Developing Food Derived Compounds for Health The Innovation Process

Transcription

1 Developing Food Derived Compounds for Health The Innovation Process Plants for Health Danish Food and Drink Federation June 15th, 2011 Kevin Prudence Innovation Project Manager

2 DSM Nutrition a healthy market leader DSM creates innovative products and services in Life Sciences and Materials Sciences, contributing to the quality of life. DSM s products are used globally in a wide range of markets and applications, supporting a healthier, more sustainable and enjoyable way of life. Key Products Polymer intermediates 17% Other 6% 37% Nutrition Vitamins Cultures Carotenoids Preservation Nutritional Ingredients systems UV Filters Yeast extracts Food, Beverage & feed enzymes DSM key data 2010 Performance materials 31% 9% Pharma Net Sales: million EBIT: 752 million Employees: ~ Page 1

3 Innovation defined From idea to implementation Both radical and incremental innovation are required in order to: Meet existing unmet needs; At our Customers (B2B) At Consumer (B2C) Anticipate future needs of; Customer Consumer A good hockey player plays where the puck is. A great hockey player plays where the puck is going to be. Wayne Gretsky Page 2

4 The Innovation Engine Breaking science Consumer research Market trends Customers Ideas Box Idea Identification Idea Evaluation External sourcing Licensing / Venturing / M&A Feasibility Development Scale-up Launch Page 3 Market Growth

5 Innovation.from basic to optimal nutrition Discovery Production Formulation Safety Efficacy Marketing Genomics Extraction Emulsification Metabolism Nutrigenomics Global Organization Proteomics Biochemistry Photochemistry Chemical Synthesis Fermentation Bio- Transformation Milling Micronisation Spray drying Extrusion Granulation Mutagenicity Repro-Toxicity Carcinogencity Drug interactions In vitro proof Animal Studies Human Studies Branded Products Technical Service Application Development Regulatory Support IP Protection Sight and Life donations Relief Feeding Schemes Nutrition Improvement / Staple Food Fortification Projects Health and Wellness Personalized Nutrition Page 4

6 The Innovation Engine For new ingredients the following criteria have to be met safe history of human consumption freedom to operate potential for IP accessible scientifically sound evidence of benefit Page 5

7 How can we Health you? Page 6

8 Consumers are interested in different aspects of mental health & performance Page 7

9 Mental health & performance Segmentation Mental health & performance is important for everyone - from the very young to the very old Consumers understand that a number of very different aspects are covered by the term brain health The relative importance to the consumer of the various aspects is different -according to gender, age and lifestyle Page 8

10 Mental health & performance Cognition Optimal Mental Development (neurodevelopment, infants, toddlers, adolescents) Healthy Brain Aging (slow down mental aging / reduce degeneration,( Retaining mental sharpness as I age ) Learning & Memory Attention / Concentration / Vigilance Mental Energy Mood Motivation & creativity Mood enhancement Relief of mental fatigue Anxiety relief Relaxation / Relief of Stress symptoms Sleep Sleep (fall asleep, stay asleep, sleep quality) Page 9

11 Evolution of benefits in beverage segmentation Natural & Healthy Superfruit & Natural & Healthy Energy drink Memory Focus Relaxation Mood Energy shot Page 10 Sleep

12 Background to brain function Developing Food Derived Compounds for Health The Innovation Process May Plants 16, 2011 for Health Danish Food and Drink Federation June 15th, 2011 Kevin Prudence Innovation Project Manager

13 Balanced brain function requires balanced action of neurotransmitters Motivation Goal orientation Stimulation Pleasure Reward Wakefulness Concentration Functions & mechanisms of different neurotransmitters are interlinked & overlap and cannot be completely separated from each other Mood Happiness Sadness Anxiety Alertness Energy Fatigue Stress Page 12

14 Balanced brain function requires balanced action of neurotransmitters axon Communication of information between neurons, involves the movement of chemical neurotransmitters across the synapse The neurotransmitter exerts its effect until it is removed from the synapse by: Diffusion Degradation / Metabolism Re-uptake / re-absorbtion Slowing these processes, increases the residence time of the neurotransmitters in the synapse & so increases their effect synapse signal Page 13

15 DSM s pure compound and extract library An oregano-extract was one of those identified through research to find new ingredients from food with positive effects on cognition and mood. This oregano-extract (orévida) was found after profiling food extract libraries for in-vitro activity in assays for serotonin-re-uptake, noradrenaline-reuptake, dopamine re-uptake and monoamine-oxidase (MAO) A&B activity. Sources of food plant extracts? > 4000 pure compounds (individual phytochemicals) > 1200 food plant extracts > fractions from extracts Feb, 2011 Page 14

16 Project progress Preclinical The active components in the extract have been identified The mechanisms of action are well elucidated In vivo, the levels of the active components in the extract increase in the brain after oral administration After administration the levels of neurotransmitter are increased in the brain Pre-clinical studies in validated animal models have shown beneficial effects of the extract on behavior Safety No genotoxicity No reprotoxicity No adverse effect level has been determined in 13w toxicity trial The effective dose is safe and exhibits no adverse side effects No interference with drug metabolizing CYP enzymes orévida is well tolerated (in rodents and humans) Clinical The extract improved attention and vigilance in a first in human trial as measured by waking electroencephalograph (EEG) and Event Related Potentials (ERP) Page 15

17 The Innovation Funnel Idea Identification Idea Evaluation Feasibility Development Scale-up Launch Market Growth Page 16

18 Thank you for your attention!