(NRL) Nutraceuticals ResearchLab

Transcription

1 (NRL)

2 Nutraceuticals Immunostimulating Chemopreventive Performance Anti-oxidative FOODS Edible Cosmetics Skin aging prevention Skin whitening DRUGS COSMETICS Cosmeceuticals Anti-wrinkle Skin whitening UV-protection

3 concept multi-disciplinary approach concept multi-disciplinary approach

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5 (1) The food industry has the opportunity to improve the health and well-being of its customers and/or to reduce their risk of disease through foods with added activities. (2) Functional foods are those that can be demonstrated to benefit target functions in the body in a way that improves the state of health and/or reduces the risk of disease. They are foods that are consumed as part of a normal diet rather than pills or supplements. (3) Foods based on functionality will need to link the scientific basis of such a functionality to the communication of its benefit to the general public. (4) Both the efficacy and the safety of the food components with health benefits will require evidence based on the measurement of scientific biomarkers relevant to their biological responses and health end points. (5) Sound evidence from human studies based on intermediate health end points using accepted biomarkers will provide the basis for promotional messages divided into two categories enhanced function and reduced risk of disease. (6) Success in solving key scientific and technological challenges will only be achieved by interdisciplinary research programs to exploit the scientific concepts in functional-food science.

6 Functional Foods Physiological Functions beyond Nutritional Functions

7 Efficacy Safety - Clinical studies - Epidemiological studies - Animal studies - In vitro studies - Toxicity tests - Food & drug interactions - Clinical studies - Epidemiological studies Consumer Communication Industrial Success

8 FDA Health Claims with Significant Scientific Agreement (SSA) Calcium & Osteoporosis Dietary Lipids (Fat) & Cancer Dietary Saturated Fat & Cholesterol and Risk of Coronary Heart Disease Dietary Non-carcinogenic Carbohydrate Sweeteners & Dental Caries Fiber-containing Grain Products, Fruits & Vegetables and Cancer Folic Acid & Neural Tube Defects Fruits and Vegetables & Cancer Fruits, Vegetables and Grain Products that contain Fiber, particularly Soluble fiber, & Risk of Coronary Heart Disease Sodium & Hypertension Soluble Fiber from Certain Foods & Risk of Coronary Heart Disease Soy Protein & Risk of Coronary Heart Disease Stanols/Sterols & Risk of Coronary Heart Disease

9 FDA Qualified Health Claim Selenium & Cancer Antioxidant Vitamins & Cancer Nuts & Heart Disease Walnuts & Heart Disease Omega-3 Fatty Acids & Coronary Heart Disease B Vitamins & Vascular Disease Phosphatidylserine & Cognitive Dysfunction and Dementia 0.8 mg Folic Acid & Neural Tube Birth Defects - Suggestive, but not Conclusive -

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11 Marketing of Functional Foods Death Marketing Focus on disease and health risk Ex) Novatis : Avica (1999) Life Marketing Focus on well-being and healthy life style Ex) General Mills : Whole grains Nutritionally Positive Foods

12 Traditional Food Additives - Added to foods due to thin nutritional value or technical functionality - e.g. acidulants, antioxidants, flavorings, stabilizers, etc Functional Food Ingredients - Added to foods produce an intended health-related effect on the consumer - e.g. flavonoids, phytosterol, peptide, dietary fiber, etc

13 Conventional, synthetic or extracted single components ingredients Plant extracts or complex mixture containing the ingredients Products derived from novel source or processes e.g. products of fermentation or biotechnology

14 Acidulants Sweeners Antioxidants Colorants Flavorings Stabilizers Emulsifiers Preservatives Food Additive (Food Function) Functional Ingredients (Physiological Efficacy) Flavonoids Phytosterols Phytoestrogens Saponins Oligosaccharides Dietary Fibers Non-starch polysaccharides Natural pigments Antioxidants

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16 & Green tea extract Ginseng extract (saponin) (sphingolipid, )

17 (Specific) (Bulky) Nutraceuticals Dietary supplements Phytomedicine Food ingridients ex) ex),,, ex) ginseng extract, green tea extract, xylitol, fiber, chitosan, calcium, etc

18 Materials Synthetics Products Drugs Examples Vaccine Anticancer Antivirus Phytochemicals (Purified) GM Foods Phytomedicines Medicinal Foods Mistletoe Tomato Vaccine Functional Ingredients Phytochemicals (Extract) Dietary Supplements Nutraceuticals Functional Foods Vitamins / Minerals Soy Isoflavones Whole Grains Food Materials Food Ingredients Foods Cereals, Juices

19 Phytochemicals Major Source Vegetable Fruits Herbs Seaweeds Allium vegetable (garlic, onions, chives, leeks) Cruciferous vegetables (broccoli, cauliflower, cabbage, Brussels sprouts, kale, turnips, bok choy, kohlrabi) Solanaceous vegetable (tomatoes, peppers) Umbelliferous vegetable (carrots, celery, cilantro, persley, parnips) Compositae plants (artichoke) Citrus fruits (oranges, lemons, grapefruit) Glucarates Other fruits (grapes, berries, cherries, apples, cantaloupe, watermelon, pomegranate) Beans, grains, seeds (soybeans, oats, barley, brown, rice, whole wheat, flax seed) Herbs, spices (ginger, mint, rosermary, thyme, oregano, Sage, basil, tmneric, caraway, fennel) Licorice root Green tea Food Alkyl sulfides Indoles/glucosinolates Sulfaforaphane Isothiocyanates/thiocyanates Thiols Lycopene Carotenoids Phthalides Polyacetylenes Silymarin Monoterpenes (limonene) Carotenoids Ellagic acid Phenols Flavonoids (quercetin) Flavonoids (isoflavones) Phytic acid Saponins Gingerols, Curcumin Flavonoids Monoterpenes (limonene) Glycyrrhizin Catechins Phytochemical(s)

