Coat Color in Labrador Retrievers
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- Ami Bond
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1 Coat Color in Labrador Retrievers Sunny Cocoa Midnight
2 Metabolic Networks Introduction On your note sheet, write a definition for what you think metabolism means. HINT: my mom used to tell me when I was a kid that I had a fast metabolism so I could eat anything I wanted to and not gain weight. What did she mean?
3 Metabolism All the enzyme reactions occurring within a cell or whole organism This doesn t have to only do with food. It s how ANYTHING in your body is made, including proteins! Come up with an example of metabolism in your body and write it on your note sheet.
4 Network Review On your note sheet, write down your definition of the following words: Network an interconnected or interrelated web, group, or system. Nodes members of the network Edge the relationships between the nodes Now write an example of each and be prepared to share.
5 Compare and contrast these networks. Food Web Network Cell Phone Network
6 Compare and contrast a food web and cell phone network The nodes The edges Types and meaning of the relationships Properties of the edges Directionality of the arrows Scale of the network Boundary of network
7 Lactase Lab Lactose is composed of Galactose and Glucose glucose galactose Lactase breaks lactose into
8 Remember this? Glucose Galactose Lactase Glucose + Galactose lactase Lactose How can we represent this with nodes and edges?
9 Glucose Lactose Lactase Galactose What do the nodes represent? What do the edges represent?
10 Key Terms Metabolism: all the enzyme reactions occurring within a cell or whole organism Metabolite: any molecule produced by chemical reactions of metabolism On your note sheet, come up with examples of each.
11 Glucose Lactose Lactase Galactose Key: Metabolites Enzyme reactions
12 Key Terms Metabolic Network: an interconnected set of enzyme reactions; the output of one reaction is the input of another Nodes = metabolites Edges = enzyme reactions
13 Lactose is produced as an output of a different enzyme reaction Glucose is used as an input to a different enzyme reaction Glucose Lactose Lactase Galactose Key: Metabolites Enzyme reactions Galactose is used as an input to a different enzyme reaction
14 Metabolic network Galactose Galactose P UDP-Galactose Lactose Glucose Glycogen UDP-Glucose Glucose-6-P ATP Glucose-1-P ADP Pi Nodes are metabolites Edges are enzyme reactions
15 Metabolic pathway Galactose Galactose P UDP-Galactose Lactose Glucose Glycogen UDP-Glucose Glucose-6-P ATP Glucose-1-P ADP Pi Nodes are metabolites Edges are enzyme reactions
16 A metabolic pathway is a series of enzyme reactions connecting one metabolite to another Like a single food chain within a food web Click here for animation of metabolic pathway
17 Metabolic Network A B C D E F Nodes = metabolites Edges = enzymatic conversion
18 What if the enzyme converting metabolite B to C is missing? X A B C D E F Nodes = metabolites Edges = enzymatic conversion
19 What if the enzyme converting metabolite B to C is missing? A B X C D E F Nodes = metabolites Edges = enzymatic conversion Result: -Accumulation of B -Decrease of C, D, E, and F
20 Coat Color in Labrador Retrievers Sunny Cocoa Midnight
21 Guiding Question: How does variation exist between organisms?
22 Labrador (dog) pigmentation Tyrosine (an amino acid) tyrosinase Dopaquinone (needed to make melanin or a pigment) Yellow pigment TRP-2 (an enzyme) Brown pigment Nodes = metabolites Edges = enzymatic conversion TRP-1 (another enzyme) Black pigment Answer the questions on your notes sheet.
23 What happens if the enzyme TRP 1 is missing? Tyrosine tyrosinase Dopaquinone Yellow pigment TRP-2 Brown pigment Nodes = metabolites Edges = enzymatic conversion TRP-1 Black pigment What color is the dog s coat? Brown
24 What happens if both the enzymes TRP 1 and TRP-2 are missing? Tyrosine tyrosinase Dopaquinone Yellow pigment TRP-2 Brown pigment Nodes = metabolites Edges = enzymatic conversion TRP-1 Black pigment What color is the dog s coat? Yellow
25 Pigment Networks Practice Complete the networks practice handout. Make sure you answer all questions.
26 Pigment Metabolic Network for the Imaginary Bioflower Blue Flower Where is the variation in these flowers? Purple Flower Blue and Purple Flowers (Color)
27 Bioflowers A colorless starting molecule is converted by enzyme X to blue pigment. Next, enzyme Y converts the blue pigment to purple pigment. 1. Diagram of the pathway. (include a key) 2. Give an explanation for a blue flower. Colorless Compound Blue Pigment Purple Pigment X Y Nodes = metabolites Edges = enzymes
28 Roundbuds
29 Roundbuds In another type of wildflower, the roundbud, red pigment is synthesized from a white precursor by enzyme Q. 1. Draw the enzyme pathway for the roundbud. It was believed that all roundbuds were red until a knowledgeable, observant teenager discovered a meadow full of white-flowered roundbuds. 2. Using your knowledge of the synthesis pathway for red pigment, give an explanation for the white roundbud variety.
30 1. Enzyme Pathway White Precursor Q Red Pigment Nodes = Metabolites Edges = Enzyme
31 It was believed that all roundbuds were red until a knowledgeable, observant teenager discovered a meadow full of white-flowered roundbuds.
32 2. Using your knowledge of the synthesis pathway for red pigment, give an explanation for the white roundbud variety. White Precusor Q Red Pigment Nodes = Metabolites Edges = Enzyme
33 Labrador retriever Images provided by:
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