Yosten, G.L.C., and Samson, W.K. (2013) Cardiovascular and antidiposgenic effects of nesfatin-1. Review. Current Pharmaceutical Design, Accepted.

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1 Gina L. C. Yosten, Ph.D. Department of Pharmacological and Physiological Science Saint Louis University School of Medicine 1402 S. Grand Blvd, Saint Louis, Missouri Office: (314) ; Cell: (314) EDUCATION AND POSITIONS : Bachelor of Science in Zoology/Biomedical Sciences University of Oklahoma, Norman, Oklahoma Summa cum laude, with Distinction : Doctor of Philosophy in Pharmacological and Physiological Science Saint Louis University, Saint Louis, Missouri : Postdoctoral fellow in Pharmacological and Physiological Science Saint Louis University, Saint Louis, Missouri 2012-present:Research Assistant Professor in Pharmacological and Physiological Sci!! Saint Louis University, Saint Louis, Missouri PUBLICATIONS PEER-REVIEWED PUBLICATIONS Yosten G.L.C., and Samson W.K. (2013) Separating thirst from hunger. In: DeLuca L, Johnson AK, Menani JV, eds. Neurobiology of Body Fluid Homeostasis. Boca Raton, Taylor & Francis, in press Yosten, G.L.C., and Samson, W.K. (2013) Cardiovascular and antidiposgenic effects of nesfatin-1. Review. Current Pharmaceutical Design, Accepted. Yosten, G.L.C., Lyu, R.M., Hsueh, A.J., Chang, J.K., Tullock, C.W., Dun, S.L., Dun, N., and Samson, W.K. (2012) A novel reproductive peptide, phoenixin. Journal of Neuroendocrinology, Published Online 11 Sept 2012, PMID: Yosten, G.L.C., Redlinger, L.J., and Samson, W.K. (2012) Evidence for an interaction of neuronostatin with the orphan G protein coupled receptor GPR107. American Journal of Physiology, Published Online 29 Aug 2012, PMID: Yosten, G.L.C., Redlinger, L.J., and Samson, W.K. (2012) Evidence for a Role of Endogenous Nesfatin-1 in the Control of Water Drinking. Journal of Neuroendocrinology, 24(7): Yosten, G.L.C., and Samson, W.K. (2012) Pressor doses of vasopressin result in only transient elevations in plasma peptide levels. Peptides, 33(2):

2 Yosten, G.L.C., Pate, A.T., and Samson, W.K. (2011) Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors. American Journal of Physiology, 300(5):R Yosten, G.L.C., and Samson, W.K. (2010) The melanocortins, not oxytocin, mediate the anorexigenic and antidispsogenic effects of neuronostatin. Peptides, 31(9): Yosten, G.L.C., and Samson, W.K. (2010) The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist. American Journal of Physiology, 298(6):R Yosten, G.L.C., and Samson, W.K. (2009) Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. American Journal of Physiology, 297(2):R Samson, W.K., Zhang, J.V., Avsian-Kretchmer, O., Cui, K., Yosten, G.L.C., Klein, C., Lyu, R., Wang, Y.X., Chen, X.Q., Yang, J., Price C.J., Hoyda, T.D., Ferguson, A.V., Yuan, X., Chang, J.K., Hsueh, A.J.W. (2008) Neuronostatin encoded by the somatostatin gene induces c-fos in brain/gut tissues and regulates neuronal and metabolic functions. Journal of Biological Chemistry, 283(46): Samson, W.K., Yosten, G. L. C., Chang, J.K., Ferguson, A.V., and White, M.M. (2008) Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis. Journal of Endocrinology, 196(3): Berkowitz, A., Yosten, G.L.C., and Ballard, R.M. (2006) Soma-dendritic morphology predicts physiology for neurons that contribute to several kinds of limb movements. Journal of Neurophysiology, 95(5): PUBLICATIONS IN REVIEW OR PREPARATION Yosten, G.L.C., and Samson, W.K. (2012) Nesfatin-1 activates CRH neurons to elevate mean arterial pressure: evidence for a central POMC-CRH-OT circuit in the control of cardiovascular function. In preparation. Kolar, G.R., Redlinger, L.J, and Yosten, G.L.C. (2012) Identification of a potential receptor for proinsulin C-peptide. In preparation. Kolar, G.R., Redlinger, L.J., and Yosten, G.L.C. (2012) Orphan GPCR expression in human cell lines: A rapid method for the detection of all known orphan receptors in human tissues. In preparation. Salvatori, A.S., Yosten, G.L.C., Corbett, J.A., and Samson, W.K. (2012) Neuronostatin acts on pancreatic alpha cells to modulate glucose homeostasis. In preparation. 2