20 Perspectives in Phytochemicals Hope New scientific findings of phytochemical efficacy for human biomarkers Bioactive materials for target-based functional food design by nutrigenomics Practical application of plant genomics for secondary metabolite control Diverse use in foods, cosmetics, drugs & household products Consumer preference for herb-in-food concept and related products Hype Inappropriate approach for synergistic effect using the extract Low possibility to find new compound or novel lending compounds Keen competition in international phytochemical business

21 Economically important phamaceuticals derived from plant, and projected 2002 worldwide sales plant-derived drugs Ref: Trend in Biotechnology 20(1), 2002

22 The gastrointestinal system - balanced intestinal flora and function as well as reduction of risk of colorectal cancer Defense against reactive oxidative species and oxidative damage The cardiovascular system - hypertension, heart function, serum lipoprotein levels, thrombosis, immune processes Substrate metabolism - obesity, insulin resistance syndrome and diabetes, osteoporosis Development, growth and differentiation Behavioral and psychological functions - mood state, cognitive performance

23 Re-finding of Physiological Values for Conventional Foods - Whole grain cereals - Grape juice: Resveratrol - Soy: Isoflavon Addition or Modification of Functional Ingredients in Foods - Flavonoids, Carotenoids, Allyl sulfur, Dietary fiber, et al. - Enzymatic modification or microbial biotrasfomation Removal of Harmful Components from Foods - Allergens - Toxic compounds - GMO

24 NRL Rice Phytic acid Polyphenol COOH HO Ferulic acid OCH 3 Phytosterol HO Tocotrienol β-sitosterol γ-oryzanol Nutraceuticals Research Lab Arabinoxylan Tocopherol

25 Rice Rice Bran Brown Rice White Rice Cosmeceuticals Dietary Supplements Functional Foods Foods (Arabinoxylan)

26 Ref: Surh, Y.-J. (2003) Nature Reviews

27 Lycopene's anti-cancer effect appears stronger when not acting alone CHAMPAIGN, Ill. New research suggests that lycopene a carotenoid in tomatoes that has been linked to a lowered risk of prostate cancer does not act alone. Scientists at the University of Illinois at Urbana- Champaign and Ohio State University say that lycopene's punch is stronger in combination with other phytochemicals in the fruit. Prof. John W. Erdman Jr. J Natl Cancer Inst Nov 5;95(21): Lycopene Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)- testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW Jr, Clinton SK.

28 Whole Grain Based Functional Foods Integrated approach (University, Government & Industry) Epidemiology & Clinical efficacy Health claims for disease prevention Public health & Consumer communication Industrial success : Global

29 In July 1999, the Food and Drug Administration (FDA) permitted the following health claim that allows qualifying products to promote the potential risk reduction for heart disease and some cancers: Diets rich in whole grain foods and other plant foods and low in total fat, saturated fat, and cholesterol may reduce the risk of heart disease and some cancers. A food manufacturer can choose to include the whole grain health claim on a food package if the product: Contains all portions of the grain kernel Contains 51% whole grain ingredient(s) or more by weight per reference amount customarily consumed Is low in fat, saturated fat, and cholesterol Meets the general requirements for health claims. This is the first authorized health claim that specifies whole grains foods in the fight against both chronic diseases in a single health claim. More than 50 scientific studies support the link between a diet rich in whole grain and the reduced risk of heart disease

30 Nutraceuticals Research Lab What is a Cosmeceuticals? ( ) Cosmetic + Pharmaceuticals => => Cosmeceuticals Anti-wrinkle, skin whitening, sunscreen, suntan,, acne etc Albert Kligman 1993 AHA(Alpha Hydroxy Acid) ( )

31 Nutraceuticals Research Lab (Cosmeceuticals) (Cosmeceuticals)

32 Nutraceuticals Research Lab : Skin whitening : Anti-wrinkle Suntan & Sunscreen :

33 Nutraceuticals Research Lab : 1,087 $(2000 ) : [ ]31,050 +[ ]16,000 =47,050 (2000 ) 4.5%, 10% - : 16%( ), 20%(2005 ) - : 22%( ), 30%(2005 ) (Datamonitor Analysis) ( )

34 Phytochemicals Nutraceuticals Research Lab from vitamins, herbs, various oils and botanical extracts may be used in Cosmeceuticals.

35 Nutrition & Sensory (General Foods) Physiological Efficacy (Functional Foods & Nutraceuticals) Nutrigenomics (Designer & Medicinal Foods) 1st generation (<2000) 2nd generation (2000~2010) 3rd generation (>2010) We are same We are not same, or We want the difference

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37 Taste Health Beauty Sensory Nutraceuticals Cosmeceuticals Nutrigenomics Customized Functional Foods

38 platform technology interface core technology

39 PHYTOCHEMICALS BIOTECH Screening & Bioassay Bioavailability Clinical evidence PROCESSING Material Technology Platform Technology Biomarkers Nutrient-gene interations NANOTECH High separation Fermentation Biofood design Nutrients delivery System(NDS) Nano particle control

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