascular volume effect of Ringer s lactate Double-tracer BV measurement Blood 1097
More informationNellix Endovascular System: Clinical Outcomes and Device Overview
Nellix Endovascular System: Clinical Outcomes and Device Overview Jeffrey P. Carpenter, MD Professor and Chief, Department of Surgery CAUTION: Investigational device. This product is under clinical investigation
More informationSetting The setting was a hospital. The economic study was carried out in Australia.
Coronary artery bypass grafting (CABG) after initially successful percutaneous transluminal coronary angioplasty (PTCA): a review of 17 years experience Barakate M S, Hemli J M, Hughes C F, Bannon P G,
More informationVascular complications following liver transplantation: A literature review of advances in 2015
Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.4254/wjh.v8.i1.36 World J Hepatol 2016 January 8; 8(1): 36-57 ISSN 1948-5182 (online) 2016 Baishideng
More informationEndovascular Treatment of Hepatic Artery Stenosis following Liver Transplantation
Endovascular Treatment of Hepatic Artery Stenosis following Liver Transplantation W. Charles Sternbergh, III, MD Professor and Chief Vascular and Endovascular Surgery Vice Chair for Research Department
More information