3 BOOK CHAPTERS Gina L. C. Yosten and Willis K. Samson Cardiovascular Neuroendocrinology Handbook of Neuroendocrinology, 2011 Editors: George Fink, Donald Pfaff, and Jon Levine Gina L. C. Yosten Novel Neuropeptides in the Control of Food Intake: Neuronostatin and Nesfatin-1 Vitamins and Hormones: Anorexia Editor: Gerry Litwack ABSTRACTS Yosten, G.L.C., and Samson, W.K. (2012) Evidence for GPR107 as a cognate receptor for neuronostatin. FASEB Journal, 26: Elrick, M., Yosten, G.L.C., and Samson, W.K. (2012) Characterization of a neuronostatin receptor in a human kidney cell line. FASEB Journal, 26: Bryant, C.W., Yosten, G.L.C., and Samson, W.K. (2012) Cospeptin, a novel reproductive hormone. FASEB Journal, 26: Yosten, G.L.C., and Samson, W.K. (2012) Nesfatin-1 acts through a central POMC- CRH-OT circuit to increase mean arterial pressure. FASEB Journal, 26: Yosten, G.L.C., and Samson, W.K. (2011) Nesfatin-1 acts in brain to regulate water intake. FASEB Journal, 25: Yosten, G.L.C., and Samson, W.K. (2011) Neuronostatin acts through the central melanocortin system to increase vasopressin secretion. FASEB Journal, 25: Yosten, G.L.C., and Samson, W.K. (2011) Evidence of a physiologic role for neuronostatin in baroreflex function. FASEB Journal, 25: Yosten, G.L.C., and Samson, W.K. (2010) The central oxytocin system mediates the actions of nesfatin-1. FASEB Journal, 24: Samson, W.K., Yosten, G.L.C., and Ferguson, A.V. (2010) Nesfatin-1 stimulates stress hormone secretion. FASEB Journal, 24:lb621. Miller, G., Salvatori, A.S., Yosten, G.L.C., and Samson, W.K. (2010) Linking a newly discovered hormone with orphan candidates: the search for a cognate ligand. FASEB Journal, 24: Yosten, G.L.C., and Samson, W.K. (2009) The central autonomic and metabolic actions of neuronostatin. Keystone Symposia on Obesity, 20:222. 3

4 Yosten, G.L.C., and Samson, W.K. (2009) Is the central melanocortin system involved in mediating the actions of neuronostatin? FASEB Journal, 23: Yosten, G.L.C., and Samson, W.K. (2008) The effects of nesfatin-1, an anorexigenic peptide, on blood pressure and lights out activity. FASEB Journal, 22:1144, Berkowitz, A., Yosten, G.L.C., and Ballard, R.M. (2005) Correlations between morphology and in-vivo physiology of scratch-activated spinal interneurons. Society of Neuroscience Abstracts, Berkowitz, A., Yosten, G.L.C., and Ballard, R.M. (2004) A distinct morphological class of rhythmic, scratch-related, spinal interneurons in turtles. The 7th Congress of the International Society for Neuroethology, Nyborg, Denmark, PO 226. EDITORIAL COMMENTARIES (Selected) Yosten GLC and Samson WK: Faculty of 1000 Biology, 23 Feb F1000.com/ #eval Yosten GLC and Samson WK: Faculty of 1000 Biology, 20 Sep F1000.com/ Yosten GLC and Samson WK: Faculty of 1000 Biology, 09 Jun F1000.com/ Yosten GLC and Samson WK: Faculty of 1000 Biology, 11 Jan HONORS AND AWARDS 2001 Jane A. Quade Scholarship in Zoology (Univ of Oklahoma) 2002 Rita Lottinville Prize for Community Service and Scholarship (Univ of Oklahoma) 2003 Golden Key International Honor Society, New Member Award (Univ of Oklahoma) 2004 Phi Beta Kappa 2009 University of Missouri Cardiovascular Day Award Winner (Second Place) 2009 APS Endocrinology and Metabolism Research Recognition Award 2010 Finalist, The Endocrine Society Presidential Poster Competition 2011 APS Mead Johnson Award in Endocrinology and Metabolism 2011 Glenn I. Hatton Award (World Congress on Neurohypophyseal Hormones) 2011 ADVANCE Future Faculty Workshop Selectee (NSF Sponsored Program) 2011 Gender Disparities in Cardiovascular Disease Travel Award (APS) 2012 APS Endocrinology and Metabolism Virendra B. Mahesh Award of Excellence in! Endocrinology 2012 MARC Travel Award to attend the 2012 NIGMS Postdoc Workshop at the NIH 2012 University of Missouri Cardiovascular Day Poster Competition (First Place) 2012 Endocrine Society Outstanding Abstract Award 4

5 PROFESSIONAL AFFILIATIONS AND ACTIVITIES SOCIETAL MEMBERSHIPS American Physiological Society American Heart Association Endocrine Society Faculty of 1000, Contributing Faculty Member Phi Beta Kappa Honor Society Golden Key International Honor Society SOCIETAL COMMITTEES 2010-present American Physiological Society Science Policy Committee 2012-present American Physiological Society Joint Program Committee 2012-present FASEB Training Subcommittee EDITORIAL BOARD International Journal of Clinical Pharmacology and Toxicology PRIMARY REVIEWER ACTIVITY American Journal of Physiology Endocrinology Journal of Neuroendocrinology Peptides Regulatory Peptides Neuroscience Letters BioFactors Psychoneuroendocrinology Progress in Neuro-Psychopharmacology & Biological Psychiatry Cellular Physiology and Biochemistry TEACHING EXPERIENCE 2008 Special Topics in Biomedical Science (first year graduate students) 2010 Advanced Topics in Pharmacological and Physiological Science (second year! graduate students) 2010 Basic Biomedical Science, Endocrinology Section (first year graduate students) 2011 Special Topics in Biomedical Science 2011 Basic Biomedical Science, Endocrinology Section 2012 Basic Biomedical Science, Endocrinology Section 2012 Special Topics in Biomedical Science 2012 Obesity Lecture, Endocrine Module (second year medical students) 2012! Reproductive Physiology at University of Medicine and Health Sciences-St. Kitts 5

6 INVITED PRESENTATIONS 2009 Latin American Initiative Physiology Symposium in Ribeirao Preto, Brazil! Neuropeptides at the Intersection of Appetite and Cardiovascular Function 2010 Physiology Symposia in Ribeirao Preto and Araraquara, Brazil! Oxytocinergic and Non-oxytocinergic Mechanisms of Melanocortin Signaling 2011 Latin American Initiative Symposia in Cordoba, Argentina! Leaving the Gene Intact, Compromising RNA translation! and! Identifying Novel Neuropeptides: Bioinformatic Discovery and Validation 2012 Physiology Symposia in Ribeirao Preto, Brazil! Bioinformatics-Based Discovery: Matching Ligands with Orphan Receptors FUNDING (PENDING) American Heart Association, Scientist Development Grant National Affiliate The role of adipokines in the central control of cardiovascular function National Institutes of Health, NIH Director s New Innovator Award (DP2) Matching Ligands and Orphan Receptors: Implications for Diabetes National Institutes of Health, R01 From Deorphanization to Physiology: GPR107 and Central Autonomic Function Washington University Institute of Clinical and Translational Sciences, Starter Grant Orphan G Protein Coupled Receptors as Molecular Markers of Glial Cell Tumors INTELLECTUAL PROPERTY AND PATENTS Title: Systems and Methods for Determining a C-Peptide Receptor, C-Peptide Receptor, and Methods of Using Same Submission Date: September 4, 2012 Provisional Patent Application 6

DEGREE (if applicable) State University of Paraiba, Brazil Bachelor 1993 Physical Therapist

DEGREE (if applicable) State University of Paraiba, Brazil Bachelor 1993 Physical Therapist BIOGRAPHICAL SKETCH NAME Jussara Marcia do Carmo era COMMONS USER NAME jdocarmo EDUCATION/TRAINING INSTITUTION AND LOCATION POSITION TITLE Associate Professor DEGREE (if applicable) YEAR(s) FIELD OF STUDY